- Must visit
Museo Nazionale del Paleolitico di Isernia
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Cheapest price on Sep 18
kr47
Average ticket price on Sep 18
kr47
Fastest journey on Sep 18
1 h
Average journey duration on Sep 18
1 h 32 m
Buses on Sep 18
2
Distance
36 km
The best way to find a cheap bus ticket from Cassino to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Cassino to Isernia will cost around kr47 if you buy it on the day, but the cheapest tickets can be found for only kr47.
On Fri, Sep 18, we found 2 buses from Cassino to Isernia, including 1 direct services.
On Fri, Sep 18 the direct buses cover the 36 km distance in an average of 1 h 32 m but if you time it right, some buses will get you there in just 1 h .
On Fri, Sep 18 the slowest buses will take 2 h 3 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
Regionale 5805 · Autobus CB106
Autobus RM114
Autobus RM114
Regionale 5805 · Autobus CB106Omio recommends booking the train as it is the most popular option from Cassino to Isernia among Omio's users. If you are prioritising price, take the train, with an average ticket price of kr45 For those with little time, consider booking a train, which has an average total journey time of 1h 24m. Average ticket prices depend on the travel mode: a train costs an average of kr45, while a train costs an average of kr45.
Distance: 22 miles (36 km)
| Bus | Most popular Train | Driving |
|---|---|---|
kr45 Average price Cheapest | kr66 Average price (fuel + tolls) | |
1h 24m Average total duration Fastest 54m Onboard + 30m Additional time* | 55m Average total duration (door-to-door) | |
Direct Options | Direct Options | Direct Options |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Regionale | Departure Time 03:50AM | Arrival Time 05:45AM | Duration 1h55 | Departure days Mon, Thu, Sat | Cheapest price kr45 |
Operator Regionale | Departure Time 04:34AM | Arrival Time 06:45AM | Duration 2h11 | Departure days Wed, Thu | Cheapest price kr45 |
Operator Regionale | Departure Time 04:50AM | Arrival Time 06:45AM | Duration 1h55 | Departure days Mon, Wed, Thu, Sat | Cheapest price kr45 |
Operator Regionale | Departure Time 05:42AM | Arrival Time 07:45AM | Duration 2h03 | Departure days Fri | Cheapest price kr47 |
Operator BlaBlaCar | Departure Time 07:30AM | Arrival Time 09:10AM | Duration 1h40 | Departure days Tue | Cheapest price kr129 |
Operator BlaBlaCar | Departure Time 05:00PM | Arrival Time 05:10PM | Duration 0h10 | Departure days Tue | Cheapest price kr24 |
Operator Regionale | Departure Time 05:55PM | Arrival Time 06:55PM | Duration 1h00 | Departure days Mon, Wed | Cheapest price kr45 |
Operator Regionale | Departure Time 06:55PM | Arrival Time 07:55PM | Duration 1h00 | Departure days Mon, Wed, Thu, Sat | Cheapest price kr45 |
Operator Regionale | Departure Time 07:55PM | Arrival Time 08:55PM | Duration 1h00 | Departure days Fri | Cheapest price kr47 |
Operator BlaBlaCar | Departure Time 08:30PM | Arrival Time 08:40PM | Duration 0h10 | Departure days Tue | Cheapest price kr24 |
The table below shows live departures for Cassino to Isernia buses for today, Thursday, September 17. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:55 PM Cassino | 1h00 | 7:55 PM Isernia | 0 transfersDirect | |
| Friday, September 18 | |||||
Regionale 5805 · Autobus CB106 | 5:42 AM Cassino station | 2h03 | 7:45 AM Isernia station | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a bus from Cassino to Isernia and enjoy the approximately 22 miles (36 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 04:50, the last at 22:00.
Distance 22 miles (36 km) |
First bus 4:50 AM |
Last bus 10:00 PM |
Cheapest Month Sep |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Sun |
Best time to book 7 days |
Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.
Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.
Main historic street lined with palaces, churches, and shops. The best walk for absorbing Isernia's old-town atmosphere.
The historic center preserves medieval lanes, arches, and layered architecture. Ideal for slow exploration and local street photography.
Central square near the cathedral and Fontana Fraterna. A practical starting point for discovering the city's key monuments.
Fresh pasta sheets layered with rich pork ragù, mozzarella, and caciocavallo. A Sunday and feast-day classic in Molise with deep family tradition.
Small handmade cavatelli pasta, often served with tomato sauce, pork, or seasonal vegetables. It is one of Molise’s best-known home-style staples.
Rustic soup of field greens, potatoes, beans, and cornbread or stale bread. A traditional peasant dish from the Isernia area, especially in colder months.
Established restaurant known for Molisan cooking, handmade pasta, and local meats in a refined but welcoming setting.
Well-regarded traditional venue serving regional specialties, grilled meats, and classic local dishes in a rustic atmosphere.
Casual, popular spot for pizza and southern Italian dishes, suited to an easy meal with locals and families.
Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.
Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.
Find answers to the most common questions about traveling from Cassino to Isernia by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

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