- Must visit
Pinacoteca di Brera
One of Italy’s top art museums, featuring masterpieces by Mantegna, Bellini, Raphael, Caravaggio, and Piero della Francesca.










Cheapest price
$74
Average price
$114
Fastest journey
13h 45m
Average duration
17h 6m
Buses per day
36
Distance
654 km
Omio recommends booking the flight as it is the most popular option from Prague to Milan among Omio's users. If you are prioritising price take the bus with prices starting from $57. For those with little time consider booking a flight which can get you there in 2h 38m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.6 - 1.6kg. The ticket price range depends on the travel mode: a bus costs an average of $57, and a flight costs an average of $33.
Distance: 401 miles (646 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$84 Average price Cheapest | $173 Average price | $131 Average price | $259 Average price (fuel + tolls) |
16h 25m Average total duration 15h 55m Onboard + 30m Additional time* | 5h 38m Average total duration Fastest 2h 38m Onboard + 3h 0m Additional time* | 14h 39m Average total duration 14h 9m Onboard + 30m Additional time* | 9h 2m Average total duration (door-to-door) |
0.6 - 1.6kg CO2 emissions Lowest | 1.9 - 3.9kg CO2 emissions | - CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Prague to Milan:
A bus is $47 (€39) less than a train for this route with tickets for a train from Prague to Milan costing on average $131 (€108).
A bus is $90 (€74) less than a flight for this route with tickets for a flight from Prague to Milan costing on average $173 (€143).
Other travel options to Milan take longer:
Train takes on average 14h 9m.
Bus takes on average 15h 55m.
Tickets start at around $84 (€69) compared to roughly $259 (€213) in fuel and tolls — a saving of about $175 (€144). The journey takes 15h 55m versus 9h 2m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, Infobus, Musil Tour.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:30AM | Arrival Time 09:00PM | Duration 18h30 | Departure days Everyday | Cheapest price $92 |
Operator FlixBus | Departure Time 03:40AM | Arrival Time 11:05PM | Duration 19h25 | Departure days Tue, Wed | Cheapest price $105 |
Operator FlixBus | Departure Time 08:30AM | Arrival Time 02:50AM | Duration 18h20 | Departure days Sat | Cheapest price $101 |
Operator FlixBus | Departure Time 08:45AM | Arrival Time 11:05PM | Duration 14h20 | Departure days Everyday | Cheapest price $97 |
Operator FlixBus | Departure Time 09:00AM | Arrival Time 11:05PM | Duration 14h05 | Departure days Everyday | Cheapest price $97 |
Operator FlixBus | Departure Time 09:20AM | Arrival Time 02:15AM | Duration 16h55 | Departure days Everyday | Cheapest price $92 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 02:15AM | Duration 16h35 | Departure days Everyday | Cheapest price $92 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 02:50AM | Duration 15h55 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $105 |
Operator FlixBus | Departure Time 12:50PM | Arrival Time 06:30AM | Duration 17h40 | Departure days Everyday | Cheapest price $107 |
Operator FlixBus | Departure Time 12:55PM | Arrival Time 06:30AM | Duration 17h35 | Departure days Sun | Cheapest price $156 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 06:30AM | Duration 17h25 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $107 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 02:50AM | Duration 12h50 | Departure days Sun | Cheapest price $101 |
Operator FlixBus | Departure Time 02:15PM | Arrival Time 02:50AM | Duration 12h35 | Departure days Sun | Cheapest price $101 |
Operator FlixBus | Departure Time 02:30PM | Arrival Time 06:30AM | Duration 16h00 | Departure days Everyday | Cheapest price $102 |
Operator FlixBus | Departure Time 03:05PM | Arrival Time 06:30AM | Duration 15h25 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $103 |
Operator FlixBus | Departure Time 03:10PM | Arrival Time 06:30AM | Duration 15h20 | Departure days Everyday | Cheapest price $103 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 10:25AM | Duration 18h25 | Departure days Wed, Thu, Fri, Sat | Cheapest price $118 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 10:25AM | Duration 18h10 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $118 |
