The cheapest and fastest buses from Columbia, MO to Indianapolis, IN
Cheapest price
$234
Average price
$234
Fastest journey
10 h 50 m
Average duration
11 h 20 m
Buses per day
2
Distance
539 km
The best way to find a cheap bus ticket from Columbia, MO to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Columbia, MO to Indianapolis, IN will cost around $234 if you buy it on the day, but the cheapest tickets can be found for only $234.
It's difficult to get from Columbia, MO to Indianapolis, IN without transferring at least once.




Live departures
Columbia, MO to Indianapolis, IN bus times
The table below shows live departures for Columbia, MO to Indianapolis, IN buses for today, Wednesday, February 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:30 AM Columbia, MO | 10h50 | 7:20 PM Indianapolis, IN | 1 transfer | |
![]() | 8:05 PM Columbia, MO | 11h50 | 7:55 AM Indianapolis, IN | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Columbia, MO to Indianapolis, IN by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Columbia, MO to Indianapolis, IN buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of to find the best option for your trip from Columbia, MO to Indianapolis, IN.
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Why book with Omio over Wanderu?
Journey information
Overview: Bus from Columbia, MO to Indianapolis, IN
Buses from Columbia, MO to Indianapolis, IN run on average 4 times per day, taking around 11h 18m. Cheap bus tickets for this journey start at $235 (€187) if you book in advance.
There are 1 buses per day. The earliest bus runs at 03:30, the last at 23:30. The fastest bus covers the 334 miles (539 km) distance in 10h 50m.
Distance 334 miles (539 km) |
Average bus duration 11h 18m |
Cheapest ticket price $235 (€187) |
Buses per day 4 |
Direct buses 1 |
Fastest bus 10h 50m |
First bus 03:30 |
Last bus 23:30 |
Bus providers: Greyhound from Columbia, MO to Indianapolis, INYou can travel by bus between Columbia, MO to Indianapolis, IN with Greyhound for as low as $235 (€187). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Columbia, MO to Indianapolis, IN
Find answers to the most common questions about traveling from Columbia, MO to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Indianapolis Motor Speedway, a historic racing circuit known for hosting the Indianapolis 500
- The Children's Museum of Indianapolis, the world's largest children's museum featuring interactive exhibits
- Indianapolis Zoo, a popular attraction with diverse animal exhibits and a botanical garden
- Indiana State Museum, showcasing the state's history, art, and science through various exhibits
- White River State Park, a sprawling urban park offering trails, gardens, and cultural attractions.
- Indianapolis Museum of Art at Newfields, a vast art museum with extensive collections and beautiful gardens
- Attend a race at the Indianapolis Motor Speedway, home of the iconic Indy 500
- Explore the interactive exhibits and educational programs at The Children's Museum of Indianapolis
- Visit the dolphin pavilion and animal habitats at the Indianapolis Zoo
- Enjoy a walk along the canal and cultural attractions at White River State Park.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Columbia, MO to Indianapolis, IN
Most popular bus connections from Columbia, MO
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