- Must visit
Uffizi Gallery
World-famous gallery with Botticelli, Leonardo, and Michelangelo. Essential for understanding Renaissance painting and one of Florence’s top visits.
Omio recommends booking the train as it is the most popular option from Sant'Agnello to Florence among Omio's users. If you are prioritising price take the bus with prices starting from CHF42. For those with little time consider booking a train which can get you there in 3h 23m. The ticket price range depends on the travel mode: a bus costs an average of CHF42, and a flight costs an average of CHF143.
Distance: 270 miles (435 km)
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
CHF89 Average price | CHF46 Average price Cheapest | CHF194 Average price | CHF83 Average price (fuel + tolls) |
3h 53m Average total duration Fastest 3h 23m Onboard + 30m Additional time* | 5h 40m Average total duration 5h 10m Onboard + 30m Additional time* | 14h 33m Average total duration 11h 33m Onboard + 3h 0m Additional time* | 5h 11m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Sant'Agnello to Florence:
A bus is CHF44 less than a train for this route with tickets for a train from Sant'Agnello to Florence costing on average CHF89.
A bus is CHF149 less than a flight for this route with tickets for a flight from Sant'Agnello to Florence costing on average CHF194.
Other travel options to Florence take longer:
Bus takes on average 5h 10m.
Flight takes on average 11h 33m.
You'll arrive about 1h 48m sooner (3h 23m by train vs 5h 11m by car). Tickets start at around CHF89 compared to roughly CHF83 in fuel and tolls — so you're paying a bit more, but getting hours of your day back, a city-centre arrival, and the freedom to work or relax instead of drive.
Driving makes more sense if you're travelling as a group (where fuel costs split several ways), want to stop along the way, or need a car once you arrive.
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Sant'Agnello to Florence run on average 4 times per day, taking around 3h 23m. Cheap train tickets for this journey start at CHF89 but you can travel from only CHF42 by bus.
The earliest train runs at 03:45, the last at 22:22. The fastest train covers the 270 miles (435 km) distance in 5h 32m.
Distance 270 miles (435 km) |
Average train duration 3h 23m |
Cheapest ticket price CHF89 |
Trains per day 4 |
Fastest train 5h 32m |
First train 3:45 AM |
Last train 10:22 PM |
Cheapest Month Aug |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 35 days |
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
World-famous gallery with Botticelli, Leonardo, and Michelangelo. Essential for understanding Renaissance painting and one of Florence’s top visits.
Houses Michelangelo’s David alongside major Renaissance sculptures. A must for first-time visitors interested in Florence’s artistic legacy.
Monastic museum with Fra Angelico frescoes and tranquil cells. Ideal for experiencing spiritual art in one of Florence’s most atmospheric spaces.
Florence’s monumental main square, framed by civic buildings and sculpture. A must for first impressions, history, and lively urban atmosphere.
The cathedral square is Florence’s ceremonial heart, surrounded by the Duomo, Baptistery, and bell tower. Essential for architecture lovers.
Riverside viewpoint with one of Florence’s classic panoramas. Best at sunset for sweeping views over the Arno, domes, and historic center.
Thick Florentine T-bone steak from Chianina beef, grilled rare over coals. It is the city's signature celebratory dish and a classic of Tuscan cuisine.
A rustic Tuscan bread soup with black cabbage, cannellini beans, vegetables, and olive oil. A beloved frugal dish rooted in Florentine home cooking.
A thick soup of bread, tomatoes, basil, garlic, and olive oil, served warm or at room temperature. It celebrates simple Tuscan ingredients and stale bread.
Three-Michelin-star fine dining by Enoteca Pinchiorri, known for refined Italian cuisine and an exceptional wine cellar. Elegant and formal.
Legendary casual stop for Lampredotto sandwiches and other tripe specialties. Simple, authentic street food experience in central Florence.
Historic steakhouse famed for Bistecca Alla Fiorentina and classic Tuscan dishes. Traditional, bustling atmosphere near Santa Croce.
Moderate for Italy: hotels in the center are pricier, but dining and transit are reasonable versus Rome or Venice.
Service is often included. Round up or leave €1-2 at cafés, 5-10% for great restaurant service, and round up taxi fares.
Official public transport app
Firenze Santa Maria Novella -> Piazza del Duomo, Florence
Find answers to the most common questions about traveling from Sant'Agnello to Florence by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, this guide helps you travel smarter and with confidence.

Most Sant'Agnello to Florence trains use the Sant'Agnello to Firenze Santa Maria Novella station pair, with some services arriving at Firenze Campo di Marte. Use this guide to compare Sant'Agnello and Florence train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Sant'Agnello has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food options include: Il Ruttino, Jolly Blu
Free.
Ticket office support is available at Sant'Agnello. Information desks are located in the main hall.
Luggage storage is available at Sant'Agnello.
Available at Sant'Agnello: Parking, Taxis, WC.
Available at Sant'Agnello: Bike Parking.
Accessibility facilities are available at Sant'Agnello.
Nearby hotels include Hotel Corallo Sorrento, Hotel Mediterraneo Sorrento, Hotel Alpha.
Firenze Santa Maria Novella is 1 km from Florence city centre. Public transport options include:
Firenze Santa Maria Novella has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: 12oz Coffee Joint, Casa Maioli, Don Nino, Fratelli Cuore, McDonald´s, Panella, Segafredo Zanetti, Spizzico, Venchi, & many more
Free WiFi (30 minutes limit). ATMs are located in the basement in the shopping center next to the Feltrinelli bookshop and between Celio and Mango shops.
The ticket office is open Mon - Sun: 06:00 - 21:00. Information desks are located inside and outside the station.
Luggage storage is provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
Available at Firenze Santa Maria Novella: Parking, Taxis, WC.
Available at Firenze Santa Maria Novella: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Firenze Santa Maria Novella: Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
Nearby hotels include Hotel Luxor Florence, Joy Hotel Florence, Diplomat Hotel Florence.
Firenze Campo di Marte is 2 km from Florence city centre. Public transport options include:
Firenze Campo di Marte has practical services for this route, including Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, and Bike Rental.
Food options include: Moka Café
The ticket office is open Mon - Sun: 07:15 - 20:45.
Available at Firenze Campo di Marte: Taxis, WC.
Available at Firenze Campo di Marte: Bike Parking, Bike Rental.
Accessibility facilities are available at Firenze Campo di Marte: The station is fully accessible, with step-free access throughout the station.
Nearby hotels include Florence Stadium B&B, Hotel Villa Liana, Hotel della Robbia.
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