- Must visit
USS Midway Museum
Museum aboard the historic aircraft carrier USS Midway with restored aircraft, flight deck exhibits, and audio tours on San Diego Bay.
Flights from St. Louis, MO to San Diego, CA depart on average 53 times per day, taking around 7h 22m. Cheap flight tickets for this journey start at $148 (€120) but you can travel from only $137 (€111) by bus.
The earliest flight runs at 05:00, the last at 22:49. The fastest flight covers the 1560 miles (2512 km) distance in 6h 5m. August is the cheapest month to fly.
Distance 1560 miles (2512 km) |
Average flight duration 7h 22m |
Cheapest ticket price $148 (€120) |
Flights per day 53 |
Fastest flight 6h 5m |
First flight 5:00 AM |
Last flight 10:49 PM |
Cheapest Month Aug |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jul - Sep |
Best time to book 6 days |
Cheapest price
$148
Average price
$194
Fastest journey
8 h 18 m
Average duration
8 h 43 m
Flights per day
3
Distance
2512 km
The best way to find a cheap flight ticket from St. Louis, MO to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to San Diego, CA will cost around $194 if you buy it on the day, but the cheapest tickets can be found for only $148.
Of the 3 flights that leave St. Louis, MO for San Diego, CA onWed, Jun 17, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jun 17 the direct flights cover the 2512 km distance in an average of 8 h 43 m but if you time it right, some flights will get you there in just 8 h 18 m .
On Wed, Jun 17 the longest flights will take 9 h 13 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Diego, CA among Omio's users. If you are prioritising price take the flight with prices starting from $148. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a flight costs an average of $148, and a train costs an average of $217.
Distance: 1560 miles (2512 km)
| Flight | Most popular Train | Bus | Driving |
|---|---|---|---|
$264 Average price Cheapest | $280 Average price | $277 Average price | $384 Average price (fuel + tolls) |
10h 22m Average total duration Fastest 7h 22m Onboard + 3h 0m Additional time* | 61h 41m Average total duration 61h 11m Onboard + 30m Additional time* | 39h 10m Average total duration 38h 40m Onboard + 30m Additional time* | 26h 33m Average total duration (door-to-door) |
![]() Most popular airline | ![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from St. Louis, MO to San Diego, CA:
A flight is $13 (€11) less than a bus for this route with tickets for a bus from St. Louis, MO to San Diego, CA costing on average $277 (€225).
A flight is $17 (€13) less than a train for this route with tickets for a train from St. Louis, MO to San Diego, CA costing on average $280 (€227).
Other travel options to San Diego, CA take longer:
Bus takes on average 38h 40m.
Train takes on average 61h 11m.
The table below shows live departures for St. Louis, MO to San Diego, CA flights for today, Tuesday, June 16. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
UA362 · UA2309 | 5:10 AM St. Louis Lambert International Airport | 5h55 | 9:05 AM San Diego International Airport | 1 transfer | |
UA362 · UA2391 · UA2177 | 5:10 AM St. Louis Lambert International Airport | 8h41 | 11:51 AM San Diego International Airport | 2 transfers | |
UA362 · UA5507 | 5:10 AM St. Louis Lambert International Airport | 9h50 | 1:00 PM McClellan–Palomar Airport | 1 transfer | |
UA2104 · UA1826 | 6:00 AM St. Louis Lambert International Airport | 15h52 | 7:52 PM San Diego International Airport | 1 transfer | |
UA2104 · UA1343 | 6:00 AM St. Louis Lambert International Airport | 16h53 | 8:53 PM San Diego International Airport | 1 transfer | |
UA1008 · UA660 | 6:00 AM St. Louis Lambert International Airport | 7h21 | 11:21 AM San Diego International Airport | 1 transfer | |
AS473 · AS467 | 6:02 AM St. Louis Lambert International Airport | 8h59 | 1:01 PM San Diego International Airport | 1 transfer | |
AS473 · AS1428 · AS2406 | 6:02 AM St. Louis Lambert International Airport | 14h18 | 6:20 PM San Diego International Airport | 2 transfers | |
AS473 · AS383 · AS3388 | 6:02 AM St. Louis Lambert International Airport | 13h45 | 5:47 PM San Diego International Airport | 2 transfers | |
AS473 · AS1328 · AS3311 | 6:02 AM St. Louis Lambert International Airport | 12h24 | 4:26 PM San Diego International Airport | 2 transfers | |
