- Must visit
National Museum
Prague’s main museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, science, and history collections.
Omio recommends booking the flight as it is the most popular option from Brussels to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $57. For those with little time consider booking a flight which can get you there in 2h 5m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.6kg. The ticket price range depends on the travel mode: a bus costs an average of $57, and a flight costs an average of $33.
Distance: 445 miles (717 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$84 Average price Cheapest | $193 Average price | $128 Average price | $181 Average price (fuel + tolls) |
15h 45m Average total duration 15h 15m Onboard + 30m Additional time* | 5h 5m Average total duration Fastest 2h 5m Onboard + 3h 0m Additional time* | 13h 20m Average total duration 12h 50m Onboard + 30m Additional time* | 8h 38m Average total duration (door-to-door) |
0.7 - 1.8kg CO2 emissions | 2.2 - 4.3kg CO2 emissions | 0.2 - 0.6kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Brussels to Prague:
A bus is $44 (€36) less than a train for this route with tickets for a train from Brussels to Prague costing on average $128 (€105).
A bus is $109 (€90) less than a flight for this route with tickets for a flight from Brussels to Prague costing on average $193 (€159).
Other travel options to Prague take longer:
Train takes on average 12h 50m.
Bus takes on average 15h 15m.
Tickets start at around $84 (€69) compared to roughly $181 (€149) in fuel and tolls — a saving of about $97 (€80). The journey takes 15h 15m versus 8h 38m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, Infobus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:20AM | Arrival Time 07:10PM | Duration 17h50 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $80 |
Operator FlixBus | Departure Time 03:15AM | Arrival Time 09:10PM | Duration 17h55 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $83 |
Operator FlixBus | Departure Time 03:40PM | Arrival Time 10:10AM | Duration 18h30 | Departure days Everyday | Cheapest price $92 |
Operator FlixBus | Departure Time 03:55PM | Arrival Time 10:10AM | Duration 18h15 | Departure days Wed, Fri, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 08:55AM | Duration 16h40 | Departure days Everyday | Cheapest price $77 |
Operator FlixBus | Departure Time 04:40PM | Arrival Time 10:05AM | Duration 17h25 | Departure days Mon, Wed, Thu, Sat, Sun | Cheapest price $100 |
Operator BlaBlaCar Bus | Departure Time 05:35PM | Arrival Time 09:45AM | Duration 16h10 | Departure days Mon, Fri | Cheapest price $77 |
Operator FlixBus | Departure Time 05:40PM | Arrival Time 12:45PM | Duration 19h05 | Departure days Fri | Cheapest price $220 |
Operator RegioJet a.s. | Departure Time 06:30PM | Arrival Time 06:25AM | Duration 11h55 | Departure days Sun | Cheapest price $103 |
Operator FlixBus | Departure Time 08:15PM | Arrival Time 04:45PM | Duration 20h30 | Departure days Fri | Cheapest price $134 |
Operator FlixBus | Departure Time 10:30PM | Arrival Time 01:30PM | Duration 15h00 | Departure days Everyday | Cheapest price $72 |
The table below shows live departures for Brussels to Prague buses for tomorrow, Saturday, July 11. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 3:15 AM Brussels, Brussels South (Gare du Midi) | 17h55 | 9:10 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 3:15 AM Brussels, Brussels South (Gare du Midi) | 17h55 | 9:10 PM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus · FlixBus | 3:40 PM Brussels, Avenue des Magnolias (King Baudouin) | 18h30 | 10:10 AM Praha, ÚAN Florenc | 2 transfers | |
FlixBus · FlixBus | 4:15 PM Brussels, Brussels South (Gare du Midi) | 16h40 | 8:55 AM Praha, Na Knížecí | 1 transfer | |
FlixBus | 4:15 PM Brussels, Brussels South (Gare du Midi) | 14h40 | 6:55 AM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 4:40 PM Brussels, Brussels South (Gare du Midi) | 17h25 | 10:05 AM Praha, Na Knížecí | 1 transfer | |
FlixBus | 10:30 PM Brussels, Brussels South (Gare du Midi) | 15h00 | 1:30 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 10:30 PM Brussels, Brussels South (Gare du Midi) | 17h40 | 4:10 PM Praha, Černý Most | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Brussels to Prague run on average 14 times per day, taking around 15h 15m. Cheap bus tickets for this journey start at $57 (€47) but you can travel from only $13 (€11) by train.
There are 2 buses per day. The earliest bus runs at 00:10, the last at 23:50. The fastest bus covers the 445 miles (717 km) distance in 11h 50m.
