- Must visit
San Diego Museum of Art
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
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Journey information
Overview: St. Louis, MO to San Diego, CA flight
USAUSA
Flights from St. Louis, MO to San Diego, CA depart on average 53 times per day, taking around 7h 22m. Cheap flight tickets for this journey start at $147 but you can travel from only $136 by bus.
The earliest flight runs at 05:00, the last at 22:49. The fastest flight covers the 1560 miles (2512 km) distance in 6h 5m. August is the cheapest month to fly.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $136
Distance 1560 miles (2512 km) |
Average flight duration 7h 22m |
Cheapest ticket price $147 |
Flights per day 53 |
Fastest flight 6h 5m |
First flight 5:00 AM |
Last flight 10:49 PM |
Cheapest Month Aug |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jul - Sep |
Best time to book 6 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $136
The cheapest and fastest flights from St. Louis, MO to San Diego, CA
Showing times and prices for Aug 01
Cheapest price
$220
Average price
$253
Fastest journey
6 h 49 m
Average duration
8 h 1 m
Flights per day
3
Distance
2512 km
Cheap tickets
The best way to find a cheap flight ticket from St. Louis, MO to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to San Diego, CA will cost around $253 if you buy it on the day, but the cheapest tickets can be found for only $220.
Fast flights
Of the 3 flights that leave St. Louis, MO for San Diego, CA onSat, Aug 01, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Aug 01 the direct flights cover the 2512 km distance in an average of 8 h 1 m but if you time it right, some flights will get you there in just 6 h 49 m .
On Sat, Aug 01 the longest flights will take 8 h 37 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
5:46 PM8h37St. Louis, MO2:23 AMSan Diego, CA$2201One-way0 transfers- 10:20 AM6h49St. Louis, MO5:09 PMSan Diego, CA$2621One-way0 transfers
- 4:46 PM8h37St. Louis, MO1:23 AMSan Diego, CA$2771One-way0 transfers
- 10:20 AM6h49St. Louis, MO5:09 PMSan Diego, CA$2621One-way0 transfers
- 5:46 PM8h37St. Louis, MO2:23 AMSan Diego, CA$2201One-way0 transfers
- 4:46 PM8h37St. Louis, MO1:23 AMSan Diego, CA$2771One-way0 transfers
Travel Information
Compare train, bus, and flight for St. Louis, MO to San Diego, CA
Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Diego, CA among Omio's users. If you are prioritising price take the flight with prices starting from $147. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a flight costs an average of $147, and a train costs an average of $216.
Distance: 1560 miles (2512 km)
Compare flight with
| Flight | Most popular Train | Bus | Driving |
|---|---|---|---|
$262 Average price Cheapest | $279 Average price | $276 Average price | $381 Average price (fuel + tolls) |
10h 22m Average total duration Fastest 7h 22m Onboard + 3h 0m Additional time* | 61h 41m Average total duration 61h 11m Onboard + 30m Additional time* | 39h 10m Average total duration 38h 40m Onboard + 30m Additional time* | 26h 33m Average total duration (door-to-door) |
Most popular airline |  Most popular train company |  Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to San Diego, CA is a flight with an average price of $262.
This is compared to other travel options from St. Louis, MO to San Diego, CA:
A flight is $13 less than a bus for this route with tickets for a bus from St. Louis, MO to San Diego, CA costing on average $276.
A flight is $17 less than a train for this route with tickets for a train from St. Louis, MO to San Diego, CA costing on average $279.
The fastest way to travel from St. Louis, MO to San Diego, CA is by flight with an average journey time of 7h 22m.
Other travel options to San Diego, CA take longer:
Bus takes on average 38h 40m.
