- Must visit
The Charleston Museum
America’s first museum with natural history, decorative arts, and Charleston stories across several historic sites.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Frederick, MD to Charleston, SC
Showing times and prices for Jul 30
Cheapest price
$159
Average price
$159
Fastest journey
1 d 8 h 5 m
Average duration
1 d 8 h 5 m
Buses per day
1
Distance
772 km
Cheap tickets
The best way to find a cheap bus ticket from Frederick, MD to Charleston, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frederick, MD to Charleston, SC will cost around $159 if you buy it on the day, but the cheapest tickets can be found for only $159.
Fast buses
Of the 1 buses that leave Frederick, MD for Charleston, SC on Thu, Jul 30, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Jul 30 the direct buses cover the 772 km distance in an average of 1 d 8 h 5 m but if you time it right, some buses will get you there in just 1 d 8 h 5 m .
On Thu, Jul 30 the slowest buses will take 1 d 8 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:25 PM32h05Frederick, MD10:30 PMCharleston, SC$1591One-way0 transfers
- 2:25 PM32h05Frederick, MD10:30 PMCharleston, SC$1591One-way0 transfers
Travel Information
Compare bus, train, and flight for Frederick, MD to Charleston, SC
Omio recommends booking the flight as it is the most popular option from Frederick, MD to Charleston, SC among Omio's users. If you are prioritising price take the bus with prices starting from $95. For those with little time consider booking a flight which can get you there in 4h 34m. The ticket price range depends on the travel mode: a bus costs an average of $95, and a flight costs an average of $83.
Distance: 479 miles (772 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
$118 Average price Cheapest | $232 Average price | $206 Average price |
27h 52m Average total duration 27h 22m Onboard + 30m Additional time* | 7h 34m Average total duration Fastest 4h 34m Onboard + 3h 0m Additional time* | 17h 42m Average total duration 17h 12m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Frederick, MD to Charleston, SC is a bus with an average price of $118 (€98).
This is compared to other travel options from Frederick, MD to Charleston, SC:
A bus is $87 (€72) less than a train for this route with tickets for a train from Frederick, MD to Charleston, SC costing on average $206 (€169).
A bus is $114 (€94) less than a flight for this route with tickets for a flight from Frederick, MD to Charleston, SC costing on average $232 (€191).
The fastest way to travel from Frederick, MD to Charleston, SC is by flight with an average journey time of 4h 34m.
Other travel options to Charleston, SC take longer:
Train takes on average 17h 12m.
Bus takes on average 27h 22m.
It's helpful to compare your options as there are 3 ways to travel between Frederick, MD and Charleston, SC including taking a bus, train, and flight.
We recommend using the bus as it is the most popular way to get from Frederick, MD to Charleston, SC among Omio's users.
Frederick, MD to Charleston, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 04:35AM | Arrival Time 10:30PM | Duration 17h55 | Departure days Sun | Cheapest price $101 |
Operator Greyhound USA | Departure Time 10:25AM | Arrival Time 07:54PM | Duration 33h29 | Departure days Mon, Tue, Fri | Cheapest price $0.00 |
Operator FlixBus | Departure Time 02:25PM | Arrival Time 10:30PM | Duration 32h05 | Departure days Thu | Cheapest price $159 |
Operator FlixBus | Departure Time 03:25PM | Arrival Time 11:30PM | Duration 32h05 | Departure days Wed | Cheapest price $95 |
Live departures
Frederick, MD to Charleston, SC bus times
The table below shows live departures for Frederick, MD to Charleston, SC buses for tomorrow, Thursday, July 30. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 2:25 PM Frederick, MD | 32h05 | 10:30 PM Charleston, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Frederick, MD to Charleston, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Thu
Jul 30
Jul 30
Fri
Jul 31
Jul 31
Sat
Aug 01
Aug 01
Sun
Aug 02
Aug 02
Mon
Aug 03
Aug 03
Tue
Aug 04
Aug 04
Wed
Aug 05
Aug 05
Why should you book Frederick, MD to Charleston, SC buses with Omio?
Greyhound operates all buses services from Frederick, MD to Charleston, SC.
Omio is an official ticket reseller for all your travel options from Frederick, MD to Charleston, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Frederick, MD to Charleston, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Frederick, MD to Charleston, SC.
Journey information
Overview: Bus from Frederick, MD to Charleston, SC
USAUSA
Buses from Frederick, MD to Charleston, SC run on average 2 times per day, taking around 27h 22m. Cheap bus tickets for this journey start at $95 (€78) but you can travel from only $83 (€68) by flight.
The earliest bus runs at 00:35, the last at 21:34. The fastest bus covers the 479 miles (772 km) distance in 17h 55m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $83 (€68)
Distance 479 miles (772 km) |
Average bus duration 27h 22m |
Cheapest ticket price $95 (€78) |
Buses per day 2 |
Fastest bus 17h 55m |
First bus 12:35 AM |
Last bus 9:34 PM |
Cheapest Month Nov |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $83 (€68)
Bus providers: Greyhound from Frederick, MD to Charleston, SCYou can travel by bus between Frederick, MD to Charleston, SC with Greyhound for as low as $83 (€68). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
17h 55m
Cheapest Price
$101 (€83)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Charleston, SC
Things to do in Charleston, SC
Discover the best of Charleston, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Charleston, SC trip today.