AS473 · AS1380 · AS3036 | 6:02 AM St. Louis Lambert International Airport | 15h19 | 7:21 PM San Diego International Airport | 2 transfers | |
AS473 · AS681 · AS2406 | 6:02 AM St. Louis Lambert International Airport | 14h18 | 6:20 PM San Diego International Airport | 2 transfers | |
AS473 · AS3079 · AS3111 | 6:02 AM St. Louis Lambert International Airport | 9h25 | 1:27 PM San Diego International Airport | 2 transfers | |
AS473 · AS1321 · AS2257 | 6:02 AM St. Louis Lambert International Airport | 15h33 | 7:35 PM San Diego International Airport | 2 transfers | |
AS473 · AS336 | 6:02 AM St. Louis Lambert International Airport | 18h05 | 10:07 PM San Diego International Airport | 1 transfer | |
AS473 · AS1380 · AS2406 | 6:02 AM St. Louis Lambert International Airport | 14h18 | 6:20 PM San Diego International Airport | 2 transfers | |
AS473 · AS335 · AS3429 | 6:02 AM St. Louis Lambert International Airport | 12h47 | 4:49 PM San Diego International Airport | 2 transfers | |
AS473 · AS1388 | 6:02 AM St. Louis Lambert International Airport | 16h47 | 8:49 PM San Diego International Airport | 1 transfer | |
AS473 · AS1348 | 6:02 AM St. Louis Lambert International Airport | 15h34 | 7:36 PM San Diego International Airport | 1 transfer | |
AS473 · AS1380 · AS3439 | 6:02 AM St. Louis Lambert International Airport | 11h12 | 3:14 PM San Diego International Airport | 2 transfers | |
AS473 · AS1428 · AS3036 | 6:02 AM St. Louis Lambert International Airport | 15h19 | 7:21 PM San Diego International Airport | 2 transfers | |
AS473 · AS1398 | 6:02 AM St. Louis Lambert International Airport | 19h30 | 11:32 PM San Diego International Airport | 1 transfer | |
AS473 · AS335 · AS3211 | 6:02 AM St. Louis Lambert International Airport | 14h34 | 6:36 PM San Diego International Airport | 2 transfers | |
AS473 · AS680 · AS3337 | 6:02 AM St. Louis Lambert International Airport | 14h07 | 6:09 PM San Diego International Airport | 2 transfers | |
AS473 · AS681 · AS3036 | 6:02 AM St. Louis Lambert International Airport | 15h19 | 7:21 PM San Diego International Airport | 2 transfers | |
UA6283 · UA2399 | 6:14 AM St. Louis Lambert International Airport | 9h07 | 1:21 PM San Diego International Airport | 1 transfer | |
UA6283 · UA2491 | 6:14 AM St. Louis Lambert International Airport | 6h37 | 10:51 AM San Diego International Airport | 1 transfer | |
UA4028 · UA2399 | 8:35 AM St. Louis Lambert International Airport | 6h46 | 1:21 PM San Diego International Airport | 1 transfer | |
UA4506 · UA2054 | 8:43 AM St. Louis Lambert International Airport | 13h40 | 8:23 PM San Diego International Airport | 1 transfer | |
UA4506 · UA2163 | 8:43 AM St. Louis Lambert International Airport | 8h20 | 3:03 PM San Diego International Airport | 1 transfer | |
UA2459 · UA1302 | 9:06 AM St. Louis Lambert International Airport | 7h49 | 2:55 PM San Diego International Airport | 1 transfer | |
UA2459 · UA1940 | 9:06 AM St. Louis Lambert International Airport | 5h35 | 12:41 PM San Diego International Airport | 1 transfer | |
UA2459 · UA5507 | 9:06 AM St. Louis Lambert International Airport | 5h54 | 1:00 PM McClellan–Palomar Airport | 1 transfer | |
UA4517 · UA2683 | 10:25 AM St. Louis Lambert International Airport | 7h00 | 3:25 PM San Diego International Airport | 1 transfer | |
UA4517 · UA1334 · UA1343 | 10:25 AM St. Louis Lambert International Airport | 12h28 | 8:53 PM San Diego International Airport | 2 transfers | |
UA4395 · UA1334 · UA1343 | 11:25 AM St. Louis Lambert International Airport | 11h28 | 8:53 PM San Diego International Airport | 2 transfers | |
UA4395 · UA1577 · UA1343 | 11:25 AM St. Louis Lambert International Airport | 11h28 | 8:53 PM San Diego International Airport | 2 transfers | |
UA4395 · UA1577 · UA5508 | 11:25 AM St. Louis Lambert International Airport | 11h02 | 8:27 PM McClellan–Palomar Airport | 2 transfers | |
UA3573 · UA1826 | 12:23 PM St. Louis Lambert International Airport | 9h29 | 7:52 PM San Diego International Airport | 1 transfer | |
UA3573 · UA1626 | 12:23 PM St. Louis Lambert International Airport | 13h17 | 11:40 PM San Diego International Airport | 1 transfer | |
UA4454 · UA2054 | 12:55 PM St. Louis Lambert International Airport | 9h28 | 8:23 PM San Diego International Airport | 1 transfer | |