Train takes on average 61h 11m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
Live departures
St. Louis, MO to San Diego, CA flight times
The table below shows live departures for St. Louis, MO to San Diego, CA flights for today, Friday, July 31. You can also manually refresh the results below to see updated flight journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 1:58 PM St. Louis, MO | 6h05 | 8:03 PM San Diego, CA | 0 transfersDirect | |
 | 3:05 PM St. Louis, MO | 8h33 | 11:38 PM San Diego, CA | 0 transfersDirect | |
| 4:46 PM St. Louis, MO | 8h37 | 1:23 AM San Diego, CA | 0 transfersDirect | |
| 5:46 PM St. Louis, MO | 8h37 | 2:23 AM San Diego, CA | 0 transfersDirect | |
| 6:34 PM St. Louis, MO | 9h33 | 4:07 AM San Diego, CA | 0 transfersDirect | |
| 10:21 PM St. Louis, MO | 8h12 | 6:33 AM San Diego, CA | 0 transfersDirect | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to San Diego, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book St. Louis, MO to San Diego, CA flights with Omio?
American Airlines operates all flights services from St. Louis, MO to San Diego, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to San Diego, CA.
Why book with Omio vs American Airlines?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare American Airlines with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to San Diego, CA.
Why book with Omio over Trip, Edreams or Skyscanner?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to San Diego, CA.
Airlines: American Airlines from St. Louis, MO to San Diego, CAFind the best flights between St. Louis, MO to San Diego, CA with Omio's travel partners American Airlines from $136. We can find you the best deals, schedules and tickets when comparing and booking the best trip.
American Airlines
About
American Airlines is one of the largest airlines in the world, connecting travelers to hundreds of destinations across the United States, Latin America, Europe, Asia, and beyond. Operating from major hubs such as Dallas/Fort Worth, Miami, and Charlotte, American offers a wide range of travel options. Passengers can choose from Economy with affordable fares, Premium Economy with extra space, or Business and First Class featuring flat-bed seats, premium dining, and lounge access. With a modern fleet and membership in the oneworld alliance, American Airlines combines global reach with comfort and reliability.
Luggage & cancellation policy
Average Duration
6h 5m
Cheapest Price
$147
Luggage included
1 carry-on bag (22 x 14 x 9 inches) and 1 personal item (18 x 14 x 8 inches) included in most fares
Additional luggage
Checked bags fees vary by route. First checked bag typically $30, second $40 on domestic flights
Cancellation Policy
Basic Economy tickets cannot be changed or refunded. Other fares allow changes with fee, refunds subject to fare rules.
Pregnant on board
Passengers can fly up to 36 weeks for single pregnancies, 32 weeks for multiple pregnancies. Medical certificate required within 7 days of departure if within 4 weeks of due date.
Unaccompagned minor
Children ages 5-14 can travel alone using American Airlines Unaccompanied Minor Service. Service fee is $150 each way.
Amenities on board the airplane
Wifi
Food sold onboard
USB plugs
Accessibility
American Airlines provides wheelchair assistance and special services for passengers with disabilities. Assistance must be requested at least 48 hours before departure.
Pets
Small dogs and cats allowed in cabin for $125 fee. Must be in approved carrier under seat. Service animals allowed.
Entertaiment on board
Complete guide to San Diego, CA
Things to do in San Diego, CA
Discover the best of San Diego, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego, CA trip today.
- Must visit
Museum of Contemporary Art San Diego
Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.
- Must visit
USS Midway Museum
Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.
- Must visit
Balboa Park
Balboa Park is San Diego's grand cultural park, packed with gardens, architecture, museums, and walkable plazas worth lingering in.
- Must visit
Gaslamp Quarter
Historic Gaslamp Quarter offers Victorian-era streets, nightlife energy, and preserved downtown architecture for an atmospheric walk.
- Must visit
La Jolla Cove
Dramatic seaside cliffs and walking paths in La Jolla, famous for waves, sea lions, and sweeping Pacific views.
Fish Taco
A San Diego staple: grilled fish in a soft tortilla with cabbage, crema, and salsa. Popularized by Baja influence and coastal seafood culture.
California Burrito
French fries, carne asada, cheese, guacamole, and crema wrapped in a flour tortilla. A late-night local favorite born in San Diego taquerias.
- Gluten-free
Sea Urchin (Uni)
Fresh local sea urchin served raw, prized for its rich, buttery taste. It reflects San Diego's access to Pacific seafood and sushi culture.
Sushi Ota
Celebrated sushi restaurant specializing in omakase and pristine seafood, including uni. Intimate, polished, and highly respected by locals.
