Travel Information
Compare train and bus for Rome to Isernia
Omio recommends booking the train as it is the most popular option from Rome to Isernia among Omio's users. If you are prioritising price take the train with prices starting from $16. For those with little time consider booking a bus which can get you there in 2h 13m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.0 - 0.1kg. The ticket price range depends on the travel mode: a train costs an average of $16, and a bus costs an average of $10.
Distance: 92 miles (149 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
$17 Average price Cheapest | $17 Average price | $49 Average price (fuel + tolls) |
3h 40m Average total duration 3h 10m Onboard + 30m Additional time* | 2h 43m Average total duration Fastest 2h 13m Onboard + 30m Additional time* | 2h 12m Average total duration (door-to-door) |
0.0 - 0.1kg CO2 emissions Lowest | 0.1 - 0.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Isernia:
A train is $0.10 (€0.08) less than a bus for this route with tickets for a bus from Rome to Isernia costing on average $17 (€14).
Other travel options to Isernia take longer:
Train takes on average 3h 10m.
Travel optionsfrom Rome to Isernia
How to get from Rome to Isernia by train, bus or flight.
Our recommendation
The best way to travel from Rome to Isernia is by taking a bus because it’s the best combination of price and speed.
0584:30 PM2h30Roma, Autostazione Tiburtina7:00 PMIsernia, Piazza della Repubblica (F. Martino bus station)$61One-way0 transfers
Cheapest
0584:30 PM2h30Roma, Autostazione Tiburtina7:00 PMIsernia, Piazza della Repubblica (F. Martino bus station)$61One-way0 transfers
Fastest
Regionale 233692:35 PM2h05Rome Termini4:40 PMIsernia station$171One-way0 transfers
Other options
Regionale 233659:07 AM2h08Rome Termini11:15 AMIsernia station$171One-way0 transfers
Regionale 233636:15 AM2h12Rome Termini8:27 AMIsernia station$171One-way0 transfers
Regionale 234255:38 PM2h14Rome Tiburtina7:52 PMIsernia station$171One-way0 transfers
BUS LP789+
Regionale 5816 · Regionale 2338411:19 PM7h43Rome Termini7:02 AMIsernia station$281One-way2 transfers
FlixBus2:50 PM2h25Roma, Autostazione Tiburtina5:15 PMIsernia, Piazza della Repubblica (F. Martino bus station)$411One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Rome to Isernia
Travel to Isernia easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Rome to Isernia.

This is compared to other travel options from Rome to Isernia:
A train is $0.10 (€0.08) less than a bus for this route with tickets for a bus from Rome to Isernia costing on average $17 (€14).
Other travel options to Isernia take longer:
Train takes on average 3h 10m.
- Around 10 trains per day.
- Around 10 buses per day.
However, we recommend checking specific travel dates for your route between Rome and Isernia as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Rome Termini and arrive in Isernia station.
- Buses mostly depart from Roma, Autostazione Tiburtina and arrive in Isernia, Piazza della Repubblica (F. Martino bus station).
- Travel with Regionale, Intercity to go to Isernia by train.
- Travel with FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A. to go to Isernia by bus.
- 2 direct trains per day with Regionale.
- 6 direct buses per day with FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A..
Travelling from Rome to Isernia: related information
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