- Must visit
The Children's Museum Of Indianapolis
The world's largest children's museum, known for interactive science, history, and culture exhibits that appeal to both families and adults.
Cheapest price
$158
Average price
$159
Fastest journey
14 h 50 m
Average duration
19 h 3 m
Buses per day
4
Distance
910 km
The best way to find a cheap bus ticket from Syracuse, NY to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Syracuse, NY to Indianapolis, IN will cost around $159 if you buy it on the day, but the cheapest tickets can be found for only $158.
It's difficult to get from Syracuse, NY to Indianapolis, IN without transferring at least 2 times.
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FlixBusOmio recommends booking the train as it is the most popular option from Syracuse, NY to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from $119. For those with little time consider booking a flight which can get you there in 6h 4m. The ticket price range depends on the travel mode: a bus costs an average of $119, and a flight costs an average of $336.
Distance: 565 miles (910 km)
| Bus | Most popular Train | Flight |
|---|---|---|
$173 Average price Cheapest | $245 Average price | $418 Average price |
22h 50m Average total duration 22h 20m Onboard + 30m Additional time* | 18h 30m Average total duration 18h 0m Onboard + 30m Additional time* | 9h 4m Average total duration Fastest 6h 4m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Syracuse, NY to Indianapolis, IN:
A bus is $71 (€59) less than a train for this route with tickets for a train from Syracuse, NY to Indianapolis, IN costing on average $245 (€201).
A bus is $245 (€202) less than a flight for this route with tickets for a flight from Syracuse, NY to Indianapolis, IN costing on average $418 (€344).
Other travel options to Indianapolis, IN take longer:
Train takes on average 18h 0m.
Bus takes on average 22h 20m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 04:30AM | Arrival Time 03:00AM | Duration 22h30 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $125 |
Operator Greyhound | Departure Time 04:30AM | Arrival Time 07:20PM | Duration 14h50 | Departure days Everyday | Cheapest price $111 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 04:45PM | Duration 21h10 | Departure days Everyday | Cheapest price $110 |
The table below shows live departures for Syracuse, NY to Indianapolis, IN buses for today, Friday, July 10. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
· · | 7:35 PM Syracuse, Walsh Cir (Syracuse Bus Station), NY | 21h10 | 4:45 PM Indianapolis, Illinois St (Greyhound Bus Station) | 2 transfers | |
· + FlixBus | 7:35 PM Syracuse, Walsh Cir (Syracuse Bus Station), NY | 17h40 | 1:15 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 2 transfers | |
| Saturday, July 11 | |||||
· · · | 4:30 AM Syracuse, Walsh Cir (Syracuse Bus Station), NY | 14h50 | 7:20 PM Indianapolis, Illinois St (Greyhound Bus Station) | 3 transfers | |
FlixBus+ · · | 4:30 AM Syracuse, Walsh Cir (Syracuse Bus Station), NY | 22h30 | 3:00 AM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Syracuse, NY to Indianapolis, IN run on average 4 times per day, taking around 22h 20m. Cheap bus tickets for this journey start at $119 (€98) if you book in advance.
The earliest bus runs at 00:15, the last at 23:30. The fastest bus covers the 565 miles (910 km) distance in 21h 40m.
Distance 565 miles (910 km) |
Average bus duration 22h 20m |
Cheapest ticket price $119 (€98) |
Buses per day 4 |
Fastest bus 21h 40m |
First bus 12:15 AM |
Last bus 11:30 PM |
Cheapest Month Sep |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 21 days |
Discover the best of Indianapolis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis trip today.
The world's largest children's museum, known for interactive science, history, and culture exhibits that appeal to both families and adults.
A major art museum with strong global collections, contemporary exhibitions, and extensive gardens and grounds for walking.
A favorite for motorsport fans, featuring historic race cars and the story of the Indianapolis 500 and the speedway.
The symbolic heart of Indianapolis, centered on the city's signature monument and surrounded by historic buildings, events, and photo spots.
A major urban park linking museums, trails, canal views, and event spaces, making it one of the best all-purpose visitor areas downtown.
A lively cultural corridor known for independent shops, public art, nightlife, and one of the city's most popular walking atmospheres.
Indiana’s signature sandwich: a breaded and fried pork cutlet served on a bun, often comically larger than the bread. It is a classic Hoosier comfort food strongly associated with Indianapolis and the
The official Indiana state pie, made with a rich custard-like filling of cream, sugar, and butter in a flaky crust. It is a traditional Hoosier dessert closely tied to local baking heritage.
Indianapolis is famous for a fiery version of shrimp cocktail served with very spicy horseradish-forward sauce, made iconic by classic local steakhouses. It is one of the city’s best-known starter
Historic downtown steakhouse best known for USDA Prime steaks and its legendary spicy shrimp cocktail. Classic, upscale, and one of Indianapolis’s most iconic dining institutions.
Popular casual restaurant in the Mass Ave area specializing in fried chicken, Southern sides, and a lively tavern feel. Good for approachable comfort food in a busy setting.
Well-known modern American restaurant in the Fletcher Place area, celebrated for seasonal dishes, strong cocktails, and a stylish contemporary atmosphere.
Generally moderate by U.S. standards, with affordable casual dining and coffee, while hotels and fine dining cost more during major events.
Tip 18-20% in restaurants; 20%+ for great service. Tip USD 1-2 per drink at bars, round up or 10-15% for taxis, and tip hotel staff USD 2-5 as appropriate.
Find answers to the most common questions about traveling from Syracuse, NY to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

Most Syracuse, NY to Indianapolis, IN buses use the Syracuse, Walsh Cir (Syracuse Bus Station) to Indianapolis, Illinois St (Greyhound Bus Station) station pair, with some services arriving at Indianapolis, E Washington St / N Delaware St (City/County Building). Use this guide to compare Syracuse, NY and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
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