- Must visit
Museo Nazionale del Paleolitico di Isernia
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Cheapest price on Sep 18
$14
Average ticket price on Sep 18
$14
Fastest journey on Sep 18
3 h 23 m
Average journey duration on Sep 18
3 h 23 m
Buses on Sep 18
2
Distance
76 km
The best way to find a cheap bus ticket from Termoli to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Termoli to Isernia will cost around $14 if you buy it on the day, but the cheapest tickets can be found for only $14.
On Fri, Sep 18, we found 2 buses from Termoli to Isernia, including 2 direct services.
On Fri, Sep 18 the direct buses cover the 76 km distance in an average of 3 h 23 m but if you time it right, some buses will get you there in just 3 h 23 m .
On Fri, Sep 18 the slowest buses will take 3 h 23 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the bus as it is the most popular option from Termoli to Isernia among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $26 For those with little time, consider booking a bus, which has an average total journey time of 3h 17m. Average ticket prices depend on the travel mode: a bus costs an average of $26, while a train costs an average of $48.
Distance: 47 miles (76 km)
Most popular Bus | Train | Driving |
|---|---|---|
$26 Average price Cheapest | $48 Average price | $24 Average price (fuel + tolls) |
3h 17m Average total duration Fastest 2h 47m Onboard + 30m Additional time* | 5h 13m Average total duration 4h 43m Onboard + 30m Additional time* | 1h 28m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Termoli to Isernia:
A bus is $22 less than a train for this route with tickets for a train from Termoli to Isernia costing on average $48.
Other travel options to Isernia take longer:
Train takes on average 4h 43m.
Tickets start at around $26 compared to roughly $24 in fuel and tolls — a saving of about $-2.64. The journey takes 2h 47m versus 1h 28m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 04:55AM | Arrival Time 11:34AM | Duration 6h39 | Departure days Wed | Cheapest price $19 |
Operator Marino Autolinee | Departure Time 06:15AM | Arrival Time 08:25AM | Duration 2h10 | Departure days Wed | Cheapest price $15 |
Operator Regionale | Departure Time 12:10PM | Arrival Time 03:26PM | Duration 3h16 | Departure days Sun | Cheapest price $12 |
Operator Regionale | Departure Time 02:10PM | Arrival Time 05:59PM | Duration 3h49 | Departure days Wed | Cheapest price $14 |
Operator Regionale | Departure Time 03:50PM | Arrival Time 07:13PM | Duration 3h23 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $14 |
Operator Regionale | Departure Time 04:50PM | Arrival Time 08:13PM | Duration 3h23 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $14 |
Operator Regionale | Departure Time 05:50PM | Arrival Time 08:40PM | Duration 2h50 | Departure days Wed | Cheapest price $14 |
The table below shows live departures for Termoli to Isernia buses for tomorrow, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:50 PM Termoli | 3h23 | 7:13 PM Isernia | 0 transfersDirect | |
![]() | 4:50 PM Termoli | 3h23 | 8:13 PM Isernia | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Termoli to Isernia run on average 2 times per day, taking around 2h 47m. Cheap bus tickets for this journey start at $15 if you book in advance.
There are 1 buses per day. The earliest bus runs at 07:10, the last at 17:50. The fastest bus covers the 47 miles (76 km) distance in 2h 10m.
Distance 47 miles (76 km) |
Average bus duration 2h 47m |
Cheapest ticket price $15 |
Buses per day 2 |
Direct buses 1 |
Fastest bus 2h 10m |
First bus 7:10 AM |
Last bus 5:50 PM |
Cheapest Month Mar |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Apr - Jun |
Busiest Day Mon |
Least Busy Day Mon |
Best time to book 1 day |
Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.
Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.
Main historic street lined with palaces, churches, and shops. The best walk for absorbing Isernia's old-town atmosphere.
The historic center preserves medieval lanes, arches, and layered architecture. Ideal for slow exploration and local street photography.
Central square near the cathedral and Fontana Fraterna. A practical starting point for discovering the city's key monuments.
Fresh pasta sheets layered with rich pork ragù, mozzarella, and caciocavallo. A Sunday and feast-day classic in Molise with deep family tradition.
Small handmade cavatelli pasta, often served with tomato sauce, pork, or seasonal vegetables. It is one of Molise’s best-known home-style staples.
Rustic soup of field greens, potatoes, beans, and cornbread or stale bread. A traditional peasant dish from the Isernia area, especially in colder months.
Established restaurant known for Molisan cooking, handmade pasta, and local meats in a refined but welcoming setting.
Well-regarded traditional venue serving regional specialties, grilled meats, and classic local dishes in a rustic atmosphere.
Casual, popular spot for pizza and southern Italian dishes, suited to an easy meal with locals and families.
Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.
Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.
Find answers to the most common questions about traveling from Termoli to Isernia by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

Most Termoli to Isernia buses use the Termoli, Terminal Bus to Isernia, Piazza della Repubblica (Autostazione F. Martino) station pair. Use this guide to compare Termoli and Isernia bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Isernia, Piazza della Repubblica (Autostazione F. Martino) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Nearby cafés and fast food outlets.
Wi-Fi is available at Isernia, Piazza della Repubblica (Autostazione F. Martino). ATMs are aTM located near the entrance.
Ticket office support is available at Isernia, Piazza della Repubblica (Autostazione F. Martino).
Available at Isernia, Piazza della Repubblica (Autostazione F. Martino): Parking, Taxis, WC.
Accessibility facilities are available at Isernia, Piazza della Repubblica (Autostazione F. Martino): Wheelchair accessible facility.
Here are some other resources that might have the information you need