Travel Information
Compare bus, train, and flight for Mainz to Brussels
Omio recommends booking the train as it is the most popular option from Mainz to Brussels among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $35 For those with little time, consider booking a flight, which has an average total journey time of 3h 0m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.3kg. Average ticket prices depend on the travel mode: a bus costs an average of $35, while a flight costs an average of $280.
Distance: 183 miles (295 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
$102 Average price | $35 Average price Cheapest | $280 Average price |
4h 15m Average total duration 3h 45m Onboard + 30m Additional time* | 5h 58m Average total duration 5h 28m Onboard + 30m Additional time* | 3h 0m Average total duration Fastest 1h 0m Onboard + 2h 0m Additional time* |
0.1 - 0.3kg CO2 emissions Lowest | 0.3 - 0.7kg CO2 emissions | 0.9 - 1.8kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Mainz to Brussels
How to get from Mainz to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Mainz to Brussels is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus8:20 AM8h20Mainz, Binger Schlag (Kurzzeitparkplatz)4:40 PMSchaerbeek, Bd Roi Albert II (Bruxelles Gare Du Nord)$221One-way1 transfer
Cheapest
FlixBus · FlixBus8:20 AM8h20Mainz, Binger Schlag (Kurzzeitparkplatz)4:40 PMSchaerbeek, Bd Roi Albert II (Bruxelles Gare Du Nord)$221One-way1 transfer
Fastest
SN261010:45 AM1h05Frankfurt am Main Airport11:50 AMBrussels Airport$3291One-way0 transfers
Other options
IC 2047 · ICE 31411:20 AM4h15Mainz Hbf3:35 PMBrussels-Midi$991One-way1 transfer
IC 2049 · ICE 169:20 AM4h15Mainz Hbf1:35 PMBrussels-Midi$991One-way1 transfer
Bus RE2 · ICE 820 · S6 · ICE 168:09 AM5h26Bahnstrecke Mainz–Mannheim1:35 PMBrussels-Midi$1011One-way3 transfers
FlixBus12:05 PM5h50Mainz, Binger Schlag (Kurzzeitparkplatz)5:55 PMSchaerbeek, Bd Roi Albert II (Bruxelles Gare Du Nord)$301One-way0 transfers
30483 · 501007:25 AM13h25Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)8:50 PMBrussels, Brussels South (Gare du Midi)$441One-way1 transfer
30485 · 161312:25 PM13h48Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)2:13 AMBrussels, Brussels South (Gare du Midi)$441One-way1 transfer
KL1814 · KL17037:00 AM2h40Frankfurt am Main Airport9:40 AMBrussels Airport$3081One-way1 transfer
SN26167:35 PM1h05Frankfurt am Main Airport8:40 PMBrussels Airport$3291One-way0 transfers
SN26144:25 PM1h05Frankfurt am Main Airport5:30 PMBrussels Airport$3291One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Mainz to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mainz to Brussels.

This is compared to other travel options from Mainz to Brussels:
A bus is $67 (€54) less than a train for this route with tickets for a train from Mainz to Brussels costing on average $102 (€83).
A bus is $244 (€198) less than a flight for this route with tickets for a flight from Mainz to Brussels costing on average $280 (€226).
Other travel options to Brussels take longer:
Train takes on average 4h 15m.
Bus takes on average 5h 58m.
- Around 28 flights per day.
- Around 5 trains per day.
- Around 4 buses per day.
However, we recommend checking specific travel dates for your route between Mainz and Brussels as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Brussels Airport.
- Trains mostly depart from Mainz Hbf and arrive in Brussels-Midi.
- Buses mostly depart from Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) and arrive in Schaerbeek, Bd Roi Albert II (Bruxelles Gare Du Nord).
- Travel with FlixBus, BlaBlaCar, BlaBlaCar Bus to go to Brussels by bus.
- Travel with Deutsche Bahn to go to Brussels by train.
- Travel with Lufthansa, Brussels Airlines to go to Brussels by flight.
- 2 direct buses per day with FlixBus, BlaBlaCar.
- 6 direct flights per day with Brussels Airlines.
Travelling from Mainz to Brussels: related information
Here are some other resources that might have the information you need