Distance 445 miles (717 km) |
Average bus duration 15h 15m |
Cheapest ticket price $57 (€47) |
Buses per day 14 |
Direct buses 2 |
Fastest bus 11h 50m |
First bus 12:10 AM |
Last bus 11:50 PM |
Cheapest Month Sep |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Sat |
Least Busy Day Sun |
Best time to book 49 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s main museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, science, and history collections.
One of Prague’s most significant museum institutions, preserving Jewish history through synagogues, exhibitions, and the Old Jewish Cemetery.
A leading city gallery in a Gothic landmark on Old Town Square, hosting major modern and contemporary art exhibitions.
Prague’s historic heart, surrounded by major monuments and lively at all times of day; essential for first-time visitors.
A picturesque Baroque district below Prague Castle with quiet lanes, embassies, gardens, and classic city charm.
A major boulevard-like square central to modern Czech history, shopping, and the city’s urban energy.
Marinated beef sirloin with a creamy root-vegetable sauce, bread dumplings, cranberry, and whipped cream. It is one of the most iconic Czech Sunday and festive dishes.
Roast pork served with bread dumplings and braised sauerkraut. This is a classic Czech pub and home-style meal strongly associated with Bohemian cooking.
Czech goulash is a rich beef stew seasoned with onion and paprika, usually served with bread dumplings. It is a staple of traditional Prague taverns and beer halls.
A Michelin-starred restaurant offering contemporary Czech fine dining with seasonal ingredients, tasting menus, and a sophisticated modern atmosphere.
An elegant grand café offering refined Czech and Central European dishes, excellent breakfasts, and classic pastries in a beautifully restored interior.
A well-regarded Old Town restaurant focused on updated Czech cuisine, including svíčková and goulash, in a polished but approachable setting.
Moderate for Europe: beer, transit, and casual meals are good value; central hotels cost more.
About 10% in restaurants for good service, often rounded up. Tip taxis modestly by rounding up. No tip is expected for fast food, but small change is appreciated in cafés.
Official public transport app
Praha Hlavní Nádraží, Prague -> Staroměstské Náměstí, Prague
Find answers to the most common questions about traveling from Brussels to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

Most Brussels to Prague buses use the Brussels, Brussels South (Gare du Midi) to Praha, ÚAN Florenc station pair, with some services arriving at Praha, Na Knížecí. Use this guide to compare Brussels and Prague bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Brussels, Brussels South (Gare du Midi) is 2 km from Brussels city centre. Public transport options include:
Brussels, Brussels South (Gare du Midi) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Midi (in the station), Belgian Bites (in the station), Fritland Express (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance and throughout the station.
Ticket office support is available at Brussels, Brussels South (Gare du Midi).
Available at Brussels, Brussels South (Gare du Midi): Parking, Taxis, WC.
Accessibility facilities are available at Brussels, Brussels South (Gare du Midi): Elevators, ramps.
Brussels-Noord is 1 km from Brussels city centre. Public transport options include:
Brussels-Noord has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Noord (in the station), Quick Brussels Noord (in the station), Le Pain Quotidien (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance and in the waiting area.
Ticket office support is available at Brussels-Noord.
Available at Brussels-Noord: Parking, Taxis, WC.
Accessibility facilities are available at Brussels-Noord: Elevators, ramps.
Praha, ÚAN Florenc is 1 km from Prague city centre. Public transport options include:
Praha, ÚAN Florenc has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Florenc (in the station), Bistro Florenc (0.2 km), Restaurace U Rozvařilů (0.5 km).
Free Wi-Fi. ATMs are located inside the station, offering multiple currency options.
Ticket office support is available at Praha, ÚAN Florenc.
Available at Praha, ÚAN Florenc: Parking, Taxis, WC.
Accessibility facilities are available at Praha, ÚAN Florenc: Elevators, ramps.
Praha, Na Knížecí is 2 km from Prague city centre. Public transport options include:
Praha, Na Knížecí has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, and WC.
Food options include: Café Na Knížecí (in the station), Bistro Praha (0.2 km), Restaurace U Knížete (0.5 km).
Free Wi-Fi. ATMs are located near the entrance.
Available at Praha, Na Knížecí: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Na Knížecí: Elevators, ramps.
Praha, Hlavní Nádraží is 1 km from Prague city centre. Public transport options include:
Praha, Hlavní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Czech Bistro (in the station), Fast Food Express (in the station), Bohemian Café (0.2 km).
Free Wi-Fi. ATMs are located near the main entrance and ticketing area.
Ticket office support is available at Praha, Hlavní Nádraží.
Available at Praha, Hlavní Nádraží: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Hlavní Nádraží: Elevators, ramps.
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