- Must visit
Museo Nazionale del Paleolitico di Isernia
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
The best way to find a cheap bus ticket from Fiumicino to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Fiumicino to Isernia will cost around €46 if you buy it on the day, but the cheapest tickets can be found for only €39.
It's difficult to get from Fiumicino to Isernia without transferring at least once.
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Buses from Fiumicino to Isernia run on average 2 times per day, taking around 5h 19m. Cheap bus tickets for this journey start at €29 but you can travel from only €22 by train.
The earliest bus runs at 04:05, the last at 18:57. The fastest bus covers the 104 miles (168 km) distance in 4h 34m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Fiumicino to Isernia.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:05AM | Arrival Time 09:44AM | Duration 7h39 | Departure days Tue | Cheapest price €45 |
Operator FlixBus | Departure Time 03:05AM | Arrival Time 10:24AM | Duration 7h19 | Departure days Tue | Cheapest price €29 |
Operator FlixBus | Departure Time 04:05AM | Arrival Time 11:35AM | Duration 7h30 | Departure days Mon, Wed, Sat, Sun | Cheapest price €32 |
Operator FlixBus | Departure Time 06:50AM | Arrival Time 04:04PM | Duration 9h14 | Departure days Thu, Fri | Cheapest price €59 |
Operator BlaBlaCar | Departure Time 08:40AM | Arrival Time 10:00AM | Duration 1h20 | Departure days Sat | Cheapest price €14 |
Operator FlixBus | Departure Time 08:50AM | Arrival Time 06:20PM | Duration 9h30 | Departure days Mon, Sat, Sun | Cheapest price €36 |
Operator BlaBlaCar | Departure Time 03:30PM | Arrival Time 05:30PM | Duration 2h00 | Departure days Sat | Cheapest price €13 |
Operator BlaBlaCar | Departure Time 05:00PM | Arrival Time 06:10PM | Duration 1h10 | Departure days Wed | Cheapest price €9 |
The table below shows live departures for Fiumicino to Isernia buses for tomorrow, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 4:05 AM Fiumicino, Aeroporto Leonardo de Vinci (T3 Arrivi - Stazione degli autobus) | 7h39 | 11:44 AM Isernia, Piazza della Repubblica (F. Martino bus station) | 1 transfer | |
FlixBus · FlixBus | 8:50 AM Fiumicino, Aeroporto Leonardo de Vinci (T3 Arrivi - Stazione degli autobus) | 9h14 | 6:04 PM Isernia, Piazza della Repubblica (F. Martino bus station) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Fiumicino to Isernia with FlixBus. Overnight buses available on this route with FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.
Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.
Main historic street lined with palaces, churches, and shops. The best walk for absorbing Isernia's old-town atmosphere.
The historic center preserves medieval lanes, arches, and layered architecture. Ideal for slow exploration and local street photography.
Central square near the cathedral and Fontana Fraterna. A practical starting point for discovering the city's key monuments.
Fresh pasta sheets layered with rich pork ragù, mozzarella, and caciocavallo. A Sunday and feast-day classic in Molise with deep family tradition.
Small handmade cavatelli pasta, often served with tomato sauce, pork, or seasonal vegetables. It is one of Molise’s best-known home-style staples.
Rustic soup of field greens, potatoes, beans, and cornbread or stale bread. A traditional peasant dish from the Isernia area, especially in colder months.
Established restaurant known for Molisan cooking, handmade pasta, and local meats in a refined but welcoming setting.
Well-regarded traditional venue serving regional specialties, grilled meats, and classic local dishes in a rustic atmosphere.
Casual, popular spot for pizza and southern Italian dishes, suited to an easy meal with locals and families.
Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.
Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Isernia.
Find answers to the most common questions about traveling from Fiumicino to Isernia by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

Most Fiumicino to Isernia buses use the to Isernia, Piazza della Repubblica (Autostazione F. Martino) station pair. Use this guide to compare Fiumicino and Isernia bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Isernia, Piazza della Repubblica (Autostazione F. Martino) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Nearby cafés and fast food outlets.
Wi-Fi is available at Isernia, Piazza della Repubblica (Autostazione F. Martino). ATMs are aTM located near the entrance.
Ticket office support is available at Isernia, Piazza della Repubblica (Autostazione F. Martino).
Available at Isernia, Piazza della Repubblica (Autostazione F. Martino): Parking, Taxis, WC.
Accessibility facilities are available at Isernia, Piazza della Repubblica (Autostazione F. Martino): Wheelchair accessible facility.