The cheapest and fastest buses from Santa Ana, CA to Chicago, IL
Cheapest price
$864
Average price
$864
Fastest journey
2 d 5 h 40 m
Average duration
2 d 5 h 40 m
Buses per day
1
Distance
2787 km
The best way to find a cheap bus ticket from Santa Ana, CA to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Ana, CA to Chicago, IL will cost around $864 if you buy it on the day, but the cheapest tickets can be found for only $864.
It's difficult to get from Santa Ana, CA to Chicago, IL without transferring at least 2 times.


Travel Information
Compare train, bus, and flight for Santa Ana, CA to Chicago, IL
Omio recommends booking the train as it is the most popular option from Santa Ana, CA to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from €102. For those with little time consider booking a flight which can get you there in 4h 9m. The ticket price range depends on the travel mode: a bus costs an average of €102, and a flight costs an average of €168.
Distance: 1731 miles (2787 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€172 Average price Cheapest | €214 Average price | €288 Average price |
53h 11m Average total duration 52h 41m Onboard + 30m Additional time* | 43h 18m Average total duration 42h 48m Onboard + 30m Additional time* | 7h 9m Average total duration Fastest 4h 9m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Santa Ana, CA to Chicago, IL bus times
The table below shows live departures for Santa Ana, CA to Chicago, IL buses for tomorrow, Thursday, November 27. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:15 AM Santa Ana, CA | 53h40 | 2:55 PM Chicago, IL | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Santa Ana, CA to Chicago, IL by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Santa Ana, CA to Chicago, IL
Buses from Santa Ana, CA to Chicago, IL run on average 3 times per day, taking around 52h 41m. Cheap bus tickets for this journey start at $126 (€102) if you book in advance.
The earliest bus runs at 06:10, the last at 22:00. The fastest bus covers the 1731 miles (2787 km) distance in 51h 40m.
Distance 1731 miles (2787 km) |
Average bus duration 52h 41m |
Cheapest ticket price $126 (€102) |
Buses per day 3 |
Fastest bus 51h 40m |
First bus 06:10 |
Last bus 22:00 |
Bus providers: Greyhound from Santa Ana, CA to Chicago, ILYou can travel by bus between Santa Ana, CA to Chicago, IL with Greyhound for as low as $126 (€102). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Santa Ana, CA to Chicago, IL
Find answers to the most common questions about traveling from Santa Ana, CA to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. Rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U. S. Offering free admission.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Santa Ana, CA to Chicago, IL, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Santa Ana, CA to Chicago, IL
Most popular bus connections from Santa Ana, CA
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