- Must visit
National Museum
Prague’s flagship museum on Wenceslas Square, with major natural history, history, and cultural collections in a monumental Neo-Renaissance building.
Cheapest price
$76
Average price
$97
Fastest journey
14 h 40 m
Average duration
16 h 22 m
Buses per day
10
Distance
717 km
The best way to find a cheap bus ticket from Brussels to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Brussels to Prague will cost around $97 if you buy it on the day, but the cheapest tickets can be found for only $76.
Of the 10 buses that leave Brussels for Prague on Wed, May 27, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, May 27 the direct buses cover the 717 km distance in an average of 16 h 22 m but if you time it right, some buses will get you there in just 14 h 40 m .
On Wed, May 27 the slowest buses will take 17 h 50 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Brussels to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $59. For those with little time consider booking a flight which can get you there in 2h 5m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.6kg. The ticket price range depends on the travel mode: a bus costs an average of $59, and a flight costs an average of $33.
Distance: 445 miles (717 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$86 Average price Cheapest | $197 Average price | $130 Average price | $184 Average price (fuel + tolls) |
15h 45m Average total duration 15h 15m Onboard + 30m Additional time* | 5h 5m Average total duration Fastest 2h 5m Onboard + 3h 0m Additional time* | 13h 20m Average total duration 12h 50m Onboard + 30m Additional time* | 8h 38m Average total duration (door-to-door) |
0.7 - 1.8kg CO2 emissions | 2.2 - 4.3kg CO2 emissions | 0.2 - 0.6kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Brussels to Prague:
A bus is $45 (€36) less than a train for this route with tickets for a train from Brussels to Prague costing on average $130 (€105).
A bus is $111 (€90) less than a flight for this route with tickets for a flight from Brussels to Prague costing on average $197 (€159).
Other travel options to Prague take longer:
Train takes on average 12h 50m.
Bus takes on average 15h 15m.
Tickets start at around $86 (€69) compared to roughly $184 (€149) in fuel and tolls — a saving of about $99 (€80). The journey takes 15h 15m versus 8h 38m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, Infobus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:20AM | Arrival Time 07:10PM | Duration 17h50 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $63 |
Operator FlixBus | Departure Time 03:15AM | Arrival Time 09:10PM | Duration 17h55 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $58 |
Operator BlaBlaCar Bus | Departure Time 03:30PM | Arrival Time 09:45AM | Duration 18h15 | Departure days Mon | Cheapest price $76 |
Operator FlixBus | Departure Time 03:40PM | Arrival Time 10:10AM | Duration 18h30 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $56 |
Operator FlixBus | Departure Time 03:55PM | Arrival Time 10:10AM | Duration 18h15 | Departure days Wed, Fri, Sun | Cheapest price $87 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 06:55AM | Duration 14h40 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $56 |
Operator FlixBus | Departure Time 04:40PM | Arrival Time 10:05AM | Duration 17h25 | Departure days Mon, Sat, Sun | Cheapest price $58 |
Operator BlaBlaCar Bus | Departure Time 05:35PM | Arrival Time 09:45AM | Duration 16h10 | Departure days Fri | Cheapest price $68 |
Operator RegioJet a.s. | Departure Time 06:30PM | Arrival Time 06:25AM | Duration 11h55 | Departure days Thu, Sun | Cheapest price $62 |
Operator FlixBus | Departure Time 10:30PM | Arrival Time 01:30PM | Duration 15h00 | Departure days Everyday | Cheapest price $56 |
The table below shows live departures for Brussels to Prague buses for today, Tuesday, May 26. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 10:30 PM Brussels, Brussels South (Gare du Midi) | 15h00 | 1:30 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 10:30 PM Brussels, Brussels South (Gare du Midi) | 17h40 | 4:10 PM Praha, Černý Most | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:30 PM Brussels, Brussels South (Gare du Midi) | 21h30 | 8:00 PM Prague, Central Train Station | 2 transfers | |
