- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Cheapest price
$258
Average price
$258
Fastest journey
1 d 6 h
Average duration
1 d 6 h
Buses per day
1
Distance
910 km
The best way to find a cheap bus ticket from Syracuse, NY to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Syracuse, NY to Indianapolis, IN will cost around $258 if you buy it on the day, but the cheapest tickets can be found for only $258.
Of the 1 buses that leave Syracuse, NY for Indianapolis, IN on Wed, Aug 26, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 26 the direct buses cover the 910 km distance in an average of 1 d 6 h but if you time it right, some buses will get you there in just 1 d 6 h .
On Wed, Aug 26 the slowest buses will take 1 d 6 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Omio recommends booking the train as it is the most popular option from Syracuse, NY to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from $80. For those with little time consider booking a flight which can get you there in 5h 16m. The ticket price range depends on the travel mode: a bus costs an average of $80, and a flight costs an average of $285.
Distance: 565 miles (910 km)
| Bus | Most popular Train | Flight |
|---|---|---|
$118 Average price Cheapest | $235 Average price | $287 Average price |
22h 50m Average total duration 22h 20m Onboard + 30m Additional time* | 18h 30m Average total duration 18h 0m Onboard + 30m Additional time* | 8h 16m Average total duration Fastest 5h 16m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Syracuse, NY to Indianapolis, IN:
A bus is $117 (€94) less than a train for this route with tickets for a train from Syracuse, NY to Indianapolis, IN costing on average $235 (€189).
A bus is $168 (€136) less than a flight for this route with tickets for a flight from Syracuse, NY to Indianapolis, IN costing on average $287 (€231).
Other travel options to Indianapolis, IN take longer:
Train takes on average 18h 0m.
Bus takes on average 22h 20m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:00AM | Arrival Time 07:00AM | Duration 30h00 | Departure days Wed | Cheapest price $258 |
Operator FlixBus | Departure Time 04:30AM | Arrival Time 03:00AM | Duration 22h30 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $107 |
Operator Greyhound | Departure Time 04:30AM | Arrival Time 07:25PM | Duration 14h55 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $106 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 04:45PM | Duration 21h10 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $106 |
The table below shows live departures for Syracuse, NY to Indianapolis, IN buses for today, Monday, August 24. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
· · | 7:35 PM Syracuse, Walsh Cir (Syracuse Bus Station), NY | 21h10 | 4:45 PM Indianapolis, Illinois St (Greyhound Bus Station) | 2 transfers | |
· + FlixBus | 7:35 PM Syracuse, Walsh Cir (Syracuse Bus Station), NY | 17h40 | 1:15 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 2 transfers | |
| Tuesday, August 25 | |||||
![]() | 1:00 AM Syracuse, NY | 30h00 | 7:00 AM Indianapolis, IN | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, flight, and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Syracuse, NY to Indianapolis, IN run on average 4 times per day, taking around 22h 20m. Cheap bus tickets for this journey start at $80 (€64) if you book in advance.
The earliest bus runs at 00:15, the last at 23:30. The fastest bus covers the 565 miles (910 km) distance in 14h 50m.
Distance 565 miles (910 km) |
Average bus duration 22h 20m |
Cheapest ticket price $80 (€64) |
Buses per day 4 |
Fastest bus 14h 50m |
First bus 12:15 AM |
Last bus 11:30 PM |
Cheapest Month Jul |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 21 days |
Discover the best of Indianapolis, IN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis, IN trip today.
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
Find answers to the most common questions about traveling from Syracuse, NY to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

Most Syracuse, NY to Indianapolis, IN buses use the Syracuse, Walsh Cir (Syracuse Bus Station) to Indianapolis, Illinois St (Greyhound Bus Station) station pair, with some services arriving at Indianapolis, E Washington St / N Delaware St (City/County Building). Use this guide to compare Syracuse, NY and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Syracuse, Walsh Cir (Syracuse Bus Station) is 3 km from Syracuse city centre. Public transport options include:
Syracuse, Walsh Cir (Syracuse Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available throughout the station. ATMs are aTMs are located near the entrance.
Ticket office support is available at Syracuse, Walsh Cir (Syracuse Bus Station).
Available at Syracuse, Walsh Cir (Syracuse Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Syracuse, Walsh Cir (Syracuse Bus Station): The station is wheelchair accessible.
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Fast food outlets are available.
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
Indianapolis, E Washington St / N Delaware St (City/County Building) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Indianapolis, E Washington St / N Delaware St (City/County Building). ATMs are available at Indianapolis, E Washington St / N Delaware St (City/County Building).
Ticket office support is available at Indianapolis, E Washington St / N Delaware St (City/County Building).
Available at Indianapolis, E Washington St / N Delaware St (City/County Building): Parking, Taxis, WC.
Accessibility facilities are available at Indianapolis, E Washington St / N Delaware St (City/County Building): Wheelchair accessible buses available.
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