- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Cheapest price on Sep 19
$52
Average ticket price on Sep 19
$85
Fastest journey on Sep 19
4 h 6 m
Average journey duration on Sep 19
4 h 19 m
Trains on Sep 19
31
Distance
400 km
The best way to find a cheap train ticket from Mestre to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mestre to Rome will cost around $85 if you buy it on the day, but the cheapest tickets can be found for only $52.
It's difficult to get from Mestre to Rome without transferring at least once.
Regionale 16826 · Regionale Veloce 3898+
InterCityNotte 770
Regionale 16825+
InterCityNotte 770
Regionale 16755 · Regionale Veloce 3963+
Intercity 1589
Regionale 16777 · Regionale Veloce 3975+
Intercity 597
Regionale 16037 · Regionale Veloce 3961+
Intercity 583
Regionale 16870+
FRECCIAROSSA 9466
Regionale 16836 · Regionale Veloce 3637+
FRECCIAROSSA 9405
Regionale 16037+
FRECCIAROSSA 9401
Regionale 16757+
FRECCIAROSSA 9405
Regionale 16768+
FRECCIAROSSA 9431Omio recommends booking the train as it is the most popular option from Mestre to Rome among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $39 For those with little time, consider booking a flight, which has an average total journey time of 4h 23m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of $39, while a flight costs an average of $464.
Distance: 248 miles (400 km)
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$85 Average price | $39 Average price Cheapest | $464 Average price | $157 Average price (fuel + tolls) |
5h 7m Average total duration 4h 37m Onboard + 30m Additional time* | 7h 36m Average total duration 7h 6m Onboard + 30m Additional time* | 4h 23m Average total duration Fastest 2h 23m Onboard + 2h 0m Additional time* | 5h 10m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.0kg CO2 emissions | 1.2 - 2.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mestre to Rome:
A bus is $46 less than a train for this route with tickets for a train from Mestre to Rome costing on average $85.
A bus is $425 less than a flight for this route with tickets for a flight from Mestre to Rome costing on average $464.
Other travel options to Rome take longer:
Train takes on average 4h 37m.
Bus takes on average 7h 6m.
The journey is about 33m faster (4h 37m by train vs 5h 10m by car) and roughly $72 cheaper once you factor in fuel and tolls ($85 vs $157). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Direct services run with Frecciarossa, Italo, Intercity.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
The table below shows live departures for Mestre to Rome trains for today, Friday, September 18. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 16801 · Regionale Veloce 3983+ FRECCIAROSSA 9653 | 4:28 PM Venezia Mestre Ospedale | 4h42 | 9:10 PM Rome Termini | 2 transfers | |
Regionale 16805+ FRECCIAROSSA 9433 | 4:56 PM Venezia Mestre Ospedale | 4h34 | 9:30 PM Rome Termini | 1 transfer | |
Regionale 16809 · Regionale Veloce 3985+ FRECCIAROSSA 9661 | 5:26 PM Venezia Mestre Ospedale | 4h44 | 10:10 PM Rome Termini | 2 transfers | |
Regionale 16852+ FRECCIAROSSA 9435 | 5:58 PM Venezia Mestre Ospedale | 4h27 | 10:25 PM Rome Termini | 1 transfer | |
Regionale 16258+ FRECCIAROSSA 9437 | 6:58 PM Venezia Mestre Ospedale | 4h32 | 11:30 PM Rome Termini | 1 transfer | |
