- Must visit
National Museum
Prague’s flagship museum on Wenceslas Square, with major natural history, history, and cultural collections in a monumental Neo-Renaissance building.
Cheapest price
$157
Average price
$204
Fastest journey
19 h 55 m
Average duration
20 h 15 m
Buses per day
40
Distance
923 km
The best way to find a cheap bus ticket from Rome to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Rome to Prague will cost around $204 if you buy it on the day, but the cheapest tickets can be found for only $157.
Of the 40 buses that leave Rome for Prague on Sat, May 30, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, May 30 the direct buses cover the 923 km distance in an average of 20 h 15 m but if you time it right, some buses will get you there in just 19 h 55 m .
On Sat, May 30 the slowest buses will take 20 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Rome to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $69. For those with little time consider booking a flight which can get you there in 2h 50m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.3kg. The ticket price range depends on the travel mode: a bus costs an average of $69, and a train costs an average of $293.
Distance: 573 miles (923 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$113 Average price Cheapest | $151 Average price | $297 Average price | $358 Average price (fuel + tolls) |
20h 23m Average total duration 19h 53m Onboard + 30m Additional time* | 5h 50m Average total duration Fastest 2h 50m Onboard + 3h 0m Additional time* | 18h 2m Average total duration 17h 32m Onboard + 30m Additional time* | 13h 23m Average total duration (door-to-door) |
0.9 - 2.3kg CO2 emissions Lowest | 2.8 - 5.5kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Prague:
A bus is $38 (€31) less than a flight for this route with tickets for a flight from Rome to Prague costing on average $151 (€122).
A bus is $184 (€148) less than a train for this route with tickets for a train from Rome to Prague costing on average $297 (€239).
Other travel options to Prague take longer:
Train takes on average 17h 32m.
Bus takes on average 19h 53m.
Tickets start at around $113 (€91) compared to roughly $358 (€288) in fuel and tolls — a saving of about $245 (€197). The journey takes 19h 53m versus 13h 23m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 07:30AM | Arrival Time 05:45AM | Duration 22h15 | Departure days Wed, Thu, Sat, Sun | Cheapest price $114 |
Operator FlixBus | Departure Time 09:30AM | Arrival Time 08:55AM | Duration 23h25 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $105 |
Operator FlixBus | Departure Time 10:40AM | Arrival Time 11:30AM | Duration 24h50 | Departure days Everyday | Cheapest price $117 |
Operator FlixBus | Departure Time 11:10AM | Arrival Time 10:45AM | Duration 23h35 | Departure days Tue, Wed, Fri | Cheapest price $121 |
Operator FlixBus | Departure Time 11:50AM | Arrival Time 10:35AM | Duration 22h45 | Departure days Fri, Sat, Sun | Cheapest price $148 |
Operator FlixBus | Departure Time 12:00PM | Arrival Time 11:45AM | Duration 23h45 | Departure days Mon, Tue, Wed, Thu | Cheapest price $122 |
Operator FlixBus | Departure Time 12:10PM | Arrival Time 10:35AM | Duration 22h25 | Departure days Everyday | Cheapest price $116 |
Operator FlixBus | Departure Time 12:20PM | Arrival Time 01:20PM | Duration 25h00 | Departure days Everyday | Cheapest price $114 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 10:35AM | Duration 21h50 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $106 |
Operator RegioJet a.s. | Departure Time 01:00PM | Arrival Time 09:10AM | Duration 20h10 | Departure days Wed, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 01:30PM | Duration 24h25 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $106 |
Operator FlixBus | Departure Time 05:00PM | Arrival Time 08:00PM | Duration 27h00 | Departure days Everyday | Cheapest price $104 |
Operator FlixBus | Departure Time 05:05PM | Arrival Time 05:35PM | Duration 24h30 | Departure days Everyday | Cheapest price $111 |
Operator FlixBus | Departure Time 05:25PM | Arrival Time 01:30PM | Duration 20h05 | Departure days Everyday | Cheapest price $107 |
Operator FlixBus | Departure Time 06:15PM | Arrival Time 09:30PM | Duration 27h15 | Departure days Fri, Sat, Sun | Cheapest price $144 |
