- Must visit
Uffizi Galleries
Florence’s premier art museum, famed for Botticelli, Leonardo, Michelangelo, and Raphael. One of Italy’s essential museum visits and often requires advance booking in busy seasons.
Cheapest price
$28
Average price
$61
Fastest journey
2 h 19 m
Average duration
2 h 36 m
Trains per day
16
Distance
207 km
The best way to find a cheap train ticket from Mestre to Florence is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mestre to Florence will cost around $61 if you buy it on the day, but the cheapest tickets can be found for only $28.
It's difficult to get from Mestre to Florence without transferring at least once.
Regionale 16809 · Regionale Veloce 3985 · Regionale 17851
Regionale 16037 · Regionale Veloce 3961+
Intercity 583
Regionale 16809 · Regionale Veloce 3985+
Intercity 599
Regionale 16781 · Regionale Veloce 3977+
Intercity 597
Regionale 16775+
Intercity 584
Regionale 16037+
FRECCIAROSSA 9401
Regionale 16836 · Regionale Veloce 3637+
FRECCIAROSSA 9405
Regionale 16852+
FRECCIAROSSA 9435
Regionale 16757+
FRECCIAROSSA 9405
Regionale 16845+
FRECCIAROSSA 9403Omio recommends booking the train as it is the most popular option from Mestre to Florence among Omio's users. If you are prioritising price take the train with prices starting from $15. For those with little time consider booking a train which can get you there in 2h 59m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.2kg. The ticket price range depends on the travel mode: a train costs an average of $15, and a bus costs an average of $12.
Distance: 128 miles (207 km)
Most popular Train | Bus |
|---|---|
$32 Average price Cheapest | $58 Average price |
3h 29m Average total duration Fastest 2h 59m Onboard + 30m Additional time* | 3h 55m Average total duration 3h 25m Onboard + 30m Additional time* |
0.1 - 0.2kg CO2 emissions Lowest | 0.2 - 0.5kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mestre to Florence:
A train is $26 (€21) less than a bus for this route with tickets for a bus from Mestre to Florence costing on average $58 (€47).
Other travel options to Florence take longer:
Bus takes on average 3h 25m.
The table below shows live departures for Mestre to Florence trains for today, Wednesday, June 3. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 16258+ FRECCIAROSSA 9437 | 6:58 PM Venezia Mestre Ospedale | 2h41 | 9:39 PM Florence Santa Maria Novella | 1 transfer | |
| Thursday, June 4 | |||||
Regionale 16037+ FRECCIAROSSA 9401 | 5:20 AM Venezia Mestre Ospedale | 2h19 | 7:39 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 16037 · Regionale Veloce 3961+ Intercity 583 | 5:20 AM Venezia Mestre Ospedale | 4h52 | 10:12 AM Florence Rifredi | 2 transfers | |
Regionale 16845+ FRECCIAROSSA 9403 | 5:58 AM Venezia Mestre Ospedale | 2h41 | 8:39 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 16757+ FRECCIAROSSA 9405 | 6:58 AM Venezia Mestre Ospedale | 2h41 | 9:39 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 16836 · Regionale Veloce 3637+ FRECCIAROSSA 9405 | 7:02 AM Venezia Mestre Ospedale | 2h37 | 9:39 AM Florence Santa Maria Novella | 2 transfers | |
Regionale 16775+ Intercity 584 | 12:26 PM Venezia Mestre Ospedale | 3h49 | 4:15 PM Florence Rifredi | 1 transfer | |
Regionale 16779+ FRECCIAROSSA 9729 · FRECCIAROSSA 8519 | 12:58 PM Venezia Mestre Ospedale | 3h26 | 4:24 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 16781 · Regionale Veloce 3977+ Intercity 597 | 1:26 PM Venezia Mestre Ospedale | 4h01 | 5:27 PM Florence Rifredi | 2 transfers | |
Regionale 16791+ Intercity 594 | 2:58 PM Venezia Mestre Ospedale | 3h27 | 6:25 PM Florence Rifredi | 1 transfer | |
