- Must visit
Royal Museums of Fine Arts of Belgium
Premier fine arts complex with Old Masters, Magritte, and modern collections, essential for understanding Belgian and European art.
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The cheapest and fastest buses from Palermo to Brussels
Showing times, prices and bookable tickets for Sep 17
Cheapest price on Sep 17
$324
Average ticket price on Sep 17
$324
Fastest journey on Sep 17
1 d 18 h 35 m
Average journey duration on Sep 17
1 d 18 h 35 m
Buses on Sep 17
1
Distance
1583 km
Cheap tickets
The best way to find a cheap bus ticket from Palermo to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Palermo to Brussels will cost around $324 if you buy it on the day, but the cheapest tickets can be found for only $324.
Fast buses
It's difficult to get from Palermo to Brussels without transferring at least 3 times.
FlixBus · FlixBus · FlixBus · FlixBus9:10 PM42h35Palermo, Via Tommaso Fazello (Terminal Bus)3:45 PMBrussels, Brussels South (Gare du Midi)$3241One-way3 transfers
- FlixBus · FlixBus · FlixBus · FlixBus9:10 PM42h35Palermo, Via Tommaso Fazello (Terminal Bus)3:45 PMBrussels, Brussels South (Gare du Midi)$3241One-way3 transfers
Travel Information
Compare bus and flight for Palermo to Brussels
Omio recommends booking the flight as it is the most popular option from Palermo to Brussels among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $271 For those with little time, consider booking a flight, which has an average total journey time of 5h 50m. Average ticket prices depend on the travel mode: a bus costs an average of $271, while a flight costs an average of $436.
Distance: 983 miles (1583 km)
Compare bus with
| Bus | Most popular Flight | Driving |
|---|---|---|
$271 Average price Cheapest | $436 Average price | $383 Average price (fuel + tolls) |
39h 53m Average total duration 39h 23m Onboard + 30m Additional time* | 5h 50m Average total duration Fastest 3h 50m Onboard + 2h 0m Additional time* | 26h 4m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Palermo to Brussels is a bus with an average price of $271 (€220).
This is compared to other travel options from Palermo to Brussels:
A bus is $166 (€135) less than a flight for this route with tickets for a flight from Palermo to Brussels costing on average $436 (€355).
The fastest way to travel from Palermo to Brussels is by flight with an average journey time of 3h 50m.
Other travel options to Brussels take longer:
Bus takes on average 39h 23m.
It's helpful to compare your options as there are 2 ways to travel between Palermo and Brussels including taking a bus and flight.
We recommend using the flight as it is the most popular way to get from Palermo to Brussels among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $271 (€220) compared to roughly $383 (€311) in fuel and tolls — a saving of about $112 (€91). The journey takes 39h 23m versus 26h 4m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Palermo to Brussels Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:25PM | Arrival Time 12:45PM | Duration 45h20 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $127 |
Operator FlixBus | Departure Time 09:10PM | Arrival Time 05:55PM | Duration 44h45 | Departure days Everyday | Cheapest price $128 |
Live departures
Palermo to Brussels bus times
The table below shows live departures for Palermo to Brussels buses for today, Wednesday, September 16. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus · FlixBus · FlixBus · FlixBus | 9:10 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 44h45 | 5:55 PM Brussels, Brussels South (Gare du Midi) | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Palermo to Brussels by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Sep 17
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Why should you book Palermo to Brussels buses with Omio?
FlixBus as well as Autoservizi Salemi Srl offer buses services from Palermo to Brussels.
Omio is an official ticket reseller for all your travel options from Palermo to Brussels.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Autoservizi Salemi Srl to find the best option for your trip from Palermo to Brussels.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Palermo to Brussels.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Palermo to Brussels.
Journey information
Overview: Bus from Palermo to Brussels
Italy
Belgium
Buses from Palermo to Brussels run on average 2 times per day, taking around 39h 23m. Cheap bus tickets for this journey start at $127 (€103) but you can travel from only $37 (€30) by flight.
The earliest bus runs at 09:10, the last at 22:00. The fastest bus covers the 983 miles (1583 km) distance in 37h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $37 (€30)
Distance 983 miles (1583 km) |
Average bus duration 39h 23m |
Cheapest ticket price $127 (€103) |
Buses per day 2 |
Fastest bus 37h 10m |
First bus 9:10 AM |
Last bus 10:00 PM |
Cheapest Month Dec |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Tue |
Best time to book 2 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $37 (€30)
Bus providers: FlixBus from Palermo to BrusselsYou can travel by bus between Palermo to Brussels with FlixBus for as low as $37 (€30). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
37h 10m
Cheapest FlixBus Price
$127 (€103)
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Brussels
Things to do in Brussels
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
- Must visit
Magritte Museum
Dedicated to surrealist René Magritte, this popular museum presents major works and context for one of Belgium’s most celebrated artists.
- Must visit
Comics Art Museum
Leading comic art museum in a Horta-designed building, highlighting Tintin, the Smurfs, and Belgium’s influential comics culture.
