- Must visit
Alabama Museum of Natural History
Main university museum featuring natural history, archaeology, and regional exhibits, with broad appeal for first-time visitors.
Omio recommends booking the train as it is the most popular option from Greenville, SC to Tuscaloosa, AL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $80 For those with little time, consider booking a flight, which has an average total journey time of 5h 26m. Average ticket prices depend on the travel mode: a bus costs an average of $80, while a flight costs an average of $715.
Distance: 317 miles (511 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$80 Average price Cheapest | $107 Average price | $715 Average price | $71 Average price (fuel + tolls) |
9h 1m Average total duration 8h 31m Onboard + 30m Additional time* | 9h 57m Average total duration 9h 27m Onboard + 30m Additional time* | 5h 26m Average total duration Fastest 3h 26m Onboard + 2h 0m Additional time* | 5h 15m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Greenville, SC to Tuscaloosa, AL:
A bus is $26 less than a train for this route with tickets for a train from Greenville, SC to Tuscaloosa, AL costing on average $107.
A bus is $635 less than a flight for this route with tickets for a flight from Greenville, SC to Tuscaloosa, AL costing on average $715.
Other travel options to Tuscaloosa, AL take longer:
Bus takes on average 8h 31m.
Train takes on average 9h 27m.
Tickets start at around $80 compared to roughly $71 in fuel and tolls — a saving of about $-9.60. The journey takes 8h 31m versus 5h 15m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 11:40PM | Arrival Time 08:35AM | Duration 8h55 | Departure days Tue | Cheapest price $114 |
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Greenville, SC to Tuscaloosa, AL run on average 3 times per day, taking around 8h 31m. Cheap bus tickets for this journey start at $51 if you book in advance.
The earliest bus runs at 07:45, the last at 22:00. The fastest bus covers the 317 miles (511 km) distance in 6h 30m.
Distance 317 miles (511 km) |
Average bus duration 8h 31m |
Cheapest ticket price $51 |
Buses per day 3 |
Fastest bus 6h 30m |
First bus 7:45 AM |
Last bus 10:00 PM |
Cheapest Month Jul |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Jan - Mar |
Discover the best of Tuscaloosa, AL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Tuscaloosa, AL trip today.
Main university museum featuring natural history, archaeology, and regional exhibits, with broad appeal for first-time visitors.
Contemporary gallery on campus presenting rotating exhibitions by regional and national artists in a compact modern space.
Student-centered art museum with rotating exhibitions and programs that highlight contemporary practice and campus creativity.
Riverfront park with trails, green space, and event areas, ideal for relaxed walks and views near downtown.
Popular downtown district with shops, nightlife, public art, and frequent events, making it a practical base for exploring on foot.
Large campus green framed by historic university buildings, suited to walking, photos, and a sense of campus traditions.
Find answers to the most common questions about traveling from Greenville, SC to Tuscaloosa, AL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Tuscaloosa, AL, this guide helps you travel smarter and with confidence.

Most Greenville, SC to Tuscaloosa, AL buses use the Greenville, Woodruff Rd ("Raceway" gas station) to Tuscaloosa, Greensboro Ave (Bus Station) station pair. Use this guide to compare Greenville, SC and Tuscaloosa, AL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Limited dining options available in adjacent areas.
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Tuscaloosa, Greensboro Ave (Bus Station) is 3 km from Tuscaloosa city centre. Public transport options include:
Tuscaloosa, Greensboro Ave (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tuscaloosa, Greensboro Ave (Bus Station). ATMs are available at Tuscaloosa, Greensboro Ave (Bus Station).
Ticket office support is available at Tuscaloosa, Greensboro Ave (Bus Station).
Available at Tuscaloosa, Greensboro Ave (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Tuscaloosa, Greensboro Ave (Bus Station): Wheelchair accessible.
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