- Must visit
Museo Nazionale del Paleolitico di Isernia
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Rome to Isernia
Showing times and prices for Aug 05
Cheapest price
$20
Average price
$21
Fastest journey
2 h 25 m
Average duration
2 h 28 m
Buses per day
2
Distance
149 km
Cheap tickets
The best way to find a cheap bus ticket from Rome to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Rome to Isernia will cost around $21 if you buy it on the day, but the cheapest tickets can be found for only $20.
Fast buses
Of the 2 buses that leave Rome for Isernia on Wed, Aug 05, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 149 km distance in an average of 2 h 28 m but if you time it right, some buses will get you there in just 2 h 25 m .
On Wed, Aug 05 the slowest buses will take 2 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus2:50 PM2h25Roma, Autostazione Tiburtina5:15 PMIsernia, Piazza della Repubblica (F. Martino bus station)$201One-way0 transfers
0584:30 PM2h30Roma, Autostazione Tiburtina7:00 PMIsernia, Piazza della Repubblica (F. Martino bus station)$221One-way0 transfers
- FlixBus2:50 PM2h25Roma, Autostazione Tiburtina5:15 PMIsernia, Piazza della Repubblica (F. Martino bus station)$201One-way0 transfers
- 0584:30 PM2h30Roma, Autostazione Tiburtina7:00 PMIsernia, Piazza della Repubblica (F. Martino bus station)$221One-way0 transfers
Travel Information
Compare train and bus for Rome to Isernia
Omio recommends booking the train as it is the most popular option from Rome to Isernia among Omio's users. If you are prioritising price take the train with prices starting from $17. For those with little time consider booking a bus which can get you there in 2h 13m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.0 - 0.1kg. The ticket price range depends on the travel mode: a train costs an average of $17, and a bus costs an average of $10.
Distance: 92 miles (149 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
$17 Average price | $17 Average price Cheapest | $50 Average price (fuel + tolls) |
2h 43m Average total duration Fastest 2h 13m Onboard + 30m Additional time* | 3h 40m Average total duration 3h 10m Onboard + 30m Additional time* | 2h 12m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions | 0.0 - 0.1kg CO2 emissions Lowest | - CO2 emissions |
Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
The cheapest way to travel from Rome to Isernia is a train with an average price of $17.
This is compared to other travel options from Rome to Isernia:
A train is $0.10 less than a bus for this route with tickets for a bus from Rome to Isernia costing on average $17.
The fastest way to travel from Rome to Isernia is by bus with an average journey time of 2h 13m.
Other travel options to Isernia take longer:
Train takes on average 3h 10m.
It's helpful to compare your options as there are 2 ways to travel between Rome and Isernia including taking a train and bus.
We recommend using the train as it is the most popular way to get from Rome to Isernia among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $17 compared to roughly $50 in fuel and tolls — a saving of about $32. The journey takes 2h 13m versus 2h 12m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A..
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Rome to Isernia Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator BlaBlaCar | Departure Time 02:20AM | Arrival Time 03:30AM | Duration 1h10 | Departure days Fri | Cheapest price $8 |
Operator BlaBlaCar | Departure Time 02:30AM | Arrival Time 03:40AM | Duration 1h10 | Departure days Sat | Cheapest price $11 |
Operator BlaBlaCar | Departure Time 03:40AM | Arrival Time 04:50AM | Duration 1h10 | Departure days Tue | Cheapest price $12 |
Operator Regionale | Departure Time 06:15AM | Arrival Time 08:35AM | Duration 2h20 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $17 |
Operator BlaBlaCar | Departure Time 06:40AM | Arrival Time 08:10AM | Duration 1h30 | Departure days Sat | Cheapest price $11 |
Operator BlaBlaCar | Departure Time 06:50AM | Arrival Time 08:00AM | Duration 1h10 | Departure days Fri | Cheapest price $8 |
Operator BlaBlaCar | Departure Time 07:00AM | Arrival Time 08:30AM | Duration 1h30 | Departure days Mon, Wed, Sun | Cheapest price $8 |
Operator BlaBlaCar | Departure Time 08:00AM | Arrival Time 09:40AM | Duration 1h40 | Departure days Tue, Wed | Cheapest price $11 |
