- Must visit
Pinacoteca di Brera
One of Italy’s top art museums, featuring masterpieces by Mantegna, Bellini, Raphael, Caravaggio, and Piero della Francesca.
Cheapest price
€99
Average price
€123
Fastest journey
19 h 10 m
Average duration
21 h 49 m
Buses per day
4
Distance
887 km
The best way to find a cheap bus ticket from Palermo to Milan is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Palermo to Milan will cost around €123 if you buy it on the day, but the cheapest tickets can be found for only €99.
It's difficult to get from Palermo to Milan without transferring at least once.
S202 · S122
S202 · S122
FlixBus · FlixBus
FlixBus · FlixBus
S202 · S122
S202 · S122
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Palermo to Milan among Omio's users. If you are prioritising price take the flight with prices starting from €17. For those with little time consider booking a flight which can get you there in 1h 59m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.3 - 0.8kg. The ticket price range depends on the travel mode: a flight costs an average of €17, and a train costs an average of €67.
Distance: 551 miles (887 km)
| Bus | Most popular Flight | Train | Ferry | Driving |
|---|---|---|---|---|
€100 Average price | €65 Average price Cheapest | €124 Average price | €76 Average price | €106 Average price (fuel + tolls) |
19h 49m Average total duration 19h 19m Onboard + 30m Additional time* | 4h 59m Average total duration Fastest 1h 59m Onboard + 3h 0m Additional time* | 15h 46m Average total duration 15h 16m Onboard + 30m Additional time* | 21h 2m Average total duration 20h 2m Onboard + 1h 0m Additional time* | 25h 7m Average total duration (door-to-door) |
0.9 - 2.2kg CO2 emissions | - CO2 emissions | 0.3 - 0.8kg CO2 emissions Lowest | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | ![]() Most popular ferry company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Palermo to Milan:
A flight is €11 less than a ferry for this route with tickets for a ferry from Palermo to Milan costing on average €76.
A flight is €35 less than a bus for this route with tickets for a bus from Palermo to Milan costing on average €100.
A flight is €59 less than a train for this route with tickets for a train from Palermo to Milan costing on average €124.
Other travel options to Milan take longer:
Train takes on average 15h 16m.
Bus takes on average 19h 19m.
Ferry takes on average 20h 2m.
You'll arrive about 5h 48m sooner (19h 19m by bus vs 25h 7m by car) and save roughly €6 compared to fuel and tolls (€100 vs €106). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by FlixBus, Itabus, BlaBlaCar, Autoservizi Salemi Srl.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator BlaBlaCar | Departure Time 06:00AM | Arrival Time 11:30PM | Duration 17h30 | Departure days Mon | Cheapest price €62 |
Operator BlaBlaCar | Departure Time 07:00AM | Arrival Time 11:20PM | Duration 16h20 | Departure days Sun | Cheapest price €85 |
Operator FlixBus | Departure Time 09:10AM | Arrival Time 07:50AM | Duration 22h40 | Departure days Mon, Fri, Sat, Sun | Cheapest price €131 |
Operator FlixBus | Departure Time 03:25PM | Arrival Time 08:20PM | Duration 28h55 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price €159 |
Operator Salemi | Departure Time 06:00PM | Arrival Time 01:10PM | Duration 19h10 | Departure days Mon, Wed, Thu, Fri, Sun | Cheapest price €92 |
Operator BlaBlaCar | Departure Time 07:20PM | Arrival Time 11:20AM | Duration 16h00 | Departure days Fri | Cheapest price €127 |
Operator FlixBus | Departure Time 09:10PM | Arrival Time 08:55PM | Duration 23h45 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price €110 |
The table below shows live departures for Palermo to Milan buses for today, Tuesday, August 25. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 3:25 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 28h55 | 8:20 PM Sesto San Giovanni, Piazza Primo Maggio (Stazione ferroviaria) | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Palermo to Milan run on average 6 times per day, taking around 19h 19m. Cheap bus tickets for this journey start at €70 but you can travel from only €17 by flight.
