- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
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The cheapest and fastest buses from Iowa City, IA to St. Louis, MO
Showing times and prices for Jul 16
Cheapest price
$36
Average price
$36
Fastest journey
5 h 5 m
Average duration
5 h 5 m
Buses per day
1
Distance
356 km
Cheap tickets
The best way to find a cheap bus ticket from Iowa City, IA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Iowa City, IA to St. Louis, MO will cost around $36 if you buy it on the day, but the cheapest tickets can be found for only $36.
Fast buses
Of the 1 buses that leave Iowa City, IA for St. Louis, MO on Thu, Jul 16, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Jul 16 the direct buses cover the 356 km distance in an average of 5 h 5 m but if you time it right, some buses will get you there in just 5 h 5 m .
On Thu, Jul 16 the slowest buses will take 5 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
12:30 AM5h05Iowa City, IA5:35 AMSt. Louis, MO$361One-way0 transfers
- 12:30 AM5h05Iowa City, IA5:35 AMSt. Louis, MO$361One-way0 transfers
Travel Information
Compare bus and flight for Iowa City, IA to St. Louis, MO
Omio recommends booking the bus as it is the most popular option from Iowa City, IA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $36. For those with little time consider booking a flight which can get you there in 4h 59m. The ticket price range depends on the travel mode: a bus costs an average of $36, and a flight costs an average of $273.
Distance: 221 miles (356 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$58 Average price Cheapest | $349 Average price | $53 Average price (fuel + tolls) |
5h 35m Average total duration 5h 5m Onboard + 30m Additional time* | 7h 59m Average total duration Fastest 4h 59m Onboard + 3h 0m Additional time* | 4h 0m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Iowa City, IA to St. Louis, MO is a bus with an average price of $58 (€48).
This is compared to other travel options from Iowa City, IA to St. Louis, MO:
A bus is $291 (€240) less than a flight for this route with tickets for a flight from Iowa City, IA to St. Louis, MO costing on average $349 (€288).
The fastest way to travel from Iowa City, IA to St. Louis, MO is by flight with an average journey time of 4h 59m.
Other travel options to St. Louis, MO take longer:
Bus takes on average 5h 5m.
It's helpful to compare your options as there are 2 ways to travel between Iowa City, IA and St. Louis, MO including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Iowa City, IA to St. Louis, MO among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about -2h -5m sooner (5h 5m by bus vs 4h 0m by car) and save roughly $-5.41 (€-4.46) compared to fuel and tolls ($58 (€48) vs $53 (€44)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by Greyhound.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Iowa City, IA to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:30AM | Arrival Time 05:35AM | Duration 5h05 | Departure days Mon, Tue, Thu, Sat, Sun | Cheapest price $36 |
Operator Infobus | Departure Time 09:55AM | Arrival Time 05:00PM | Duration 7h05 | Departure days Tue, Thu | Cheapest price $108 |
Operator FlixBus | Departure Time 05:40PM | Arrival Time 12:25PM | Duration 18h45 | Departure days Fri | Cheapest price $176 |
Operator Greyhound | Departure Time 07:30PM | Arrival Time 12:35AM | Duration 5h05 | Departure days Tue, Thu | Cheapest price $35 |
Operator FlixBus | Departure Time 08:45PM | Arrival Time 12:25PM | Duration 15h40 | Departure days Fri | Cheapest price $106 |
Live departures
Iowa City, IA to St. Louis, MO bus times
The table below shows live departures for Iowa City, IA to St. Louis, MO buses for today, Tuesday, July 14. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 0 | 9:55 AM Iowa City, IA | 7h05 | 5:00 PM St. Louis, MO | 0 transfersDirect | |
| 7:30 PM Iowa City, S Riverside Dr (Kum & Go), IA | 5h05 | 12:35 AM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
| Wednesday, July 15 | |||||
| 12:30 AM Iowa City, IA | 5h05 | 5:35 AM St. Louis, MO | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Iowa City, IA to St. Louis, MO by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Iowa City, IA to St. Louis, MO buses with Omio?
