- Must visit
Museo Nazionale del Paleolitico di Isernia
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Cheapest price
€6
Average price
€6
Fastest journey
1 h 55 m
Average duration
2 h
Buses per day
3
Distance
36 km
The best way to find a cheap bus ticket from Cassino to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Cassino to Isernia will cost around €6 if you buy it on the day, but the cheapest tickets can be found for only €6.
Of the 3 buses that leave Cassino for Isernia on Tue, Aug 04, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Aug 04 the direct buses cover the 36 km distance in an average of 2 h but if you time it right, some buses will get you there in just 1 h 55 m .
On Tue, Aug 04 the slowest buses will take 2 h 11 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Buses from Cassino to Isernia run on average 7 times per day, taking around 46m. Cheap bus tickets for this journey start at €6 if you book in advance.
There are 5 buses per day. The earliest bus runs at 04:50, the last at 22:00. The fastest bus covers the 22 miles (36 km) distance in 1h 0m.
Distance 22 miles (36 km) |
Average bus duration 46m |
Cheapest ticket price €6 |
Buses per day 7 |
Direct buses 5 |
Fastest bus 1h 0m |
First bus 4:50 AM |
Last bus 10:00 PM |
Cheapest Month May |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Tue |
Least Busy Day Wed |
Best time to book 21 days |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Regionale | Departure Time 03:50AM | Arrival Time 05:45AM | Duration 1h55 | Departure days Mon, Tue, Thu, Fri, Sat | Cheapest price €6 |
Operator Regionale | Departure Time 04:34AM | Arrival Time 06:45AM | Duration 2h11 | Departure days Tue, Wed, Thu, Fri | Cheapest price €6 |
Operator Regionale | Departure Time 04:50AM | Arrival Time 06:45AM | Duration 1h55 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price €6 |
Operator Regionale | Departure Time 05:55PM | Arrival Time 06:55PM | Duration 1h00 | Departure days Mon, Wed, Fri | Cheapest price €6 |
Operator Regionale | Departure Time 06:55PM | Arrival Time 07:55PM | Duration 1h00 | Departure days Mon, Wed, Thu, Sat | Cheapest price €6 |
The table below shows live departures for Cassino to Isernia buses for today, Monday, August 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:55 PM Cassino | 1h00 | 6:55 PM Isernia | 0 transfersDirect | |
![]() | 6:55 PM Cassino | 1h00 | 7:55 PM Isernia | 0 transfersDirect | |
| Tuesday, August 4 | |||||
![]() | 3:50 AM Cassino | 1h55 | 5:45 AM Isernia | 0 transfersDirect | |
![]() | 4:34 AM Cassino | 2h11 | 6:45 AM Isernia | 0 transfersDirect | |
![]() | 4:50 AM Cassino | 1h55 | 6:45 AM Isernia | 0 transfersDirect | |
Find all the dates and times for this journey
Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.
Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.
Main historic street lined with palaces, churches, and shops. The best walk for absorbing Isernia's old-town atmosphere.
The historic center preserves medieval lanes, arches, and layered architecture. Ideal for slow exploration and local street photography.
Central square near the cathedral and Fontana Fraterna. A practical starting point for discovering the city's key monuments.
Fresh pasta sheets layered with rich pork ragù, mozzarella, and caciocavallo. A Sunday and feast-day classic in Molise with deep family tradition.
Small handmade cavatelli pasta, often served with tomato sauce, pork, or seasonal vegetables. It is one of Molise’s best-known home-style staples.
Rustic soup of field greens, potatoes, beans, and cornbread or stale bread. A traditional peasant dish from the Isernia area, especially in colder months.
Established restaurant known for Molisan cooking, handmade pasta, and local meats in a refined but welcoming setting.
Well-regarded traditional venue serving regional specialties, grilled meats, and classic local dishes in a rustic atmosphere.
Casual, popular spot for pizza and southern Italian dishes, suited to an easy meal with locals and families.
Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.
Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.
Find answers to the most common questions about traveling from Cassino to Isernia by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

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