- Must visit
Grand Place
Grand square at Brussels’ heart, lined with ornate guildhalls and lively events, perfect for first-time visitors and evening atmosphere.
- Must visit
Parc du Cinquantenaire
Large urban park with the triumphal arch, museums, and wide lawns, excellent for walking, picnics, and classic city photographs.
- Must visit
Mont des Arts
Popular hilltop viewpoint and garden terrace with one of the best panoramas over central Brussels, especially at sunset.
Moules-Frites
Mussels steamed with white wine, celery and onion, often served with fries. A Brussels brasserie classic, especially popular in mussel season.
- Vegetarian
- Gluten-free
Frites
Double-fried potato fries, traditionally served in paper cones with sauces. They are a point of national pride and central to everyday Belgian street food.
Carbonnade Flamande
A rich beef and onion stew braised with Belgian dark beer. It is a beloved comfort dish found in traditional Brussels restaurants.
Bozar Restaurant
Two-Michelin-star restaurant by chef Karen Torosyan, celebrated for pâté en croûte and inventive fine dining in an intimate setting.
Brasserie La Paix
Elegant Belle Époque brasserie serving refined Belgian classics, seafood and game in a grand old-world dining room.
Maison Dandoy
Famous casual stop for Brussels waffles with many toppings. Popular, fast-moving and central for a classic sweet local treat.
Euro (€)
Moderate for Western Europe: hotels can be pricey, but dining and transit are manageable for most tourists.
Average meal costs
- Budget
- €8-15 for fast food or casual takeaway.
- Mid-range
- €20-35 per person for a standard restaurant meal.
- Fine dining
- €70+ per person for upscale restaurants.
- Coffee
- €3-5 for cappuccino or latte.
Tipping culture
Service is usually included. Round up or leave 5-10% for great restaurant service; round up taxi fares; small change is fine in cafes.
STIB-MIVB
Get the appOfficial public transport app
Prices
- Single ticket
- €2.50
- Day pass
- €8.40
To the city center
Brussels South (Gare du Midi) -> Brussels Central Station, Brussels
- Distance
- 2 km
- Travel time
- 5 min
- Contactless bank card payment is available on STIB-MIVB trams, buses, and metro gates. Buy the cheapest fare for occasional travel this way.
- Brussels South is also called Gare du Midi or Zuidstation. Validate paper tickets before boarding or at metro gates.
FAQs: Bus from Palermo to Brussels
Find answers to the most common questions about traveling from Palermo to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Palermo to Brussels can start from as little as $127 (€103) when you book in advance. The average bus ticket price for Palermo to Brussels is $271 (€220) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Palermo to Brussels is 37h 10m to travel the 983 miles (1583 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Palermo to Brussels leaves at 9:10 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Palermo to Brussels leaves at 10:00 PM.
There are 2 buses a day from Palermo to Brussels which require at least one change with FlixBus, Autoservizi Salemi Srl. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Palermo to Brussels, you can count on FlixBus, Autoservizi Salemi Srl for the best way to get you to Brussels. You can also check all possible bus companies who offer a service between Palermo and Brussels and compare the amenities they offer before buying a bus ticket.
When departing from Palermo , you have various bus station options to start your journey from including Palermo, Via Tommaso Fazello (Terminal Bus) . When arriving in Brussels , you can end your journey in bus stations like Brussels, Brussels South (Gare du Midi), Brussels, Gare Du Midi, Brussels, Avenue des Magnolias (King Baudouin), Schaerbeek, Bd Roi Albert II (Bruxelles Gare Du Nord) .Passengers board the bus most frequently from Palermo, Via Tommaso Fazello (Terminal Bus), which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Brussels, Brussels South (Gare du Midi), located 2 away from the city centre.
A trip to Brussels from Palermo is worth doing but not as a day trip with a journey time of 37h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Palermo to Brussels is December.
It's helpful to compare your options as there are 2 ways to travel between Palermo and Brussels including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Palermo to Brussels:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Palermo to Brussels for bus company FlixBus.
Some of the most interesting sights to explore in Brussels are:
- Grand Place, a UNESCO World Heritage site known for its opulent guildhalls and vibrant flower market
- Atomium, an iconic structure and museum offering panoramic views of the city
- Manneken Pis, a famous bronze statue symbolizing the irreverent spirit of Brussels
- Royal Palace of Brussels, the official palace of the Belgian king with impressive architecture and gardens
- Magritte Museum, dedicated to the works of surrealist artist René Magritte, featuring an extensive collection of his paintings and drawings.
The best things to do in Brussels include:
- Explore the vibrant Marolles district, known for its eclectic mix of antique shops and street art
- Enjoy a leisurely stroll through the picturesque Parc du Cinquantenaire, home to impressive arches and museums
- Sample Belgian chocolates at one of the city's renowned chocolatiers
- Discover the lively atmosphere of the Saint-Géry district, filled with trendy bars and cafes
- Attend a performance at the historic La Monnaie opera house, showcasing world-class productions.
Whether you can cancel your bus ticket from Palermo to Brussels depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Palermo to Brussels.
