- Must visit
Greensboro Science Center
A popular science museum, aquarium, and zoo complex with interactive exhibits and family-friendly programming. One of Greensboro’s most visited attractions.
Omio recommends booking the bus as it is the most popular option from Knoxville, TN to Greensboro, NC among Omio's users. If you are prioritising price take the bus with prices starting from $153. For those with little time consider booking a bus which can get you there in 12h 10m. The ticket price range depends on the travel mode: a bus costs an average of $153, and a bus costs an average of $153.
Distance: 231 miles (372 km)
Most popular Bus | Driving |
|---|---|
$178 Average price Cheapest | $16 Average price (fuel + tolls) |
12h 40m Average total duration Fastest 12h 10m Onboard + 30m Additional time* | 4h 20m Average total duration (door-to-door) |
Direct Options | Direct Options |
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:40AM | Arrival Time 12:50PM | Duration 12h10 | Departure days Sun | Cheapest price $153 |
Operator Greyhound | Departure Time 11:40PM | Arrival Time 11:50AM | Duration 12h10 | Departure days Tue, Thu, Fri | Cheapest price $159 |
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Knoxville, TN to Greensboro, NC run on average 1 times per day, taking around 12h 10m. Cheap bus tickets for this journey start at $153 (€123) if you book in advance.
The earliest bus runs at 09:30, the last at 19:25. The fastest bus covers the 231 miles (372 km) distance in 12h 10m.
Distance 231 miles (372 km) |
Average bus duration 12h 10m |
Cheapest ticket price $153 (€123) |
Buses per day 1 |
Fastest bus 12h 10m |
First bus 9:30 AM |
Last bus 7:25 PM |
Cheapest Month Sep |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of Greensboro — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greensboro trip today.
A popular science museum, aquarium, and zoo complex with interactive exhibits and family-friendly programming. One of Greensboro’s most visited attractions.
Located in the former F.W. Woolworth building, this museum interprets the 1960 Greensboro sit-ins and the broader Civil Rights Movement. A nationally significant site.
The University of North Carolina at Greensboro’s art museum, known for its strong collection of modern and contemporary American art and rotating exhibitions.
The city’s main visitor area, combining historic streets, public art, entertainment venues, and walkable blocks with many key attractions nearby.
A beautifully landscaped public garden popular for peaceful walks, seasonal blooms, and photo spots.
A scenic wetland boardwalk and nature area known for its wooden paths, quiet atmosphere, and strong local popularity.
Slow-smoked pork shoulder chopped or pulled and dressed in the state’s signature tangy vinegar-based sauce. It is one of the Piedmont region’s most iconic foods.
A red slaw made with cabbage, vinegar, ketchup, and spices, commonly served on barbecue trays or sandwiches across central North Carolina.
Smoked or pit-cooked chicken basted with a peppery vinegar sauce, a longtime barbecue staple in North Carolina cookouts and restaurants.
Well-known upscale-casual restaurant with European and Southern influences, dependable service, and a refined but comfortable atmosphere.
Popular casual Greensboro spot known for creative burgers, good beer selection, and lively atmosphere. A local favorite for upscale comfort food.
Polished bistro offering French-inspired American cuisine, strong brunch, and an elegant dining room near the Proximity Hotel.
Generally affordable by U.S. standards. Budget dining is easy to find, while hotels and upscale meals are moderately priced.
Tip 18-20% in restaurants for table service. Tip USD 1-2 per drink at bars, round up or tip 10-15% for taxis, and tip hotel staff for assistance.
Find answers to the most common questions about traveling from Knoxville, TN to Greensboro, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greensboro, NC, this guide helps you travel smarter and with confidence.

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