Travel Information
Compare train and bus for Karlsruhe to Lyon
Omio recommends booking the train as it is the most popular option from Karlsruhe to Lyon among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $52 For those with little time, consider booking a train, which has an average total journey time of 5h 26m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of $52, while a train costs an average of $97.
Distance: 278 miles (449 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
$97 Average price | $52 Average price Cheapest | $148 Average price (fuel + tolls) |
5h 26m Average total duration Fastest 4h 56m Onboard + 30m Additional time* | 9h 21m Average total duration 8h 51m Onboard + 30m Additional time* | 5h 54m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Lyon:
A bus is $45 (€38) less than a train for this route with tickets for a train from Karlsruhe to Lyon costing on average $97 (€81).
Other travel options to Lyon take longer:
Bus takes on average 9h 21m.
The journey is about 58m faster (4h 56m by train vs 5h 54m by car) and roughly $52 (€43) cheaper once you factor in fuel and tolls ($97 (€81) vs $148 (€124)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Travel optionsfrom Karlsruhe to Lyon
How to get from Karlsruhe to Lyon by train, bus or flight.
Our recommendation
The best way to travel from Karlsruhe to Lyon is by taking a bus because it’s the best combination of price and speed.
Normal11:15 AM9h25Karlsruhe, Hinterm Hauptbahnhof (Südeingang)8:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$291One-way0 transfers
Cheapest
Normal11:15 AM9h25Karlsruhe, Hinterm Hauptbahnhof (Südeingang)8:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$291One-way0 transfers
Fastest
95803:12 PM4h46Karlsruhe Hbf7:58 PMLyon Part Dieu$1871One-way0 transfers
Other options
4719+
96217 · 17773+
67049:07 AM7h37Karlsruhe Hbf4:44 PMLyon Part Dieu$1321One-way4 transfers
STR 3+
TGV 95802:53 PM5h05Europaplatz/Post Galerie (Karlstraße)7:58 PMLyon Part Dieu$1471One-way1 transfer
12179+
95688:06 AM4h53Karlsruhe Hbf12:59 PMLyon Part Dieu$1581One-way1 transfer
FlixBus4:05 AM8h45Karlsruhe Hbf12:50 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$511One-way0 transfers
FlixBus11:55 PM8h20Karlsruhe Hbf8:15 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$531One-way0 transfers
FlixBus12:55 AM9h35Karlsruhe Hbf10:30 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$531One-way0 transfers
ICE 202+
AF1219 · AF73708:59 AM13h01Karlsruhe Hbf10:00 PMLyon Saint Exupery Airport$3661One-way2 transfers
ICE 376 · ICE 614+
AF1219 · AF73707:59 AM14h01Karlsruhe Hbf10:00 PMLyon Saint Exupery Airport$3661One-way3 transfers
ICE 204+
KL1818 · KL14336:59 AM10h36Karlsruhe Hbf5:35 PMLyon Saint Exupery Airport$3661One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Karlsruhe to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Karlsruhe to Lyon.

This is compared to other travel options from Karlsruhe to Lyon:
A bus is $45 (€38) less than a train for this route with tickets for a train from Karlsruhe to Lyon costing on average $97 (€81).
Other travel options to Lyon take longer:
Bus takes on average 9h 21m.
- Around 15 trains per day.
- Around 7 buses per day.
However, we recommend checking specific travel dates for your route between Karlsruhe and Lyon as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Karlsruhe Hbf and arrive in Lyon Part Dieu.
- Buses mostly depart from Karlsruhe Hbf and arrive in Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
- Travel with TGV, SNCF | TGV INOUI, SNCF TER | Operated by SNCF Voyageurs 1187, SNCF | Intercités de nuit, TER to go to Lyon by train.
- Travel with FlixBus, BlaBlaCar Bus, Alsa to go to Lyon by bus.
- 1 direct trains per day with TGV, SNCF | TGV INOUI.
- 6 direct buses per day with FlixBus, BlaBlaCar Bus, Alsa.
Travelling from Karlsruhe to Lyon: related information
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