- Must visit
Museo Nazionale del Paleolitico di Isernia
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Cheapest price on Sep 19
$15
Average ticket price on Sep 19
$15
Fastest journey on Sep 19
2 h 25 m
Average journey duration on Sep 19
2 h 28 m
Buses on Sep 19
2
Distance
149 km
The best way to find a cheap bus ticket from Rome to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Rome to Isernia will cost around $15 if you buy it on the day, but the cheapest tickets can be found for only $15.
On Sat, Sep 19, we found 2 buses from Rome to Isernia, including 2 direct services.
On Sat, Sep 19 the direct buses cover the 149 km distance in an average of 2 h 28 m but if you time it right, some buses will get you there in just 2 h 25 m .
On Sat, Sep 19 the slowest buses will take 2 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
058
FlixBus
FlixBus
058Omio recommends booking the train as it is the most popular option from Rome to Isernia among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $21 For those with little time, consider booking a bus, which has an average total journey time of 3h 8m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.0 - 0.1kg. Average ticket prices depend on the travel mode: a bus costs an average of $21, while a train costs an average of $33.
Distance: 92 miles (149 km)
| Bus | Most popular Train | Driving |
|---|---|---|
$21 Average price Cheapest | $33 Average price | $50 Average price (fuel + tolls) |
3h 8m Average total duration Fastest 2h 38m Onboard + 30m Additional time* | 3h 18m Average total duration 2h 48m Onboard + 30m Additional time* | 2h 12m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions | 0.0 - 0.1kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Isernia:
A bus is $13 less than a train for this route with tickets for a train from Rome to Isernia costing on average $33.
Other travel options to Isernia take longer:
Train takes on average 2h 48m.
Tickets start at around $21 compared to roughly $50 in fuel and tolls — a saving of about $29. The journey takes 2h 38m versus 2h 12m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar, Marino Autolinee, ATM Azienda di Trasporti Molisana S.p.A..
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator BlaBlaCar | Departure Time 04:50AM | Arrival Time 06:30AM | Duration 1h40 | Departure days Sat | Cheapest price $15 |
Operator Regionale | Departure Time 06:15AM | Arrival Time 08:35AM | Duration 2h20 | Departure days Tue | Cheapest price $17 |
Operator BlaBlaCar | Departure Time 07:00AM | Arrival Time 08:40AM | Duration 1h40 | Departure days Sat | Cheapest price $18 |
Operator BlaBlaCar | Departure Time 07:30AM | Arrival Time 09:10AM | Duration 1h40 | Departure days Mon | Cheapest price $12 |
Operator BlaBlaCar | Departure Time 08:00AM | Arrival Time 09:40AM | Duration 1h40 | Departure days Sat | Cheapest price $18 |
Operator BlaBlaCar | Departure Time 09:00AM | Arrival Time 10:40AM | Duration 1h40 | Departure days Mon | Cheapest price $12 |
Operator BlaBlaCar | Departure Time 09:30AM | Arrival Time 11:10AM | Duration 1h40 | Departure days Mon | Cheapest price $12 |
Operator BlaBlaCar | Departure Time 09:40AM | Arrival Time 10:50AM | Duration 1h10 | Departure days Sun | Cheapest price $8 |
Operator BlaBlaCar | Departure Time 10:10AM | Arrival Time 11:40AM | Duration 1h30 | Departure days Sun | Cheapest price $14 |
Operator BlaBlaCar | Departure Time 11:10AM | Arrival Time 12:40PM | Duration 1h30 | Departure days Fri | Cheapest price $13 |
Operator BlaBlaCar | Departure Time 11:50AM | Arrival Time 01:00PM | Duration 1h10 | Departure days Fri | Cheapest price $12 |
Operator BlaBlaCar | Departure Time 12:20PM | Arrival Time 02:20PM | Duration 2h00 | Departure days Sat | Cheapest price $20 |
Operator FlixBus | Departure Time 12:50PM | Arrival Time 03:00PM | Duration 2h10 | Departure days Wed, Thu | Cheapest price $15 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 04:00PM | Duration 2h10 | Departure days Wed, Thu | Cheapest price $14 |
Operator FlixBus | Departure Time 02:50PM | Arrival Time 05:15PM | Duration 2h25 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $13 |
Operator BlaBlaCar | Departure Time 03:00PM | Arrival Time 04:30PM | Duration 1h30 | Departure days Fri | Cheapest price $13 |
Operator BlaBlaCar | Departure Time 04:20PM | Arrival Time 05:50PM | Duration 1h30 | Departure days Sat | Cheapest price $15 |
Operator Marino Autolinee | Departure Time 04:30PM | Arrival Time 07:00PM | Duration 2h30 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $11 |