Regionale 16791+ FRECCIAROSSA 9427 | 2:58 PM Venezia Mestre Ospedale | 2h41 | 5:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16768+ FRECCIAROSSA 9431 | 3:58 PM Venezia Mestre Ospedale | 2h41 | 6:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16805+ FRECCIAROSSA 9433 | 4:58 PM Venezia Mestre Ospedale | 2h41 | 7:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16809 · Regionale Veloce 3985+ Intercity 599 | 5:26 PM Venezia Mestre Ospedale | 3h56 | 9:22 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 16809 · Regionale Veloce 3985 · Regionale 17851 | 5:26 PM Venezia Mestre Ospedale | 4h44 | 10:10 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 16852+ FRECCIAROSSA 9435 | 5:58 PM Venezia Mestre Ospedale | 2h41 | 8:39 PM Florence Santa Maria Novella | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Mestre to Florence run on average 18 times per day, taking around 2h 59m. Cheap train tickets for this journey start at $15 (€12) but you can travel from only $12 (€10) by bus.
There are 2 trains per day. The earliest train runs at 00:25, the last at 23:18. The fastest train covers the 128 miles (207 km) distance in 2h 3m.
Distance 128 miles (207 km) |
Average train duration 2h 59m |
Cheapest ticket price $15 (€12) |
Trains per day 18 |
Direct trains 2 |
Fastest train 2h 3m |
First train 12:25 AM |
Last train 11:18 PM |
Cheapest Month Jan |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Fri |
Best time to book 77 days |
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
Florence’s premier art museum, famed for Botticelli, Leonardo, Michelangelo, and Raphael. One of Italy’s essential museum visits and often requires advance booking in busy seasons.
Best known for Michelangelo’s David, this compact but world-famous museum also holds important Florentine paintings and sculpture. Timed entry is commonly advisable.
Outstanding museum for original sculptures and treasures from Florence Cathedral, including works by Donatello, Ghiberti, and Michelangelo. A superb companion to the Duomo complex.
The monumental heart of Florence, surrounded by the cathedral, baptistery, and bell tower. Essential for first-time visitors and iconic city views.
Historic civic square lined with statues and anchored by Palazzo Vecchio. A lively open-air showcase of Florence’s political and artistic heritage.
The city’s most famous viewpoint, especially popular at sunset for sweeping panoramas over Florence. A social-media favorite and classic photo stop.
A Thick-Cut T-Bone Steak From Chianina Beef, Charcoal-Grilled Rare. It Is Florence’s Signature Dish And A Classic Of Tuscan Cooking.
A Hearty Tuscan Soup Of Bread, Cannellini Beans, Kale, And Vegetables, Traditionally Reboiled The Next Day For Deeper Flavor.
A Rustic Tomato And Bread Soup With Garlic, Olive Oil, And Basil. It Is A Beloved Florentine Comfort Dish.
A Refined Michelin-Starred Restaurant Offering Creative Tuscan Cuisine In An Elegant Contemporary Setting.
An Old-Style Florentine Institution Known For Its Butter Chicken, Artichoke Omelette, And Traditional Tuscan Atmosphere.
Historic, Bustling Trattoria Near Mercato Centrale, Famous For Florentine Classics Such As Bistecca Alla Fiorentina And Ribollita.
Moderate for Italy: museums and central hotels cost more, while casual dining and local transport stay reasonable.
Service is often included or covered by a coperto. Tipping is not mandatory; round up or leave 5-10% for very good service. Small change is fine in cafes; round up taxi fares.
Official public transport app
Florence Santa Maria Novella -> Piazza del Duomo, Florence
Find answers to the most common questions about traveling from Mestre to Florence by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, this guide helps you travel smarter and with confidence.

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