- Must visit
Uffizi Gallery
World-famous gallery with Botticelli, Leonardo, and Michelangelo. Essential for understanding Renaissance painting and one of Florence’s top visits.
We are not able to find a train between these two places.
Cheapest price
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Omio recommends booking the train as it is the most popular option from Mestre to Florence among Omio's users. If you are prioritising price take the train with prices starting from $15. For those with little time consider booking a train which can get you there in 2h 59m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.2kg. The ticket price range depends on the travel mode: a train costs an average of $15, and a bus costs an average of $12.
Distance: 128 miles (207 km)
Most popular Train | Bus |
|---|---|
$31 Average price Cheapest | $57 Average price |
3h 29m Average total duration Fastest 2h 59m Onboard + 30m Additional time* | 3h 55m Average total duration 3h 25m Onboard + 30m Additional time* |
0.1 - 0.2kg CO2 emissions Lowest | 0.2 - 0.5kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mestre to Florence:
A train is $26 (€21) less than a bus for this route with tickets for a bus from Mestre to Florence costing on average $57 (€47).
Other travel options to Florence take longer:
Bus takes on average 3h 25m.
The table below shows live departures for Mestre to Florence trains for tomorrow, Monday, July 20. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 16037 · Regionale Veloce 3961+ Intercity 583 | 5:18 AM Venezia Mestre Ospedale | 4h54 | 10:12 AM Florence Rifredi | 2 transfers | |
Regionale 16037+ FRECCIAROSSA 9401 | 5:18 AM Venezia Mestre Ospedale | 2h21 | 7:39 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 16845+ FRECCIAROSSA 9403 | 5:56 AM Venezia Mestre Ospedale | 2h43 | 8:39 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 16757+ FRECCIAROSSA 9405 | 6:56 AM Venezia Mestre Ospedale | 2h43 | 9:39 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 16836 · Regionale Veloce 3637+ FRECCIAROSSA 9405 | 7:04 AM Venezia Mestre Ospedale | 2h35 | 9:39 AM Florence Santa Maria Novella | 2 transfers | |
Regionale 16874+ FRECCIAROSSA 9411 | 8:58 AM Venezia Mestre Ospedale | 2h41 | 11:39 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 16680+ FRECCIAROSSA 9413 | 9:58 AM Venezia Mestre Ospedale | 2h41 | 12:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16680+ Intercity 584 | 9:58 AM Venezia Mestre Ospedale | 4h57 | 2:55 PM Florence Rifredi | 1 transfer | |
Regionale 16232+ FRECCIAROSSA 8419 | 11:58 AM Venezia Mestre Ospedale | 2h41 | 2:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16779 · Regionale Veloce 3977+ Intercity 597 | 12:56 PM Venezia Mestre Ospedale | 4h31 | 5:27 PM Florence Rifredi | 2 transfers | |
Regionale 16779+ FRECCIAROSSA 9421 | 12:56 PM Venezia Mestre Ospedale | 2h43 | 3:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16783+ FRECCIAROSSA 9425 | 1:56 PM Venezia Mestre Ospedale | 2h43 | 4:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16791+ FRECCIAROSSA 9427 | 2:58 PM Venezia Mestre Ospedale | 2h41 | 5:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16791+ Intercity 594 | 2:58 PM Venezia Mestre Ospedale | 3h27 | 6:25 PM Florence Rifredi | 1 transfer | |
Regionale 16768+ FRECCIAROSSA 9431 | 3:58 PM Venezia Mestre Ospedale | 2h41 | 6:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16805+ FRECCIAROSSA 9433 | 4:56 PM Venezia Mestre Ospedale | 2h43 | 7:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16809 · Regionale Veloce 3985+ Intercity 599 | 5:26 PM Venezia Mestre Ospedale | 3h56 | 9:22 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 16809 · Regionale Veloce 3985 · Regionale 17851 | 5:26 PM Venezia Mestre Ospedale | 4h44 | 10:10 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 16852+ FRECCIAROSSA 9435 | 5:58 PM Venezia Mestre Ospedale | 2h41 | 8:39 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 16258+ FRECCIAROSSA 9437 | 6:58 PM Venezia Mestre Ospedale | 2h41 | 9:39 PM Florence Santa Maria Novella | 1 transfer | |
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Mestre to Florence run on average 18 times per day, taking around 2h 59m. Cheap train tickets for this journey start at $15 (€12) but you can travel from only $12 (€10) by bus.
There are 2 trains per day. The earliest train runs at 00:25, the last at 23:18. The fastest train covers the 128 miles (207 km) distance in 2h 3m.
Distance 128 miles (207 km) |
Average train duration 2h 59m |
Cheapest ticket price $15 (€12) |
Trains per day 18 |
Direct trains 2 |
Fastest train 2h 3m |
First train 12:25 AM |
Last train 11:18 PM |
Cheapest Month Jan |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Fri |
Best time to book 77 days |
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
World-famous gallery with Botticelli, Leonardo, and Michelangelo. Essential for understanding Renaissance painting and one of Florence’s top visits.