UA1382 · UA1334 · UA1343 | 1:13 PM St. Louis Lambert International Airport | 9h40 | 8:53 PM San Diego International Airport | 2 transfers | |
UA1382 · UA745 | 1:13 PM St. Louis Lambert International Airport | 7h17 | 6:30 PM San Diego International Airport | 1 transfer | |
UA1380 · UA5529 | 1:38 PM St. Louis Lambert International Airport | 9h05 | 8:43 PM McClellan–Palomar Airport | 1 transfer | |
AS618 · AS336 | 2:50 PM St. Louis Lambert International Airport | 9h17 | 10:07 PM San Diego International Airport | 1 transfer | |
AS618 · AS1471 | 2:50 PM St. Louis Lambert International Airport | 21h33 | 10:23 AM San Diego International Airport | 1 transfer | |
AS618 · AS1398 | 2:50 PM St. Louis Lambert International Airport | 10h42 | 11:32 PM San Diego International Airport | 1 transfer | |
UA1483 · UA5529 | 4:48 PM St. Louis Lambert International Airport | 5h55 | 8:43 PM McClellan–Palomar Airport | 1 transfer | |
UA1483 · UA540 | 4:48 PM St. Louis Lambert International Airport | 5h58 | 8:46 PM San Diego International Airport | 1 transfer | |
UA1639 · UA1182 | 5:29 PM St. Louis Lambert International Airport | 7h10 | 10:39 PM San Diego International Airport | 1 transfer | |
AS1538 · AS1394 | 5:37 PM St. Louis Lambert International Airport | 21h50 | 1:27 PM San Diego International Airport | 1 transfer | |
AS1538 · AS577 | 5:37 PM St. Louis Lambert International Airport | 18h28 | 10:05 AM San Diego International Airport | 1 transfer | |
UA2482 · UA5510 | 7:23 PM St. Louis Lambert International Airport | 17h39 | 11:02 AM McClellan–Palomar Airport | 1 transfer | |
UA2482 · UA1980 | 7:23 PM St. Louis Lambert International Airport | 14h46 | 8:09 AM San Diego International Airport | 1 transfer | |
AS647 · AS1346 | 7:56 PM St. Louis Lambert International Airport | 20h22 | 2:18 PM San Diego International Airport | 1 transfer | |
AS647 · AS467 | 7:56 PM St. Louis Lambert International Airport | 19h05 | 1:01 PM San Diego International Airport | 1 transfer | |
AS647 · AS1471 | 7:56 PM St. Louis Lambert International Airport | 16h27 | 10:23 AM San Diego International Airport | 1 transfer | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of San Diego — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego trip today.
Museum aboard the historic aircraft carrier USS Midway with restored aircraft, flight deck exhibits, and audio tours on San Diego Bay.
Balboa Park art museum known for Spanish old masters, South Asian works, and rotating exhibitions in a landmark building.
Leading contemporary art museum with major postwar and current works, especially strong in Southern California and Pacific Rim artists.
Vast cultural park with gardens, museums, Spanish Colonial Revival architecture, walking paths, and some of San Diego's best photo spots.
Scenic cove known for sea lions, clear water, coastal cliffs, and highly shareable sunset and ocean-view walks.
Wide sandy beach beside the Hotel del Coronado, popular for walking, photography, and classic Southern California scenery.
Beer-battered or grilled local fish in tortillas, usually topped with cabbage, crema, and salsa. A signature coastal San Diego staple with strong Baja influence.
A San Diego original burrito filled with carne asada, fries, cheese, and salsa. It is one of the city’s most iconic late-night and casual foods.
French fries topped with carne asada, cheese, guacamole, sour cream, and salsa. This indulgent dish is strongly associated with San Diego taco shop culture.
Popular waterfront seafood restaurant serving fresh local catch, fish tacos, and sandwiches in a relaxed harbor setting near the fishing fleet.
Historic, no-frills Mexican restaurant famous for house-made tortillas, rolled tacos, and comforting traditional plates. A beloved local institution with a classic atmosphere.
Iconic casual spot in Ocean Beach known for oversized burgers, fries, and a lively beach-town vibe. A long-standing San Diego favorite.
Prices are high by U.S. standards, especially for hotels, dining, and parking near the coast and downtown.
Tip 18-20% at restaurants, 20%+ for great service. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and valet.
Find answers to the most common questions about traveling from St. Louis, MO to San Diego, CA by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.

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