Operator BlaBlaCar | Departure Time 08:30AM | Arrival Time 09:50AM | Duration 1h20 | Departure days Wed | Cheapest price $12 |
Operator BlaBlaCar | Departure Time 08:40AM | Arrival Time 09:50AM | Duration 1h10 | Departure days Tue | Cheapest price $12 |
Operator BlaBlaCar | Departure Time 09:00AM | Arrival Time 10:50AM | Duration 1h50 | Departure days Tue, Sun | Cheapest price $12 |
Operator Regionale | Departure Time 09:07AM | Arrival Time 11:25AM | Duration 2h18 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $17 |
Operator BlaBlaCar | Departure Time 09:10AM | Arrival Time 10:10AM | Duration 1h00 | Departure days Wed, Thu | Cheapest price $9 |
Operator Intercity | Departure Time 09:26AM | Arrival Time 02:10PM | Duration 4h44 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $44 |
Operator Frecciarossa | Departure Time 10:35AM | Arrival Time 02:10PM | Duration 3h35 | Departure days Thu, Fri, Sat | Cheapest price $56 |
Operator BlaBlaCar | Departure Time 10:50AM | Arrival Time 12:10PM | Duration 1h20 | Departure days Fri | Cheapest price $9 |
Operator Frecciarossa | Departure Time 10:51AM | Arrival Time 02:30PM | Duration 3h39 | Departure days Sun | Cheapest price $47 |
Operator BlaBlaCar | Departure Time 11:00AM | Arrival Time 12:30PM | Duration 1h30 | Departure days Sun | Cheapest price $12 |
Operator Frecciarossa | Departure Time 11:00AM | Arrival Time 02:10PM | Duration 3h10 | Departure days Sat | Cheapest price $82 |
Operator BlaBlaCar | Departure Time 11:10AM | Arrival Time 01:20PM | Duration 2h10 | Departure days Tue | Cheapest price $14 |
Operator BlaBlaCar | Departure Time 11:20AM | Arrival Time 12:30PM | Duration 1h10 | Departure days Thu | Cheapest price $12 |
Operator Intercity | Departure Time 11:26AM | Arrival Time 04:10PM | Duration 4h44 | Departure days Sun | Cheapest price $44 |
Operator BlaBlaCar | Departure Time 12:00PM | Arrival Time 01:30PM | Duration 1h30 | Departure days Mon, Sun | Cheapest price $8 |
Operator BlaBlaCar | Departure Time 12:10PM | Arrival Time 01:20PM | Duration 1h10 | Departure days Mon | Cheapest price $12 |
Operator Regionale | Departure Time 01:07PM | Arrival Time 03:25PM | Duration 2h18 | Departure days Mon, Thu, Fri, Sat | Cheapest price $17 |
Operator Frecciarossa | Departure Time 01:15PM | Arrival Time 04:10PM | Duration 2h55 | Departure days Mon, Thu, Fri, Sun | Cheapest price $54 |
Operator BlaBlaCar | Departure Time 01:20PM | Arrival Time 02:30PM | Duration 1h10 | Departure days Thu | Cheapest price $8 |
Operator BlaBlaCar | Departure Time 01:40PM | Arrival Time 03:10PM | Duration 1h30 | Departure days Sat | Cheapest price $11 |
Operator BlaBlaCar | Departure Time 02:10PM | Arrival Time 03:20PM | Duration 1h10 | Departure days Sat | Cheapest price $9 |
Operator Regionale | Departure Time 02:35PM | Arrival Time 04:55PM | Duration 2h20 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $17 |
Operator BlaBlaCar | Departure Time 02:40PM | Arrival Time 03:50PM | Duration 1h10 | Departure days Wed | Cheapest price $11 |
Operator FlixBus | Departure Time 02:50PM | Arrival Time 05:15PM | Duration 2h25 | Departure days Everyday | Cheapest price $19 |
Operator BlaBlaCar | Departure Time 02:50PM | Arrival Time 04:00PM | Duration 1h10 | Departure days Mon | Cheapest price $10 |
Operator Frecciarossa | Departure Time 03:57PM | Arrival Time 07:20PM | Duration 3h23 | Departure days Mon, Sat, Sun | Cheapest price $55 |
Operator BlaBlaCar | Departure Time 04:00PM | Arrival Time 05:30PM | Duration 1h30 | Departure days Mon, Tue, Wed, Sun | Cheapest price $8 |
Operator BlaBlaCar | Departure Time 04:10PM | Arrival Time 05:20PM | Duration 1h10 | Departure days Fri | Cheapest price $9 |
Operator BlaBlaCar | Departure Time 04:20PM | Arrival Time 05:40PM | Duration 1h20 | Departure days Wed | Cheapest price $13 |
Operator Marino Autolinee | Departure Time 04:30PM | Arrival Time 07:00PM | Duration 2h30 | Departure days Everyday | Cheapest price $15 |
Operator BlaBlaCar | Departure Time 05:00PM | Arrival Time 06:30PM | Duration 1h30 | Departure days Wed | Cheapest price $13 |
Operator BlaBlaCar | Departure Time 05:10PM | Arrival Time 06:30PM | Duration 1h20 | Departure days Wed | Cheapest price $11 |
Operator Regionale | Departure Time 05:40PM | Arrival Time 07:55PM | Duration 2h15 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $17 |
