- Must visit
Vatican Museums
World-famous museum complex with the Sistine Chapel, Raphael Rooms, and major classical and Renaissance collections. Timed entry is strongly recommended due to very high demand.
Cheapest price
$57
Average price
$92
Fastest journey
16 h 25 m
Average duration
17 h 41 m
Buses per day
14
Distance
852 km
The best way to find a cheap bus ticket from Karlsruhe to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlsruhe to Rome will cost around $92 if you buy it on the day, but the cheapest tickets can be found for only $57.
Of the 14 buses that leave Karlsruhe for Rome on Sat, Jun 13, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 13 the direct buses cover the 852 km distance in an average of 17 h 41 m but if you time it right, some buses will get you there in just 16 h 25 m .
On Sat, Jun 13 the slowest buses will take 18 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the bus as it is the most popular option from Karlsruhe to Rome among Omio's users. If you are prioritising price take the bus with prices starting from $57. For those with little time consider booking a train which can get you there in 12h 28m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.1kg. The ticket price range depends on the travel mode: a bus costs an average of $57, and a train costs an average of $367.
Distance: 529 miles (852 km)
Most popular Bus | Train | Driving |
|---|---|---|
$81 Average price Cheapest | $399 Average price | $339 Average price (fuel + tolls) |
21h 36m Average total duration 21h 6m Onboard + 30m Additional time* | 12h 58m Average total duration Fastest 12h 28m Onboard + 30m Additional time* | 12h 4m Average total duration (door-to-door) |
0.9 - 2.1kg CO2 emissions Lowest | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Rome:
A bus is $318 (€258) less than a train for this route with tickets for a train from Karlsruhe to Rome costing on average $399 (€323).
Other travel options to Rome take longer:
Train takes on average 12h 28m.
Bus takes on average 21h 6m.
Tickets start at around $81 (€66) compared to roughly $339 (€275) in fuel and tolls — a saving of about $258 (€209). The journey takes 21h 6m versus 12h 4m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:20AM | Arrival Time 09:10PM | Duration 17h50 | Departure days Everyday | Cheapest price $74 |
Operator FlixBus | Departure Time 04:55AM | Arrival Time 11:00PM | Duration 18h05 | Departure days Everyday | Cheapest price $68 |
Operator FlixBus | Departure Time 05:15AM | Arrival Time 11:40PM | Duration 18h25 | Departure days Sat, Sun | Cheapest price $96 |
Operator Marino Autolinee | Departure Time 09:30AM | Arrival Time 04:30AM | Duration 19h00 | Departure days Thu, Sat | Cheapest price $143 |
Operator FlixBus | Departure Time 10:26AM | Arrival Time 08:30AM | Duration 22h04 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $76 |
Operator FlixBus | Departure Time 11:05AM | Arrival Time 05:35AM | Duration 18h30 | Departure days Everyday | Cheapest price $72 |
Operator FlixBus | Departure Time 11:15AM | Arrival Time 09:20AM | Duration 22h05 | Departure days Tue, Wed | Cheapest price $68 |
Operator FlixBus | Departure Time 12:30PM | Arrival Time 07:05AM | Duration 18h35 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $86 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 09:30AM | Duration 19h30 | Departure days Mon | Cheapest price $71 |
Operator FlixBus | Departure Time 02:23PM | Arrival Time 01:20PM | Duration 22h57 | Departure days Thu, Fri, Sun | Cheapest price $89 |
Operator FlixBus | Departure Time 03:29PM | Arrival Time 04:30PM | Duration 25h01 | Departure days Mon | Cheapest price $82 |
Operator FlixBus | Departure Time 04:20PM | Arrival Time 09:30AM | Duration 17h10 | Departure days Tue, Wed, Thu, Fri | Cheapest price $68 |
Operator FlixBus | Departure Time 05:05PM | Arrival Time 01:15PM | Duration 20h10 | Departure days Everyday | Cheapest price $69 |
Operator FlixBus | Departure Time 06:15PM | Arrival Time 01:15PM | Duration 19h00 | Departure days Tue | Cheapest price $72 |
Operator FlixBus | Departure Time 07:29PM | Arrival Time 03:20PM | Duration 19h51 | Departure days Fri, Sun | Cheapest price $86 |
Operator FlixBus | Departure Time 08:10PM | Arrival Time 01:50PM | Duration 17h40 | Departure days Everyday | Cheapest price $53 |
Operator FlixBus | Departure Time 10:40PM | Arrival Time 05:50PM | Duration 19h10 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $75 |
Operator FlixBus | Departure Time 11:00PM | Arrival Time 06:05PM | Duration 19h05 | Departure days Everyday | Cheapest price $68 |
Operator FlixBus | Departure Time 11:40PM | Arrival Time 06:45PM | Duration 19h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $78 |
Operator FlixBus | Departure Time 11:55PM | Arrival Time 11:45PM | Duration 23h50 | Departure days Mon, Thu, Fri | Cheapest price $73 |