Operator FlixBus | Departure Time 05:10PM | Arrival Time 09:10AM | Duration 16h00 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $126 |
Operator FlixBus | Departure Time 05:15PM | Arrival Time 10:30AM | Duration 17h15 | Departure days Everyday | Cheapest price $84 |
Operator FlixBus | Departure Time 05:30PM | Arrival Time 10:30AM | Duration 17h00 | Departure days Everyday | Cheapest price $84 |
Operator FlixBus | Departure Time 05:45PM | Arrival Time 11:55AM | Duration 18h10 | Departure days Everyday | Cheapest price $92 |
Operator FlixBus | Departure Time 06:20PM | Arrival Time 09:00AM | Duration 14h40 | Departure days Everyday | Cheapest price $86 |
Operator FlixBus | Departure Time 06:30PM | Arrival Time 09:00AM | Duration 14h30 | Departure days Everyday | Cheapest price $86 |
Operator FlixBus | Departure Time 06:55PM | Arrival Time 09:10AM | Duration 14h15 | Departure days Fri | Cheapest price $135 |
Operator FlixBus | Departure Time 07:25PM | Arrival Time 09:10AM | Duration 13h45 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $105 |
Operator FlixBus | Departure Time 08:10PM | Arrival Time 12:40PM | Duration 16h30 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $101 |
Operator FlixBus | Departure Time 08:20PM | Arrival Time 12:40PM | Duration 16h20 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $101 |
Operator FlixBus | Departure Time 08:25PM | Arrival Time 03:30PM | Duration 19h05 | Departure days Fri, Sun | Cheapest price $145 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 12:50PM | Duration 15h25 | Departure days Everyday | Cheapest price $105 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 02:45PM | Duration 16h55 | Departure days Everyday | Cheapest price $104 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 03:30PM | Duration 17h30 | Departure days Tue, Wed | Cheapest price $117 |
Operator FlixBus | Departure Time 10:25PM | Arrival Time 02:45PM | Duration 16h20 | Departure days Everyday | Cheapest price $106 |
Operator RegioJet a.s. | Departure Time 11:00PM | Arrival Time 01:00PM | Duration 14h00 | Departure days Fri | Cheapest price $122 |
Operator FlixBus | Departure Time 11:40PM | Arrival Time 02:45PM | Duration 15h05 | Departure days Everyday | Cheapest price $89 |
Operator FlixBus | Departure Time 11:45PM | Arrival Time 05:25PM | Duration 17h40 | Departure days Everyday | Cheapest price $99 |
Operator FlixBus | Departure Time 11:50PM | Arrival Time 02:45PM | Duration 14h55 | Departure days Everyday | Cheapest price $74 |
The table below shows live departures for Prague to Milan buses for today, Tuesday, July 14. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 3:40 AM Praha, Na Knížecí | 19h25 | 11:05 PM Milano, Autostazione Lampugnano | 2 transfers | |
FlixBus · FlixBus | 8:45 AM Praha, ÚAN Florenc | 14h20 | 11:05 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 9:00 AM Prague, Central Train Station | 14h05 | 11:05 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 9:20 AM Praha, ÚAN Florenc | 16h55 | 2:15 AM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 9:40 AM Praha, Na Knížecí | 16h35 | 2:15 AM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:55 AM Praha, Na Knížecí | 19h35 | 6:30 AM Milano, Autostazione Lampugnano | 2 transfers | |
FlixBus · FlixBus · FlixBus | 12:50 PM Praha, M. Horákové (Hradčanská) | 17h40 | 6:30 AM Milano, Autostazione Lampugnano | 2 transfers | |
FlixBus · FlixBus · FlixBus | 1:05 PM Prague, Central Train Station | 19h50 | 8:55 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
FlixBus · FlixBus | 1:05 PM Prague, Central Train Station | 18h05 | 7:10 AM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 2:30 PM Praha, Černý Most | 16h00 | 6:30 AM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus · FlixBus | 2:30 PM Praha, Černý Most | 19h45 | 10:15 AM Milano, Milan Linate Airport | 2 transfers | |
FlixBus · FlixBus · FlixBus | 3:05 PM Praha, Zličín | 15h25 | 6:30 AM Milano, Autostazione Lampugnano | 2 transfers | |
