Travel Information
Compare bus and train for Karlsruhe to Brussels
Omio recommends booking the train as it is the most popular option from Karlsruhe to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $21. For those with little time consider booking a train which can get you there in 3h 36m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.3kg. The ticket price range depends on the travel mode: a bus costs an average of $21, and a train costs an average of $44.
Distance: 219 miles (354 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
$114 Average price | $42 Average price Cheapest | $71 Average price (fuel + tolls) |
4h 6m Average total duration Fastest 3h 36m Onboard + 30m Additional time* | 7h 55m Average total duration 7h 25m Onboard + 30m Additional time* | 5h 30m Average total duration (door-to-door) |
0.1 - 0.3kg CO2 emissions Lowest | 0.4 - 0.9kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Brussels:
A bus is $72 (€72) less than a train for this route with tickets for a train from Karlsruhe to Brussels costing on average $114 (€114).
Other travel options to Brussels take longer:
Bus takes on average 7h 25m.
Travel optionsfrom Karlsruhe to Brussels
How to get from Karlsruhe to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Karlsruhe to Brussels is by taking a bus because it’s the best combination of price and speed.
30493 · 473912:25 AM8h15Karlsruhe, Hinterm Hauptbahnhof (Südeingang)8:40 AMBrussels, Brussels South (Gare du Midi)$501One-way1 transfer
Cheapest
30493 · 473912:25 AM8h15Karlsruhe, Hinterm Hauptbahnhof (Südeingang)8:40 AMBrussels, Brussels South (Gare du Midi)$501One-way1 transfer
Fastest
ICE 204 · ICE 3166:59 AM4h36Karlsruhe Hbf11:35 AMBrussels-Midi$881One-way1 transfer
Other options
IC 60402 · ICE 181:24 AM8h11Karlsruhe Hbf9:35 AMBrussels-Midi$571One-way1 transfer
S6 · 4550 · ICE 183:25 AM6h10Karlsruhe Hbf9:35 AMBrussels-Midi$811One-way2 transfers
ICE 2594 · ICE 9558 · Bus 82117 · IC 21335:59 AM7h29Karlsruhe Hbf1:28 PMBrussels-Midi$931One-way3 transfers
FlixBus · FlixBus3:15 AM10h40Karlsruhe Hbf1:55 PMBrussels, Brussels South (Gare du Midi)$571One-way1 transfer
FlixBus · FlixBus4:35 PM10h50Karlsruhe Hbf3:25 AMBrussels, Brussels South (Gare du Midi)$591One-way1 transfer
51510 · 47439:05 PM7h50Karlsruhe, Hinterm Hauptbahnhof (Südeingang)4:55 AMBrussels, Brussels South (Gare du Midi)$701One-way1 transfer
ICE 204+
SN26126:59 AM6h41Karlsruhe Hbf1:40 PMBrussels Airport$3671One-way1 transfer
ICE 76 · ICE 1014+
SN26126:37 AM7h03Karlsruhe Hbf1:40 PMBrussels Airport$3671One-way2 transfers
ICE 204+
SN26146:59 AM10h31Karlsruhe Hbf5:30 PMBrussels Airport$3671One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Karlsruhe to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Karlsruhe to Brussels.

This is compared to other travel options from Karlsruhe to Brussels:
A bus is $72 (€72) less than a train for this route with tickets for a train from Karlsruhe to Brussels costing on average $114 (€114).
Other travel options to Brussels take longer:
Bus takes on average 7h 25m.
- Around 5 trains per day.
- Around 4 buses per day.
However, we recommend checking specific travel dates for your route between Karlsruhe and Brussels as scheduled services by bus and train can vary by season or day of the week.
- Buses mostly depart from Karlsruhe Hbf and arrive in Brussels, Brussels South (Gare du Midi).
- Trains mostly depart from Karlsruhe Hbf and arrive in Brussels-Midi.
- Travel with FlixBus, BlaBlaCar Bus, BlaBlaCar, Union Ivkoni International to go to Brussels by bus.
- Travel with Deutsche Bahn, Deutsche Bahn Intercity (DB IC), Deutsche Bahn Regio (DB Regional) to go to Brussels by train.
- 1 direct buses per day with FlixBus, BlaBlaCar.
Travelling from Karlsruhe to Brussels: related information
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