Operator BlaBlaCar | Departure Time 06:00PM | Arrival Time 07:20PM | Duration 1h20 | Departure days Thu, Sat | Cheapest price $9 |
Operator Frecciarossa | Departure Time 06:05PM | Arrival Time 09:45PM | Duration 3h40 | Departure days Mon, Sat, Sun | Cheapest price $45 |
Operator BlaBlaCar | Departure Time 07:30PM | Arrival Time 09:00PM | Duration 1h30 | Departure days Thu | Cheapest price $10 |
Operator BlaBlaCar | Departure Time 08:10PM | Arrival Time 09:20PM | Duration 1h10 | Departure days Tue, Fri | Cheapest price $8 |
Operator Regionale | Departure Time 08:15PM | Arrival Time 10:35PM | Duration 2h20 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $17 |
Operator BlaBlaCar | Departure Time 11:40PM | Arrival Time 12:50AM | Duration 1h10 | Departure days Tue | Cheapest price $11 |
Live departures
Rome to Isernia bus times
The table below shows live departures for Rome to Isernia buses for today, Tuesday, August 4. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus | 2:50 PM Roma, Autostazione Tiburtina | 2h25 | 5:15 PM Isernia, Piazza della Repubblica (F. Martino bus station) | 0 transfersDirect | |
| 058 | 4:30 PM Roma, Autostazione Tiburtina | 2h30 | 7:00 PM Isernia, Piazza della Repubblica (F. Martino bus station) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Rome to Isernia by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Wed
Aug 05
Aug 05
Thu
Aug 06
Aug 06
Fri
Aug 07
Aug 07
Sat
Aug 08
Aug 08
Sun
Aug 09
Aug 09
Mon
Aug 10
Aug 10
Tue
Aug 11
Aug 11
Wed
Aug 12
Aug 12
Thu
Aug 13
Aug 13
Fri
Aug 14
Aug 14
Sat
Aug 15
Aug 15
Sun
Aug 16
Aug 16
Mon
Aug 17
Aug 17
Tue
Aug 18
Aug 18
Why should you book Rome to Isernia buses with Omio?
FlixBus as well as ATM Azienda di Trasporti Molisana S.p.A. offer buses services from Rome to Isernia.
Omio is an official ticket reseller for all your travel options from Rome to Isernia.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of ATM Azienda di Trasporti Molisana S.p.A. to find the best option for your trip from Rome to Isernia.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Rome to Isernia.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Rome to Isernia.
Journey information
Overview: Bus from Rome to Isernia
ItalyItaly
Buses from Rome to Isernia run on average 10 times per day, taking around 2h 13m. Cheap bus tickets for this journey start at $10 if you book in advance.
There are 6 buses per day. The earliest bus runs at 02:45, the last at 23:56. The fastest bus covers the 92 miles (149 km) distance in 2h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 92 miles (149 km) |
Average bus duration 2h 13m |
Cheapest ticket price $10 |
Buses per day 10 |
Direct buses 6 |
Fastest bus 2h 10m |
First bus 2:45 AM |
Last bus 11:56 PM |
Cheapest Month Mar |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Sun |
Least Busy Day Fri |
Best time to book 4 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A. from Rome to IserniaYou can travel by bus between Rome to Isernia with FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A. for as low as $10. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
2h 10m
Cheapest Price
$10
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
BlaBlaCar
About
BlaBlaCar is a French online marketplace for carpooling, connecting drivers with empty seats and passengers traveling to the same destination to share costs. Founded in 2006, it operates in Europe and Latin America, boasting 26 million active members. The platform also includes BlaBlaCar Bus, an intercity bus service. BlaBlaCar's name comes from its rating system for drivers' chattiness: "Bla" for quiet, "BlaBla" for talkative, and "BlaBlaBla" for very chatty. The company aims to be the leading marketplace for shared travel, offering affordable and sustainable solutions by combining carpooling with bus journeys.
Luggage & cancellation policy
BlaBlaCar frequency
5 a day
ATM Azienda di Trasporti Molisana S.p.A.
Luggage & cancellation policy
Average Duration
2h 10m
Cheapest Price
$12
ATM Azienda di Trasporti Molisana S.p.A. frequency
2 a day
Complete guide to Isernia
Things to do in Isernia
Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.
- Recommended
Museo Archeologico di Santa Maria delle Monache
Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.
- Recommended
Complesso Monumentale di Santa Maria delle Monache
Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.