FlixBus · FlixBus | 3:10 PM Praha, ÚAN Florenc | 15h20 | 6:30 AM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus · FlixBus | 5:15 PM Praha, ÚAN Florenc | 17h00 | 10:15 AM Milano, Milan Linate Airport | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:15 PM Praha, ÚAN Florenc | 17h15 | 10:30 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:30 PM Prague, Central Train Station | 16h45 | 10:15 AM Milano, Milan Linate Airport | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:30 PM Prague, Central Train Station | 17h00 | 10:30 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:45 PM Praha, Na Knížecí | 18h10 | 11:55 AM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
FlixBus · FlixBus | 5:45 PM Praha, Na Knížecí | 15h15 | 9:00 AM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus | 6:20 PM Praha, ÚAN Florenc | 14h40 | 9:00 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus | 6:30 PM Prague, Central Train Station | 14h30 | 9:00 AM Milano, Autostazione Lampugnano | 0 transfersDirect | |
FlixBus · FlixBus · FlixBus | 7:25 PM Praha, Zličín | 17h15 | 12:40 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
FlixBus · FlixBus | 7:25 PM Praha, Zličín | 13h45 | 9:10 AM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 8:10 PM Praha, ÚAN Florenc | 16h30 | 12:40 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 1 transfer | |
FlixBus · FlixBus | 8:20 PM Prague, Central Train Station | 16h20 | 12:40 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 1 transfer | |
FlixBus · FlixBus | 9:25 PM Praha, ÚAN Florenc | 15h25 | 12:50 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 9:50 PM Praha, Na Knížecí | 19h00 | 4:50 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 10:00 PM Praha, ÚAN Florenc | 17h30 | 3:30 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 10:25 PM Praha, M. Horákové (Hradčanská) | 17h05 | 3:30 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus | 11:40 PM Praha, ÚAN Florenc | 17h10 | 4:50 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus · FlixBus | 11:40 PM Praha, ÚAN Florenc | 17h30 | 5:10 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
FlixBus · FlixBus | 11:45 PM Praha, ÚAN Florenc | 17h40 | 5:25 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus · FlixBus | 11:45 PM Praha, ÚAN Florenc | 21h10 | 8:55 PM Milano, Milan Linate Airport | 2 transfers | |
FlixBus · FlixBus · FlixBus | 11:50 PM Prague, Central Train Station | 21h05 | 8:55 PM Milano, Milan Linate Airport | 2 transfers | |
FlixBus · FlixBus | 11:50 PM Prague, Central Train Station | 17h00 | 4:50 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus · FlixBus | 11:50 PM Prague, Central Train Station | 17h20 | 5:10 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
| Wednesday, July 15 | |||||
FlixBus · FlixBus · FlixBus | 2:30 AM Prague, Central Train Station | 18h40 | 9:10 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 2 transfers | |
FlixBus · FlixBus | 2:30 AM Prague, Central Train Station | 15h00 | 5:30 PM Milano, Autostazione Lampugnano | 1 transfer | |
FlixBus · FlixBus · FlixBus | 2:30 AM Prague, Central Train Station | 18h25 | 8:55 PM Milano, Milan Linate Airport | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Prague to Milan run on average 39 times per day, taking around 15h 55m. Cheap bus tickets for this journey start at $57 (€47) but you can travel from only $33 (€27) by flight.
There are 2 buses per day. The earliest bus runs at 00:15, the last at 23:55. The fastest bus covers the 401 miles (646 km) distance in 12h 50m.
Distance 401 miles (646 km) |
Average bus duration 15h 55m |
Cheapest ticket price $57 (€47) |
Buses per day 39 |
Direct buses 2 |
Fastest bus 12h 50m |
First bus 12:15 AM |
Last bus 11:55 PM |
Cheapest Month May |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Thu |
Best time to book 14 days |
Discover the best of Milan — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Milan trip today.
One of Italy’s top art museums, featuring masterpieces by Mantegna, Bellini, Raphael, Caravaggio, and Piero della Francesca.
This contemporary art museum near Porta Romana presents rotating exhibitions in a striking former industrial distillery complex.
Italy’s leading science museum is set in a former monastery and features Leonardo galleries, trains, aircraft, and a submarine.
Milan’s central square frames the cathedral and major civic buildings, making it the city’s essential meeting point and photo stop.
