The cheapest and fastest buses from Frederick, MD to Charleston, SC
Cheapest price
$132
Average price
$132
Fastest journey
14 h
Average duration
14 h
Buses per day
1
Distance
772 km
The best way to find a cheap bus ticket from Frederick, MD to Charleston, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frederick, MD to Charleston, SC will cost around $132 if you buy it on the day, but the cheapest tickets can be found for only $132.
Of the 1 buses that leave Frederick, MD for Charleston, SC on Sun, Mar 15, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Mar 15 the direct buses cover the 772 km distance in an average of 14 h but if you time it right, some buses will get you there in just 14 h .
On Sun, Mar 15 the slowest buses will take 14 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for Frederick, MD to Charleston, SC
Omio recommends booking the flight as it is the most popular option from Frederick, MD to Charleston, SC among Omio's users. If you are prioritising price take the bus with prices starting from $96. For those with little time consider booking a flight which can get you there in 5h 13m. The ticket price range depends on the travel mode: a bus costs an average of $96, and a train costs an average of $247.
Distance: 479 miles (772 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
$96 Average price Cheapest | $245 Average price | $247 Average price |
32h 35m Average total duration 32h 5m Onboard + 30m Additional time* | 8h 13m Average total duration Fastest 5h 13m Onboard + 3h 0m Additional time* | 17h 42m Average total duration 17h 12m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Frederick, MD to Charleston, SC bus times
The table below shows live departures for Frederick, MD to Charleston, SC buses for tomorrow, Saturday, March 14. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:05 AM Frederick, MD | 14h00 | 8:05 PM Charleston, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Frederick, MD to Charleston, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 15
Mar 16
Mar 17
Mar 18
Mar 19
Mar 20
Mar 21
Why should you book Frederick, MD to Charleston, SC buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Frederick, MD to Charleston, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Frederick, MD to Charleston, SC.
Journey information
Overview: Bus from Frederick, MD to Charleston, SC
Buses from Frederick, MD to Charleston, SC run on average 2 times per day, taking around 32h 5m. Cheap bus tickets for this journey start at $96 (€78) if you book in advance.
The earliest bus runs at 01:05, the last at 21:34. The fastest bus covers the 479 miles (772 km) distance in 32h 5m.
Distance 479 miles (772 km) |
Average bus duration 32h 5m |
Cheapest ticket price $96 (€78) |
Buses per day 2 |
Fastest bus 32h 5m |
First bus 01:05 |
Last bus 21:34 |
Cheapest month Nov |
Cheapest day Thu |
High season Jan - Mar |
Low season Apr - Jun |
Bus providers: Greyhound from Frederick, MD to Charleston, SCYou can travel by bus between Frederick, MD to Charleston, SC with Greyhound for as low as $96 (€78). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Frederick, MD to Charleston, SC
Find answers to the most common questions about traveling from Frederick, MD to Charleston, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Charleston, SC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Frederick, MD to Charleston, SC
Most popular bus connections from Frederick, MD
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