- Must visit
Museo Nazionale del Paleolitico di Isernia
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Cheapest price on Sep 19
$17
Average ticket price on Sep 19
$32
Fastest journey on Sep 19
2 h 5 m
Average journey duration on Sep 19
2 h 12 m
Trains on Sep 19
12
Distance
149 km
The best way to find a cheap train ticket from Rome to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Rome to Isernia will cost around $32 if you buy it on the day, but the cheapest tickets can be found for only $17.
On Sat, Sep 19, we found 12 trains from Rome to Isernia, including 5 direct services.
On Sat, Sep 19 the direct trains cover the 149 km distance in an average of 2 h 12 m but if you time it right, some trains will get you there in just 2 h 5 m .
On Sat, Sep 19 the slowest trains will take 2 h 19 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
Regionale 23365
Regionale 23363
Regionale 23381
Regionale 5835 · Autobus RM114
Regionale 23367
Regionale 23369
Regionale 23365
Regionale 23363
Regionale 23367
Regionale 23381Omio recommends booking the train as it is the most popular option from Rome to Isernia among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $21 For those with little time, consider booking a bus, which has an average total journey time of 3h 8m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.0 - 0.1kg. Average ticket prices depend on the travel mode: a bus costs an average of $21, while a train costs an average of $33.
Distance: 92 miles (149 km)
Most popular Train | Bus | Driving |
|---|---|---|
$33 Average price | $21 Average price Cheapest | $50 Average price (fuel + tolls) |
3h 18m Average total duration 2h 48m Onboard + 30m Additional time* | 3h 8m Average total duration Fastest 2h 38m Onboard + 30m Additional time* | 2h 12m Average total duration (door-to-door) |
0.0 - 0.1kg CO2 emissions Lowest | 0.1 - 0.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Isernia:
A bus is $13 less than a train for this route with tickets for a train from Rome to Isernia costing on average $33.
Other travel options to Isernia take longer:
Train takes on average 2h 48m.
Tickets start at around $33 compared to roughly $50 in fuel and tolls — a saving of about $16. The journey takes 2h 48m versus 2h 12m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Direct services run with Regionale.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Rome to Isernia trains for today, Friday, September 18. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
InterCityNotte 789+ Regionale 5816 · Regionale 23384 | 11:56 PM Rome Termini | 7h06 | 7:02 AM Isernia station | 2 transfers | |
| Saturday, September 19 | |||||
Regionale 23363 | 6:15 AM Rome Termini | 2h12 | 8:27 AM Isernia station | 0 transfersDirect | |
Regionale 23365 | 9:07 AM Rome Termini | 2h08 | 11:15 AM Isernia station | 0 transfersDirect | |
FRECCIAROSSA 9515+ Regionale 5190 | 11:00 AM Rome Termini | 3h04 | 2:04 PM Isernia station | 1 transfer | |
Regionale 23367 | 1:07 PM Rome Termini | 2h16 | 3:23 PM Isernia station | 0 transfersDirect | |
Regionale 23369 | 2:35 PM Rome Termini | 2h05 | 4:40 PM Isernia station | 0 transfersDirect | |
Regionale 5893 · Regionale 5196 | 2:53 PM Rome Termini | 4h27 | 7:20 PM Isernia station | 1 transfer | |
Regionale 12623 · Regionale 5829 · Regionale 5196 | 3:42 PM Rome Termini | 3h38 | 7:20 PM Isernia station | 2 transfers | |
FRECCIAROSSA 9535+ Regionale 5196 | 4:05 PM Rome Termini | 3h15 | 7:20 PM Isernia station | 1 transfer | |
Regionale 20033 · Regionale 23425 | 5:21 PM Rome Termini | 2h31 | 7:52 PM Isernia station | 1 transfer | |
Regionale 5835 · Autobus RM114 | 6:07 PM Rome Termini | 2h48 | 8:55 PM Isernia station | 1 transfer | |
FRECCIAROSSA 8519+ Regionale 23495 | 6:20 PM Rome Termini | 3h23 | 9:43 PM Isernia station | 1 transfer | |
Regionale 23381 | 8:07 PM Rome Termini | 2h19 | 10:26 PM Isernia station | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Rome to Isernia run on average 10 times per day, taking around 2h 48m. Cheap train tickets for this journey start at $16 but you can travel from only $6 by bus.