- Must visit
Gibbes Museum of Art
Leading Southern museum for contemporary art, known for bold exhibitions and strong local creative connections.
- Must visit
International African American Museum
Powerful museum on Gadsden’s Wharf interpreting the African American journey and Charleston’s global significance.
- Must visit
The Battery
Legendary waterfront promenade lined with antebellum homes, harbor breezes, and some of Charleston’s best views.
- Must visit
East Battery
Historic defensive seawall and walk beside White Point Garden, ideal for sunset, mansions, and harbor panoramas.
- Must visit
Charleston City Market
Lively pedestrian-friendly market district known for crafts, architecture, and easy access to major downtown sights.
- Gluten-free
Perloo
A Lowcountry rice dish with shrimp, sausage, or chicken simmered in rich broth. It reflects Charleston's Gullah Geechee and coastal cooking traditions.
- Gluten-free
Shrimp And Grits
Stone-ground grits cooked creamy and topped with local shrimp, often with bacon or gravy. It is one of Charleston's signature brunch and supper dishes.
She-Crab Soup
A rich soup of blue crab, crab roe, cream, and sherry. This classic Charleston dish is closely tied to the city's historic seafood culture.
Circa 1886 Restaurant
Historic fine-dining restaurant focused on seasonal Lowcountry cuisine. Known for polished Southern hospitality and dishes using regional ingredients.
The Ordinary
Upscale seafood restaurant celebrated for local oysters and inventive Lowcountry dishes. Stylish, lively, and one of Charleston's best-known dining rooms.
Magnolias
Refined Southern restaurant in the Historic District, known for shrimp and grits, seafood, and polished service in an elegant setting.
US Dollar ($)
Moderate for a US coastal city; hotels and dining in the historic district run higher, while transit is limited and many visitors rely on walking, rideshare, or car hire.
Average meal costs
- Budget
- $10-18 for fast food or casual lunch.
- Mid-range
- $25-45 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale restaurants.
- Coffee
- $4-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% in restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip screens; small tips are appreciated but optional.
FAQs: Bus from Frederick, MD to Charleston, SC
Find answers to the most common questions about traveling from Frederick, MD to Charleston, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Charleston, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Frederick, MD to Charleston, SC can start from as little as $95 (€78) when you book in advance. The average bus ticket price for Frederick, MD to Charleston, SC is $118 (€98) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Frederick, MD to Charleston, SC is 17h 55m to travel the 479 miles (772 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Frederick, MD to Charleston, SC leaves at 12:35 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Frederick, MD to Charleston, SC leaves at 9:34 PM.
There are 2 buses a day from Frederick, MD to Charleston, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Frederick, MD to Charleston, SC, you can count on Greyhound for the best way to get you to Charleston, SC. You can also check all possible bus companies who offer a service between Frederick, MD and Charleston, SC and compare the amenities they offer before buying a bus ticket.
A trip to Charleston, SC from Frederick, MD is worth doing but not as a day trip with a journey time of 17h 55m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Frederick, MD to Charleston, SC is November.
It's helpful to compare your options as there are 3 ways to travel between Frederick, MD and Charleston, SC including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from Frederick, MD to Charleston, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Frederick, MD to Charleston, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Frederick, MD to Charleston, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Frederick, MD to Charleston, SC.
Yes, the following luggage options are included when booking a bus ticket from Frederick, MD to Charleston, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Frederick, MD to Charleston, SC:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Frederick, MD to Charleston, SC.
You can reserve your seat on the bus from Frederick, MD to Charleston, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Frederick, MD to Charleston, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Frederick, MD to Charleston, SC with the following bus company: Greyhound.
Since neither Frederick, MD nor Charleston, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Frederick, MD to Charleston, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Charleston, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like the historic district and popular tourist spots. Beware of overly aggressive street vendors and unofficial taxi services that may overcharge. Additionally, travelers should avoid leaving valuables unattended and be cautious when using ride-sharing apps to ensure the driver matches the booking details. Staying aware of surroundings and using authorized services helps minimize safety risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Frederick, MD to Charleston, SC
Most Frederick, MD to Charleston, SC buses use the Frederick, East Street (Transit Center) to Charleston, Gaynor Avenue (Greyhound Bus Station) station pair. Use this guide to compare Frederick, MD and Charleston, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Frederick
Arrival bus stations in Charleston
Frederick, East Street (Transit Center)
City-centre transport
Getting to Frederick, East Street (Transit Center) from Frederick city centre
TrainSouthwest Chief · 63h 13m · $963
Southwest Chief · 67h 1m · $1177
BusGreyhound US1210 · 63h 11m · $639
Charleston, Gaynor Avenue (Greyhound Bus Station)
City-centre transport
Getting to Charleston, Gaynor Avenue (Greyhound Bus Station) from Charleston city centre
Bus10 · 32m · every ~4 min
10 · 41m · every ~4 min
Most popular bus connections from Frederick, MD
More options for your journey from Frederick, MD to Charleston, SC
Here are some other resources that might have the information you need
Most popular buses to and from Charleston, SC and Frederick, MD
Most popular bus connections to Charleston, SC
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