- Must visit
Corso Marcelli
Main historic street lined with palaces, churches, and shops. The best walk for absorbing Isernia's old-town atmosphere.
- Must visit
Centro Storico di Isernia
The historic center preserves medieval lanes, arches, and layered architecture. Ideal for slow exploration and local street photography.
- Recommended
Piazza Celestino V
Central square near the cathedral and Fontana Fraterna. A practical starting point for discovering the city's key monuments.
Lasagne Alla Molisana
Fresh pasta sheets layered with rich pork ragù, mozzarella, and caciocavallo. A Sunday and feast-day classic in Molise with deep family tradition.
Cavatelli
Small handmade cavatelli pasta, often served with tomato sauce, pork, or seasonal vegetables. It is one of Molise’s best-known home-style staples.
- Vegetarian
- Vegan
Pampanella E Minestra Di Erbe
Rustic soup of field greens, potatoes, beans, and cornbread or stale bread. A traditional peasant dish from the Isernia area, especially in colder months.
Ristorante Da Lulù
Established restaurant known for Molisan cooking, handmade pasta, and local meats in a refined but welcoming setting.
Osteria Le Antiche Mura
Well-regarded traditional venue serving regional specialties, grilled meats, and classic local dishes in a rustic atmosphere.
Ristorante Pizzeria La Strada
Casual, popular spot for pizza and southern Italian dishes, suited to an easy meal with locals and families.
Euro (€)
Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.
Average meal costs
- Budget
- €8-12 for fast food or a simple meal.
- Mid-range
- €20-35 per person for a restaurant meal.
- Fine dining
- €50+ per person for upscale dining.
- Coffee
- €1.20-2.50 for espresso or cappuccino.
Tipping culture
Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.
FAQs: Bus from Rome to Isernia
Find answers to the most common questions about traveling from Rome to Isernia by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Rome to Isernia can start from as little as $10 when you book in advance. The average bus ticket price for Rome to Isernia is $17 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Rome to Isernia is 2h 10m to travel the 92 miles (149 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Rome to Isernia leaves at 2:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Rome to Isernia leaves at 11:56 PM.
Yes, there are 6 direct buses a day from Rome to Isernia with FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A.. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Rome to Isernia, you can count on FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A. for the best way to get you to Isernia. You can also check all possible bus companies who offer a service between Rome and Isernia and compare the amenities they offer before buying a bus ticket.
A trip to Isernia from Rome is worth doing but not as a day trip with a journey time of 2h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Rome to Isernia is March.
It's helpful to compare your options as there are 2 ways to travel between Rome and Isernia including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Rome to Isernia:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Rome to Isernia for bus company FlixBus.
Whether you can cancel your bus ticket from Rome to Isernia depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Rome to Isernia.
Yes, the following luggage options are included when booking a bus ticket from Rome to Isernia:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Rome to Isernia:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Rome to Isernia. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Rome to Isernia with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Rome to Isernia with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Rome to Isernia with the following bus company: FlixBus.
Since both Rome and Isernia are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the train as it is the most popular way to get from Rome to Isernia among Omio's users.
Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.
In Isernia, travelers should be cautious of petty theft, especially in crowded areas and near transportation hubs. It is advisable to stay vigilant with personal belongings and avoid accepting unsolicited offers from strangers. There are no widespread reports of specific scams targeting visitors, but standard travel precautions apply, such as using official taxi services and verifying ticket purchases to ensure safety and avoid fraud.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Rome to Isernia
Most Rome to Isernia buses use the Roma, Autostazione Tiburtina to Isernia, Piazza della Repubblica (Autostazione F. Martino) station pair. Use this guide to compare Rome and Isernia bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Rome
Arrival bus stations in Isernia
Roma, Autostazione Tiburtina
City-centre transport
Getting to Roma, Autostazione Tiburtina from Rome city centre
Bus490, 495 · 16m · $2 · every ~22 min
SubwayMeb · 7m · $2 · every ~15 min
Ciampino, Aeroporto Internazionale di Roma–Ciampino "G. B. Pastine"
City-centre transport
Getting to Ciampino, Aeroporto Internazionale di Roma–Ciampino "G. B. Pastine" from Rome city centre
TrainRe, 12629 · 15m · $2 · every ~8 min
BusN574, 522, 554, 546, N522 · 25m · $1
30m · $2
40m · $9 · every ~3 min
SIT Bus Shuttle · 45m · $5
Isernia, Piazza della Repubblica (Autostazione F. Martino)
More options for your journey from Rome to Isernia
Here are some other resources that might have the information you need
Most popular buses to and from Isernia and Rome
Most popular bus connections to Isernia
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
