Travel Information
Compare train and bus for Rome to Isernia
Omio recommends booking the train as it is the most popular option from Rome to Isernia among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $21 For those with little time, consider booking a bus, which has an average total journey time of 3h 8m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.0 - 0.1kg. Average ticket prices depend on the travel mode: a bus costs an average of $21, while a train costs an average of $33.
Distance: 92 miles (149 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
$33 Average price | $21 Average price Cheapest | $49 Average price (fuel + tolls) |
3h 18m Average total duration 2h 48m Onboard + 30m Additional time* | 3h 8m Average total duration Fastest 2h 38m Onboard + 30m Additional time* | 2h 12m Average total duration (door-to-door) |
0.0 - 0.1kg CO2 emissions Lowest | 0.1 - 0.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Isernia:
A bus is $12 less than a train for this route with tickets for a train from Rome to Isernia costing on average $33.
Other travel options to Isernia take longer:
Train takes on average 3h 18m.
Tickets start at around $33 compared to roughly $49 in fuel and tolls — a saving of about $16. The journey takes 2h 48m versus 2h 12m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom Rome to Isernia
How to get from Rome to Isernia by train, bus or flight.
Our recommendation
The best way to travel from Rome to Isernia is by taking a bus because it’s the best combination of price and speed.
0584:30 PM2h30Roma, Autostazione Tiburtina7:00 PMIsernia, Piazza della Repubblica (F. Martino bus station)$111One-way0 transfers
Cheapest
0584:30 PM2h30Roma, Autostazione Tiburtina7:00 PMIsernia, Piazza della Repubblica (F. Martino bus station)$111One-way0 transfers
Fastest
Regionale 233692:35 PM2h05Rome Termini4:40 PMIsernia station$171One-way0 transfers
Other options
Regionale 233659:07 AM2h08Rome Termini11:15 AMIsernia station$171One-way0 transfers
Regionale 233636:15 AM2h12Rome Termini8:27 AMIsernia station$171One-way0 transfers
Regionale 234255:38 PM2h14Rome Tiburtina7:52 PMIsernia station$171One-way0 transfers
FlixBus2:50 PM2h25Roma, Autostazione Tiburtina5:15 PMIsernia, Piazza della Repubblica (F. Martino bus station)$181One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Rome to Isernia
Travel to Isernia easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Rome to Isernia.

This is compared to other travel options from Rome to Isernia:
A bus is $12 less than a train for this route with tickets for a train from Rome to Isernia costing on average $33.
Other travel options to Isernia take longer:
Train takes on average 3h 18m.
- Around 10 trains per day.
- Around 2 buses per day.
However, we recommend checking specific travel dates for your route between Rome and Isernia as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Rome Termini and arrive in Isernia station.
- Buses mostly depart from Roma, Autostazione Tiburtina and arrive in Isernia, Piazza della Repubblica (F. Martino bus station).
- Travel with Marino Autolinee, FlixBus to go to Isernia by bus.
- Travel with Frecciarossa, Intercity, Regionale, Intercity Notte to go to Isernia by train.
- 1 direct buses per day with Marino Autolinee, FlixBus.
- 5 direct trains per day with Regionale.
Travelling from Rome to Isernia: related information
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