Travel Information
Compare train and bus for Karlsruhe to Rome
Omio recommends booking the bus as it is the most popular option from Karlsruhe to Rome among Omio's users. If you are prioritising price, take the train, with an average ticket price of $34 For those with little time, consider booking a flight, which has an average total journey time of 5h 47m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.9 - 2.1kg. Average ticket prices depend on the travel mode: a train costs an average of $34, while a flight costs an average of $141.
Distance: 529 miles (852 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$115 Average price | $34 Average price Cheapest | $141 Average price | $330 Average price (fuel + tolls) |
17h 42m Average total duration 17h 12m Onboard + 30m Additional time* | 9h 49m Average total duration 9h 19m Onboard + 30m Additional time* | 5h 47m Average total duration Fastest 3h 47m Onboard + 2h 0m Additional time* | 12h 4m Average total duration (door-to-door) |
0.9 - 2.1kg CO2 emissions Lowest | - CO2 emissions | 2.6 - 5.1kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Rome:
A train is $81 (€68) less than a bus for this route with tickets for a bus from Karlsruhe to Rome costing on average $115 (€96).
A train is $107 (€90) less than a flight for this route with tickets for a flight from Karlsruhe to Rome costing on average $141 (€118).
Other travel options to Rome take longer:
Train takes on average 9h 49m.
Bus takes on average 17h 42m.
Tickets start at around $115 (€96) compared to roughly $330 (€277) in fuel and tolls — a saving of about $215 (€180). The journey takes 17h 12m versus 12h 4m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Karlsruhe to Rome
How to get from Karlsruhe to Rome by train, bus or flight.
Our recommendation
The best way to travel from Karlsruhe to Rome is by taking a bus because it’s the best combination of price and speed.
FlixBus8:10 PM17h40Karlsruhe Hbf1:50 PMRoma, Autostazione Tiburtina$511One-way0 transfers
Cheapest
FlixBus8:10 PM17h40Karlsruhe Hbf1:50 PMRoma, Autostazione Tiburtina$511One-way0 transfers
Fastest
ICE 9591 · ICE 518+
LH51482:06 PM6h19Karlsruhe Hbf8:25 PMRome Leonardo da Vinci Fiumicino Airport$3101One-way2 transfers
Other options
FlixBus · FlixBus · FlixBus11:00 PM18h50Karlsruhe Hbf5:50 PMRoma, Autostazione (Metro Anagnina)$901One-way2 transfers
FlixBus · FlixBus5:05 PM19h10Karlsruhe Hbf12:15 PMRoma, Autostazione (Metro Anagnina)$951One-way1 transfer
FlixBus · FlixBus5:05 PM16h25Karlsruhe Hbf9:30 AMRoma, Autostazione Tiburtina$971One-way1 transfer
ICE 72 · ICE 916+
U229952:37 PM8h18Karlsruhe Hbf10:55 PMRome Leonardo da Vinci Fiumicino Airport$2061One-way2 transfers
ICE 106+
U229953:05 PM7h50Karlsruhe Hbf10:55 PMRome Leonardo da Vinci Fiumicino Airport$2111One-way1 transfer
ICE 9591 · ICE 518+
U229952:06 PM8h49Karlsruhe Hbf10:55 PMRome Leonardo da Vinci Fiumicino Airport$2111One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Karlsruhe to Rome
Travel to Rome easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Karlsruhe to Rome.

This is compared to other travel options from Karlsruhe to Rome:
A train is $81 (€68) less than a bus for this route with tickets for a bus from Karlsruhe to Rome costing on average $115 (€96).
A train is $107 (€90) less than a flight for this route with tickets for a flight from Karlsruhe to Rome costing on average $141 (€118).
Other travel options to Rome take longer:
Train takes on average 9h 49m.
Bus takes on average 17h 42m.
- Around 12 buses per day.
- Around 3 trains per day.
- Around 2 flights per day.
However, we recommend checking specific travel dates for your route between Karlsruhe and Rome as scheduled services by train and bus can vary by season or day of the week.
- Flights mostly depart from Karlsruhe/Baden-Baden Airport and arrive in Rome Leonardo da Vinci Fiumicino Airport.
- Trains mostly depart from Karlsruhe Hbf and arrive in Rome Termini.
- Buses mostly depart from Karlsruhe Hbf and arrive in Roma, Autostazione Tiburtina.
- Travel with Malta Air to go to Rome by flight.
- Travel with FlixBus, Marino Autolinee, BlaBlaCar Bus to go to Rome by bus.
- Travel with Frecciarossa, Italo to go to Rome by train.
- 1 direct buses per day with FlixBus.
Travelling from Karlsruhe to Rome: related information
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