- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Cheapest price
$122
Average price
$123
Fastest journey
17 h 50 m
Average duration
18 h 40 m
Buses per day
2
Distance
1209 km
The best way to find a cheap bus ticket from Jacksonville, FL to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Jacksonville, FL to St. Louis, MO will cost around $123 if you buy it on the day, but the cheapest tickets can be found for only $122.
It's difficult to get from Jacksonville, FL to St. Louis, MO without transferring at least once.
FlixBus · FlixBus
FlixBus+
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FlixBus · FlixBus
FlixBus+
· Omio recommends booking the train as it is the most popular option from Jacksonville, FL to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $95. For those with little time consider booking a flight which can get you there in 6h 47m. The ticket price range depends on the travel mode: a bus costs an average of $95, and a train costs an average of $168.
Distance: 751 miles (1209 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$128 Average price Cheapest | $269 Average price | $243 Average price | $181 Average price (fuel + tolls) |
19h 46m Average total duration 19h 16m Onboard + 30m Additional time* | 40h 53m Average total duration 40h 23m Onboard + 30m Additional time* | 9h 47m Average total duration Fastest 6h 47m Onboard + 3h 0m Additional time* | 13h 8m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Jacksonville, FL to St. Louis, MO:
A bus is $115 (€92) less than a flight for this route with tickets for a flight from Jacksonville, FL to St. Louis, MO costing on average $243 (€195).
A bus is $141 (€113) less than a train for this route with tickets for a train from Jacksonville, FL to St. Louis, MO costing on average $269 (€216).
Other travel options to St. Louis, MO take longer:
Bus takes on average 19h 16m.
Train takes on average 40h 23m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 10:00AM | Arrival Time 09:20AM | Duration 24h20 | Departure days Tue | Cheapest price $116 |
Operator FlixBus | Departure Time 04:30PM | Arrival Time 09:20AM | Duration 17h50 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $98 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 03:55PM | Duration 19h30 | Departure days Everyday | Cheapest price $97 |
Operator Greyhound | Departure Time 11:15PM | Arrival Time 09:20AM | Duration 35h05 | Departure days Tue | Cheapest price $142 |
The table below shows live departures for Jacksonville, FL to St. Louis, MO buses for today, Sunday, August 23. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+ · | 9:25 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 19h30 | 3:55 PM St. Louis, S 15th St (Civic center) | 2 transfers | |
| Monday, August 24 | |||||
FlixBus · FlixBus | 4:30 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 17h50 | 9:20 AM St. Louis, S 15th St (Civic center) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Jacksonville, FL to St. Louis, MO run on average 2 times per day, taking around 19h 16m. Cheap bus tickets for this journey start at $95 (€76) if you book in advance.
The earliest bus runs at 01:55, the last at 23:45. The fastest bus covers the 751 miles (1209 km) distance in 17h 50m.
Distance 751 miles (1209 km) |
Average bus duration 19h 16m |
Cheapest ticket price $95 (€76) |
Buses per day 2 |
Fastest bus 17h 50m |
First bus 1:55 AM |
Last bus 11:45 PM |
Cheapest Month Oct |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Oct - Dec |
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
Find answers to the most common questions about traveling from Jacksonville, FL to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

Most Jacksonville, FL to St. Louis, MO buses use the Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St to St. Louis, S 15th St (Civic center) station pair, with some services arriving at St. Louis, Lambert International Airport. Use this guide to compare Jacksonville, FL and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 km from Jacksonville city centre. Public transport options include:
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. ATMs are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Ticket office support is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Parking, Taxis, WC.
Accessibility facilities are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Wheelchair accessible entrances.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
St. Louis, Lambert International Airport is 19 km from St. Louis city centre. Public transport options include:
St. Louis, Lambert International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Multiple dining options available in terminals.
Free Wi-Fi available throughout the airport. ATMs are aTMs available in terminal areas.
Ticket office support is available at St. Louis, Lambert International Airport.
Available at St. Louis, Lambert International Airport: Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, Lambert International Airport: Wheelchair accessible facilities available.
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