The cheapest and fastest buses from Santa Ana, CA to San Francisco, CA
Cheapest price
$73
Average price
$105
Fastest journey
11 h 20 m
Average duration
13 h 53 m
Buses per day
2
Distance
608 km
The best way to find a cheap bus ticket from Santa Ana, CA to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Ana, CA to San Francisco, CA will cost around $105 if you buy it on the day, but the cheapest tickets can be found for only $73.
Of the 2 buses that leave Santa Ana, CA for San Francisco, CA on Thu, Feb 26, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Feb 26 the direct buses cover the 608 km distance in an average of 13 h 53 m but if you time it right, some buses will get you there in just 11 h 20 m .
On Thu, Feb 26 the slowest buses will take 16 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train, bus, and flight for Santa Ana, CA to San Francisco, CA
Omio recommends booking the train as it is the most popular option from Santa Ana, CA to San Francisco, CA among Omio's users. If you are prioritising price take the train with prices starting from $66. For those with little time consider booking a flight which can get you there in 1h 30m. The ticket price range depends on the travel mode: a train costs an average of $66, and a flight costs an average of $77.
Distance: 377 miles (608 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
$105 Average price | $73 Average price Cheapest | $310 Average price |
11h 8m Average total duration 10h 38m Onboard + 30m Additional time* | 11h 42m Average total duration 11h 12m Onboard + 30m Additional time* | 4h 30m Average total duration Fastest 1h 30m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Santa Ana, CA to San Francisco, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Amtrak | Departure Time 06:01AM | Arrival Time 07:15PM | Duration 13h14 | Departure days Wed | Cheapest price $86 |
Operator Amtrak | Departure Time 10:04AM | Arrival Time 09:40PM | Duration 11h36 | Departure days Wed | Cheapest price $66 |
Operator Amtrak | Departure Time 06:04PM | Arrival Time 05:45AM | Duration 11h41 | Departure days Wed | Cheapest price $66 |
Operator Greyhound | Departure Time 07:30PM | Arrival Time 08:05AM | Duration 12h35 | Departure days Wed | Cheapest price $171 |
Operator Greyhound | Departure Time 09:20PM | Arrival Time 07:15AM | Duration 9h55 | Departure days Wed, Fri | Cheapest price $138 |
Live departures
Santa Ana, CA to San Francisco, CA bus times
The table below shows live departures for Santa Ana, CA to San Francisco, CA buses for today, Wednesday, February 25. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets | |
|---|---|---|---|---|---|---|
769 Pacific Surfliner · 4769 AMTRAK | 6:04 PM Santa Ana Station, Santa Ana, CA | 11h36 | 5:40 AM San Francisco, CA | 1 transfer | ||
| Thursday, February 26 | ||||||
785 Pacific Surfliner · 4785 AMTRAK | 2:04 AM Santa Ana Station, Santa Ana, CA | 11h41 | 1:45 PM San Francisco, CA | 1 transfer | ||
undefined · undefined+ FlixBus | 3:30 AM Santa Ana, E Santa Ana Blvd (Train Station) | 12h35 | 4:05 PM San Francisco, Townsend Street / 5th Street, CA | 2 transfers | ||
![]() | 3:30 AM Santa Ana, CA | 16h25 | 7:55 PM San Francisco, CA | 0 transfersDirect | ||
![]() | 5:20 AM Santa Ana, E Santa Ana Blvd (Train Station) | 9h55 | 3:15 PM San Francisco, Transit Center Bay 29 | 0 transfersDirect | ||
![]() | 4:45 PM Santa Ana, CA | 11h20 | 4:05 AM San Francisco, CA | 0 transfersDirect | ||
This is the last bus of the day. | ||||||
Find all the dates and times for this journey
Compare prices and tickets Santa Ana, CA to San Francisco, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 26
Feb 27
Feb 28
Mar 01
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Mar 03
Mar 04
Why should you book Santa Ana, CA to San Francisco, CA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Santa Ana, CA to San Francisco, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Santa Ana, CA to San Francisco, CA.
Journey information
Overview: Bus from Santa Ana, CA to San Francisco, CA
Buses from Santa Ana, CA to San Francisco, CA run on average 16 times per day, taking around 10h 38m. Cheap bus tickets for this journey start at $41 (€33) if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:15, the last at 23:50. The fastest bus covers the 377 miles (608 km) distance in 9h 55m.
Distance 377 miles (608 km) |
Average bus duration 10h 38m |
Cheapest ticket price $41 (€33) |
Buses per day 16 |
Direct buses 1 |
Fastest bus 9h 55m |
First bus 00:15 |
Last bus 23:50 |
Bus providers: Greyhound from Santa Ana, CA to San Francisco, CAYou can travel by bus between Santa Ana, CA to San Francisco, CA with Greyhound for as low as $41 (€33). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Santa Ana, CA to San Francisco, CA
Find answers to the most common questions about traveling from Santa Ana, CA to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Santa Ana, CA to San Francisco, CA
Most popular bus connections from Santa Ana, CA
More options for your journey from Santa Ana, CA to San Francisco, CA
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