The cheapest and fastest buses from Palermo to Brussels
Cheapest price
$133
Average price
$231
Fastest journey
1 d 17 h 5 m
Average duration
1 d 23 h 3 m
Buses per day
2
Distance
1583 km
The best way to find a cheap bus ticket from Palermo to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Palermo to Brussels will cost around $231 if you buy it on the day, but the cheapest tickets can be found for only $133.
Of the 2 buses that leave Palermo for Brussels on Thu, Mar 19, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Mar 19 the direct buses cover the 1583 km distance in an average of 1 d 23 h 3 m but if you time it right, some buses will get you there in just 1 d 17 h 5 m .
On Thu, Mar 19 the slowest buses will take 2 d 5 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare bus and flight for Palermo to Brussels
Omio recommends booking the flight as it is the most popular option from Palermo to Brussels among Omio's users. If you are prioritising price take the flight with prices starting from $33. For those with little time consider booking a flight which can get you there in 3h 22m. The ticket price range depends on the travel mode: a flight costs an average of $33, and a bus costs an average of $133.
Distance: 983 miles (1583 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
$238 Average price | $118 Average price Cheapest |
38h 51m Average total duration 38h 21m Onboard + 30m Additional time* | 6h 22m Average total duration Fastest 3h 22m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options |
Palermo to Brussels Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:10PM | Arrival Time 03:50PM | Duration 46h40 | Departure days Mon | Cheapest price $205 |
Live departures
Palermo to Brussels bus times
The table below shows live departures for Palermo to Brussels buses for today, Wednesday, March 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:25 PM Palermo | 48h25 | 2:50 PM Brussels | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Palermo to Brussels by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 19
Mar 20
Mar 21
Mar 22
Mar 23
Mar 24
Mar 25
Why should you book Palermo to Brussels buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Palermo to Brussels.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Palermo to Brussels.
Journey information
Overview: Bus from Palermo to Brussels
Buses from Palermo to Brussels run on average 3 times per day, taking around 38h 21m. Cheap bus tickets for this journey start at $133 (€108) but you can travel from only $33 (€27) by flight.
The earliest bus runs at 09:10, the last at 22:00. The fastest bus covers the 983 miles (1583 km) distance in 39h 20m.
Distance 983 miles (1583 km) |
Average bus duration 38h 21m |
Cheapest ticket price $133 (€108) |
Buses per day 3 |
Fastest bus 39h 20m |
First bus 09:10 |
Last bus 22:00 |
Bus providers: FlixBus from Palermo to BrusselsYou can travel by bus between Palermo to Brussels with FlixBus for as low as $33 (€27). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Palermo to Brussels
Find answers to the most common questions about traveling from Palermo to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Grand Place, a UNESCO World Heritage site known for its opulent guildhalls and vibrant flower market
- Atomium, an iconic structure and museum offering panoramic views of the city
- Manneken Pis, a famous bronze statue symbolizing the irreverent spirit of Brussels
- Royal Palace of Brussels, the official palace of the Belgian king with impressive architecture and gardens
- Magritte Museum, dedicated to the works of surrealist artist René Magritte, featuring an extensive collection of his paintings and drawings.
- Explore the vibrant Marolles district, known for its eclectic mix of antique shops and street art
- Enjoy a leisurely stroll through the picturesque Parc du Cinquantenaire, home to impressive arches and museums
- Sample Belgian chocolates at one of the city's renowned chocolatiers
- Discover the lively atmosphere of the Saint-Géry district, filled with trendy bars and cafes
- Attend a performance at the historic La Monnaie opera house, showcasing world-class productions.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Palermo to Brussels
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Midi (in the station)
- Belgian Bites (in the station)
- Fritland Express (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 27, 49, 50, 78 Metro: 2, 6 Train: IC, S, Thalys, Eurostar
Most popular bus connections from Palermo
More options for your journey from Palermo to Brussels
Here are some other resources that might have the information you need

