- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
The best way to find a cheap train ticket from Mestre to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mestre to Rome will cost around $106 if you buy it on the day, but the cheapest tickets can be found for only $62.
It's difficult to get from Mestre to Rome without transferring at least once.
Regionale 16825+
InterCityNotte 35678
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Regionale 16791+
Intercity 594
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Regionale 16874+
Intercity 584
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Regionale 16781 · Regionale Veloce 3977+
Intercity 597
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Regionale 16037 · Regionale Veloce 3961+
Intercity 583
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Regionale 16870+
FRECCIAROSSA 9466
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Regionale 16037+
FRECCIAROSSA 9401
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Regionale 16836 · Regionale Veloce 3637+
FRECCIAROSSA 9405
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Regionale 16757+
FRECCIAROSSA 9405
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Regionale 16232+
FRECCIAROSSA 8419
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Trains from Mestre to Rome run on average 24 times per day, taking around 4h 34m. Cheap train tickets for this journey start at $19 but you can travel from only $6 by bus.
The earliest train runs at 00:15, the last at 23:49. The fastest train covers the 248 miles (400 km) distance in 3h 33m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Mestre to Rome.
The table below shows live departures for Mestre to Rome trains for today, Monday, November 2. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 16258+ FRECCIAROSSA 9437 | 6:58 PM Venezia Mestre Ospedale | 4h32 | 11:30 PM Rome Termini | 1 transfer | |
Regionale 16825+ InterCityNotte 35678 | 8:28 PM Venezia Mestre Ospedale | 10h07 | 6:35 AM Rome Termini | 1 transfer | |
| Tuesday, November 3 | |||||
Regionale 16037 · Regionale Veloce 3961+ Intercity 583 | 5:18 AM Venezia Mestre Ospedale | 8h09 | 1:27 PM Rome Tiburtina | 2 transfers | |
Regionale 16037+ FRECCIAROSSA 9401 | 5:18 AM Venezia Mestre Ospedale | 4h15 | 9:33 AM Rome Termini | 1 transfer | |
Regionale 16845+ FRECCIAROSSA 9403 | 5:56 AM Venezia Mestre Ospedale | 4h29 | 10:25 AM Rome Termini | 1 transfer | |
Regionale 16121+ FRECCIAROSSA 8801 · FRECCIAROSSA 9611 | 6:26 AM Venezia Mestre Ospedale | 4h44 | 11:10 AM Rome Termini | 2 transfers | |
Regionale 16757+ FRECCIAROSSA 9405 | 6:56 AM Venezia Mestre Ospedale | 4h26 | 11:22 AM Rome Termini | 1 transfer | |
Regionale 16836 · Regionale Veloce 3637+ FRECCIAROSSA 9405 | 7:04 AM Venezia Mestre Ospedale | 4h18 | 11:22 AM Rome Termini | 2 transfers | |
Regionale 16870+ FRECCIAROSSA 9466 | 7:58 AM Venezia Mestre Ospedale | 4h07 | 12:05 PM Rome Termini | 1 transfer | |
Regionale 16811 · Regionale Veloce 3967+ FRECCIAROSSA 9619 | 8:36 AM Venezia Mestre Ospedale | 4h34 | 1:10 PM Rome Termini | 2 transfers | |
Regionale 16874+ FRECCIAROSSA 9411 | 8:58 AM Venezia Mestre Ospedale | 4h32 | 1:30 PM Rome Termini | 1 transfer | |
Regionale 16874+ Intercity 584 | 8:58 AM Venezia Mestre Ospedale | 7h22 | 4:20 PM Rome Termini | 1 transfer | |
Regionale 16726 · Regionale 3997+ FRECCIAROSSA 9623 | 9:28 AM Venezia Mestre Ospedale | 4h42 | 2:10 PM Rome Termini | 2 transfers | |
Regionale 16680+ FRECCIAROSSA 9413 | 9:58 AM Venezia Mestre Ospedale | 4h27 | 2:25 PM Rome Termini | 1 transfer | |
Regionale 16232+ FRECCIAROSSA 8419 | 11:58 AM Venezia Mestre Ospedale | 4h26 | 4:24 PM Rome Termini | 1 transfer | |
Regionale 16775 · Regionale Veloce 3975+ FRECCIAROSSA 9637 | 12:26 PM Venezia Mestre Ospedale | 4h44 | 5:10 PM Rome Termini | 2 transfers | |
Regionale 16779+ FRECCIAROSSA 9421 | 12:56 PM Venezia Mestre Ospedale | 4h28 | 5:24 PM Rome Termini | 1 transfer | |
Regionale 16781 · Regionale Veloce 3977+ Intercity 597 | 1:26 PM Venezia Mestre Ospedale | 7h41 | 9:07 PM Rome Tiburtina | 2 transfers | |
Regionale 16781 · Regionale Veloce 3977+ FRECCIAROSSA 9641 | 1:26 PM Venezia Mestre Ospedale | 4h47 | 6:13 PM Rome Termini | 2 transfers | |
Regionale 16783+ FRECCIAROSSA 9425 | 1:56 PM Venezia Mestre Ospedale | 4h29 | 6:25 PM Rome Termini | 1 transfer | |
Regionale 16787 · Regionale Veloce 3979+ FRECCIAROSSA 9645 | 2:28 PM Venezia Mestre Ospedale | 4h47 | 7:15 PM Rome Termini | 2 transfers | |
Regionale 16791+ Intercity 594 | 2:58 PM Venezia Mestre Ospedale | 7h22 | 10:20 PM Rome Termini | 1 transfer | |
Regionale 16791+ FRECCIAROSSA 9427 | 2:58 PM Venezia Mestre Ospedale | 4h27 | 7:25 PM Rome Termini | 1 transfer | |