There are 5 trains per day. The earliest train runs at 04:50, the last at 23:56. The fastest train covers the 92 miles (149 km) distance in 1h 59m.
Distance 92 miles (149 km) |
Average train duration 2h 48m |
Cheapest ticket price $16 |
Trains per day 10 |
Direct trains 5 |
Fastest train 1h 59m |
First train 4:50 AM |
Last train 11:56 PM |
Cheapest Month Jan |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Sat |
Least Busy Day Fri |
Best time to book 14 days |
Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.
Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.
Main historic street lined with palaces, churches, and shops. The best walk for absorbing Isernia's old-town atmosphere.
The historic center preserves medieval lanes, arches, and layered architecture. Ideal for slow exploration and local street photography.
Central square near the cathedral and Fontana Fraterna. A practical starting point for discovering the city's key monuments.
Fresh pasta sheets layered with rich pork ragù, mozzarella, and caciocavallo. A Sunday and feast-day classic in Molise with deep family tradition.
Small handmade cavatelli pasta, often served with tomato sauce, pork, or seasonal vegetables. It is one of Molise’s best-known home-style staples.
Rustic soup of field greens, potatoes, beans, and cornbread or stale bread. A traditional peasant dish from the Isernia area, especially in colder months.
Established restaurant known for Molisan cooking, handmade pasta, and local meats in a refined but welcoming setting.
Well-regarded traditional venue serving regional specialties, grilled meats, and classic local dishes in a rustic atmosphere.
Casual, popular spot for pizza and southern Italian dishes, suited to an easy meal with locals and families.
Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.
Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.
Official public transport app
Isernia Railway Station -> Piazza Andrea d'Isernia
Find answers to the most common questions about traveling from Rome to Isernia by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

Most Rome to Isernia trains use the Roma Termini to Isernia station pair. Use this guide to compare Rome and Isernia train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Roma Termini is 1 km from Rome city centre. Public transport options include:
Roma Termini has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Acafe, Moka Café, Roadhouse Grill, McDonald's, Gusto, Chef Express, Coop Minimarket, Mercato Centrale
Free WiFi in the station. ATMs are there are ATMs in various locations around the station.
The ticket office is open Mon - Sun: 06:30 - 22:00. Information desks are located near Platform 24.
Luggage storage is provided by KiPoint and located on Platform 24. Open every day from 06:00 to 23:00.
Available at Roma Termini: Parking, Taxis, WC.
Available at Roma Termini: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Termini: The Sala Blu, Trenitalia's office of assistance for disabled travelers, is located next to Platform 1.
Nearby hotels include Archi di Roma Guest House, Gemma di Roma, The Liberty Boutique Hotel.
Roma Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma Tiburtina has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Rock n’ Coffee Roma, Arabian Kebab, Ingredienti, McDonald’s, Numb's Bakery Café
Free, limited Wi-Fi available in the station for 15 minutes. ATMs are located on the ground floor level.
The ticket office is open Mon - Sun: 06:35 - 20:20. Information desks are located inside the main terminal. .
Luggage storage is luggage lockers are located in the station lobby.
Available at Roma Tiburtina: Parking, Taxis, WC.
Available at Roma Tiburtina: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Tiburtina: Accessible facilities include elevators and escalators.
Nearby hotels include B&B Rome Tiburtina, B&B Alba Domus Roma, Hotel delle Province.
Roma Ostiense is 2 km from Rome city centre. Public transport options include:
Roma Ostiense has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: Ramen Bar Akira, Eataly Roma
Free. ATMs are available in the train station.
Ticket office support is available at Roma Ostiense. Information desks are located in the main hall.
Luggage storage is available at Roma Ostiense. Lost and found is available at the station.
Available at Roma Ostiense: Parking, Taxis, WC.
Available at Roma Ostiense: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Ostiense: Elevators, ramps, restrooms.
Nearby hotels include Hotel Abitart, Hotel San Anselmo, Hotel Villa San Pio.
Isernia has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food options include: Pasta e Pizza, Ristorante da Adriano
Free.
Ticket office support is available at Isernia. Information desks are located in the main hall.
Luggage storage is available at Isernia. Lost and found is available at the station.
Available at Isernia: Parking, Taxis, WC.
Available at Isernia: Bike Parking.
Accessibility facilities are available at Isernia: Ramps.
Nearby hotels include Grand Hotel Europa, Hotel Ristorante Sayonara, Hotel La Tequila.
Here are some other resources that might have the information you need