Journey information
Overview: Greenville, SC to Chicago, IL flight
Flights from Greenville, SC to Chicago, IL depart on average 27 times per day, taking around 4h 4m. Cheap flight tickets for this journey start at $336 (€268) but you can travel from only $126 (€101) by bus.
There are 1 flights per day. The earliest flight runs at 00:02, the last at 23:55. The fastest flight covers the 561 miles (903 km) distance in 2h 24m. February is the cheapest month to fly.
Distance 561 miles (903 km) |
Average flight duration 4h 4m |
Cheapest ticket price $336 (€268) |
Flights per day 27 |
Direct flights 1 |
Fastest flight 2h 24m |
Cheapest month February |
First flight 00:02 |
Last flight 23:55 |
Travel Information
Compare bus, train, and flight for Greenville, SC to Chicago, IL
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from $126. For those with little time consider booking a flight which can get you there in 4h 4m. The ticket price range depends on the travel mode: a bus costs an average of $126, and a flight costs an average of $336.
Distance: 561 miles (903 km)
Compare flight with
| Flight | Most popular Bus | Train |
|---|---|---|
$451 Average price | $146 Average price Cheapest | $245 Average price |
7h 4m Average total duration Fastest 4h 4m Onboard + 3h 0m Additional time* | 19h 10m Average total duration 18h 40m Onboard + 30m Additional time* | 32h 30m Average total duration 32h 0m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Greenville, SC to Chicago, IL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Greenville, SC to Chicago, IL Flight
Find answers to the most common questions about traveling from Greenville, SC to Chicago, IL by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Chicago Air and Water Show, an exhilarating display of military and civilian aircraft performing daring maneuvers over Lake Michigan
- Lollapalooza, a massive music festival featuring top artists across multiple genres in Grant Park
- Chicago Gourmet, a premier culinary event celebrating the city's vibrant food scene with tastings, cooking demonstrations, and wine pairings.
- Memorial Day, the unofficial start of summer with vibrant outdoor activities and events
- Independence Day, spectacular fireworks and festive celebrations throughout the city
- Labor Day, a lively atmosphere with various festivals and pleasant weather.
popular airports
Popular airports from Greenville, SC to Chicago, IL
- Free Wi-Fi available throughout the airport.
- Shops are located in all terminals, including duty-free and brands like Hudson and MAC Cosmetics.
- Parking available with options including hourly, daily, and economy lots, approximately 2.85€ ($3) per hour.
- Restaurants are located in all terminals, offering a variety of cuisines including American and intertiol. Top options include Tortas Frontera and Publican Tavern.
- Available outside the terminal.
- Elevators, ramps, toilets
- Available throughout the airport.
- Hotels such as Hilton Chicago O'Hare are located on airport grounds, with others like the Hyatt Regency nearby.
- Showers are available in some lounges, such as the United Club, but access may require a fee or membership.
- Lounges available, including United Club and American Airlines Admirals Club.
- Lost and Found located in terminal 1, near the baggage claim area.
- Car rental services are available at the Multi-Modal Facility, with companies like Hertz and Avis.
- CTA Blue Line, O'Hare Station, 45 minutes to city center
Most popular flights from Greenville, SC
More options for your journey from Greenville, SC to Chicago, IL
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