- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
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The cheapest and fastest buses from Santa Ana, CA to Chicago, IL
Showing times and prices for Aug 26
Cheapest price
$288
Average price
$288
Fastest journey
2 d 2 h 50 m
Average duration
2 d 2 h 50 m
Buses per day
1
Distance
2787 km
Cheap tickets
The best way to find a cheap bus ticket from Santa Ana, CA to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Ana, CA to Chicago, IL will cost around $288 if you buy it on the day, but the cheapest tickets can be found for only $288.
Fast buses
Of the 1 buses that leave Santa Ana, CA for Chicago, IL on Wed, Aug 26, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 26 the direct buses cover the 2787 km distance in an average of 2 d 2 h 50 m but if you time it right, some buses will get you there in just 2 d 2 h 50 m .
On Wed, Aug 26 the slowest buses will take 2 d 2 h 50 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
6:35 PM50h50Santa Ana, CA9:25 PMChicago, IL$2881One-way0 transfers
- 6:35 PM50h50Santa Ana, CA9:25 PMChicago, IL$2881One-way0 transfers
Travel Information
Compare train, bus, and flight for Santa Ana, CA to Chicago, IL
Omio recommends booking the train as it is the most popular option from Santa Ana, CA to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from $149. For those with little time consider booking a flight which can get you there in 6h 11m. The ticket price range depends on the travel mode: a bus costs an average of $149, and a flight costs an average of $276.
Distance: 1731 miles (2787 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$313 Average price Cheapest | $614 Average price | $620 Average price | $418 Average price (fuel + tolls) |
49h 37m Average total duration 49h 7m Onboard + 30m Additional time* | 50h 36m Average total duration 50h 6m Onboard + 30m Additional time* | 9h 11m Average total duration Fastest 6h 11m Onboard + 3h 0m Additional time* | 29h 5m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Santa Ana, CA to Chicago, IL is a bus with an average price of $313 (€253).
This is compared to other travel options from Santa Ana, CA to Chicago, IL:
A bus is $301 (€243) less than a train for this route with tickets for a train from Santa Ana, CA to Chicago, IL costing on average $614 (€495).
A bus is $307 (€247) less than a flight for this route with tickets for a flight from Santa Ana, CA to Chicago, IL costing on average $620 (€500).
The fastest way to travel from Santa Ana, CA to Chicago, IL is by flight with an average journey time of 6h 11m.
Other travel options to Chicago, IL take longer:
Bus takes on average 49h 7m.
Train takes on average 50h 6m.
It's helpful to compare your options as there are 3 ways to travel between Santa Ana, CA and Chicago, IL including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from Santa Ana, CA to Chicago, IL among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Santa Ana, CA to Chicago, IL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 07:40AM | Arrival Time 04:05PM | Duration 54h25 | Departure days Fri, Sun | Cheapest price $206 |
Operator Greyhound | Departure Time 11:35AM | Arrival Time 04:25PM | Duration 50h50 | Departure days Fri, Sun | Cheapest price $192 |
Operator Greyhound | Departure Time 03:45PM | Arrival Time 09:05PM | Duration 53h20 | Departure days Tue, Sat | Cheapest price $260 |
Operator Greyhound | Departure Time 06:35PM | Arrival Time 09:25PM | Duration 50h50 | Departure days Mon, Wed, Thu, Sat | Cheapest price $288 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 10:25PM | Duration 50h50 | Departure days Thu, Sat | Cheapest price $316 |
Operator Greyhound | Departure Time 09:25PM | Arrival Time 04:20AM | Duration 52h55 | Departure days Fri, Sun | Cheapest price $217 |
Live departures
Santa Ana, CA to Chicago, IL bus times
The table below shows live departures for Santa Ana, CA to Chicago, IL buses for today, Tuesday, August 25. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 3:45 PM Santa Ana, CA | 53h20 | 9:05 PM Chicago, IL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Santa Ana, CA to Chicago, IL by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Santa Ana, CA to Chicago, IL buses with Omio?
Greyhound operates all buses services from Santa Ana, CA to Chicago, IL.
Omio is an official ticket reseller for all your travel options from Santa Ana, CA to Chicago, IL.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Santa Ana, CA to Chicago, IL.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Santa Ana, CA to Chicago, IL.
Journey information
Overview: Bus from Santa Ana, CA to Chicago, IL
USAUSA
Buses from Santa Ana, CA to Chicago, IL run on average 3 times per day, taking around 49h 7m. Cheap bus tickets for this journey start at $149 (€120) if you book in advance.
