Travel Information
Compare train and bus for Karlsruhe to Brussels
Omio recommends booking the train as it is the most popular option from Karlsruhe to Brussels among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $49 For those with little time, consider booking a train, which has an average total journey time of 4h 5m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.3kg. Average ticket prices depend on the travel mode: a bus costs an average of $49, while a train costs an average of $120.
Distance: 219 miles (354 km)
Compare train with
Most popular Train | Bus |
|---|---|
$120 Average price | $49 Average price Cheapest |
4h 5m Average total duration Fastest 3h 35m Onboard + 30m Additional time* | 7h 13m Average total duration 6h 43m Onboard + 30m Additional time* |
0.1 - 0.3kg CO2 emissions Lowest | 0.4 - 0.9kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Karlsruhe to Brussels
How to get from Karlsruhe to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Karlsruhe to Brussels is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus3:15 AM10h40Karlsruhe Hbf1:55 PMBrussels, Brussels South (Gare du Midi)$261One-way1 transfer
Cheapest
FlixBus · FlixBus3:15 AM10h40Karlsruhe Hbf1:55 PMBrussels, Brussels South (Gare du Midi)$261One-way1 transfer
Fastest
ICE 202 · ICE 168:59 AM4h36Karlsruhe1:35 PMBrussels-Midi$1811One-way1 transfer
Other options
ICE 372 · IC 2045 · ICE 1411:59 AM5h36Karlsruhe5:35 PMBrussels-Midi$1411One-way2 transfers
ICE 372 · ICE 610 · ICE 310 · IC 363711:59 AM4h49Karlsruhe4:48 PMBrussels-Midi$1481One-way3 transfers
ICE 376 · IC 2049 · ICE 167:59 AM5h36Karlsruhe1:35 PMBrussels-Midi$1561One-way2 transfers
30493 · 146612:25 AM13h05Karlsruhe, Hinterm Hauptbahnhof (Südeingang)1:30 PMBrussels, Brussels South (Gare du Midi)$541One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sep 07
Sep 08
Sep 09
Sep 10
Sep 11
Sep 12
Sep 13
Sep 14
Sep 15
Sep 16
Sep 17
Sep 18
Sep 19
Sep 20
More than 1,000 travel companies trust us to sell their tickets all in one place.
FAQs: Travel from Karlsruhe to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Karlsruhe to Brussels.

This is compared to other travel options from Karlsruhe to Brussels:
A bus is $71 (€57) less than a train for this route with tickets for a train from Karlsruhe to Brussels costing on average $120 (€97).
Other travel options to Brussels take longer:
Bus takes on average 7h 13m.
- Around 5 trains per day.
- Around 3 buses per day.
However, we recommend checking specific travel dates for your route between Karlsruhe and Brussels as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Karlsruhe Hbf and arrive in Brussels-Midi.
- Buses mostly depart from Karlsruhe Hbf and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with FlixBus, BlaBlaCar Bus, BlaBlaCar to go to Brussels by bus.
- Travel with Deutsche Bahn, Deutsche Bahn Intercity (DB IC), Deutsche Bahn Regio (DB Regional) to go to Brussels by train.
- 1 direct buses per day with FlixBus, BlaBlaCar.
Travelling from Karlsruhe to Brussels: related information
Here are some other resources that might have the information you need
