- Must visit
Cincinnati Art Museum
A major art museum with broad global collections, strong Cincinnati ties, and free admission, set in scenic Eden Park.
The best way to find a cheap bus ticket from Knoxville, TN to Cincinnati, OH is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Knoxville, TN to Cincinnati, OH will cost around $46 if you buy it on the day, but the cheapest tickets can be found for only $46.
On Sat, Oct 31, we found 1 buses from Knoxville, TN to Cincinnati, OH, including 1 direct services.
On Sat, Oct 31 the direct buses cover the 353 km distance in an average of 5 h 25 m but if you time it right, some buses will get you there in just 5 h 25 m .
On Sat, Oct 31 the slowest buses will take 5 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Knoxville, TN to Cincinnati, OH run on average 1 times per day, taking around 5h 40m. Cheap bus tickets for this journey start at $37 if you book in advance.
There are 1 buses per day. The earliest bus runs at 13:20, the last at 22:00. The fastest bus covers the 219 miles (353 km) distance in 5h 25m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Knoxville, TN to Cincinnati, OH.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 07:25AM | Duration 5h25 | Departure days Mon, Sat | Cheapest price $46 |
Operator Greyhound | Departure Time 10:00PM | Arrival Time 02:40AM | Duration 5h40 | Departure days Sat | Cheapest price $40 |
The table below shows live departures for Knoxville, TN to Cincinnati, OH buses for tomorrow, Friday, October 30. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:00 AM Knoxville, TN | 5h25 | 7:25 AM Cincinnati, OH | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Knoxville, TN to Cincinnati, OH with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Cincinnati, OH — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Cincinnati, OH trip today.
A major art museum with broad global collections, strong Cincinnati ties, and free admission, set in scenic Eden Park.
A family-focused museum inside Union Terminal featuring Cincinnati history, natural history, and rotating science and culture exhibits.
A nationally significant museum preserving Underground Railroad history through immersive exhibits on freedom and civil rights.
The city’s signature riverfront park offers fountains, swings, events, and excellent skyline views along the Ohio River.
A lively historic district known for preserved 19th-century architecture, murals, shops, and one of the best urban walks in Cincinnati.
A civic square lined with historic buildings and event spaces, central to downtown festivals, markets, and everyday city life.
Cincinnati chili is a spiced meat sauce served over spaghetti or hot dogs, then topped with cheese. It is the city's most iconic comfort food.
Goetta is a German-American loaf of pork, beef, oats, and spices, sliced and fried crisp. It reflects the city's strong German heritage.
A cheese coney is a small hot dog in a bun topped with Cincinnati chili, mustard, onions, and shredded cheddar. It is a beloved local quick meal.
Beloved local chain serving ice cream made by the French Pot method. A must for Cincinnati's signature black raspberry chocolate chip.
Refined Midwestern restaurant known for seasonal tasting menus, polished service, and one of Cincinnati's top fine dining experiences.
Historic chili parlor famed for Cincinnati chili, cheese coneys, and a classic local diner feel in the Camp Washington area.
Moderate for U.S. city breaks: hotels are often cheaper than larger metros, dining is mid-priced, and public transit is limited so rideshares or parking can add costs.
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or cafe order if service is good.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Cincinnati, OH.
Find answers to the most common questions about traveling from Knoxville, TN to Cincinnati, OH by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Cincinnati, OH, this guide helps you travel smarter and with confidence.

Most Knoxville, TN to Cincinnati, OH buses use the Knoxville, Kirkwood Street to Cincinnati, Greyhound Bus Station station pair. Use this guide to compare Knoxville, TN and Cincinnati, OH bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Knoxville, Kirkwood Street is 5 km from Knoxville city centre. Public transport options include:
Knoxville, Kirkwood Street has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Knoxville, Kirkwood Street. ATMs are available at Knoxville, Kirkwood Street.
Ticket office support is available at Knoxville, Kirkwood Street.
Available at Knoxville, Kirkwood Street: Parking, Taxis, WC.
Accessibility facilities are available at Knoxville, Kirkwood Street: Wheelchair accessible buses available.
Cincinnati, Greyhound Bus Station is 12 km from Cincinnati city centre. Public transport options include:
Cincinnati, Greyhound Bus Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available in the waiting area. ATMs are aTM machines available inside the station.
Ticket office support is available at Cincinnati, Greyhound Bus Station.
Available at Cincinnati, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Cincinnati, Greyhound Bus Station: Wheelchair accessible entrances and seating available.
Check bus stations information for Knoxville, TN and Cincinnati, OH, including where buses depart and arrive on this route.