Regionale 16793 · Regionale Veloce 3981+ FRECCIAROSSA 9649 | 3:26 PM Venezia Mestre Ospedale | 4h50 | 8:16 PM Rome Termini | 2 transfers | |
Regionale 16768+ FRECCIAROSSA 9431 | 3:58 PM Venezia Mestre Ospedale | 4h27 | 8:25 PM Rome Termini | 1 transfer | |
Regionale 16801 · Regionale Veloce 3983+ FRECCIAROSSA 9653 | 4:28 PM Venezia Mestre Ospedale | 4h42 | 9:10 PM Rome Termini | 2 transfers | |
Regionale 16805+ FRECCIAROSSA 9433 | 4:56 PM Venezia Mestre Ospedale | 4h34 | 9:30 PM Rome Termini | 1 transfer | |
Regionale 16809 · Regionale Veloce 3985+ FRECCIAROSSA 9661 | 5:26 PM Venezia Mestre Ospedale | 4h44 | 10:10 PM Rome Termini | 2 transfers | |
Regionale 16852+ FRECCIAROSSA 9435 | 5:58 PM Venezia Mestre Ospedale | 4h27 | 10:25 PM Rome Termini | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Trains from Mestre to Rome with Frecciarossa, Italo, and Intercity. Night trains available on this route with Intercity Notte. High-speed trains available on this route with Frecciarossa and Italo. Regional trains available on this route with Regionale. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Roma Termini -> Piazza Di Spagna, Rome
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Rome.
Find answers to the most common questions about traveling from Mestre to Rome by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Mestre to Rome trains use the Venezia Mestre Ospedale to Roma Termini station pair, with some services arriving at Roma Tiburtina. Use this guide to compare Mestre and Rome train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Venezia Mestre Ospedale is 2 km from Mestre city centre. Public transport options include:
Venezia Mestre Ospedale has practical services for this route, including Parking, Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, and Information Desk.
Food and drink options are available at Venezia Mestre Ospedale.
Ticket office support is available at Venezia Mestre Ospedale. Information desks are located near the main entrance.
Available at Venezia Mestre Ospedale: Parking, Taxis, WC.
Available at Venezia Mestre Ospedale: Bike Parking.
Accessibility facilities are available at Venezia Mestre Ospedale.
Nearby hotels include Hotel Villa Sara, Hotel Altieri, Hotel Ducale.
Roma Termini is 1 km from Rome city centre. Public transport options include:
Roma Termini has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Acafe, Moka Café, Roadhouse Grill, McDonald's, Gusto, Chef Express, Coop Minimarket, Mercato Centrale
Free WiFi in the station. ATMs are there are ATMs in various locations around the station.
The ticket office is open Mon - Sun: 06:30 - 22:00. Information desks are located near Platform 24.
Luggage storage is provided by KiPoint and located on Platform 24. Open every day from 06:00 to 23:00.
Available at Roma Termini: Parking, Taxis, WC.
Available at Roma Termini: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Termini: The Sala Blu, Trenitalia's office of assistance for disabled travelers, is located next to Platform 1.
Nearby hotels include Archi di Roma Guest House, Gemma di Roma, The Liberty Boutique Hotel.
Roma Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma Tiburtina has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Rock n’ Coffee Roma, Arabian Kebab, Ingredienti, McDonald’s, Numb's Bakery Café
Free, limited Wi-Fi available in the station for 15 minutes. ATMs are located on the ground floor level.
The ticket office is open Mon - Sun: 06:35 - 20:20. Information desks are located inside the main terminal. .
Luggage storage is luggage lockers are located in the station lobby.
Available at Roma Tiburtina: Parking, Taxis, WC.
Available at Roma Tiburtina: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Tiburtina: Accessible facilities include elevators and escalators.
Nearby hotels include B&B Rome Tiburtina, B&B Alba Domus Roma, Hotel delle Province.
Roma Trastevere is 2 km from Rome city centre. Public transport options include:
Roma Trastevere has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food options include: Trattoria Da Enzo al 29, Osteria der Belli
Free. ATMs are available in the train station.
Ticket office support is available at Roma Trastevere. Information desks are located in the main hall.
Luggage storage is available at Roma Trastevere. Lost and found is available at the station.
Available at Roma Trastevere: Parking, Taxis, WC.
Available at Roma Trastevere: Bike Parking.
Accessibility facilities are available at Roma Trastevere: Elevators, ramps, restrooms.
Nearby hotels include Hotel San Francesco, Hotel Ripa Roma, Hotel Santa Maria.
Check train stations information for Mestre and Rome, including where trains depart and arrive on this route.