Travel Information
Compare train and bus for Mestre to Florence
Omio recommends booking the train as it is the most popular option from Mestre to Florence among Omio's users. If you are prioritising price take the train with prices starting from $18. For those with little time consider booking a train which can get you there in 2h 58m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.2kg. The ticket price range depends on the travel mode: a train costs an average of $18, and a bus costs an average of $12.
Distance: 128 miles (207 km)
Compare train with
Most popular Train | Bus |
|---|---|
$40 Average price Cheapest | $46 Average price |
3h 28m Average total duration Fastest 2h 58m Onboard + 30m Additional time* | 3h 55m Average total duration 3h 25m Onboard + 30m Additional time* |
0.1 - 0.2kg CO2 emissions Lowest | 0.2 - 0.5kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mestre to Florence:
A train is $7 (€5) less than a bus for this route with tickets for a bus from Mestre to Florence costing on average $46 (€37).
Other travel options to Florence take longer:
Bus takes on average 3h 25m.
Travel optionsfrom Mestre to Florence
How to get from Mestre to Florence by train, bus or flight.
Our recommendation
The best way to travel from Mestre to Florence is by taking a train because it’s the best combination of price and speed.
Regionale 16775+
Intercity 58412:26 PM3h49Venezia Mestre Ospedale4:15 PMFlorence Rifredi$2401One-way1 transfer
Cheapest
Regionale 16809 · Regionale Veloce 3985 · Regionale 178515:26 PM4h44Venezia Mestre Ospedale10:10 PMFlorence Santa Maria Novella$1741One-way2 transfers
Fastest
Regionale 16037+
FRECCIAROSSA 94015:20 AM2h19Venezia Mestre Ospedale7:39 AMFlorence Santa Maria Novella$4691One-way1 transfer
Other options
Regionale 16781 · Regionale Veloce 3977+
Intercity 5971:26 PM4h01Venezia Mestre Ospedale5:27 PMFlorence Rifredi$2101One-way2 transfers
Regionale 16791+
Intercity 5942:58 PM3h27Venezia Mestre Ospedale6:25 PMFlorence Rifredi$2401One-way1 transfer
Regionale 16809 · Regionale Veloce 3985+
Intercity 5995:26 PM3h56Venezia Mestre Ospedale9:22 PMFlorence Santa Maria Novella$2101One-way2 transfers
065 · 0559:30 PM3h45Venezia, Viale Stazione (Mestre Stazione - fermata ATVO)1:15 AMScandicci, Villa Costanza (Florence)$3871One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Mestre to Florence
Travel to Florence easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mestre to Florence.

This is compared to other travel options from Mestre to Florence:
A train is $7 (€5) less than a bus for this route with tickets for a bus from Mestre to Florence costing on average $46 (€37).
Other travel options to Florence take longer:
Bus takes on average 3h 25m.
- Around 18 trains per day.
- Around 5 buses per day.
However, we recommend checking specific travel dates for your route between Mestre and Florence as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Venezia Mestre Ospedale and arrive in Florence Santa Maria Novella.
- Buses mostly depart from Venezia, Viale Stazione / Via Dante (Mestre Stazione) and arrive in Scandicci, Villa Costanza (Florence).
- Travel with Frecciarossa, Italo, Regionale, Intercity to go to Florence by train.
- Travel with Itabus, FlixBus, BlaBlaCar, Marino Autolinee to go to Florence by bus.
- 2 direct trains per day with Frecciarossa, Italo.
- 4 direct buses per day with Itabus, FlixBus, BlaBlaCar.
Travelling from Mestre to Florence: related information
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