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Getting to Prague from Paris is easy, and there are bus, train and flight routes every day of the week. Flying is definitely the fastest and most convenient way to travel. The journey takes 1 hour 40 minutes, compared with over 12 hours for both buses and trains.
Return trips from Prague to Paris are also available.
Flixbus, Regiojet and Eurolines all run daily buses from Paris to Prague. The earliest bus of the day departs from Porte Maillot bus station at 1:00 p.m., while the final bus leaves at 11:55 p.m. Most services include a change along the way, but there are two direct buses every day. These take 14 hours 30 minutes to reach Prague. That's around 5 hours faster than indirect services.
The best way to travel by train between Paris and Prague is probably to include a stopover in Munich. You can catch direct trains from Paris to Munich with SNCF, which takes around 8 hours. Then, you can transfer to a Prague-bound train, which takes about 4 hours 30 minutes. If you schedule your trip well, the whole journey can take 13 hours to complete.
If you need to be in Prague quickly, flying is the only way to travel. Every day, flights from Paris to Prague are provided by Air France, Easyjet, CSA and Transavia, meaning that budget flights are available. The earliest flight leaves at 7:25 a.m., and there are 8 flights in total, finishing at 8:15 p.m. All flights leave from Charles de Gaulle airport, except for Transavia's services, which take off from Orly.