The cheapest and fastest buses from Santa Ana, CA to San Luis Obispo, CA
Cheapest price
$54
Average price
$58
Fastest journey
6 h 35 m
Average duration
6 h 50 m
Buses per day
2
Distance
308 km
The best way to find a cheap bus ticket from Santa Ana, CA to San Luis Obispo, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Ana, CA to San Luis Obispo, CA will cost around $58 if you buy it on the day, but the cheapest tickets can be found for only $54.
Of the 2 buses that leave Santa Ana, CA for San Luis Obispo, CA on Fri, Feb 06, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Feb 06 the direct buses cover the 308 km distance in an average of 6 h 50 m but if you time it right, some buses will get you there in just 6 h 35 m .
On Fri, Feb 06 the slowest buses will take 7 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train and bus for Santa Ana, CA to San Luis Obispo, CA
Omio recommends booking the train as it is the most popular option from Santa Ana, CA to San Luis Obispo, CA among Omio's users. If you are prioritising price take the bus with prices starting from €26. For those with little time consider booking a train which can get you there in 6h 29m. The ticket price range depends on the travel mode: a bus costs an average of €26, and a train costs an average of €42.
Distance: 191 miles (308 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
€37 Average price Cheapest | €42 Average price |
7h 18m Average total duration 6h 48m Onboard + 30m Additional time* | 6h 59m Average total duration Fastest 6h 29m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Santa Ana, CA to San Luis Obispo, CA bus times
The table below shows live departures for Santa Ana, CA to San Luis Obispo, CA buses for today, Thursday, February 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 4:15 PM Santa Ana, CA | 6h35 | 10:50 PM San Luis Obispo, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Santa Ana, CA to San Luis Obispo, CA by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 06
Feb 07
Feb 08
Feb 09
Feb 10
Feb 11
Feb 12
Journey information
Overview: Bus from Santa Ana, CA to San Luis Obispo, CA
Buses from Santa Ana, CA to San Luis Obispo, CA run on average 6 times per day, taking around 6h 48m. Cheap bus tickets for this journey start at $32 (€26) if you book in advance.
The earliest bus runs at 03:45, the last at 23:45. The fastest bus covers the 191 miles (308 km) distance in 6h 35m.
Distance 191 miles (308 km) |
Average bus duration 6h 48m |
Cheapest ticket price $32 (€26) |
Buses per day 6 |
Fastest bus 6h 35m |
First bus 03:45 |
Last bus 23:45 |
FAQs: Bus from Santa Ana, CA to San Luis Obispo, CA
Find answers to the most common questions about traveling from Santa Ana, CA to San Luis Obispo, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Luis Obispo, CA, this guide helps you travel smarter and with confidence.

- Bubblegum Alley, a narrow alleyway famous for its walls covered in layers of chewed gum left by visitors
- Mission San Luis Obispo de Tolosa, a historic Spanish mission founded in 1772 with a museum and beautiful gardens
- Bishop Peak, a popular hiking destination offering panoramic views of the city and surrounding landscapes
- San Luis Obispo Museum of Art, a contemporary art museum showcasing works by regional and national artists
- Avila Beach, a nearby coastal spot known for its sandy shores and scenic pier.
- Stroll through Downtown SLO, a vibrant area with shops, restaurants, and the famous Thursday Night Farmers' Market
- Attend a performance at the Fremont Theater, a historic venue known for its art deco architecture and live events
- Visit the San Luis Obispo Children's Museum, offering interactive exhibits and activities for kids
- Explore the local wineries and vineyards, enjoying tastings and tours in the Edna Valley wine region
- Discover the natural beauty of Montana de Oro State Park, with its rugged cliffs, secluded beaches, and scenic hiking trails.
popular bus stations
Popular bus stations from Santa Ana, CA to San Luis Obispo, CA
Most popular bus connections from Santa Ana, CA
More options for your journey from Santa Ana, CA to San Luis Obispo, CA
Here are some other resources that might have the information you need
