Travel Information
Compare train and bus for Rome to Isernia
Omio recommends booking the train as it is the most popular option from Rome to Isernia among Omio's users. If you are prioritising price take the train with prices starting from $17. For those with little time consider booking a bus which can get you there in 2h 13m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.0 - 0.1kg. The ticket price range depends on the travel mode: a train costs an average of $17, and a bus costs an average of $10.
Distance: 92 miles (149 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
$17 Average price Cheapest | $17 Average price | $50 Average price (fuel + tolls) |
3h 40m Average total duration 3h 10m Onboard + 30m Additional time* | 2h 43m Average total duration Fastest 2h 13m Onboard + 30m Additional time* | 2h 12m Average total duration (door-to-door) |
0.0 - 0.1kg CO2 emissions Lowest | 0.1 - 0.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Isernia:
A train is $0.10 (€0.08) less than a bus for this route with tickets for a bus from Rome to Isernia costing on average $17 (€14).
Other travel options to Isernia take longer:
Train takes on average 3h 10m.
Travel optionsfrom Rome to Isernia
How to get from Rome to Isernia by train, bus or flight.
Our recommendation
The best way to travel from Rome to Isernia is by taking a bus because it’s the best combination of price and speed.
treno 23365 effettuato con bus CB7049:07 AM2h18Rome Termini11:25 AMIsernia station$171One-way0 transfers
Cheapest
treno 23365 effettuato con bus CB7049:07 AM2h18Rome Termini11:25 AMIsernia station$171One-way0 transfers
Fastest
treno 23365 effettuato con bus CB7049:07 AM2h18Rome Termini11:25 AMIsernia station$171One-way0 transfers
Other options
Regionale 21063 · Regionale 519210:36 AM5h17Rome Termini3:53 PMIsernia station$281One-way1 transfer
Intercity 727+
Regionale 519211:26 AM4h27Rome Termini3:53 PMIsernia station$451One-way1 transfer
Intercity 551+
Regionale 51749:26 AM4h38Rome Termini2:04 PMIsernia station$461One-way1 transfer
treno 23369 effettuato con bus CB7082:35 PM2h20Rome Termini4:55 PMIsernia station$171One-way0 transfers
treno 23363 effettuato con bus CB7026:15 AM2h20Rome Termini8:35 AMIsernia station$171One-way0 transfers
treno 23379 effettuato con bus CB7128:15 PM2h20Rome Termini10:35 PMIsernia station$171One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Rome to Isernia
Travel to Isernia easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Rome to Isernia.

This is compared to other travel options from Rome to Isernia:
A train is $0.10 (€0.08) less than a bus for this route with tickets for a bus from Rome to Isernia costing on average $17 (€14).
Other travel options to Isernia take longer:
Train takes on average 3h 10m.
- Around 10 trains per day.
- Around 10 buses per day.
However, we recommend checking specific travel dates for your route between Rome and Isernia as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Rome Termini and arrive in Isernia station.
- Buses mostly depart from Roma, Autostazione Tiburtina and arrive in Isernia, Piazza della Repubblica (F. Martino bus station).
- Travel with FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A. to go to Isernia by bus.
- Travel with Regionale, Intercity to go to Isernia by train.
- 6 direct buses per day with FlixBus, BlaBlaCar, ATM Azienda di Trasporti Molisana S.p.A..
- 2 direct trains per day with Regionale.
Travelling from Rome to Isernia: related information
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