- Must visit
Saint Louis Art Museum
Major fine arts museum in Forest Park with a strong encyclopedic collection spanning ancient to contemporary works. A top cultural stop in the city.
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The cheapest and fastest buses from Jacksonville, FL to St. Louis, MO
Showing times and prices for Jul 09
Cheapest price
$148
Average price
$155
Fastest journey
17 h 50 m
Average duration
18 h 40 m
Buses per day
2
Distance
1209 km
Cheap tickets
The best way to find a cheap bus ticket from Jacksonville, FL to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Jacksonville, FL to St. Louis, MO will cost around $155 if you buy it on the day, but the cheapest tickets can be found for only $148.
Fast buses
It's difficult to get from Jacksonville, FL to St. Louis, MO without transferring at least once.
FlixBus+
· 9:25 PM19h30Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St3:55 PMSt. Louis, S 15th St (Civic center)$1481One-way2 transfers- FlixBus · FlixBus4:30 PM17h50Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St9:20 AMSt. Louis, S 15th St (Civic center)$1621One-way1 transfer
- FlixBus · FlixBus4:30 PM17h50Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St9:20 AMSt. Louis, S 15th St (Civic center)$1621One-way1 transfer
- FlixBus+ · 9:25 PM19h30Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St3:55 PMSt. Louis, S 15th St (Civic center)$1481One-way2 transfers
Travel Information
Compare bus, flight, and train for Jacksonville, FL to St. Louis, MO
Omio recommends booking the train as it is the most popular option from Jacksonville, FL to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $211. For those with little time consider booking a flight which can get you there in 10h 7m. The ticket price range depends on the travel mode: a bus costs an average of $211, and a flight costs an average of $223.
Distance: 751 miles (1209 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$275 Average price Cheapest | $526 Average price | $531 Average price | $174 Average price (fuel + tolls) |
21h 33m Average total duration 21h 3m Onboard + 30m Additional time* | 40h 53m Average total duration 40h 23m Onboard + 30m Additional time* | 13h 7m Average total duration Fastest 10h 7m Onboard + 3h 0m Additional time* | 13h 8m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Jacksonville, FL to St. Louis, MO is a bus with an average price of $275 (€226).
This is compared to other travel options from Jacksonville, FL to St. Louis, MO:
A bus is $251 (€206) less than a train for this route with tickets for a train from Jacksonville, FL to St. Louis, MO costing on average $526 (€433).
A bus is $256 (€211) less than a flight for this route with tickets for a flight from Jacksonville, FL to St. Louis, MO costing on average $531 (€437).
The fastest way to travel from Jacksonville, FL to St. Louis, MO is by flight with an average journey time of 10h 7m.
Other travel options to St. Louis, MO take longer:
Bus takes on average 21h 3m.
Train takes on average 40h 23m.
It's helpful to compare your options as there are 3 ways to travel between Jacksonville, FL and St. Louis, MO including taking a bus, flight, and train.
We recommend using the train as it is the most popular way to get from Jacksonville, FL to St. Louis, MO among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Jacksonville, FL to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 10:00AM | Arrival Time 09:20AM | Duration 24h20 | Departure days Tue | Cheapest price $143 |
Operator FlixBus | Departure Time 04:30PM | Arrival Time 09:20AM | Duration 17h50 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $130 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 03:55PM | Duration 19h30 | Departure days Everyday | Cheapest price $129 |
Operator Greyhound | Departure Time 11:15PM | Arrival Time 09:20AM | Duration 35h05 | Departure days Tue | Cheapest price $159 |
Live departures
Jacksonville, FL to St. Louis, MO bus times
The table below shows live departures for Jacksonville, FL to St. Louis, MO buses for today, Wednesday, July 8. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus · FlixBus | 4:30 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 17h50 | 9:20 AM St. Louis, S 15th St (Civic center) | 1 transfer | |
| FlixBus+ · | 9:25 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 19h30 | 3:55 PM St. Louis, S 15th St (Civic center) | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Jacksonville, FL to St. Louis, MO by bus, flight, or train
Compare bus, flight, and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Jacksonville, FL to St. Louis, MO buses with Omio?
Greyhound as well as FlixBus offer buses services from Jacksonville, FL to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from Jacksonville, FL to St. Louis, MO.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Jacksonville, FL to St. Louis, MO.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, flight and train to ensure you get the best deal for traveling from Jacksonville, FL to St. Louis, MO.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Jacksonville, FL to St. Louis, MO.
- Multiple modes of transport: Omio allows you to compare travel options including bus, flight and train to find the ideal travel option from Jacksonville, FL to St. Louis, MO.
Journey information
Overview: Bus from Jacksonville, FL to St. Louis, MO
USAUSA
Buses from Jacksonville, FL to St. Louis, MO run on average 3 times per day, taking around 21h 3m. Cheap bus tickets for this journey start at $211 (€174) if you book in advance.