Regionale 16831+ InterCityNotte 770 | 9:26 PM Venezia Mestre Ospedale | 9h09 | 6:35 AM Rome Termini | 1 transfer | |
| Saturday, September 19 | |||||
Regionale 16037 · Regionale Veloce 3961+ Intercity 583 | 5:18 AM Venezia Mestre Ospedale | 8h31 | 1:49 PM Rome Ostiense | 2 transfers | |
Regionale 16037+ FRECCIAROSSA 9401 | 5:18 AM Venezia Mestre Ospedale | 4h20 | 9:38 AM Rome Termini | 1 transfer | |
Regionale 16845+ FRECCIAROSSA 9403 | 5:56 AM Venezia Mestre Ospedale | 4h29 | 10:25 AM Rome Termini | 1 transfer | |
Regionale 16755 · Regionale Veloce 3963+ Intercity 1589 | 6:26 AM Venezia Mestre Ospedale | 8h46 | 3:12 PM Rome Ostiense | 2 transfers | |
Regionale 16755+ FRECCIAROSSA 8801 · FRECCIAROSSA 9611 | 6:26 AM Venezia Mestre Ospedale | 4h45 | 11:11 AM Rome Termini | 2 transfers | |
Regionale 16757+ FRECCIAROSSA 9405 | 6:56 AM Venezia Mestre Ospedale | 4h26 | 11:22 AM Rome Termini | 1 transfer | |
Regionale 16836 · Regionale Veloce 3637+ FRECCIAROSSA 9405 | 7:04 AM Venezia Mestre Ospedale | 4h18 | 11:22 AM Rome Termini | 2 transfers | |
Regionale 16870+ FRECCIAROSSA 9466 | 7:58 AM Venezia Mestre Ospedale | 4h06 | 12:04 PM Rome Termini | 1 transfer | |
Regionale 16874+ Intercity 584 | 8:58 AM Venezia Mestre Ospedale | 7h22 | 4:20 PM Rome Termini | 1 transfer | |
Regionale 16874+ FRECCIAROSSA 9411 | 8:58 AM Venezia Mestre Ospedale | 4h37 | 1:35 PM Rome Termini | 1 transfer | |
Regionale 16726 · Regionale 3997+ FRECCIAROSSA 9623 | 9:28 AM Venezia Mestre Ospedale | 4h42 | 2:10 PM Rome Termini | 2 transfers | |
Regionale 16680+ FRECCIAROSSA 9413 | 9:58 AM Venezia Mestre Ospedale | 4h27 | 2:25 PM Rome Termini | 1 transfer | |
Regionale 17277 · Regionale Veloce 3971+ FRECCIAROSSA 9627 | 10:26 AM Venezia Mestre Ospedale | 4h44 | 3:10 PM Rome Termini | 2 transfers | |
Regionale 17277+ FRECCIAROSSA 9415 | 10:26 AM Venezia Mestre Ospedale | 5h09 | 3:35 PM Rome Termini | 1 transfer | |
Regionale 16777 · Regionale Veloce 3975+ Intercity 597 | 12:26 PM Venezia Mestre Ospedale | 8h54 | 9:20 PM Rome Ostiense | 2 transfers | |
Regionale 16777+ FRECCIAROSSA 9421 | 12:26 PM Venezia Mestre Ospedale | 4h59 | 5:25 PM Rome Termini | 1 transfer | |
Regionale 16220 · Regionale Veloce 3649+ FRECCIAROSSA 9421 | 12:32 PM Venezia Mestre Ospedale | 4h53 | 5:25 PM Rome Termini | 2 transfers | |
Regionale 16783+ FRECCIAROSSA 9425 | 1:56 PM Venezia Mestre Ospedale | 4h29 | 6:25 PM Rome Termini | 1 transfer | |
Regionale 16787+ FRECCIAROSSA 9427 | 2:28 PM Venezia Mestre Ospedale | 4h57 | 7:25 PM Rome Termini | 1 transfer | |
Regionale 16787 · Regionale Veloce 3979+ FRECCIAROSSA 9645 | 2:28 PM Venezia Mestre Ospedale | 4h47 | 7:15 PM Rome Termini | 2 transfers | |
Regionale 16787+ Intercity 594 | 2:28 PM Venezia Mestre Ospedale | 7h52 | 10:20 PM Rome Termini | 1 transfer | |
Regionale 16793 · Regionale Veloce 3981+ FRECCIAROSSA 9649 | 3:26 PM Venezia Mestre Ospedale | 4h49 | 8:15 PM Rome Termini | 2 transfers | |
Regionale 16768+ FRECCIAROSSA 9431 | 3:58 PM Venezia Mestre Ospedale | 4h26 | 8:24 PM Rome Termini | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Mestre to Rome run on average 24 times per day, taking around 4h 37m. Cheap train tickets for this journey start at $19 but you can travel from only $6 by bus.