This artistic district offers charming lanes, Brera atmosphere, boutiques, and easy access to galleries and evening strolls.
A large landscaped park behind the castle, perfect for walks, skyline views, and reaching landmarks like the Arch of Peace.
Saffron risotto cooked with butter, stock and cheese. It is Milan's signature dish, linked to the city's love of rich northern Italian rice cookery.
Breaded veal cutlet fried in butter until golden. A classic Milanese main, prized for its simple preparation and long-standing local tradition.
Slow-braised veal shanks with vegetables, wine and broth, often finished with gremolata. A hearty Lombard specialty commonly paired with risotto.
Three-Michelin-star fine dining by Enrico Bartolini in MUDEC. Expect refined Italian tasting menus in a polished contemporary setting.
Historic Milanese restaurant near the Duomo, famous for risotto and cotoletta. Traditional, elegant rooms and a strong local culinary identity.
Long-running local favorite for classic Milanese cuisine, especially risotto and ossobuco. Warm, old-school atmosphere in the Brera area.
Moderate for Western Europe. Hotels and central dining can be pricey, but transit is affordable and budget meals, aperitivo deals, and local cafes help keep daily costs reasonable.
Tipping is modest. Service may be included. Round up or leave €1-2 at cafes, 5-10% for good restaurant service, and round up taxi fares.
Official public transport app
Orio al Serio, Milan Bergamo Airport (Bus station) -> Milano Centrale, Milan
Find answers to the most common questions about traveling from Prague to Milan by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milan, this guide helps you travel smarter and with confidence.

Most Prague to Milan buses use the Praha, ÚAN Florenc to Milano, Autostazione Lampugnano station pair, with some services arriving at Milano, San Donato - Settore B (Viale Giuseppe Impastato). Use this guide to compare Prague and Milan bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Praha, ÚAN Florenc is 1 km from Prague city centre. Public transport options include:
Praha, ÚAN Florenc has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Florenc (in the station), Bistro Florenc (0.2 km), Restaurace U Rozvařilů (0.5 km).
Free Wi-Fi. ATMs are located inside the station, offering multiple currency options.
Ticket office support is available at Praha, ÚAN Florenc.
Available at Praha, ÚAN Florenc: Parking, Taxis, WC.
Accessibility facilities are available at Praha, ÚAN Florenc: Elevators, ramps.
Praha, Hlavní Nádraží is 1 km from Prague city centre. Public transport options include:
Praha, Hlavní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Czech Bistro (in the station), Fast Food Express (in the station), Bohemian Café (0.2 km).
Free Wi-Fi. ATMs are located near the main entrance and ticketing area.
Ticket office support is available at Praha, Hlavní Nádraží.
Available at Praha, Hlavní Nádraží: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Hlavní Nádraží: Elevators, ramps.
Praha, Na Knížecí is 2 km from Prague city centre. Public transport options include:
Praha, Na Knížecí has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, and WC.
Food options include: Café Na Knížecí (in the station), Bistro Praha (0.2 km), Restaurace U Knížete (0.5 km).
Free Wi-Fi. ATMs are located near the entrance.
Available at Praha, Na Knížecí: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Na Knížecí: Elevators, ramps.
Milano, Autostazione Lampugnano is 5 km from Milan city centre. Public transport options include:
Milano, Autostazione Lampugnano has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Lampugnano (in the station), Trattoria Milano (0.5 km), Pizza Express (0.7 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Milano, Autostazione Lampugnano.
Available at Milano, Autostazione Lampugnano: Parking, Taxis, WC.
Accessibility facilities are available at Milano, Autostazione Lampugnano: Elevators, ramps.
Milano, San Donato - Settore B (Viale Giuseppe Impastato) is 6 km from Milan city centre. Public transport options include:
Milano, San Donato - Settore B (Viale Giuseppe Impastato) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Italiana (in the station), Fast Food Express (in the station), Trattoria Milano (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance for cash withdrawals.
Ticket office support is available at Milano, San Donato - Settore B (Viale Giuseppe Impastato).
Available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Parking, Taxis, WC.
Accessibility facilities are available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Elevators, ramps.
Here are some other resources that might have the information you need