- Must visit
Cincinnati Art Museum
Major art museum in Eden Park with a broad collection spanning ancient to contemporary works. A core cultural stop in the city.
Omio recommends booking the bus as it is the most popular option from Knoxville, TN to Cincinnati, OH among Omio's users. If you are prioritising price take the bus with prices starting from $47. For those with little time consider booking a bus which can get you there in 5h 23m. The ticket price range depends on the travel mode: a bus costs an average of $47, and a bus costs an average of $47.
Distance: 219 miles (353 km)
Most popular Bus | Driving |
|---|---|
$58 Average price Cheapest | $53 Average price (fuel + tolls) |
5h 53m Average total duration Fastest 5h 23m Onboard + 30m Additional time* | 3h 40m Average total duration (door-to-door) |
![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 07:25AM | Duration 5h25 | Departure days Mon, Sun | Cheapest price $47 |
Operator Greyhound | Departure Time 10:00PM | Arrival Time 03:25AM | Duration 5h25 | Departure days Mon, Fri | Cheapest price $44 |
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Knoxville, TN to Cincinnati, OH run on average 1 times per day, taking around 5h 23m. Cheap bus tickets for this journey start at $47 (€38) if you book in advance.
There are 1 buses per day. The earliest bus runs at 13:20, the last at 22:00. The fastest bus covers the 219 miles (353 km) distance in 5h 25m.
Distance 219 miles (353 km) |
Average bus duration 5h 23m |
Cheapest ticket price $47 (€38) |
Buses per day 1 |
Direct buses 1 |
Fastest bus 5h 25m |
First bus 1:20 PM |
Last bus 10:00 PM |
Cheapest Month Aug |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Apr - Jun |
Discover the best of Cincinnati — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Cincinnati trip today.
Major art museum in Eden Park with a broad collection spanning ancient to contemporary works. A core cultural stop in the city.
Museum on the Ohio River focused on the history of slavery, resistance, and freedom movements in the United States.
Large museum complex inside Cincinnati's iconic Art Deco train terminal, housing history, science, and family-friendly exhibits.
Historic neighborhood known for 19th-century architecture, walkable blocks, murals, and strong local character.
Popular riverfront park with walking paths, swings, fountains, and postcard views of the Ohio River and bridges.
Large hilltop park with gardens, museums, and scenic overlooks toward the river and Kentucky hills.
A uniquely spiced meat sauce with hints of cinnamon and cocoa, served over spaghetti or hot dogs and topped with cheese, onions, or beans. It is the city’s signature dish.
A Cincinnati-style hot dog topped with mustard, Cincinnati chili, diced onions, and a mound of shredded cheddar. It is a classic local fast-food favorite.
A traditional German-American breakfast meat made from pork, beef, steel-cut oats, and spices, then sliced and fried crisp. It reflects the city’s strong German heritage.
A well-known rustic Italian restaurant downtown, loved for handmade pasta, strong wine list, and intimate underground atmosphere.
An established upscale restaurant serving refined contemporary American and European-influenced dishes in an elegant setting.
A famous old-school steakhouse with polished service, prime steaks, seafood, and a glamorous dining room.
Moderate by U.S. standards. Hotels vary by season, while dining, coffee, and local transport are usually reasonably priced for visitors.
Tip 18-20% in restaurants. Bartenders USD 1-2 per drink. Round up or tip 10-15% for taxis. Tip hotel staff and delivery drivers; tipping is expected for most services.
Find answers to the most common questions about traveling from Knoxville, TN to Cincinnati, OH by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Cincinnati, OH, this guide helps you travel smarter and with confidence.

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