Operator FlixBus | Departure Time 09:00PM | Arrival Time 05:45PM | Duration 20h45 | Departure days Everyday | Cheapest price $104 |
Operator FlixBus | Departure Time 09:20PM | Arrival Time 08:15PM | Duration 22h55 | Departure days Mon, Tue | Cheapest price $121 |
Operator FlixBus | Departure Time 10:45PM | Arrival Time 10:15PM | Duration 23h30 | Departure days Mon, Tue | Cheapest price $139 |
Operator FlixBus | Departure Time 10:55PM | Arrival Time 07:30PM | Duration 20h35 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $101 |
Operator FlixBus | Departure Time 11:05PM | Arrival Time 10:35PM | Duration 23h30 | Departure days Everyday | Cheapest price $128 |
Operator FlixBus | Departure Time 11:35PM | Arrival Time 03:15AM | Duration 27h40 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $112 |
Operator FlixBus | Departure Time 11:50PM | Arrival Time 03:15AM | Duration 27h25 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $127 |
The table below shows live departures for Rome to Prague buses for today, Friday, May 29. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 10:55 PM Roma, Autostazione Tiburtina | 27h55 | 2:50 AM Prague, Central Train Station | 2 transfers | |
FlixBus · FlixBus · FlixBus | 10:55 PM Roma, Autostazione Tiburtina | 24h00 | 10:55 PM Praha, Na Knížecí | 2 transfers | |
FlixBus · FlixBus | 10:55 PM Roma, Autostazione Tiburtina | 20h25 | 7:20 PM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 10:55 PM Roma, Autostazione Tiburtina | 20h35 | 7:30 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 11:05 PM Roma, Autostazione Tiburtina | 22h25 | 9:30 PM Praha, Černý Most | 1 transfer | |
FlixBus · FlixBus | 11:05 PM Roma, Autostazione Tiburtina | 21h50 | 8:55 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus · FlixBus | 11:05 PM Roma, Autostazione Tiburtina | 23h30 | 10:35 PM Praha, Roztyly | 2 transfers | |
FlixBus · FlixBus · FlixBus | 11:35 PM Roma, Autostazione (Metro Anagnina) | 27h40 | 3:15 AM Prague, Central Train Station | 2 transfers | |
| Saturday, May 30 | |||||
FlixBus · FlixBus | 7:30 AM Roma, Autostazione Tiburtina | 22h15 | 5:45 AM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:40 AM Roma, Autostazione Tiburtina | 24h50 | 11:30 AM Praha, Zličín | 2 transfers | |
FlixBus · FlixBus · FlixBus | 11:50 AM Roma, Autostazione (Metro Anagnina) | 23h55 | 11:45 AM Praha, Na Knížecí | 2 transfers | |
FlixBus · FlixBus · FlixBus | 12:10 PM Roma, Autostazione Tiburtina | 22h25 | 10:35 AM Prague, Central Train Station | 2 transfers | |
FlixBus · FlixBus · FlixBus | 12:20 PM Roma, Autostazione Tiburtina | 23h25 | 11:45 AM Praha, Na Knížecí | 2 transfers | |
FlixBus · FlixBus · FlixBus | 12:20 PM Roma, Autostazione Tiburtina | 25h25 | 1:45 PM Praha, Černý Most | 2 transfers | |
FlixBus · FlixBus · FlixBus | 12:20 PM Roma, Autostazione Tiburtina | 25h00 | 1:20 PM Praha, Roztyly | 2 transfers | |
FlixBus · FlixBus | 12:20 PM Roma, Autostazione Tiburtina | 21h05 | 9:25 AM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus · FlixBus | 12:45 PM Roma, Autostazione (Metro Anagnina) | 24h35 | 1:20 PM Praha, Roztyly | 2 transfers | |
FlixBus · FlixBus · FlixBus | 12:45 PM Roma, Autostazione (Metro Anagnina) | 25h00 | 1:45 PM Praha, Černý Most | 2 transfers | |
FlixBus · FlixBus · FlixBus | 1:05 PM Roma, Autostazione (Metro Anagnina) | 24h25 | 1:30 PM Praha, Roztyly | 2 transfers | |
FlixBus · FlixBus | 1:05 PM Roma, Autostazione (Metro Anagnina) | 20h20 | 9:25 AM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus · FlixBus | 1:05 PM Roma, Autostazione (Metro Anagnina) | 21h30 | 10:35 AM Prague, Central Train Station | 2 transfers | |
FlixBus · FlixBus | 5:00 PM Roma, Autostazione Tiburtina | 27h00 | 8:00 PM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus · FlixBus | 5:05 PM Roma, Autostazione Tiburtina | 23h05 | 4:10 PM Praha, Černý Most | 2 transfers | |
FlixBus | 5:05 PM Roma, Autostazione Tiburtina | 20h50 | 1:55 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus · FlixBus | 5:05 PM Roma, Autostazione Tiburtina | 24h30 | 5:35 PM Praha, M. Horákové (Hradčanská) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:05 PM Roma, Autostazione Tiburtina | 23h25 | 4:30 PM Praha, Roztyly | 2 transfers | |
FlixBus | 5:05 PM Roma, Autostazione Tiburtina | 20h40 | 1:45 PM Prague, Central Train Station | 0 transfersDirect | |