Operator BlaBlaCar | Departure Time 05:00PM | Arrival Time 06:40PM | Duration 1h40 | Departure days Sun | Cheapest price $18 |
Operator BlaBlaCar | Departure Time 06:10PM | Arrival Time 07:40PM | Duration 1h30 | Departure days Fri | Cheapest price $12 |
Operator BlaBlaCar | Departure Time 06:30PM | Arrival Time 07:40PM | Duration 1h10 | Departure days Mon | Cheapest price $14 |
Operator BlaBlaCar | Departure Time 07:00PM | Arrival Time 08:20PM | Duration 1h20 | Departure days Fri | Cheapest price $12 |
Operator BlaBlaCar | Departure Time 09:00PM | Arrival Time 10:30PM | Duration 1h30 | Departure days Sun | Cheapest price $24 |
The table below shows live departures for Rome to Isernia buses for tomorrow, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 2:50 PM Roma, Autostazione Tiburtina | 2h25 | 5:15 PM Isernia, Piazza della Repubblica (F. Martino bus station) | 0 transfersDirect | |
058 | 4:30 PM Roma, Autostazione Tiburtina | 2h30 | 7:00 PM Isernia, Piazza della Repubblica (F. Martino bus station) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Rome to Isernia run on average 2 times per day, taking around 2h 38m. Cheap bus tickets for this journey start at $6 if you book in advance.
There are 1 buses per day. The earliest bus runs at 02:45, the last at 23:56. The fastest bus covers the 92 miles (149 km) distance in 2h 10m.
Distance 92 miles (149 km) |
Average bus duration 2h 38m |
Cheapest ticket price $6 |
Buses per day 2 |
Direct buses 1 |
Fastest bus 2h 10m |
First bus 2:45 AM |
Last bus 11:56 PM |
Cheapest Month Mar |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Sat |
Least Busy Day Fri |
Best time to book 28 days |
Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.
Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.
Main historic street lined with palaces, churches, and shops. The best walk for absorbing Isernia's old-town atmosphere.
The historic center preserves medieval lanes, arches, and layered architecture. Ideal for slow exploration and local street photography.
Central square near the cathedral and Fontana Fraterna. A practical starting point for discovering the city's key monuments.
Fresh pasta sheets layered with rich pork ragù, mozzarella, and caciocavallo. A Sunday and feast-day classic in Molise with deep family tradition.
Small handmade cavatelli pasta, often served with tomato sauce, pork, or seasonal vegetables. It is one of Molise’s best-known home-style staples.
Rustic soup of field greens, potatoes, beans, and cornbread or stale bread. A traditional peasant dish from the Isernia area, especially in colder months.
Established restaurant known for Molisan cooking, handmade pasta, and local meats in a refined but welcoming setting.
Well-regarded traditional venue serving regional specialties, grilled meats, and classic local dishes in a rustic atmosphere.
Casual, popular spot for pizza and southern Italian dishes, suited to an easy meal with locals and families.
Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.
Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.
Find answers to the most common questions about traveling from Rome to Isernia by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

Most Rome to Isernia buses use the Roma, Autostazione Tiburtina to Isernia, Piazza della Repubblica (Autostazione F. Martino) station pair. Use this guide to compare Rome and Isernia bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Roma, Autostazione Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma, Autostazione Tiburtina has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafes and vending machines available.
Wi-Fi is available at Roma, Autostazione Tiburtina. ATMs are aTM available near ticket office.
Ticket office support is available at Roma, Autostazione Tiburtina.
Available at Roma, Autostazione Tiburtina: Parking, Taxis, WC.
Accessibility facilities are available at Roma, Autostazione Tiburtina: Wheelchair accessible entrances and facilities.
Isernia, Piazza della Repubblica (Autostazione F. Martino) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Nearby cafés and fast food outlets.
Wi-Fi is available at Isernia, Piazza della Repubblica (Autostazione F. Martino). ATMs are aTM located near the entrance.
Ticket office support is available at Isernia, Piazza della Repubblica (Autostazione F. Martino).
Available at Isernia, Piazza della Repubblica (Autostazione F. Martino): Parking, Taxis, WC.
Accessibility facilities are available at Isernia, Piazza della Repubblica (Autostazione F. Martino): Wheelchair accessible facility.
Here are some other resources that might have the information you need