- Must visit
Mint Museum Uptown
Major Uptown museum for European, American, and contemporary art. Its collection and architecture make it Charlotte's top fine-arts stop.
Cheapest price on Sep 20
$87
Average ticket price on Sep 20
$89
Fastest journey on Sep 20
17 h 15 m
Average journey duration on Sep 20
18 h 4 m
Buses on Sep 20
7
Distance
913 km
The best way to find a cheap bus ticket from St. Louis, MO to Charlotte, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Charlotte, NC will cost around $89 if you buy it on the day, but the cheapest tickets can be found for only $87.
It's difficult to get from St. Louis, MO to Charlotte, NC without transferring at least once.
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· Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Charlotte, NC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $135 For those with little time, consider booking a flight, which has an average total journey time of 6h 19m. Average ticket prices depend on the travel mode: a bus costs an average of $135, while a train costs an average of $670.
Distance: 567 miles (913 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$135 Average price Cheapest | $605 Average price | $670 Average price | $146 Average price (fuel + tolls) |
16h 49m Average total duration 16h 19m Onboard + 30m Additional time* | 6h 19m Average total duration Fastest 4h 19m Onboard + 2h 0m Additional time* | 31h 53m Average total duration 31h 23m Onboard + 30m Additional time* | 11h 6m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from St. Louis, MO to Charlotte, NC:
A bus is $470 less than a flight for this route with tickets for a flight from St. Louis, MO to Charlotte, NC costing on average $605.
A bus is $535 less than a train for this route with tickets for a train from St. Louis, MO to Charlotte, NC costing on average $670.
Other travel options to Charlotte, NC take longer:
Bus takes on average 16h 19m.
Train takes on average 31h 23m.
Tickets start at around $135 compared to roughly $146 in fuel and tolls — a saving of about $12. The journey takes 16h 19m versus 11h 6m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:00AM | Arrival Time 11:25PM | Duration 21h25 | Departure days Everyday | Cheapest price $82 |
Operator Greyhound | Departure Time 09:00AM | Arrival Time 05:05AM | Duration 19h05 | Departure days Everyday | Cheapest price $88 |
Operator Greyhound | Departure Time 01:45PM | Arrival Time 08:40AM | Duration 17h55 | Departure days Everyday | Cheapest price $79 |
Operator Greyhound | Departure Time 01:55PM | Arrival Time 11:45AM | Duration 20h50 | Departure days Tue, Wed | Cheapest price $80 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 06:00PM | Duration 25h00 | Departure days Wed | Cheapest price $81 |
Operator Greyhound | Departure Time 04:00PM | Arrival Time 11:30AM | Duration 18h30 | Departure days Everyday | Cheapest price $82 |
Operator FlixBus | Departure Time 11:45PM | Arrival Time 06:20PM | Duration 17h35 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $85 |
The table below shows live departures for St. Louis, MO to Charlotte, NC buses for today, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
· | 9:00 AM St. Louis, S 15th St (Civic center) | 19h05 | 5:05 AM Charlotte, W 4th St (Greyhound Bus Station) | 1 transfer | |
· · | 1:45 PM St. Louis, S 15th St (Civic center) | 17h55 | 8:40 AM Charlotte, W 4th St (Greyhound Bus Station) | 2 transfers | |
FlixBus+ + FlixBus | 4:00 PM St. Louis, S 15th St (Civic center) | 18h30 | 11:30 AM Charlotte, W 4th St (Greyhound Bus Station) | 2 transfers | |
FlixBus · FlixBus | 11:45 PM St. Louis, S 15th St (Civic center) | 17h35 | 6:20 PM Charlotte, W 4th St (Greyhound Bus Station) | 1 transfer | |
| Sunday, September 20 | |||||
· + FlixBus | 1:00 AM St. Louis, S 15th St (Civic center) | 21h25 | 11:25 PM Charlotte, W 4th St (Greyhound Bus Station) | 2 transfers | |
· + FlixBus | 1:00 AM St. Louis, S 15th St (Civic center) | 21h10 | 11:10 PM Charlotte, Freedom Drive (Planet Fitness), NC | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from St. Louis, MO to Charlotte, NC run on average 6 times per day, taking around 16h 19m. Cheap bus tickets for this journey start at $92 if you book in advance.
The earliest bus runs at 00:55, the last at 23:40. The fastest bus covers the 567 miles (913 km) distance in 14h 30m.
Distance 567 miles (913 km) |
Average bus duration 16h 19m |
Cheapest ticket price $92 |
Buses per day 6 |
Fastest bus 14h 30m |
First bus 12:55 AM |
Last bus 11:40 PM |
Cheapest Month Sep |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 28 days |
Discover the best of Charlotte, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Charlotte, NC trip today.
Major Uptown museum for European, American, and contemporary art. Its collection and architecture make it Charlotte's top fine-arts stop.
Leading center for African American arts and culture, featuring exhibitions, performances, and powerful stories from Charlotte and beyond.
Regional science museum with hands-on exhibits, live demonstrations, and an IMAX Dome. Great for families and curious adults alike.
Charlotte's central business district mixes museums, plazas, public art, and skyline views. Essential for first-time visitors exploring the city core.
Creative historic district packed with murals, music venues, design shops, and converted mills. Ideal for art, walking, and local culture.
Trendy neighborhood known for rail-trail walking, street art, breweries, and restored industrial spaces. One of Charlotte's liveliest areas.
Slow-smoked chopped or pulled pork with a tangy vinegar sauce, a Carolina barbecue staple widely loved across Charlotte.
Smoky pit-cooked pork shoulder finished with mustard-based sauce, reflecting South Carolina influence common in Charlotte.
Deep-fried catfish, often served with hush puppies and slaw. It is a classic Southern comfort dish popular in the Charlotte region.
Historic barbecue spot famed for Carolina chopped pork, red slaw, and old-school Southern atmosphere.
Lively Southern dining room serving fried chicken, biscuits, shrimp and grits, and regional cocktails in South End.
Refined Southern restaurant in Uptown known for shrimp and grits, local ingredients, and an elegant modern setting.
Moderate for a major U.S. city. Hotels and dining are mid-priced, transit is affordable, and attractions often cost less than in larger hubs like New York or San Francisco.
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or coffee in cafes if service is provided.
Find answers to the most common questions about traveling from St. Louis, MO to Charlotte, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Charlotte, NC, this guide helps you travel smarter and with confidence.

Most St. Louis, MO to Charlotte, NC buses use the St. Louis, S 15th St (Civic center) to Charlotte, W 4th St (Greyhound Bus Station) station pair. Use this guide to compare St. Louis, MO and Charlotte, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Charlotte, W 4th St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Charlotte, W 4th St (Greyhound Bus Station). ATMs are available at Charlotte, W 4th St (Greyhound Bus Station).
Ticket office support is available at Charlotte, W 4th St (Greyhound Bus Station).
Available at Charlotte, W 4th St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Charlotte, W 4th St (Greyhound Bus Station): The station is wheelchair accessible.
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