- Must visit
San Diego Museum of Art
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
Omio recommends booking the flight as it is the most popular option from St. Louis, MO to San Diego, CA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $347 For those with little time, consider booking a flight, which has an average total journey time of 8h 36m. Average ticket prices depend on the travel mode: a bus costs an average of $347, while a flight costs an average of $595.
Distance: 1560 miles (2512 km)
Most popular Flight | Bus | Driving |
|---|---|---|
$595 Average price | $347 Average price Cheapest | $384 Average price (fuel + tolls) |
8h 36m Average total duration Fastest 6h 36m Onboard + 2h 0m Additional time* | 42h 0m Average total duration 41h 30m Onboard + 30m Additional time* | 26h 33m Average total duration (door-to-door) |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from St. Louis, MO to San Diego, CA:
A bus is $248 (€202) less than a flight for this route with tickets for a flight from St. Louis, MO to San Diego, CA costing on average $595 (€487).
Other travel options to San Diego, CA take longer:
Bus takes on average 41h 30m.
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a train from St. Louis, MO to San Diego, CA and enjoy the approximately 1560 miles (2512 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest train runs at 06:35, the last at 19:42.
Distance 1560 miles (2512 km) |
First train 6:35 AM |
Last train 7:42 PM |
Cheapest Month Apr |
Cheapest Day Sun |
High Season Oct - Dec |
Low Season Jul - Sep |
Discover the best of San Diego, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego, CA trip today.
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.
Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.
Balboa Park is San Diego's grand cultural park, packed with gardens, architecture, museums, and walkable plazas worth lingering in.
Historic Gaslamp Quarter offers Victorian-era streets, nightlife energy, and preserved downtown architecture for an atmospheric walk.
Dramatic seaside cliffs and walking paths in La Jolla, famous for waves, sea lions, and sweeping Pacific views.
A San Diego staple: grilled fish in a soft tortilla with cabbage, crema, and salsa. Popularized by Baja influence and coastal seafood culture.
French fries, carne asada, cheese, guacamole, and crema wrapped in a flour tortilla. A late-night local favorite born in San Diego taquerias.
Fresh local sea urchin served raw, prized for its rich, buttery taste. It reflects San Diego's access to Pacific seafood and sushi culture.
Celebrated sushi restaurant specializing in omakase and pristine seafood, including uni. Intimate, polished, and highly respected by locals.
Iconic casual seafood counter known for fish tacos, smoked fish, and harbor views. A classic stop for San Diego's Baja-inspired seafood style.
Refined fine-dining restaurant showcasing local seafood and seasonal California ingredients. Elegant room with one of the city's strongest reputations.
San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.
Find answers to the most common questions about traveling from St. Louis, MO to San Diego, CA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.

Most St. Louis, MO to San Diego, CA trains use the St. Louis Station to Old Town Station station pair, with some services arriving at Santa Fe Depot. Use this guide to compare St. Louis, MO and San Diego, CA train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
St. Louis Station has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: Landry's Seafood House, The Station Grille
Free. ATMs are available in the train station.
Ticket office support is available at St. Louis Station. Information desks are located in the main hall.
Luggage storage is available at St. Louis Station. Lost and found is available at the station.
Available at St. Louis Station: Parking, Taxis, WC.
Available at St. Louis Station: Bike Parking, Car Rental.
Accessibility facilities are available at St. Louis Station: Ramps, restrooms.
Nearby hotels include St. Louis Union Station Hotel, Curio Collection by Hilton, Courtyard St. Louis Downtown West, Drury Inn St. Louis at Union Station.
Old Town Station is 5 km from San Diego city centre. Public transport options include:
Old Town Station has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: Casa Guadalajara, Old Town Mexican Cafe
Free. ATMs are available in the train station.
Ticket office support is available at Old Town Station. Information desks are located in the main hall.
Luggage storage is available at Old Town Station. Lost and found is available at the station.
Available at Old Town Station: Parking, Taxis, WC.
Available at Old Town Station: Bike Parking, Car Rental.
Accessibility facilities are available at Old Town Station: Elevators, ramps.
Nearby hotels include Old Town Inn, Fairfield Inn & Suites by Marriott San Diego Old Town, Best Western Plus Hacienda Hotel Old Town.
Santa Fe Depot is 1 km from San Diego city centre. Public transport options include:
Santa Fe Depot has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: The Fish Market, Karl Strauss Brewing Company
Free. ATMs are available in the train station.
Ticket office support is available at Santa Fe Depot. Information desks are located in the main hall.
Luggage storage is available at Santa Fe Depot. Lost and found is available at the station.
Available at Santa Fe Depot: Parking, Taxis, WC.
Available at Santa Fe Depot: Bike Parking, Car Rental.
Accessibility facilities are available at Santa Fe Depot: Ramps.
Nearby hotels include The Westin San Diego, The Guild Hotel, San Diego, a Tribute Portfolio Hotel, Embassy Suites by Hilton San Diego Bay Downtown.
Here are some other resources that might have the information you need