Greyhound operates all buses services from Iowa City, IA to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from Iowa City, IA to St. Louis, MO.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Iowa City, IA to St. Louis, MO.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Iowa City, IA to St. Louis, MO.
Journey information
Overview: Bus from Iowa City, IA to St. Louis, MO
USAUSA
Buses from Iowa City, IA to St. Louis, MO run on average 2 times per day, taking around 5h 5m. Cheap bus tickets for this journey start at $36 (€30) if you book in advance.
The earliest bus runs at 07:50, the last at 23:30. The fastest bus covers the 221 miles (356 km) distance in 5h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 221 miles (356 km) |
Average bus duration 5h 5m |
Cheapest ticket price $36 (€30) |
Buses per day 2 |
Fastest bus 5h 5m |
First bus 7:50 AM |
Last bus 11:30 PM |
Cheapest Month Apr |
Cheapest Day Mon |
High Season Apr - Jun |
Low Season Jul - Sep |
Busiest Day Thu |
Least Busy Day Thu |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Iowa City, IA to St. Louis, MOYou can travel by bus between Iowa City, IA to St. Louis, MO with Greyhound for as low as $36 (€30). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
5h 5m
Cheapest Price
$36 (€30)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis, MO
Things to do in St. Louis, MO
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
- Recommended
Missouri History Museum
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
- Recommended
Saint Louis Science Center
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
- Must visit
Gateway Arch National Park Grounds
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
- Must visit
Forest Park
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
- Recommended
Tower Grove Park
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
- Vegetarian
Toasted Ravioli
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
- Vegetarian
Gooey Butter Cake
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Bulrush
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Ted Drewes Frozen Custard
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Pappy's Smokehouse
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
United States dollar ($)
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-35 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person at upscale restaurants.
- Coffee
- $3-5 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
FAQs: Bus from Iowa City, IA to St. Louis, MO
Find answers to the most common questions about traveling from Iowa City, IA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Iowa City, IA to St. Louis, MO can start from as little as $36 (€30) when you book in advance. The average bus ticket price for Iowa City, IA to St. Louis, MO is $58 (€48) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Iowa City, IA to St. Louis, MO is 5h 5m to travel the 221 miles (356 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Iowa City, IA to St. Louis, MO leaves at 7:50 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Iowa City, IA to St. Louis, MO leaves at 11:30 PM.
There are 2 buses a day from Iowa City, IA to St. Louis, MO which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Iowa City, IA to St. Louis, MO, you can count on Greyhound for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between Iowa City, IA and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
A trip to St. Louis, MO from Iowa City, IA is worth doing but not as a day trip with a journey time of 5h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Iowa City, IA to St. Louis, MO is April.
It's helpful to compare your options as there are 2 ways to travel between Iowa City, IA and St. Louis, MO including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Iowa City, IA to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Iowa City, IA to St. Louis, MO for bus company Greyhound.
Whether you can cancel your bus ticket from Iowa City, IA to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Iowa City, IA to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from Iowa City, IA to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Iowa City, IA to St. Louis, MO:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Iowa City, IA to St. Louis, MO.
You can reserve your seat on the bus from Iowa City, IA to St. Louis, MO with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Iowa City, IA to St. Louis, MO with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Iowa City, IA to St. Louis, MO with the following bus company: Greyhound.
Since neither Iowa City, IA nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Iowa City, IA to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Iowa City, IA to St. Louis, MO
Most Iowa City, IA to St. Louis, MO buses use the Iowa City, S Riverside Dr (Kum & Go) to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Iowa City, IA and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Iowa City
Arrival bus stations in St. Louis
Iowa City, S Riverside Dr (Kum & Go)
Iowa City, E Court St (Greyhound Bus Station)
City-centre transport
Getting to Iowa City, E Court St (Greyhound Bus Station) from Iowa City city centre
Bus12 · 5m · every ~2 min
St. Louis, S 15th St (Civic center)
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
Most popular bus connections from Iowa City, IA
More options for your journey from Iowa City, IA to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and Iowa City, IA
Most popular bus connections to St. Louis, MO
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