Mitch's Seafood
Iconic casual seafood counter known for fish tacos, smoked fish, and harbor views. A classic stop for San Diego's Baja-inspired seafood style.
Juniper and Ivy
Refined fine-dining restaurant showcasing local seafood and seasonal California ingredients. Elegant room with one of the city's strongest reputations.
US Dollar ($)
San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $25-45 per person for a mid-range meal.
- Fine dining
- $75+ per person for upscale dining.
- Coffee
- $4-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.
FAQs: St. Louis, MO to San Diego, CA Flight
Find answers to the most common questions about traveling from St. Louis, MO to San Diego, CA by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
Cheap plane tickets from St. Louis, MO to San Diego, CA can start from as little as $147 when you book in advance. The average flight ticket price for St. Louis, MO to San Diego, CA is $262 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by plane from St. Louis, MO to San Diego, CA is 6h 5m to travel the 1560 miles (2512 km) long route. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest flight from St. Louis, MO to San Diego, CA leaves at 5:00 AM. Plan your trip with the Journey Planner from Omio.
The latest flight from St. Louis, MO to San Diego, CA leaves at 10:49 PM.
There are 53 flights a day from St. Louis, MO to San Diego, CA which require at least one change with American Airlines. Schedules can vary on holidays or weekends with fewer flights.
When taking a flight from St. Louis, MO to San Diego, CA, you can count on American Airlines for the best way to get you to San Diego, CA. You can also check all possible airlines who offer a service between St. Louis, MO and San Diego, CA and compare the amenities they offer before buying a plane ticket.
Flights from St. Louis, MO to San Diego, CA generally leave from St. Louis Lambert International Airport and arrive in San Diego International Airport.St. Louis Lambert International Airport is 1 miles (2 km) away from St. Louis, MO city centre and San Diego International Airport is 2 miles (4 km) from San Diego, CA city centre.
The cheapest month for a flight from St. Louis, MO to San Diego, CA is August.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
Since neither St. Louis, MO nor San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
There is a time difference of 2 h between St. Louis, MO and San Diego, CA all year round.
The best events to attend in San Diego, CA include:
- Comic-Con International, the largest comic book and popular arts convention in the world
- San Diego County Fair, a month-long fair featuring rides, games, and local food
- San Diego Beer Week, a celebration of craft beer with tastings and events across the county
- La Jolla Music Festival, an annual event showcasing classical music performances in a picturesque coastal setting.
Some of the most interesting sights to explore in San Diego, CA are:
- Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
- USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
- La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
- Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
- Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best holidays to experience in San Diego, CA include:
- Memorial Day, ideal weather for beach activities and outdoor events
- Independence Day, spectacular fireworks and patriotic celebrations
- Labor Day, perfect for enjoying the last days of summer at the beach
- Thanksgiving, a time for family gatherings with pleasant fall weather.
The best things to do in San Diego, CA include:
- Explore the vibrant art scene at the Museum of Contemporary Art San Diego
- enjoy a harbor cruise for stunning views of the skyline and naval ships
- hike the scenic trails at Torrey Pines State Natural Reserve
- visit the Birch Aquarium to learn about marine life and ocean conservation
- experience the thrill of a whale watching tour off the coast.
The best season to visit San Diego, CA is Spring or Fall. The best weather to explore San Diego, CA is during April-June or September-November.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
For domestic flights we recommend to arrive 1.5 to 2 hours before departure. Please check the website of your departure airport if in doubt. Some airports may offer booking time slots for security checks or offer additional information on when to get there based on time of day.
Most airlines permit carry-on bags that fit within specific dimensions (e.g., 22 x 14 x 9 inches or 56 x 36 x 23 cm), including handles and wheels. Bags must fit in the overhead bin or under the seat in front of you.
Many airlines impose weight limits, commonly ranging between 7 kg (15 lbs) and 12 kg (26 lbs). Typically, passengers are allowed one carry-on bag and one personal item (for example a purse, laptop bag, or backpack). Personal items must fit under the seat in front of you. Budget Airlines (like Ryanair or Wizz Air) have stricter size and weight limits, often requiring fees for larger carry-ons. Full-Service Airlines have more lenient policies, sometimes including more spacious dimensions or higher weight limits depending on your ticket class.
