- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Cheapest price
$84
Average price
$107
Fastest journey
17 h 10 m
Average duration
17 h 51 m
Buses per day
13
Distance
852 km
The best way to find a cheap bus ticket from Karlsruhe to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlsruhe to Rome will cost around $107 if you buy it on the day, but the cheapest tickets can be found for only $84.
Of the 13 buses that leave Karlsruhe for Rome on Tue, Jul 28, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Jul 28 the direct buses cover the 852 km distance in an average of 17 h 51 m but if you time it right, some buses will get you there in just 17 h 10 m .
On Tue, Jul 28 the slowest buses will take 18 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the bus as it is the most popular option from Karlsruhe to Rome among Omio's users. If you are prioritising price take the bus with prices starting from $46. For those with little time consider booking a train which can get you there in 12h 28m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.1kg. The ticket price range depends on the travel mode: a bus costs an average of $46, and a train costs an average of $298.
Distance: 529 miles (852 km)
Most popular Bus | Train | Driving |
|---|---|---|
$66 Average price Cheapest | $323 Average price | $275 Average price (fuel + tolls) |
21h 36m Average total duration 21h 6m Onboard + 30m Additional time* | 12h 58m Average total duration Fastest 12h 28m Onboard + 30m Additional time* | 12h 4m Average total duration (door-to-door) |
0.9 - 2.1kg CO2 emissions Lowest | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Rome:
A bus is $258 (€258) less than a train for this route with tickets for a train from Karlsruhe to Rome costing on average $323 (€323).
Other travel options to Rome take longer:
Train takes on average 12h 28m.
Bus takes on average 21h 6m.
Tickets start at around $66 (€66) compared to roughly $275 (€275) in fuel and tolls — a saving of about $209 (€209). The journey takes 21h 6m versus 12h 4m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:20AM | Arrival Time 09:10PM | Duration 17h50 | Departure days Everyday | Cheapest price $72 |
Operator FlixBus | Departure Time 04:55AM | Arrival Time 11:00PM | Duration 18h05 | Departure days Everyday | Cheapest price $73 |
Operator FlixBus | Departure Time 05:15AM | Arrival Time 11:40PM | Duration 18h25 | Departure days Sat, Sun | Cheapest price $93 |
Operator Marino Autolinee | Departure Time 09:30AM | Arrival Time 04:30AM | Duration 19h00 | Departure days Thu, Sat | Cheapest price $128 |
Operator FlixBus | Departure Time 09:30AM | Arrival Time 06:05AM | Duration 20h35 | Departure days Mon | Cheapest price $123 |
Operator FlixBus | Departure Time 10:26AM | Arrival Time 08:30AM | Duration 22h04 | Departure days Mon, Tue, Wed, Fri, Sat | Cheapest price $75 |
Operator FlixBus | Departure Time 11:05AM | Arrival Time 05:35AM | Duration 18h30 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $70 |
Operator FlixBus | Departure Time 11:15AM | Arrival Time 09:20AM | Duration 22h05 | Departure days Tue, Wed | Cheapest price $78 |
Operator FlixBus | Departure Time 12:30PM | Arrival Time 07:05AM | Duration 18h35 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $119 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 09:30AM | Duration 19h30 | Departure days Mon | Cheapest price $88 |
Operator FlixBus | Departure Time 02:23PM | Arrival Time 01:20PM | Duration 22h57 | Departure days Thu, Sun | Cheapest price $122 |
Operator FlixBus | Departure Time 03:29PM | Arrival Time 04:30PM | Duration 25h01 | Departure days Mon, Wed, Thu | Cheapest price $73 |
Operator FlixBus | Departure Time 04:20PM | Arrival Time 09:30AM | Duration 17h10 | Departure days Tue, Wed, Thu, Fri | Cheapest price $71 |
Operator FlixBus | Departure Time 05:05PM | Arrival Time 12:15PM | Duration 19h10 | Departure days Everyday | Cheapest price $73 |
Operator FlixBus | Departure Time 07:29PM | Arrival Time 05:50PM | Duration 22h21 | Departure days Fri, Sun | Cheapest price $113 |
Operator FlixBus | Departure Time 08:10PM | Arrival Time 01:50PM | Duration 17h40 | Departure days Everyday | Cheapest price $72 |
Operator FlixBus | Departure Time 10:40PM | Arrival Time 05:50PM | Duration 19h10 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $85 |
Operator FlixBus | Departure Time 11:00PM | Arrival Time 06:05PM | Duration 19h05 | Departure days Everyday | Cheapest price $100 |
Operator FlixBus | Departure Time 11:40PM | Arrival Time 06:45PM | Duration 19h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $94 |
Operator FlixBus | Departure Time 11:55PM | Arrival Time 11:45PM | Duration 23h50 | Departure days Mon, Thu, Fri | Cheapest price $89 |
The table below shows live departures for Karlsruhe to Rome buses for today, Monday, July 27. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 8:10 PM Karlsruhe Hbf | 18h55 | 3:05 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus | 8:10 PM Karlsruhe Hbf | 17h40 | 1:50 PM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus · FlixBus | 10:40 PM Karlsruhe Hbf | 19h10 | 5:50 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus | 11:00 PM Karlsruhe Hbf | 19h05 | 6:05 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus | 11:40 PM Karlsruhe Hbf | 19h05 | 6:45 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 11:55 PM Karlsruhe Hbf | 23h50 | 11:45 PM Roma, Autostazione Tiburtina | 1 transfer | |
| Tuesday, July 28 | |||||
FlixBus · FlixBus | 3:20 AM Karlsruhe Hbf | 17h50 | 9:10 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 4:55 AM Karlsruhe Hbf | 18h05 | 11:00 PM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus+ FlixTrain | 10:26 AM Karlsruhe Hbf | 22h04 | 8:30 AM Roma, Autostazione Tiburtina | 2 transfers | |
FlixBus · FlixBus | 11:05 AM Karlsruhe Hbf | 18h30 | 5:35 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 11:05 AM Karlsruhe Hbf | 19h00 | 6:05 AM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus | 11:15 AM Karlsruhe Hbf | 22h05 | 9:20 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 4:20 PM Karlsruhe Hbf | 17h10 | 9:30 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus · FlixBus | 5:05 PM Karlsruhe Hbf | 19h10 | 12:15 PM Roma, Autostazione (Metro Anagnina) | 1 transfer | |
FlixBus · FlixBus | 5:05 PM Karlsruhe Hbf | 18h45 | 11:50 AM Roma, Autostazione Tiburtina | 1 transfer | |
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Karlsruhe to Rome run on average 13 times per day, taking around 21h 6m. Cheap bus tickets for this journey start at $46 (€46) if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:05, the last at 23:55. The fastest bus covers the 529 miles (852 km) distance in 17h 10m.
Distance 529 miles (852 km) |
Average bus duration 21h 6m |
Cheapest ticket price $46 (€46) |
Buses per day 13 |
Direct buses 1 |
Fastest bus 17h 10m |
First bus 12:05 AM |
Last bus 11:55 PM |
Cheapest Month Dec |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jan - Mar |
Best time to book 42 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Via Marsala, Rome -> Piazza Barberini, Rome
Find answers to the most common questions about traveling from Karlsruhe to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Karlsruhe to Rome buses use the Karlsruhe Hbf to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Karlsruhe and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need