FlixBus · FlixBus · FlixBus | 5:05 PM Roma, Autostazione Tiburtina | 25h25 | 6:30 PM Praha, Zličín | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:25 PM Roma, Autostazione (Metro Anagnina) | 20h05 | 1:30 PM Praha, ÚAN Florenc | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:25 PM Roma, Autostazione (Metro Anagnina) | 24h10 | 5:35 PM Praha, M. Horákové (Hradčanská) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:25 PM Roma, Autostazione (Metro Anagnina) | 19h55 | 1:20 PM Prague, Central Train Station | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:25 PM Roma, Autostazione (Metro Anagnina) | 22h45 | 4:10 PM Praha, Černý Most | 2 transfers | |
FlixBus · FlixBus · FlixBus | 5:25 PM Roma, Autostazione (Metro Anagnina) | 25h45 | 7:10 PM Praha, Na Knížecí | 2 transfers | |
FlixBus · FlixBus · FlixBus | 6:15 PM Roma, Autostazione (Metro Anagnina) | 26h40 | 8:55 PM Praha, ÚAN Florenc | 2 transfers | |
FlixBus · FlixBus · FlixBus | 6:15 PM Roma, Autostazione (Metro Anagnina) | 27h15 | 9:30 PM Praha, Černý Most | 2 transfers | |
FlixBus · FlixBus · FlixBus | 9:00 PM Roma, Autostazione Tiburtina | 26h55 | 11:55 PM Prague, Central Train Station | 2 transfers | |
FlixBus · FlixBus · FlixBus | 9:00 PM Roma, Autostazione Tiburtina | 22h10 | 7:10 PM Praha, Na Knížecí | 2 transfers | |
FlixBus · FlixBus | 9:00 PM Roma, Autostazione Tiburtina | 20h30 | 5:30 PM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 9:00 PM Roma, Autostazione Tiburtina | 20h45 | 5:45 PM Praha, ÚAN Florenc | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Rome to Prague run on average 38 times per day, taking around 19h 53m. Cheap bus tickets for this journey start at $69 (€56) but you can travel from only $19 (€15) by flight.
There are 2 buses per day. The earliest bus runs at 00:10, the last at 23:55. The fastest bus covers the 573 miles (923 km) distance in 20h 10m.
Distance 573 miles (923 km) |
Average bus duration 19h 53m |
Cheapest ticket price $69 (€56) |
Buses per day 38 |
Direct buses 2 |
Fastest bus 20h 10m |
First bus 12:10 AM |
Last bus 11:55 PM |
Cheapest Month May |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Sun |
Best time to book 28 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s flagship museum on Wenceslas Square, with major natural history, history, and cultural collections in a monumental Neo-Renaissance building.
A major museum complex preserving Prague’s Jewish heritage through synagogues, ceremonial objects, archives, and cemetery access.
A leading contemporary art venue in Holešovice known for ambitious exhibitions, design, and the striking Gulliver airship installation.
Prague’s historic central square, surrounded by major landmarks and lively at all hours, making it an essential first stop.
A picturesque district of Baroque streets, embassies, gardens, and hidden corners beneath Prague Castle, ideal for walking and photography.
A broad boulevard-like square central to modern Czech history, shopping, and city life, anchored by the National Museum.
Marinated beef sirloin with creamy root-vegetable sauce, bread dumplings, cranberry sauce, and whipped cream. One of the most classic Czech celebratory dishes.
Roast pork served with bread dumplings and braised cabbage. A cornerstone of traditional Czech home cooking and pub menus.
Czech-style goulash, usually beef, slower-cooked and less soupy than the Hungarian version, commonly served with dumplings. A staple in Prague pubs.
Michelin-starred restaurant offering contemporary Czech fine dining with seasonal ingredients and a sophisticated atmosphere.
Well-known restaurant near Old Town Square offering refined Czech classics in a polished but approachable setting.
Elegant grand cafe and restaurant known for excellent breakfasts, pastries, and upscale Czech and Central European dishes.
Moderate by European standards. Beer, transit, and casual meals are affordable; central hotels cost more.
Around 10% in restaurants for good service, often rounded up. Tip taxis modestly by rounding up. Not expected for counter service, but appreciated.
Official public transport app
Prague Main Railway Station, Prague -> Old Town Square, Prague
Find answers to the most common questions about traveling from Rome to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

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