The earliest bus runs at 08:45, the last at 23:10. The fastest bus covers the 1731 miles (2787 km) distance in 44h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1731 miles (2787 km) |
Average bus duration 49h 7m |
Cheapest ticket price $149 (€120) |
Buses per day 3 |
Fastest bus 44h 5m |
First bus 8:45 AM |
Last bus 11:10 PM |
Cheapest Month Oct |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Santa Ana, CA to Chicago, ILYou can travel by bus between Santa Ana, CA to Chicago, IL with Greyhound for as low as $149 (€120). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
44h 5m
Cheapest Price
$149 (€120)
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Chicago, IL
Things to do in Chicago, IL
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
- Must visit
Field Museum
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
- Must visit
Museum of Science and Industry
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
- Must visit
Millennium Park
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
- Must visit
Magnificent Mile
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
- Must visit
Chicago Riverwalk
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-Dish Pizza
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
Chicago-Style Hot Dog
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian Beef Sandwich
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Johnnie's Beef
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Superdawg Drive-In
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
Alinea
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
US dollar ($)
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $75+ per person for upscale restaurants.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
FAQs: Bus from Santa Ana, CA to Chicago, IL
Find answers to the most common questions about traveling from Santa Ana, CA to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Santa Ana, CA to Chicago, IL can start from as little as $149 (€120) when you book in advance. The average bus ticket price for Santa Ana, CA to Chicago, IL is $313 (€253) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Santa Ana, CA to Chicago, IL is 44h 5m to travel the 1731 miles (2787 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Santa Ana, CA to Chicago, IL leaves at 8:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Santa Ana, CA to Chicago, IL leaves at 11:10 PM.
There are 3 buses a day from Santa Ana, CA to Chicago, IL which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Santa Ana, CA to Chicago, IL, you can count on Greyhound for the best way to get you to Chicago, IL. You can also check all possible bus companies who offer a service between Santa Ana, CA and Chicago, IL and compare the amenities they offer before buying a bus ticket.
When departing from Santa Ana, CA , you have various bus station options to start your journey from including Santa Ana, E Santa Ana Blvd (Train Station) . When arriving in Chicago, IL , you can end your journey in bus stations like Chicago, Greyhound Bus Station, Chicago, Union Station (Amtrak), IL .Passengers board the bus most frequently from Santa Ana, E Santa Ana Blvd (Train Station), which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Chicago, Greyhound Bus Station, located 2 away from the city centre.
A trip to Chicago, IL from Santa Ana, CA is worth doing but not as a day trip with a journey time of 44h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Santa Ana, CA to Chicago, IL is October.
It's helpful to compare your options as there are 3 ways to travel between Santa Ana, CA and Chicago, IL including taking a train, bus, and flight.
Yes, there are bathrooms on board the bus from Santa Ana, CA to Chicago, IL for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from Santa Ana, CA to Chicago, IL:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Some of the most interesting sights to explore in Chicago, IL are:
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
The best things to do in Chicago, IL include:
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
Whether you can cancel your bus ticket from Santa Ana, CA to Chicago, IL depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Santa Ana, CA to Chicago, IL.
Yes, the following luggage options are included when booking a bus ticket from Santa Ana, CA to Chicago, IL:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Santa Ana, CA to Chicago, IL:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Santa Ana, CA to Chicago, IL.
You can reserve your seat on the bus from Santa Ana, CA to Chicago, IL with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Santa Ana, CA to Chicago, IL with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Santa Ana, CA to Chicago, IL with the following bus company: Greyhound.
Since neither Santa Ana, CA nor Chicago, IL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Santa Ana, CA to Chicago, IL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Santa Ana, CA to Chicago, IL
Most Santa Ana, CA to Chicago, IL buses use the Santa Ana, E Santa Ana Blvd (Train Station) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Santa Ana, CA and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Santa Ana
Arrival bus stations in Chicago
Which Santa Ana, CA station do buses to Chicago, IL leave from?
Buses from Santa Ana, CA to Chicago, IL leave from Santa Ana, E Santa Ana Blvd (Train Station). The station is 0 miles (1 km) from Santa Ana, CA city centre at Santa Ana, 1000 E Santa Ana Blvd, Santa Ana, CA 92701, USA.
Santa Ana, E Santa Ana Blvd (Train Station)Santa Ana, 1000 E Santa Ana Blvd, Santa Ana, CA 92701, USA
City-centre transport
Getting to Santa Ana, E Santa Ana Blvd (Train Station) from Santa Ana city centre
Santa Ana, E Santa Ana Blvd (Train Station) is 1 km from Santa Ana city centre. Public transport options include:
TRUE
Santa Ana, E Santa Ana Blvd (Train Station) bus station facilities and services
Santa Ana, E Santa Ana Blvd (Train Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Santa Ana, E Santa Ana Blvd (Train Station). ATMs are available at Santa Ana, E Santa Ana Blvd (Train Station).
Tickets and information
Ticket office support is available at Santa Ana, E Santa Ana Blvd (Train Station).
Parking, taxis and toilets
Available at Santa Ana, E Santa Ana Blvd (Train Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Santa Ana, E Santa Ana Blvd (Train Station): Bus access is available.
Which Chicago, IL station do buses from Santa Ana, CA arrive at?
Buses from Santa Ana, CA to Chicago, IL most often arrive at Chicago, Greyhound Bus Station. Some services arrive at Chicago, Union Station (Amtrak), so check your ticket before travel to confirm your Chicago, IL arrival station.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USA
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Bus7 · 8m · $4 · every ~6 min
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak)Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USA
City-centre transport
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Bus28, 151 · 7m · $4 · every ~13 min
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Most popular bus connections from Santa Ana, CA
More options for your journey from Santa Ana, CA to Chicago, IL
Here are some other resources that might have the information you need
Most popular buses to and from Chicago, IL and Santa Ana, CA
Most popular bus connections to Chicago, IL
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