The table below shows live departures for Karlsruhe to Rome buses for today, Friday, June 12. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 11:05 AM Karlsruhe Hbf | 19h05 | 6:10 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 12:30 PM Karlsruhe Hbf | 18h35 | 7:05 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixTrain+ FlixBus · FlixBus | 2:23 PM Karlsruhe Hbf | 22h57 | 1:20 PM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus | 4:20 PM Karlsruhe Hbf | 17h10 | 9:30 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 5:05 PM Karlsruhe Hbf | 19h10 | 12:15 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus | 5:05 PM Karlsruhe Hbf | 18h45 | 11:50 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixTrain+ FlixBus · FlixBus | 7:29 PM Karlsruhe Hbf | 22h21 | 5:50 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixTrain+ FlixBus · FlixBus | 7:29 PM Karlsruhe Hbf | 19h51 | 3:20 PM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus | 8:10 PM Karlsruhe Hbf | 18h55 | 3:05 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus | 8:10 PM Karlsruhe Hbf | 17h40 | 1:50 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus · FlixBus | 11:00 PM Karlsruhe Hbf | 18h50 | 5:50 PM Roma, Autostazione (Metro Anagnina) | 2 transfers | |
FlixBus · FlixBus | 11:40 PM Karlsruhe Hbf | 19h05 | 6:45 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 11:55 PM Karlsruhe Hbf | 23h50 | 11:45 PM Roma, Autostazione Tiburtina | 1 transfer | |
| Saturday, June 13 | |||||
FlixBus · FlixBus | 3:20 AM Karlsruhe Hbf | 17h50 | 9:10 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 4:55 AM Karlsruhe Hbf | 18h05 | 11:00 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 5:15 AM Karlsruhe Hbf | 18h25 | 11:40 PM Roma, Autostazione Tiburtina | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Karlsruhe to Rome run on average 13 times per day, taking around 21h 6m. Cheap bus tickets for this journey start at $57 (€46) if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:05, the last at 23:55. The fastest bus covers the 529 miles (852 km) distance in 17h 10m.
Distance 529 miles (852 km) |
Average bus duration 21h 6m |
Cheapest ticket price $57 (€46) |
Buses per day 13 |
Direct buses 1 |
Fastest bus 17h 10m |
First bus 12:05 AM |
Last bus 11:55 PM |
Cheapest Month Dec |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jan - Mar |
Best time to book 42 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous museum complex with the Sistine Chapel, Raphael Rooms, and major classical and Renaissance collections. Timed entry is strongly recommended due to very high demand.
One of Rome’s finest art museums, known for Bernini sculptures and paintings by Caravaggio and Raphael. Advance reservation is typically required because entry is strictly timed.
The city’s historic civic museums on Capitoline Hill, featuring Roman bronzes, imperial sculpture, and art with views over the Forum.
Elegant Baroque square built on an ancient stadium, lined with fountains, palaces, and lively street life. A classic area for strolling and people-watching.
Atmospheric neighborhood of narrow lanes, ivy-covered buildings, and busy evening streets. Popular with visitors but still one of Rome’s most characteristic areas.
Famous monumental staircase linking Piazza di Spagna and Trinità dei Monti. A highly photographed landmark and social-media favorite.
A classic Roman pasta with pecorino Romano and black pepper. It is one of the city’s most iconic dishes and a benchmark of Roman cooking.
Traditional Roman pasta made with guanciale, egg yolk, pecorino Romano, and black pepper. It is famous for its rich sauce without cream.
A beloved pasta sauce of tomato, guanciale, and pecorino Romano, closely tied to Rome’s culinary identity and served with bucatini or rigatoni.
Rome’s most famous fine-dining restaurant, offering elegant tasting menus, panoramic views, and one of the city’s most prestigious dining experiences.
A historic trattoria near the Pantheon, famous for traditional Roman dishes such as gricia, amatriciana, and seasonal specialties.
A celebrated central Rome venue known for classic Roman pasta, exceptional cured meats, and a refined but lively atmosphere.
Rome is moderate by Western Europe standards: sights are affordable, but central hotels and tourist-area dining cost more.
Service is usually included or modest. Tipping is not required, but rounding up or leaving EUR 1-2 at cafes and 5-10% at restaurants for good service is appreciated.
Official public transport app
Rome, Via Marsala / Viale Enrico De Nicola -> Roma Termini
Find answers to the most common questions about traveling from Karlsruhe to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

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