- Must visit
California Academy of Sciences
Renowned science museum with rainforest dome, aquarium, and planetarium. Interactive exhibits make it a standout for all ages.
Cheapest price
€442
Average price
€442
Fastest journey
1 d 21 h 45 m
Average duration
1 d 21 h 45 m
Buses per day
1
Distance
2614 km
The best way to find a cheap bus ticket from Columbia, MO to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Columbia, MO to San Francisco, CA will cost around €442 if you buy it on the day, but the cheapest tickets can be found for only €442.
It's difficult to get from Columbia, MO to San Francisco, CA without transferring at least 3 times.


Buses from Columbia, MO to San Francisco, CA run on average 6 times per day, taking around 47h 45m. Cheap bus tickets for this journey start at €217 if you book in advance.
The earliest bus runs at 07:46, the last at 23:25. The fastest bus covers the 1624 miles (2614 km) distance in 47h 45m.
Distance 1624 miles (2614 km) |
Average bus duration 47h 45m |
Cheapest ticket price €217 |
Buses per day 6 |
Fastest bus 47h 45m |
First bus 7:46 AM |
Last bus 11:25 PM |
Cheapest Month Mar |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Jan - Mar |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 02:40PM | Arrival Time 12:25PM | Duration 45h45 | Departure days Mon, Tue, Wed, Sun | Cheapest price €442 |
Operator Greyhound | Departure Time 07:40PM | Arrival Time 07:25PM | Duration 47h45 | Departure days Thu | Cheapest price €217 |
The table below shows live departures for Columbia, MO to San Francisco, CA buses for tomorrow, Wednesday, August 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:40 PM Columbia, MO | 45h45 | 12:25 PM San Francisco, CA | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of San Francisco, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Francisco, CA trip today.
Renowned science museum with rainforest dome, aquarium, and planetarium. Interactive exhibits make it a standout for all ages.
Major fine arts museum in Golden Gate Park with American art, textiles, and a panoramic tower. A classic cultural highlight.
Leading modern and contemporary art museum with landmark architecture and strong global collections. Essential for art-focused visitors.
Large urban park with gardens, lakes, museums, and trails. It is a must for relaxing, walking, and seeing several major attractions.
Steeply curving block lined with flowers and grand homes. This famous street offers classic photos and a quintessential San Francisco scene.
Popular waterfront promenade with bay views, piers, and ferries. Great for walking, people-watching, and connecting to nearby sights.
A crusty loaf with a tangy flavor shaped by the city’s historic wild yeast culture. It is one of San Francisco’s most iconic foods.
Fresh local Dungeness crab, often cracked and served simply or in cioppino. It is a Bay Area seasonal specialty tied to the fishing waterfront.
A tomato-based seafood stew created by Italian American fishermen in North Beach. It is a classic San Francisco dish built from the day’s catch.
Celebrated fine dining destination known for inventive tasting menus and polished service in an elegant, intimate setting.
Historic North Beach seafood house famous for cioppino, crab, and old-school San Francisco waterfront charm.
Legendary Mission taqueria known for large Mission-style burritos and a lively, no-frills local atmosphere.
Very high hotel, dining, and transport costs make San Francisco pricier than most US cities and many major tourist destinations.
Tip 18-20% at restaurants, 15-20% for taxis, and round up or tip $1 at cafes for good service.
Find answers to the most common questions about traveling from Columbia, MO to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

Most Columbia, MO to San Francisco, CA buses use the Columbia, Highway 40 W (Midway Truck Plaza) to San Francisco, Transit Center Bay 29 station pair, with some services arriving at San Francisco, Townsend Street / 5th Street. Use this guide to compare Columbia, MO and San Francisco, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Columbia, Highway 40 W (Midway Truck Plaza) is 8 km from Columbia city centre. Public transport options include:
Columbia, Highway 40 W (Midway Truck Plaza) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several fast food options available within the plaza.
Wi-Fi available inside the truck plaza building. ATMs are aTM machines are available inside the truck plaza.
Ticket office support is available at Columbia, Highway 40 W (Midway Truck Plaza).
Available at Columbia, Highway 40 W (Midway Truck Plaza): Parking, Taxis, WC.
Accessibility facilities are available at Columbia, Highway 40 W (Midway Truck Plaza): Wheelchair accessible facilities available.
Columbia, Wabash Bus Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Columbia, Wabash Bus Station. ATMs are available at Columbia, Wabash Bus Station.
Ticket office support is available at Columbia, Wabash Bus Station.
Available at Columbia, Wabash Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Columbia, Wabash Bus Station: Station is accessible for wheelchair users.
San Francisco, Transit Center Bay 29 is 2 km from San Francisco city centre. Public transport options include:
San Francisco, Transit Center Bay 29 has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at San Francisco, Transit Center Bay 29. ATMs are available at San Francisco, Transit Center Bay 29.
Ticket office support is available at San Francisco, Transit Center Bay 29.
Available at San Francisco, Transit Center Bay 29: Parking, Taxis, WC.
Accessibility facilities are available at San Francisco, Transit Center Bay 29: Wheelchair accessible areas present.
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