There are 1 buses per day. The earliest bus runs at 01:01, the last at 23:05. The fastest bus covers the 551 miles (887 km) distance in 19h 10m.
Distance 551 miles (887 km) |
Average bus duration 19h 19m |
Cheapest ticket price €70 |
Buses per day 6 |
Direct buses 1 |
Fastest bus 19h 10m |
First bus 1:01 AM |
Last bus 11:05 PM |
Cheapest Month Jul |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Wed |
Best time to book 49 days |
Discover the best of Milan — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Milan trip today.
One of Italy’s top art museums, featuring masterpieces by Mantegna, Bellini, Raphael, Caravaggio, and Piero della Francesca.
This contemporary art museum near Porta Romana presents rotating exhibitions in a striking former industrial distillery complex.
Italy’s leading science museum is set in a former monastery and features Leonardo galleries, trains, aircraft, and a submarine.
Milan’s central square frames the cathedral and major civic buildings, making it the city’s essential meeting point and photo stop.
This artistic district offers charming lanes, Brera atmosphere, boutiques, and easy access to galleries and evening strolls.
A large landscaped park behind the castle, perfect for walks, skyline views, and reaching landmarks like the Arch of Peace.
Saffron risotto cooked with butter, stock and cheese. It is Milan's signature dish, linked to the city's love of rich northern Italian rice cookery.
Breaded veal cutlet fried in butter until golden. A classic Milanese main, prized for its simple preparation and long-standing local tradition.
Slow-braised veal shanks with vegetables, wine and broth, often finished with gremolata. A hearty Lombard specialty commonly paired with risotto.
Three-Michelin-star fine dining by Enrico Bartolini in MUDEC. Expect refined Italian tasting menus in a polished contemporary setting.
Historic Milanese restaurant near the Duomo, famous for risotto and cotoletta. Traditional, elegant rooms and a strong local culinary identity.
Long-running local favorite for classic Milanese cuisine, especially risotto and ossobuco. Warm, old-school atmosphere in the Brera area.
Moderate for Western Europe. Hotels and central dining can be pricey, but transit is affordable and budget meals, aperitivo deals, and local cafes help keep daily costs reasonable.
Tipping is modest. Service may be included. Round up or leave €1-2 at cafes, 5-10% for good restaurant service, and round up taxi fares.
Official public transport app
Orio al Serio, Milan Bergamo Airport (Bus station) -> Milano Centrale, Milan
Find answers to the most common questions about traveling from Palermo to Milan by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milan, this guide helps you travel smarter and with confidence.

Most Palermo to Milan buses use the Palermo, Via Tommaso Fazello (Terminal Bus) to Milano, Autostazione Lampugnano station pair, with some services arriving at Milano, San Donato - Settore B (Viale Giuseppe Impastato). Use this guide to compare Palermo and Milan bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Milano, Autostazione Lampugnano is 5 km from Milan city centre. Public transport options include:
Milano, Autostazione Lampugnano has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Lampugnano (in the station), Trattoria Milano (0.5 km), Pizza Express (0.7 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Milano, Autostazione Lampugnano.
Available at Milano, Autostazione Lampugnano: Parking, Taxis, WC.
Accessibility facilities are available at Milano, Autostazione Lampugnano: Elevators, ramps.
Milano, San Donato - Settore B (Viale Giuseppe Impastato) is 6 km from Milan city centre. Public transport options include:
Milano, San Donato - Settore B (Viale Giuseppe Impastato) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Italiana (in the station), Fast Food Express (in the station), Trattoria Milano (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance for cash withdrawals.
Ticket office support is available at Milano, San Donato - Settore B (Viale Giuseppe Impastato).
Available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Parking, Taxis, WC.
Accessibility facilities are available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Elevators, ramps.
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