Journey information
Overview: Greenville, SC to Chicago, IL flight
Flights from Greenville, SC to Chicago, IL depart on average 5 times per day, taking around 5h 57m. Cheap flight tickets for this journey start at $179 (€145) but you can travel from only $94 (€76) by bus.
There are 1 flights per day. The earliest flight runs at 05:00, the last at 21:15. The fastest flight covers the 561 miles (903 km) distance in 3h 51m. January is the cheapest month to fly.
Distance 561 miles (903 km) |
Average flight duration 5h 57m |
Cheapest ticket price $179 (€145) |
Flights per day 5 |
Direct flights 1 |
Fastest flight 3h 51m |
Cheapest month to travel January |
First flight 05:00 |
Last flight 21:15 |
The cheapest and fastest flights from Greenville, SC to Chicago, IL
Cheapest price
$406
Average price
$406
Fastest journey
6 h 20 m
Average duration
6 h 20 m
Flights per day
1
Distance
903 km
The best way to find a cheap flight ticket from Greenville, SC to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Chicago, IL will cost around $406 if you buy it on the day, but the cheapest tickets can be found for only $406.
Of the 1 flights that leave Greenville, SC for Chicago, IL onFri, Nov 28, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Nov 28 the direct flights cover the 903 km distance in an average of 6 h 20 m but if you time it right, some flights will get you there in just 6 h 20 m .
On Fri, Nov 28 the longest flights will take 6 h 20 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for Greenville, SC to Chicago, IL
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from €76. For those with little time consider booking a flight which can get you there in 5h 57m. The ticket price range depends on the travel mode: a bus costs an average of €76, and a train costs an average of €176.
Distance: 561 miles (903 km)
Compare flight with
| Flight | Most popular Bus | Train |
|---|---|---|
€242 Average price | €123 Average price Cheapest | €302 Average price |
8h 57m Average total duration Fastest 5h 57m Onboard + 3h 0m Additional time* | 21h 30m Average total duration 21h 0m Onboard + 30m Additional time* | 32h 17m Average total duration 31h 47m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Greenville, SC to Chicago, IL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 28
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FAQs: Greenville, SC to Chicago, IL Flight
Find answers to the most common questions about traveling from Greenville, SC to Chicago, IL by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Chicago Air and Water Show, an exhilarating display of military and civilian aircraft performing daring maneuvers over Lake Michigan
- Lollapalooza, a massive music festival featuring top artists across multiple genres in Grant Park
- Chicago Gourmet, a premier culinary event celebrating the city's vibrant food scene with tastings, cooking demonstrations, and wine pairings.
- Memorial Day, the unofficial start of summer with vibrant outdoor activities and events
- Independence Day, spectacular fireworks and festive celebrations throughout the city
- Labor Day, a lively atmosphere with various festivals and pleasant weather.
Typically, passengers are allowed one carry-on bag and one personal item (for example a purse, laptop bag, or backpack). Personal items must fit under the seat in front of you.
Budget Airlines (like Ryanair or Wizz Air) have stricter size and weight limits, often requiring fees for larger carry-ons. Full-Service Airlines have more lenient policies, sometimes including more spacious dimensions or higher weight limits depending on your ticket class.
popular airports
Popular airports from Greenville, SC to Chicago, IL
- Free Wi-Fi available throughout the airport.
- Shops are located in all terminals, including duty-free and brands like Hudson and MAC Cosmetics.
- Parking available with options including hourly, daily, and economy lots, approximately 2.85€ ($3) per hour.
- Restaurants are located in all terminals, offering a variety of cuisines including American and intertiol. Top options include Tortas Frontera and Publican Tavern.
- Available outside the terminal.
- Elevators, ramps, toilets
- Available throughout the airport.
- Hotels such as Hilton Chicago O'Hare are located on airport grounds, with others like the Hyatt Regency nearby.
- Showers are available in some lounges, such as the United Club, but access may require a fee or membership.
- Lounges available, including United Club and American Airlines Admirals Club.
- Lost and Found located in terminal 1, near the baggage claim area.
- Car rental services are available at the Multi-Modal Facility, with companies like Hertz and Avis.
- CTA Blue Line, O'Hare Station, 45 minutes to city center
Most popular flights from Greenville, SC
More options for your journey from Greenville, SC to Chicago, IL
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