Houses Michelangelo’s David alongside major Renaissance sculptures. A must for first-time visitors interested in Florence’s artistic legacy.
Monastic museum with Fra Angelico frescoes and tranquil cells. Ideal for experiencing spiritual art in one of Florence’s most atmospheric spaces.
Florence’s monumental main square, framed by civic buildings and sculpture. A must for first impressions, history, and lively urban atmosphere.
The cathedral square is Florence’s ceremonial heart, surrounded by the Duomo, Baptistery, and bell tower. Essential for architecture lovers.
Riverside viewpoint with one of Florence’s classic panoramas. Best at sunset for sweeping views over the Arno, domes, and historic center.
Thick Florentine T-bone steak from Chianina beef, grilled rare over coals. It is the city's signature celebratory dish and a classic of Tuscan cuisine.
A rustic Tuscan bread soup with black cabbage, cannellini beans, vegetables, and olive oil. A beloved frugal dish rooted in Florentine home cooking.
A thick soup of bread, tomatoes, basil, garlic, and olive oil, served warm or at room temperature. It celebrates simple Tuscan ingredients and stale bread.
Three-Michelin-star fine dining by Enoteca Pinchiorri, known for refined Italian cuisine and an exceptional wine cellar. Elegant and formal.
Legendary casual stop for Lampredotto sandwiches and other tripe specialties. Simple, authentic street food experience in central Florence.
Historic steakhouse famed for Bistecca Alla Fiorentina and classic Tuscan dishes. Traditional, bustling atmosphere near Santa Croce.
Moderate for Italy: hotels in the center are pricier, but dining and transit are reasonable versus Rome or Venice.
Service is often included. Round up or leave €1-2 at cafés, 5-10% for great restaurant service, and round up taxi fares.
Official public transport app
Firenze Santa Maria Novella -> Piazza del Duomo, Florence
Find answers to the most common questions about traveling from Mestre to Florence by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, this guide helps you travel smarter and with confidence.

Most Mestre to Florence trains use the Venezia Mestre Ospedale to Firenze Santa Maria Novella station pair, with some services arriving at Firenze Rifredi. Use this guide to compare Mestre and Florence train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Venezia Mestre Ospedale is 2 km from Mestre city centre. Public transport options include:
Venezia Mestre Ospedale has practical services for this route, including Parking, Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, and Information Desk.
Food and drink options are available at Venezia Mestre Ospedale.
Ticket office support is available at Venezia Mestre Ospedale. Information desks are located near the main entrance.
Available at Venezia Mestre Ospedale: Parking, Taxis, WC.
Available at Venezia Mestre Ospedale: Bike Parking.
Accessibility facilities are available at Venezia Mestre Ospedale.
Nearby hotels include Hotel Villa Sara, Hotel Altieri, Hotel Ducale.
Firenze Santa Maria Novella is 1 km from Florence city centre. Public transport options include:
Firenze Santa Maria Novella has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: 12oz Coffee Joint, Casa Maioli, Don Nino, Fratelli Cuore, McDonald´s, Panella, Segafredo Zanetti, Spizzico, Venchi, & many more
Free WiFi (30 minutes limit). ATMs are located in the basement in the shopping center next to the Feltrinelli bookshop and between Celio and Mango shops.
The ticket office is open Mon - Sun: 06:00 - 21:00. Information desks are located inside and outside the station.
Luggage storage is provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
Available at Firenze Santa Maria Novella: Parking, Taxis, WC.
Available at Firenze Santa Maria Novella: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Firenze Santa Maria Novella: Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
Nearby hotels include Hotel Luxor Florence, Joy Hotel Florence, Diplomat Hotel Florence.
Firenze Rifredi is 3 km from Florence city centre. Public transport options include:
Firenze Rifredi has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Information Desk, and Luggage Carts.
Food options include: Trattoria Fratelli Briganti, Osteria di Poneta
Free.
Ticket office support is available at Firenze Rifredi. Information desks are located in the main hall.
Luggage storage is available at Firenze Rifredi. Lost and found is available at the station.
Available at Firenze Rifredi: Parking, Taxis, WC.
Available at Firenze Rifredi: Bike Parking, Bike Rental.
Accessibility facilities are available at Firenze Rifredi: Elevators, ramps, restrooms.
Nearby hotels include Hotel Raffaello, Hotel Corolle, Hotel Dalmazia.
Firenze Campo di Marte is 2 km from Florence city centre. Public transport options include:
Firenze Campo di Marte has practical services for this route, including Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, and Bike Rental.
Food options include: Moka Café
The ticket office is open Mon - Sun: 07:15 - 20:45.
Available at Firenze Campo di Marte: Taxis, WC.
Available at Firenze Campo di Marte: Bike Parking, Bike Rental.
Accessibility facilities are available at Firenze Campo di Marte: The station is fully accessible, with step-free access throughout the station.
Nearby hotels include Florence Stadium B&B, Hotel Villa Liana, Hotel della Robbia.
Here are some other resources that might have the information you need