Travel Information
Compare train, bus, and flight for Mainz to Lyon
Omio recommends booking the train as it is the most popular option from Mainz to Lyon among Omio's users. If you are prioritising price, take the train, with an average ticket price of €22 For those with little time, consider booking a flight, which has an average total journey time of 4h 41m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.5kg. Average ticket prices depend on the travel mode: a train costs an average of €22, while a flight costs an average of €436.
Distance: 333 miles (536 km)
Compare train with
Most popular Train | Flight | Bus | Driving |
|---|---|---|---|
€22 Average price Cheapest | €436 Average price | €61 Average price | €149 Average price (fuel + tolls) |
7h 5m Average total duration 6h 35m Onboard + 30m Additional time* | 4h 41m Average total duration Fastest 2h 41m Onboard + 2h 0m Additional time* | 13h 55m Average total duration 13h 25m Onboard + 30m Additional time* | 6h 50m Average total duration (door-to-door) |
0.2 - 0.5kg CO2 emissions Lowest | 1.6 - 3.2kg CO2 emissions | 0.5 - 1.3kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Mainz to Lyon
Compare the available ways to get from Mainz to Lyon, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Mainz to Lyon:
A train is €40 less than a bus for this route with tickets for a bus from Mainz to Lyon costing on average €61.
A train is €414 less than a flight for this route with tickets for a flight from Mainz to Lyon costing on average €436.
Other travel options to Lyon take longer:
Train takes on average 7h 5m.
Bus takes on average 13h 55m.
The journey is about 15m faster (6h 35m by train vs 6h 50m by car) and roughly €127 cheaper once you factor in fuel and tolls (€22 vs €149). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Travel optionsfrom Mainz to Lyon
How to get from Mainz to Lyon by train, bus or flight.
Our recommendation
The best way to travel from Mainz to Lyon is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus4:20 PM20h20Mainz, Binger Schlag (Kurzzeitparkplatz)12:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)€701One-way1 transfer
Cheapest
FlixBus · FlixBus4:20 PM20h20Mainz, Binger Schlag (Kurzzeitparkplatz)12:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)€701One-way1 transfer
Fastest
LH4105+
LH22488:30 AM3h50Cologne Bonn Airport12:20 PMLyon Saint Exupery Airport€6761One-way1 transfer
Other options
S6 · ICE 9590+
55378:57 AM9h02Mainz Römisches Theater station5:59 PMLyon Part Dieu€1731One-way2 transfers
S6 · ICE 9590+
121778:57 AM9h02Mainz Römisches Theater station5:59 PMLyon Part Dieu€1731One-way2 transfers
S5 · ICE 9590+
121778:26 AM9h33Mainz Römisches Theater station5:59 PMLyon Part Dieu€1731One-way2 transfers
FlixBus · FlixBus · FlixBus10:30 AM17h50Mainz, Binger Schlag (Kurzzeitparkplatz)4:20 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)€911One-way2 transfers
FlixBus · FlixBus10:40 PM14h15Mainz, Binger Schlag (Kurzzeitparkplatz)12:55 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)€1031One-way1 transfer
FlixBus · FlixBus · FlixBus8:20 AM14h55Mainz, Binger Schlag (Kurzzeitparkplatz)11:15 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)€1201One-way2 transfers
ICE 23+
LH10787:40 AM10h30Mainz Hbf6:10 PMLyon Saint Exupery Airport€3161One-way1 transfer
ICE 23+
KL1818 · KL14357:40 AM15h10Mainz Hbf10:50 PMLyon Saint Exupery Airport€3941One-way2 transfers
TK1676 · TK18077:15 PM14h00Cologne Bonn Airport9:15 AMLyon Saint Exupery Airport€4101One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Oct 23
Oct 24
Oct 25
Oct 26
Oct 27
Oct 28
Oct 29
More than 1,000 travel companies trust us to sell their tickets all in one place.
FAQs: Travel from Mainz to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Lyon.

This is compared to other travel options from Mainz to Lyon:
A train is €40 less than a bus for this route with tickets for a bus from Mainz to Lyon costing on average €61.
A train is €414 less than a flight for this route with tickets for a flight from Mainz to Lyon costing on average €436.
Other travel options to Lyon take longer:
Train takes on average 7h 5m.
Bus takes on average 13h 55m.
- Around 30 flights per day.
- Around 15 trains per day.
- Around 4 buses per day.
However, we recommend checking specific travel dates for your route between Mainz and Lyon as scheduled services by train, bus, and flight can vary by season or day of the week.
- Buses mostly depart from Mainz, Binger Schlag (Kurzzeitparkplatz) and arrive in Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
- Trains mostly depart from Mainz Römisches Theater station and arrive in Lyon Part Dieu.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Lyon Saint Exupery Airport.
- Travel with Lufthansa, BA Euroflyer, Lufthansa Cityline, KLM Cityhopper, CitizenPlane, Brussels Airlines, Lufthansa City Airlines, Air France, KLM, Air Dolomiti, Austrian Airlines, Air Baltic, Turkish Airlines, Helvetic Airways, Lot Polish Airlines, British Airways to go to Lyon by flight.
- Travel with FlixBus to go to Lyon by bus.
- Travel with TGV, SNCF | TGV INOUI, SNCF | Intercités de nuit to go to Lyon by train.
- 4 direct flights per day with Lufthansa, Air Dolomiti.
Travelling from Mainz to Lyon: related information
Here are some other resources that might have the information you need