The earliest train runs at 00:15, the last at 23:49. The fastest train covers the 248 miles (400 km) distance in 3h 33m.
Distance 248 miles (400 km) |
Average train duration 4h 37m |
Cheapest ticket price $19 |
Trains per day 24 |
Fastest train 3h 33m |
First train 12:15 AM |
Last train 11:49 PM |
Cheapest Month Aug |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Tue |
Best time to book 21 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Roma Termini -> Piazza Di Spagna, Rome
Find answers to the most common questions about traveling from Mestre to Rome by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Mestre to Rome trains use the Venezia Mestre Ospedale to Roma Termini station pair, with some services arriving at Roma Tiburtina. Use this guide to compare Mestre and Rome train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Venezia Mestre Ospedale is 2 km from Mestre city centre. Public transport options include:
Venezia Mestre Ospedale has practical services for this route, including Parking, Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, and Information Desk.
Food and drink options are available at Venezia Mestre Ospedale.
Ticket office support is available at Venezia Mestre Ospedale. Information desks are located near the main entrance.
Available at Venezia Mestre Ospedale: Parking, Taxis, WC.
Available at Venezia Mestre Ospedale: Bike Parking.
Accessibility facilities are available at Venezia Mestre Ospedale.
Nearby hotels include Hotel Villa Sara, Hotel Altieri, Hotel Ducale.
Roma Termini is 1 km from Rome city centre. Public transport options include:
Roma Termini has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Acafe, Moka Café, Roadhouse Grill, McDonald's, Gusto, Chef Express, Coop Minimarket, Mercato Centrale
Free WiFi in the station. ATMs are there are ATMs in various locations around the station.
The ticket office is open Mon - Sun: 06:30 - 22:00. Information desks are located near Platform 24.
Luggage storage is provided by KiPoint and located on Platform 24. Open every day from 06:00 to 23:00.
Available at Roma Termini: Parking, Taxis, WC.
Available at Roma Termini: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Termini: The Sala Blu, Trenitalia's office of assistance for disabled travelers, is located next to Platform 1.
Nearby hotels include Archi di Roma Guest House, Gemma di Roma, The Liberty Boutique Hotel.
Roma Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma Tiburtina has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Rock n’ Coffee Roma, Arabian Kebab, Ingredienti, McDonald’s, Numb's Bakery Café
Free, limited Wi-Fi available in the station for 15 minutes. ATMs are located on the ground floor level.
The ticket office is open Mon - Sun: 06:35 - 20:20. Information desks are located inside the main terminal. .
Luggage storage is luggage lockers are located in the station lobby.
Available at Roma Tiburtina: Parking, Taxis, WC.
Available at Roma Tiburtina: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Tiburtina: Accessible facilities include elevators and escalators.
Nearby hotels include B&B Rome Tiburtina, B&B Alba Domus Roma, Hotel delle Province.
Roma Ostiense is 2 km from Rome city centre. Public transport options include:
Roma Ostiense has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: Ramen Bar Akira, Eataly Roma
Free. ATMs are available in the train station.
Ticket office support is available at Roma Ostiense. Information desks are located in the main hall.
Luggage storage is available at Roma Ostiense. Lost and found is available at the station.
Available at Roma Ostiense: Parking, Taxis, WC.
Available at Roma Ostiense: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Ostiense: Elevators, ramps, restrooms.
Nearby hotels include Hotel Abitart, Hotel San Anselmo, Hotel Villa San Pio.
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