FlixBus · FlixBus | 10:30 PM Brussels, Brussels South (Gare du Midi) | 19h05 | 5:35 PM Praha, M. Horákové (Hradčanská) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:30 PM Brussels, Brussels South (Gare du Midi) | 20h50 | 7:20 PM Prague, Central Train Station | 2 transfers | |
FlixBus · FlixBus | 10:30 PM Brussels, Brussels South (Gare du Midi) | 20h40 | 7:10 PM Praha, Na Knížecí | 1 transfer | |
| Wednesday, May 27 | |||||
FlixBus · FlixBus | 1:20 AM Brussels, Brussels South (Gare du Midi) | 17h50 | 7:10 PM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus | 1:20 AM Brussels, Brussels South (Gare du Midi) | 17h50 | 7:10 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 3:15 AM Brussels, Brussels South (Gare du Midi) | 17h55 | 9:10 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 3:15 AM Brussels, Brussels South (Gare du Midi) | 17h55 | 9:10 PM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus · FlixBus | 3:40 PM Brussels, Avenue des Magnolias (King Baudouin) | 18h30 | 10:10 AM Praha, ÚAN Florenc | 2 transfers | |
FlixBus · FlixBus | 3:55 PM Brussels, Gare Du Midi | 18h15 | 10:10 AM Praha, ÚAN Florenc | 1 transfer | |
FlixBus | 4:15 PM Brussels, Brussels South (Gare du Midi) | 14h40 | 6:55 AM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 4:15 PM Brussels, Brussels South (Gare du Midi) | 16h40 | 8:55 AM Praha, Na Knížecí | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Brussels to Prague run on average 14 times per day, taking around 15h 15m. Cheap bus tickets for this journey start at $59 (€47) but you can travel from only $13 (€11) by train.
There are 2 buses per day. The earliest bus runs at 00:10, the last at 23:50. The fastest bus covers the 445 miles (717 km) distance in 11h 50m.
Distance 445 miles (717 km) |
Average bus duration 15h 15m |
Cheapest ticket price $59 (€47) |
Buses per day 14 |
Direct buses 2 |
Fastest bus 11h 50m |
First bus 12:10 AM |
Last bus 11:50 PM |
Cheapest Month Sep |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Sat |
Least Busy Day Sun |
Best time to book 49 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s flagship museum on Wenceslas Square, with major natural history, history, and cultural collections in a monumental Neo-Renaissance building.
A major museum complex preserving Prague’s Jewish heritage through synagogues, ceremonial objects, archives, and cemetery access.
A leading contemporary art venue in Holešovice known for ambitious exhibitions, design, and the striking Gulliver airship installation.
Prague’s historic central square, surrounded by major landmarks and lively at all hours, making it an essential first stop.
A picturesque district of Baroque streets, embassies, gardens, and hidden corners beneath Prague Castle, ideal for walking and photography.
A broad boulevard-like square central to modern Czech history, shopping, and city life, anchored by the National Museum.
Marinated beef sirloin with creamy root-vegetable sauce, bread dumplings, cranberry sauce, and whipped cream. One of the most classic Czech celebratory dishes.
Roast pork served with bread dumplings and braised cabbage. A cornerstone of traditional Czech home cooking and pub menus.
Czech-style goulash, usually beef, slower-cooked and less soupy than the Hungarian version, commonly served with dumplings. A staple in Prague pubs.
Michelin-starred restaurant offering contemporary Czech fine dining with seasonal ingredients and a sophisticated atmosphere.
Well-known restaurant near Old Town Square offering refined Czech classics in a polished but approachable setting.
Elegant grand cafe and restaurant known for excellent breakfasts, pastries, and upscale Czech and Central European dishes.
Moderate by European standards. Beer, transit, and casual meals are affordable; central hotels cost more.
Around 10% in restaurants for good service, often rounded up. Tip taxis modestly by rounding up. Not expected for counter service, but appreciated.
Official public transport app
Praha Hlavní Nádraží, Prague -> Old Town Square, Prague
Find answers to the most common questions about traveling from Brussels to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

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