The cheapest and fastest buses from St. Louis, MO to Charlotte, NC
Cheapest price
$140
Average price
$172
Fastest journey
18 h 30 m
Average duration
20 h 15 m
Buses per day
3
Distance
913 km
The best way to find a cheap bus ticket from St. Louis, MO to Charlotte, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Charlotte, NC will cost around $172 if you buy it on the day, but the cheapest tickets can be found for only $140.
Of the 3 buses that leave St. Louis, MO for Charlotte, NC on Tue, Mar 24, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Mar 24 the direct buses cover the 913 km distance in an average of 20 h 15 m but if you time it right, some buses will get you there in just 18 h 30 m .
On Tue, Mar 24 the slowest buses will take 21 h 50 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Travel Information
Compare train, bus, and flight for St. Louis, MO to Charlotte, NC
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Charlotte, NC among Omio's users. If you are prioritising price take the bus with prices starting from $118. For those with little time consider booking a flight which can get you there in 3h 53m. The ticket price range depends on the travel mode: a bus costs an average of $118, and a train costs an average of $312.
Distance: 567 miles (913 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
$187 Average price Cheapest | $916 Average price | $363 Average price |
26h 4m Average total duration 25h 34m Onboard + 30m Additional time* | 32h 22m Average total duration 31h 52m Onboard + 30m Additional time* | 6h 53m Average total duration Fastest 3h 53m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
St. Louis, MO to Charlotte, NC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:00AM | Arrival Time 11:50PM | Duration 21h50 | Departure days Sun | Cheapest price $276 |
Operator Greyhound | Departure Time 02:00AM | Arrival Time 05:00AM | Duration 26h00 | Departure days Sun | Cheapest price $430 |
Operator Greyhound | Departure Time 01:45PM | Arrival Time 08:40AM | Duration 17h55 | Departure days Sun | Cheapest price $265 |
Operator Greyhound | Departure Time 04:00PM | Arrival Time 11:30AM | Duration 18h30 | Departure days Sun | Cheapest price $252 |
Live departures
St. Louis, MO to Charlotte, NC bus times
The table below shows live departures for St. Louis, MO to Charlotte, NC buses for today, Sunday, March 22. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
undefined · undefined · undefined | 7:00 AM St. Louis, S 15th St (Civic center) | 26h00 | 9:00 AM Charlotte, W 4th St (Greyhound Bus Station) | 2 transfers | |
undefined · undefined · undefined | 6:45 PM St. Louis, S 15th St (Civic center) | 17h55 | 12:40 PM Charlotte, W 4th St (Greyhound Bus Station) | 2 transfers | |
FlixBus+ + FlixBus | 9:00 PM St. Louis, S 15th St (Civic center) | 18h30 | 3:30 PM Charlotte, W 4th St (Greyhound Bus Station) | 2 transfers | |
FlixBus+ undefined · undefined+ FlixBus | 9:00 PM St. Louis, S 15th St (Civic center) | 25h00 | 10:00 PM Charlotte, Freedom Drive (Planet Fitness), NC | 3 transfers | |
| Monday, March 23 | |||||
![]() | 5:30 AM St. Louis, MO | 20h25 | 1:55 AM Charlotte, NC | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Charlotte, NC by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 23
Mar 24
Mar 25
Mar 26
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Mar 29
Why should you book St. Louis, MO to Charlotte, NC buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Charlotte, NC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Charlotte, NC.
Journey information
Overview: Bus from St. Louis, MO to Charlotte, NC
Buses from St. Louis, MO to Charlotte, NC run on average 7 times per day, taking around 25h 34m. Cheap bus tickets for this journey start at $118 (€96) if you book in advance.
The earliest bus runs at 00:55, the last at 23:40. The fastest bus covers the 567 miles (913 km) distance in 17h 30m.
Distance 567 miles (913 km) |
Average bus duration 25h 34m |
Cheapest ticket price $118 (€96) |
Buses per day 7 |
Fastest bus 17h 30m |
First bus 00:55 |
Last bus 23:40 |
Cheapest month Jul |
Cheapest day Sat |
High season Oct - Dec |
Low season Jan - Mar |
Best day to book ahead 21 days |
Bus providers: Greyhound from St. Louis, MO to Charlotte, NCYou can travel by bus between St. Louis, MO to Charlotte, NC with Greyhound for as low as $118 (€96). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from St. Louis, MO to Charlotte, NC
Find answers to the most common questions about traveling from St. Louis, MO to Charlotte, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Charlotte, NC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- NASCAR Hall of Fame, an interactive museum dedicated to the history and heritage of NASCAR with exhibits and simulators
- Discovery Place Science, a hands-on science and technology museum featuring interactive exhibits and an IMAX theater
- Freedom Park, a 98-acre park offering walking trails, sports fields, and a picturesque lake
- Mint Museum Uptown, an art museum showcasing American, contemporary, and European art collections
- Levine Museum of the New South, focusing on post-Civil War Southern history and culture.
- Carowinds, a large amusement park featuring roller coasters and a water park
- U.S. National Whitewater Center, offering outdoor activities like whitewater rafting, kayaking, and rock climbing
- NoDa, Charlotte's historic arts and entertainment district with galleries, music venues, and unique dining experiences
- Charlotte Motor Speedway, hosting NASCAR races and other motorsport events
- Billy Graham Library, a museum and library dedicated to the life and legacy of the famous evangelist.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from St. Louis, MO to Charlotte, NC
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Charlotte, NC
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