The cheapest and fastest buses from Harrisburg, PA to Columbia, MO
Cheapest price
$264
Average price
$264
Fastest journey
23 h 40 m
Average duration
23 h 40 m
Buses per day
1
Distance
1330 km
The best way to find a cheap bus ticket from Harrisburg, PA to Columbia, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Columbia, MO will cost around $264 if you buy it on the day, but the cheapest tickets can be found for only $264.
It's difficult to get from Harrisburg, PA to Columbia, MO without transferring at least once.


Compare prices and tickets Harrisburg, PA to Columbia, MO by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Harrisburg, PA to Columbia, MO buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Harrisburg, PA to Columbia, MO
Buses from Harrisburg, PA to Columbia, MO run on average 3 times per day, taking around 21h 20m. Cheap bus tickets for this journey start at $425 (€345) if you book in advance.
The earliest bus runs at 08:30, the last at 20:35. The fastest bus covers the 826 miles (1330 km) distance in 21h 20m.
Distance 826 miles (1330 km) |
Average bus duration 21h 20m |
Cheapest ticket price $425 (€345) |
Buses per day 3 |
Fastest bus 21h 20m |
First bus 08:30 |
Last bus 20:35 |
Bus providers: Greyhound from Harrisburg, PA to Columbia, MOYou can travel by bus between Harrisburg, PA to Columbia, MO with Greyhound for as low as $425 (€345). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Harrisburg, PA to Columbia, MO
Find answers to the most common questions about traveling from Harrisburg, PA to Columbia, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Columbia, MO, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Harrisburg, PA to Columbia, MO
Most popular bus connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to Columbia, MO
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