- Must visit
Cummer Museum of Art & Gardens
Contemporary and classic art museum in downtown with rotating exhibitions, a sculpture garden, and riverfront setting.
Buses from Frederick, MD to Jacksonville, NC run on average 2 times per day, taking around 13h 33m. Cheap bus tickets for this journey start at $125 (€106) if you book in advance.
The fastest bus covers the 321 miles (518 km) distance in 10h 15m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Frederick, MD to Jacksonville, NC.
Buses from Frederick, MD to Jacksonville, NC with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Jacksonville, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Jacksonville, NC trip today.
Contemporary and classic art museum in downtown with rotating exhibitions, a sculpture garden, and riverfront setting.
University art museum featuring modern and contemporary works, changing exhibitions, and a calm campus atmosphere.
Science museum with interactive exhibits, a planetarium, and live animal displays, popular for families and curious adults.
Lively historic neighborhood with murals, shops, nightlife, and one of Jacksonville's most walkable main streets.
Historic district with restored homes, leafy streets, and local shops, ideal for architecture walks near downtown.
Urban riverfront park with lawns, event space, and broad views of the St. Johns River and downtown skyline.
Fresh local shrimp, usually wild-caught nearby and often served fried, grilled, or steamed. It reflects Jacksonville's long Atlantic and St. Johns seafood tradition.
A North Florida fish dip made from smoked local fish, mayonnaise, and seasonings. It is a common starter in Jacksonville seafood spots and beach bars.
Blue crab from nearby waters, commonly served steamed or in cakes. It is tied to the region's coastal crabbing culture and seafood markets.
Upscale riverfront dining focused on fresh seafood and steaks, with polished service and views of the St. Johns River.
Casual seafood restaurant in historic Mayport known for fresh local shrimp, fish, and old-Florida dockside atmosphere near the ferry.
Popular barbecue spot serving smoked brisket, pork, ribs, and classic Southern sides in a relaxed, family-friendly space.
Moderate for US city breaks: hotels are mid-priced, dining is reasonable, but car use or rideshares can add to daily costs.
Tip 18-20% in restaurants, $1-2 per drink at bars, round up or add 10-15% for taxis, and tipping is optional but appreciated in cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Jacksonville, NC.
Find answers to the most common questions about traveling from Frederick, MD to Jacksonville, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, NC, this guide helps you travel smarter and with confidence.

Most Frederick, MD to Jacksonville, NC buses use the Frederick, East Street (Transit Center) to Jacksonville, North Marine Blvd (Family Dollar) station pair. Use this guide to compare Frederick, MD and Jacksonville, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Frederick, East Street (Transit Center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Frederick, East Street (Transit Center). ATMs are available at Frederick, East Street (Transit Center).
Ticket office support is available at Frederick, East Street (Transit Center).
Available at Frederick, East Street (Transit Center): Parking, Taxis, WC.
Accessibility facilities are available at Frederick, East Street (Transit Center): Wheelchair accessible entry and exit points.
Jacksonville, North Marine Blvd (Family Dollar) is 2 km from Jacksonville city centre. Public transport options include:
Jacksonville, North Marine Blvd (Family Dollar) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Nearby fast food options available.
Wi-Fi is available at Jacksonville, North Marine Blvd (Family Dollar). ATMs are available at Jacksonville, North Marine Blvd (Family Dollar).
Ticket office support is available at Jacksonville, North Marine Blvd (Family Dollar).
Available at Jacksonville, North Marine Blvd (Family Dollar): Parking, Taxis, WC.
Accessibility facilities are available at Jacksonville, North Marine Blvd (Family Dollar): Level entry to buses ensures accessibility.
Check bus stations information for Frederick, MD and Jacksonville, NC, including where buses depart and arrive on this route.