- Recommended
History Center of San Luis Obispo County
Regional history museum in a restored Carnegie Library with exhibits on Indigenous communities, ranching, rail, and town life.
Omio recommends booking the bus as it is the most popular option from Indianapolis, IN to San Luis Obispo, CA among Omio's users.
Distance: 1903 miles (3064 km)
Most popular Bus | Driving |
|---|---|
$449 Average price (fuel + tolls) | |
32h 29m Average total duration (door-to-door) | |
Direct Options | Direct Options |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:10AM | Arrival Time 09:25PM | Duration 68h15 | Departure days Fri | Cheapest price $241 |
Operator Greyhound USA | Departure Time 05:00AM | Arrival Time 01:25PM | Duration 56h25 | Departure days Fri, Sat | Cheapest price $607 |
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a bus from Indianapolis, IN to San Luis Obispo, CA and enjoy the approximately 1903 miles (3064 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 09:30, the last at 23:30.
Distance 1903 miles (3064 km) |
First bus 9:30 AM |
Last bus 11:30 PM |
Cheapest Month Feb |
Cheapest Day Thu |
High Season Oct - Dec |
Low Season Jul - Sep |
Discover the best of San Luis Obispo, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Luis Obispo, CA trip today.
Regional history museum in a restored Carnegie Library with exhibits on Indigenous communities, ranching, rail, and town life.
Rail museum by the station with model layouts, restored equipment, and hands-on displays for families and train enthusiasts.
Children’s museum downtown with interactive science, art, and play exhibits designed for younger visitors and family outings.
Downtown creekside park with lawns, paths, public art, and regular community events in the center of the city.
Popular local peak with a short but steep trail, broad city views, and sunset scenery close to downtown.
Compact downtown district with shops, historic facades, galleries, and walkable streets linking major sights and events.
Find answers to the most common questions about traveling from Indianapolis, IN to San Luis Obispo, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Luis Obispo, CA, this guide helps you travel smarter and with confidence.

Most Indianapolis, IN to San Luis Obispo, CA buses use the Indianapolis, Illinois St (Greyhound Bus Station) to San Luis Obispo, Santa Barbara Ave / High St (San Luis Obispo Railroad Museum) station pair. Use this guide to compare Indianapolis, IN and San Luis Obispo, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Fast food outlets are available.
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
San Luis Obispo, Santa Barbara Ave / High St (San Luis Obispo Railroad Museum) is 1 km from San Luis Obispo city centre. Public transport options include:
San Luis Obispo, Santa Barbara Ave / High St (San Luis Obispo Railroad Museum) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at San Luis Obispo, Santa Barbara Ave / High St (San Luis Obispo Railroad Museum). ATMs are available at San Luis Obispo, Santa Barbara Ave / High St (San Luis Obispo Railroad Museum).
Ticket office support is available at San Luis Obispo, Santa Barbara Ave / High St (San Luis Obispo Railroad Museum).
Available at San Luis Obispo, Santa Barbara Ave / High St (San Luis Obispo Railroad Museum): Parking, Taxis, WC.
Accessibility facilities are available at San Luis Obispo, Santa Barbara Ave / High St (San Luis Obispo Railroad Museum): Basic accessibility features available.
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