The earliest bus runs at 01:55, the last at 23:45. The fastest bus covers the 751 miles (1209 km) distance in 17h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 751 miles (1209 km) |
Average bus duration 21h 3m |
Cheapest ticket price $211 (€174) |
Buses per day 3 |
Fastest bus 17h 40m |
First bus 1:55 AM |
Last bus 11:45 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Jan - Mar |
Low Season Apr - Jun |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Jacksonville, FL to St. Louis, MOYou can travel by bus between Jacksonville, FL to St. Louis, MO with Greyhound, FlixBus for as low as $211 (€174). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
17h 40m
Cheapest Price
$251 (€206)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
30h 40m
Cheapest Price
$211 (€174)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis
Things to do in St. Louis
Discover the best of St. Louis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis trip today.
- Must visit
City Museum
Highly original artist-built museum and playground inside a former warehouse, known for tunnels, slides, rooftop features, and immersive installations.
- Recommended
Missouri History Museum
History museum in Forest Park covering St. Louis, Missouri, and regional stories through accessible permanent and temporary exhibitions.
- Must visit
Forest Park
One of the largest urban parks in the United States, home to major cultural institutions, lakes, trails, and broad green space.
- Recommended
Central West End
Walkable neighborhood known for handsome architecture, lively streets, and a strong mix of shops, culture, and city atmosphere.
- Recommended
Delmar Loop
Popular entertainment corridor with street life, public art, music history, and a strong local identity near Washington University.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and traditionally topped with Provel cheese. It is one of the city’s most iconic local foods.
Toasted Ravioli
Breaded and fried meat- or cheese-filled ravioli, usually served with marinara. This St. Louis specialty is a classic appetizer across the city.
- Vegetarian
Gooey Butter Cake
A rich, dense cake with a buttery base and sweet, gooey topping. It is a beloved St. Louis dessert found in bakeries throughout the region.
Ted Drewes Frozen Custard
Legendary dessert stand serving frozen custard concretes and sundaes; a must-visit local institution with nostalgic charm.
Pappy's Smokehouse
Popular barbecue spot known for Memphis-style smoked ribs, pulled pork, and brisket in a lively casual setting.
Charlie Gitto's On The Hill
Established Italian restaurant in the historic Hill neighborhood, famous for toasted ravioli, pasta, and classic old-school hospitality.
United States Dollar
Generally moderate for U.S. city travel. Hotels vary, while casual dining, coffee, and local transport are fairly manageable.
Average meal costs
- Budget
- USD 10-15 for fast food or a casual lunch.
- Mid-range
- USD 20-40 per person at a mid-range restaurant.
- Fine dining
- USD 75+ per person at upscale restaurants.
- Coffee
- USD 4-6 for a regular café coffee.
Tipping culture
Tip 18-20% at restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, and round up for casual service.
FAQs: Bus from Jacksonville, FL to St. Louis, MO
Find answers to the most common questions about traveling from Jacksonville, FL to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Jacksonville, FL to St. Louis, MO can start from as little as $211 (€174) when you book in advance. The average bus ticket price for Jacksonville, FL to St. Louis, MO is $275 (€226) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Jacksonville, FL to St. Louis, MO is 17h 40m to travel the 751 miles (1209 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Jacksonville, FL to St. Louis, MO leaves at 1:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Jacksonville, FL to St. Louis, MO leaves at 11:45 PM.
There are 3 buses a day from Jacksonville, FL to St. Louis, MO which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Jacksonville, FL to St. Louis, MO, you can count on Greyhound, FlixBus for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between Jacksonville, FL and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
A trip to St. Louis, MO from Jacksonville, FL is worth doing but not as a day trip with a journey time of 17h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Jacksonville, FL to St. Louis, MO is July.
It's helpful to compare your options as there are 3 ways to travel between Jacksonville, FL and St. Louis, MO including taking a bus, flight, and train.
Yes, the following accessibility options are available when taking the bus from Jacksonville, FL to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Jacksonville, FL to St. Louis, MO for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Jacksonville, FL to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Jacksonville, FL to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from Jacksonville, FL to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Jacksonville, FL to St. Louis, MO:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Jacksonville, FL to St. Louis, MO. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Jacksonville, FL to St. Louis, MO with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Jacksonville, FL to St. Louis, MO with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Jacksonville, FL to St. Louis, MO with the following bus company: Greyhound, FlixBus.
Since neither Jacksonville, FL nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Jacksonville, FL to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Jacksonville, FL to St. Louis, MO
Most Jacksonville, FL to St. Louis, MO buses use the Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Jacksonville, FL and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Jacksonville
Arrival bus stations in St. Louis
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St
City-centre transport
Getting to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St from Jacksonville city centre
Bus1, 11, 18, 205, 3, Nassau, St. Johns, Clay · 12m · $4 · every ~18 min
1, 19, 3 · 17m · $4 · every ~17 min
SubwaySky · 10m · every ~4 min
St. Louis, S 15th St (Civic center)
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
Most popular bus connections from Jacksonville, FL
More options for your journey from Jacksonville, FL to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and Jacksonville, FL
Most popular bus connections to St. Louis, MO
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