Travel Information
Compare train, bus, and flight for Mainz to Lyon
Omio recommends booking the train as it is the most popular option from Mainz to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $43. For those with little time consider booking a flight which can get you there in 1h 34m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $43, and a flight costs an average of $137.
Distance: 333 miles (536 km)
Compare train with
Most popular Train | Flight | Bus |
|---|---|---|
$123 Average price | $287 Average price | $68 Average price Cheapest |
6h 32m Average total duration 6h 2m Onboard + 30m Additional time* | 4h 34m Average total duration Fastest 1h 34m Onboard + 3h 0m Additional time* | 10h 40m Average total duration 10h 10m Onboard + 30m Additional time* |
0.2 - 0.5kg CO2 emissions Lowest | 1.6 - 3.2kg CO2 emissions | 0.5 - 1.3kg CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Mainz to Lyon
How to get from Mainz to Lyon by train, bus or flight.
Our recommendation
The best way to travel from Mainz to Lyon is by taking a bus because it’s the best combination of price and speed.
12:00 AM19h45Mainz7:45 PMLyon$431One-way0 transfers
Cheapest
12:00 AM19h45Mainz7:45 PMLyon$431One-way0 transfers
Fastest
3:30 AM14h40Mainz6:10 PMLyon$671One-way0 transfers
Other options
9:40 PM16h05Mainz1:45 PMLyon$561One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Mainz to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Lyon.

This is compared to other travel options from Mainz to Lyon:
A bus is $80 (€64) less than a train for this route with tickets for a train from Mainz to Lyon costing on average $123 (€98).
A bus is $94 (€75) less than a flight for this route with tickets for a flight from Mainz to Lyon costing on average $137 (€109).
Other travel options to Lyon take longer:
Train takes on average 6h 39m.
Bus takes on average 10h 5m.
- Around 22 flights per day.
- Around 4 buses per day.
- Around 3 trains per day.
However, we recommend checking specific travel dates for your route between Mainz and Lyon as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Dusseldorf Airport and arrive in Lyon Saint Exupery Airport.
- Trains mostly depart from Frankfurt (Main) Hbf and arrive in Lyon Part Dieu.
- Buses mostly depart from Mainz, Binger Schlag (Kurzzeitparkplatz) and arrive in Lyon, Perrache Bus Station.
- Travel with FlixBus to go to Lyon by bus.
- Travel with Lufthansa to go to Lyon by flight.
- Travel with TGV, SNCF | TGV INOUI, Süwex to go to Lyon by train.
- 4 direct flights per day with Lufthansa.
- 1 direct trains per day with SNCF | TGV INOUI.
Travelling from Mainz to Lyon: related information
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