Travel Information
Compare bus and train for Rome to Isernia
Omio recommends booking the train as it is the most popular option from Rome to Isernia among Omio's users. If you are prioritising price take the train with prices starting from €13. For those with little time consider booking a bus which can get you there in 2h 14m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.0 - 0.1kg. The ticket price range depends on the travel mode: a train costs an average of €13, and a bus costs an average of €11.
Distance: 92 miles (149 km)
Compare train with
Most popular Train | Bus |
|---|---|
€19 Average price Cheapest | €19 Average price |
3h 59m Average total duration 3h 29m Onboard + 30m Additional time* | 2h 44m Average total duration Fastest 2h 14m Onboard + 30m Additional time* |
0.0 - 0.1kg CO2 emissions Lowest | 0.1 - 0.4kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Rome to Isernia
How to get from Rome to Isernia by train, bus or flight.
Our recommendation
The best way to travel from Rome to Isernia is by taking a bus because it’s the best combination of price and speed.
treno 23365 effettuato con bus CB704Cheapest
FlixBusFastest
FlixBusOther options
Regionale 5893 · Regionale 5196
Intercity 551+
Regionale 5190
FRECCIAROSSA 1000 8317+
Regionale 5196
treno 23367 effettuato con bus CB706
treno 23369 effettuato con bus CB708
treno 23425 effettuato con bus CB714Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Rome to Isernia
Travel to Isernia easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Rome to Isernia.

This is compared to other travel options from Rome to Isernia:
A bus is $3 (€2) less than a train for this route with tickets for a train from Rome to Isernia costing on average $16 (€13).
Other travel options to Isernia take longer:
Train takes on average 2h 16m.
- Around 10 trains per day.
- Around 7 buses per day.
However, we recommend checking specific travel dates for your route between Rome and Isernia as scheduled services by bus and train can vary by season or day of the week.
- Trains mostly depart from Rome Termini and arrive in Isernia station.
- Buses mostly depart from Roma, Autostazione Tiburtina and arrive in Isernia, Piazza della Repubblica (F. Martino bus station).
- Travel with FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A. to go to Isernia by bus.
- Travel with Regionale, Intercity, Intercity Notte to go to Isernia by train.
- 6 direct buses per day with FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A..
- 3 direct trains per day with Regionale.
Travelling from Rome to Isernia: related information
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