Yes, the following luggage options are included when booking a bus ticket from Palermo to Brussels:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Palermo to Brussels:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Palermo to Brussels. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Palermo to Brussels with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Palermo to Brussels with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Palermo to Brussels with the following bus company: FlixBus.
Since both Palermo and Brussels are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the flight as it is the most popular way to get from Palermo to Brussels among Omio's users.
Belgium uses the euro (EUR) as its currency. Travelers generally find card payments widely accepted in cities, restaurants, and shops, though carrying some cash is advisable for small purchases or in rural areas.
In Brussels, travelers should be cautious of pickpocketing, especially in crowded areas like Grand Place, public transport, and popular tourist sites. Common scams include distraction techniques and fake petitions. It's advisable to stay vigilant, avoid displaying expensive items, and use official taxi services to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Palermo to Brussels
Most Palermo to Brussels buses use the Palermo, Via Tommaso Fazello (Terminal Bus) to Brussels, Brussels South (Gare du Midi) station pair, with some services arriving at Brussel, Avenue des Magnolias (Koning Boudewijn). Use this guide to compare Palermo and Brussels bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Palermo
Arrival bus stations in Brussels
Which Brussels station do buses from Palermo arrive at?
Buses from Palermo to Brussels most often arrive at Brussels, Brussels South (Gare du Midi). Some services arrive at Brussels, Gare Du Midi, so check your ticket before travel to confirm your Brussels arrival station.
Brussels, Brussels South (Gare du Midi)Avenue Fonsny 47, 1060 Brussels, Belgium
City-centre transport
Getting to Brussels, Brussels South (Gare du Midi) from Brussels city centre
Brussels, Brussels South (Gare du Midi) is 2 km from Brussels city centre. Public transport options include:
TrainEuroCity · 4m · $1 · every ~2 min
Ice · 14m · $1
Bus48 · 16m · $4 · every ~9 min
Bus · 20m
FlixBus N1153 · 29m · $1
Subway2, 6 · 18m · $4 · every ~38 min
Brussels, Brussels South (Gare du Midi) bus station facilities and services
Brussels, Brussels South (Gare du Midi) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food and drink
Food options include: Cafeteria Midi (in the station), Belgian Bites (in the station), Fritland Express (0.5 km).
Wi-Fi and ATMs
Free Wi-Fi. ATMs are located near the main entrance and throughout the station.
Tickets and information
Ticket office support is available at Brussels, Brussels South (Gare du Midi).
Parking, taxis and toilets
Available at Brussels, Brussels South (Gare du Midi): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Brussels, Brussels South (Gare du Midi): Elevators, ramps.
Brussel, Avenue des Magnolias (Koning Boudewijn)Roi Baudouin, 1020 Bruxelles, Belgium
City-centre transport
Getting to Brussel, Avenue des Magnolias (Koning Boudewijn) from Brussels city centre
Brussel, Avenue des Magnolias (Koning Boudewijn) is 5 km from Brussels city centre. Public transport options include:
Bus811 · 22m · $1
N18 · 24m · $4
R40, R50, R41, R60 · 33m · $4 · every ~18 min
Tram93 · 40m · $4 · every ~14 min
Subway6 · 13m · $4 · every ~20 min
6 · 22m · $6 · every ~18 min
6 · 31m · $4 · every ~18 min
Brussel, Avenue des Magnolias (Koning Boudewijn) bus station facilities and services
Brussel, Avenue des Magnolias (Koning Boudewijn) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Brussel, Avenue des Magnolias (Koning Boudewijn). ATMs are available at Brussel, Avenue des Magnolias (Koning Boudewijn).
Tickets and information
Ticket office support is available at Brussel, Avenue des Magnolias (Koning Boudewijn).
Parking, taxis and toilets
Available at Brussel, Avenue des Magnolias (Koning Boudewijn): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Brussel, Avenue des Magnolias (Koning Boudewijn): Accessible for people with reduced mobility.
Brussels, Gare Du MidiBrussel-Zuid, Av. Fonsny 47B, 1060 Bruxelles, Belgium
City-centre transport
Getting to Brussels, Gare Du Midi from Brussels city centre
Brussels, Gare Du Midi is 1 km from Brussels city centre. Public transport options include:
TrainEuroCity · 4m · $1 · every ~2 min
Ice · 14m · $1
Bus48 · 16m · $4 · every ~9 min
Bus · 20m
FlixBus N1153 · 29m · $1
Subway2, 6 · 18m · $4 · every ~38 min
Brussels, Gare Du Midi bus station facilities and services
Brussels, Gare Du Midi has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Various dining options are nearby.
Wi-Fi and ATMs
Wi-Fi is available at Brussels, Gare Du Midi. ATMs are available at Brussels, Gare Du Midi.
Tickets and information
Ticket office support is available at Brussels, Gare Du Midi.
Parking, taxis and toilets
Available at Brussels, Gare Du Midi: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Brussels, Gare Du Midi: Station is accessible for individuals with disabilities.
Most popular bus connections from Palermo
More options for your journey from Palermo to Brussels
Here are some other resources that might have the information you need
Most popular buses to and from Brussels and Palermo
Most popular bus connections to Brussels
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