- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Cheapest price on Sep 19
Kč1727
Average ticket price on Sep 19
Kč1727
Fastest journey on Sep 19
9 h 50 m
Average journey duration on Sep 19
9 h 50 m
Buses on Sep 19
1
Distance
539 km
The best way to find a cheap bus ticket from Columbia, MO to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Columbia, MO to Indianapolis, IN will cost around Kč1727 if you buy it on the day, but the cheapest tickets can be found for only Kč1727.
On Sat, Sep 19, we found 1 buses from Columbia, MO to Indianapolis, IN, including 1 direct services.
On Sat, Sep 19 the direct buses cover the 539 km distance in an average of 9 h 50 m but if you time it right, some buses will get you there in just 9 h 50 m .
On Sat, Sep 19 the slowest buses will take 9 h 50 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Omio recommends booking the bus as it is the most popular option from Columbia, MO to Indianapolis, IN among Omio's users. If you are prioritising price, take the bus, with an average ticket price of Kč1357 For those with little time, consider booking a bus, which has an average total journey time of 9h 34m. Average ticket prices depend on the travel mode: a bus costs an average of Kč1357, while a bus costs an average of Kč1357.
Distance: 334 miles (539 km)
Most popular Bus | Driving |
|---|---|
Kč1357 Average price Cheapest | Kč1570 Average price (fuel + tolls) |
9h 34m Average total duration Fastest 9h 4m Onboard + 30m Additional time* | 5h 24m Average total duration (door-to-door) |
![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
Tickets start at around Kč1357 compared to roughly Kč1570 in fuel and tolls — a saving of about Kč213. The journey takes 9h 4m versus 5h 24m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:05AM | Arrival Time 11:25AM | Duration 10h20 | Departure days Thu | Cheapest price Kč2167 |
Operator Greyhound | Departure Time 08:30AM | Arrival Time 07:30PM | Duration 10h00 | Departure days Mon, Tue, Thu, Fri, Sun | Cheapest price Kč1022 |
Operator Greyhound | Departure Time 10:40AM | Arrival Time 07:30PM | Duration 7h50 | Departure days Mon, Fri, Sun | Cheapest price Kč1022 |
Operator Greyhound | Departure Time 01:30PM | Arrival Time 11:20PM | Duration 9h50 | Departure days Sat | Cheapest price Kč1727 |
Operator Greyhound | Departure Time 08:05PM | Arrival Time 07:25AM | Duration 10h20 | Departure days Mon, Tue, Thu, Fri, Sun | Cheapest price Kč1022 |
Operator FlixBus | Departure Time 08:05PM | Arrival Time 11:50AM | Duration 14h45 | Departure days Mon, Fri, Sun | Cheapest price Kč1048 |
Operator Greyhound | Departure Time 08:35PM | Arrival Time 07:25AM | Duration 9h50 | Departure days Mon, Fri, Sun | Cheapest price Kč1035 |
Operator FlixBus | Departure Time 08:35PM | Arrival Time 11:50AM | Duration 14h15 | Departure days Mon, Fri, Sun | Cheapest price Kč1035 |
The table below shows live departures for Columbia, MO to Indianapolis, IN buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
· | 8:30 AM Columbia, Wabash Bus Station, MO | 10h00 | 7:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
· | 10:40 AM Columbia, Highway 40 W (Midway Truck Plaza), MO | 7h50 | 7:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
· | 8:05 PM Columbia, Wabash Bus Station, MO | 10h20 | 7:25 AM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
+ FlixBus · FlixBus | 8:05 PM Columbia, Wabash Bus Station, MO | 14h45 | 11:50 AM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 2 transfers | |
+ FlixBus · FlixBus | 8:35 PM Columbia, Highway 40 W (Midway Truck Plaza), MO | 14h15 | 11:50 AM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 2 transfers | |
· | 8:35 PM Columbia, Highway 40 W (Midway Truck Plaza), MO | 9h50 | 7:25 AM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Columbia, MO to Indianapolis, IN run on average 6 times per day, taking around 9h 4m. Cheap bus tickets for this journey start at Kč1100 if you book in advance.
The earliest bus runs at 03:30, the last at 20:35. The fastest bus covers the 334 miles (539 km) distance in 6h 40m.
Distance 334 miles (539 km) |
Average bus duration 9h 4m |
Cheapest ticket price Kč1100 |
Buses per day 6 |
Fastest bus 6h 40m |
First bus 3:30 AM |
Last bus 8:35 PM |
Cheapest Month Aug |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Oct - Dec |
Discover the best of Indianapolis, IN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis, IN trip today.
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
Find answers to the most common questions about traveling from Columbia, MO to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

Most Columbia, MO to Indianapolis, IN buses use the Columbia, Wabash Bus Station to Indianapolis, Illinois St (Greyhound Bus Station) station pair. Use this guide to compare Columbia, MO and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Columbia, Highway 40 W (Midway Truck Plaza) is 8 km from Columbia city centre. Public transport options include:
Columbia, Highway 40 W (Midway Truck Plaza) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several fast food options available within the plaza.
Wi-Fi available inside the truck plaza building. ATMs are aTM machines are available inside the truck plaza.
Ticket office support is available at Columbia, Highway 40 W (Midway Truck Plaza).
Available at Columbia, Highway 40 W (Midway Truck Plaza): Parking, Taxis, WC.
Accessibility facilities are available at Columbia, Highway 40 W (Midway Truck Plaza): Wheelchair accessible facilities available.
Columbia, Wabash Bus Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Columbia, Wabash Bus Station. ATMs are available at Columbia, Wabash Bus Station.
Ticket office support is available at Columbia, Wabash Bus Station.
Available at Columbia, Wabash Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Columbia, Wabash Bus Station: Station is accessible for wheelchair users.
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Fast food outlets are available.
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
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