The list of items prohibited on an airplane varies by country and airline, but in general, the following items are not allowed in carry-on or checked baggage: Weapons and self-defence items, sharp objects, flammable materials, explosives, toxic substances, or liquids over 100ml (except for medications and baby essentials). In checked baggage, firearms (without authorization), explosives, large lithium batteries, and hazardous chemicals are prohibited. Electronic cigarettes must be in carry-on bags, while alcohol and dry ice have restrictions. Always check with your airline for specific regulations.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular airports
Popular airports from St. Louis, MO to San Diego, CA
Most St. Louis, MO to San Diego, CA flights use the St. Louis Lambert International Airport to San Diego International Airport airport pair, with some services landing at McClellan-Palomar Airport. Use this guide to compare St. Louis, MO and San Diego, CA airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Departure airports in St. Louis
Arrival airports in San Diego
Which St. Louis, MO airport do flights to San Diego, CA leave from?
Flights from St. Louis, MO to San Diego, CA depart from St. Louis Lambert International Airport. The airport is 1 miles (2 km) from St. Louis, MO city centre at 10701 Lambert Intertiol Blvd, St. Louis, MO 63145, USA.
St. Louis Lambert International Airport (STL)10701 Lambert Intertiol Blvd, St. Louis, MO 63145, USA
City-centre transport
Getting to St. Louis Lambert International Airport from St. Louis city centre
St. Louis Lambert International Airport is 2 km from St. Louis city centre. Public transport options include:
TrainMlr · 31m · $4 · every ~7 min
BusGreyhound US1210 · 25m · $2
St. Louis Lambert International Airport airport facilities and services
St. Louis Lambert International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants in both terminals, including fast food and sit-down options like Starbucks and Chili's
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located in both terminals.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at St. Louis Lambert International Airport: Parking, Taxis, WC.
Bike and car services
Available at St. Louis Lambert International Airport: Car Rental.
Accessibility
Accessibility facilities are available at St. Louis Lambert International Airport: Elevators, ramps.
Shops, hotels and contact
Nearby hotels include Hotels nearby, such as Marriott St. Louis Airport within walking distance..
Which San Diego, CA airport do flights from St. Louis, MO arrive at?
Flights from St. Louis, MO to San Diego, CA most often arrive at San Diego International Airport. Some flights land at McClellan-Palomar Airport, so check your ticket before travel to confirm your San Diego, CA arrival airport.
San Diego International Airport (SAN)3225 N Harbor Dr, San Diego, CA 92101, USA
City-centre transport
Getting to San Diego International Airport from San Diego city centre
San Diego International Airport is 4 km from San Diego city centre. Public transport options include:
Bus923, 992 · 12m · $6 · every ~10 min
923, 992 · 13m · $6 · every ~10 min
San Diego International Airport airport facilities and services
San Diego International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants in terminals 1 and 2, including fast food and sit-down options like The Counter and Phil's BBQ
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located in all terminals.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at San Diego International Airport: Parking, Taxis, WC.
Bike and car services
Available at San Diego International Airport: Car Rental.
Accessibility
Accessibility facilities are available at San Diego International Airport: Elevators, ramps.
Shops, hotels and contact
Nearby hotels include Hotels nearby, Sheraton San Diego Hotel & Mari within walking distance..
McClellan-Palomar Airport (CLD)2198 Palomar Airport Rd, Carlsbad, CA 92008, USA+1 760-431-4646
City-centre transport
Getting to McClellan-Palomar Airport from San Diego city centre
TrainPacific Surfliner · 2h 11m · $21 · every ~2 min
BusAmtrak Thruway Connecting Service · 2h 3m · $21
101 · 3h 3m · $28 · every ~4 min
McClellan-Palomar Airport airport facilities and services
McClellan-Palomar Airport has practical services for this route, including Accessibility.
Accessibility
Accessibility facilities are available at McClellan-Palomar Airport: The place has an entrance that is wheelchair-accessible.
More options for your journey from St. Louis, MO to San Diego, CA
Here are some other resources that might have the information you need
Most popular flights to and from San Diego, CA and St. Louis, MO
Most popular flights to San Diego, CA
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