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Travel Information
Compare train, bus, and flight for Pisa to Frankfurt am Main
Omio recommends booking the flight as it is the most popular option from Pisa to Frankfurt am Main among Omio's users. If you are prioritising price take the bus with prices starting from $70. For those with little time consider booking a flight which can get you there in 2h 26m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.7 - 1.8kg. The ticket price range depends on the travel mode: a bus costs an average of $70, and a flight costs an average of $223.
Distance: 449 miles (723 km)
Compare train with
| Train | Most popular Flight | Bus | Driving |
|---|---|---|---|
$309 Average price | $826 Average price | $111 Average price Cheapest | $293 Average price (fuel + tolls) |
12h 3m Average total duration 11h 33m Onboard + 30m Additional time* | 5h 26m Average total duration Fastest 2h 26m Onboard + 3h 0m Additional time* | 16h 17m Average total duration 15h 47m Onboard + 30m Additional time* | 10h 10m Average total duration (door-to-door) |
- CO2 emissions | 2.2 - 4.3kg CO2 emissions | 0.7 - 1.8kg CO2 emissions Lowest | - CO2 emissions |
 Most popular train company |  Most popular airline |  Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
The cheapest way to travel from Pisa to Frankfurt am Main is a bus with an average price of $111 (€89).
This is compared to other travel options from Pisa to Frankfurt am Main:
A bus is $198 (€158) less than a train for this route with tickets for a train from Pisa to Frankfurt am Main costing on average $309 (€247).
A bus is $715 (€571) less than a flight for this route with tickets for a flight from Pisa to Frankfurt am Main costing on average $826 (€660).
The fastest way to travel from Pisa to Frankfurt am Main is by flight with an average journey time of 2h 26m.
Other travel options to Frankfurt am Main take longer:
Train takes on average 11h 33m.
Bus takes on average 15h 47m.
It's helpful to compare your options as there are 3 ways to travel between Pisa and Frankfurt am Main including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from Pisa to Frankfurt am Main among Omio's users.
Take the train. It's the cheaper option, and the extra time on board is usually more relaxing than driving it.
Tickets start at around $309 (€247) compared to roughly $293 (€234) in fuel and tolls — a saving of about $-15.73 (€-12.57). The journey takes 11h 33m versus 10h 10m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Live departures
Pisa to Frankfurt am Main train times
The table below shows live departures for Pisa to Frankfurt am Main trains for today, Thursday, May 7. You can also manually refresh the results below to see updated train journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 7:47 AM Pisa | 10h57 | 6:44 PM Frankfurt am Main | 3 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pisa to Frankfurt am Main by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Pisa to Frankfurt am Main trains with Omio?
Trenitalia as well as Deutsche Bahn or Regionale offer trains services from Pisa to Frankfurt am Main.
Omio is an official ticket reseller for all your travel options from Pisa to Frankfurt am Main.
Why book with Omio vs Trenitalia?
- Compare with other providers: On Omio, you can not only buy tickets for Trenitalia, but also compare tickets for the likes of Deutsche Bahn or Regionale to find the best option for your trip from Pisa to Frankfurt am Main.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Trenitalia with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pisa to Frankfurt am Main.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Deutsche Bahn or Regionale to find the best option for your trip from Pisa to Frankfurt am Main.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pisa to Frankfurt am Main.
Journey information
Overview: Train from Pisa to Frankfurt am Main
Italy
Germany
Trains from Pisa to Frankfurt am Main run on average 1 times per day, taking around 11h 33m. Cheap train tickets for this journey start at $287 (€229) but you can travel from only $70 (€56) by bus.
The earliest train runs at 01:42, the last at 23:28. The fastest train covers the 449 miles (723 km) distance in 11h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $70 (€56)
Distance 449 miles (723 km) |
Average train duration 11h 33m |
Cheapest ticket price $287 (€229) |
Trains per day 1 |
Fastest train 11h 0m |
First train 1:42 AM |
Last train 11:28 PM |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Tue |
Least Busy Day Tue |
Best time to book 14 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $70 (€56)
Train companies: Trenitalia, Deutsche Bahn, Regionale from Pisa to Frankfurt am Main trainsTrenitalia, Deutsche Bahn, Regionale trains will get you between Pisa and Frankfurt am Main from $70 (€56). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Trenitalia
About
Trenitalia is not only Italy's national railroad company but also the country's largest train operator. Trenitalia’s fleet of trains ncludes the high-speed Frecciarossa, Frecciargento and Frecciabianca trains as well as intercity, regional and night trains. Bathrooms and WiFi access are standard on long-distance routes. In most cases, the trains also provide barrier-free access. Trenitalia offers different tickets, which vary in price and flexibility: Base, Economy, Super Economy and Ordinaria. You can even use Trenitalia discount cards on Omio. Make sure to look out for the latest offers from Trenitalia on Omio to score special deals!
Luggage & cancellation policy
Luggage included
2 pieces of hand luggage per passenger included in ticket price
Luggage storage
Overhead racks, luggage areas at end of carriages, and spaces between seat backs
Cancellation Policy
Cancellation policies vary by ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car on high-speed trains, trolley service with snacks and beverages, vending machines on some trains
Seat reservation
Optional seat reservation, costs extra except on high-speed trains where it's mandatory and included
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, and assistance service available with advance notice
Pets
Small pets in carriers travel free, larger dogs require paid ticket and muzzle, guide dogs travel free
Quiet zone
Deutsche Bahn
About
Deutsche Bahn (DB) is Germany’s main train operator, running around 40,000 domestic and international services each day. Its fleet includes a variety of train types: high-speed ICE (Intercity Express) trains, reaching up to 300 km/h; IC (Intercity) and EC (EuroCity) trains for long-distance travel; and IRE (Interregio-Express), RE (Regional Express), and RB (Regionalbahn) services for regional and local connections. While bathrooms are standard on all trains, amenities such as onboard restaurants and free Wi-Fi are available only on certain train types and routes. DB offers a wide range of fares, including Super Saver, Saver, and Flexible tickets, along with discount cards like the BahnCard 25, 50, and 100. Additional options include single tickets, day tickets, and group tickets. Popular routes include Berlin–Munich, Hamburg–Frankfurt, Cologne–Stuttgart, Berlin–Dresden, and Hamburg–Cologne, as well as numerous regional services across Germany.
Luggage & cancellation policy
Luggage included
Passengers are allowed to bring hand luggage and one additional larger item free of charge, provided they can carry it themselves
Luggage storage
Luggage can be stored in overhead racks, under the seat, or in designated luggage areas near the doors or in the middle of the carriage.
Cancellation Policy
Tickets can be canceled based on their fare conditions as mentioned in what type of train tickets are refundable?
Refund
If DB cancels a train, passengers are entitled to a full refund of the ticket price.
Amenities on board the train
Wifi
Food sold onboard
Most ICE and many IC/EC trains have:
A Bordrestaurant (restaurant car) where you can sit and eat.
A Bordbistro (bistro bar) with snacks, hot meals, and drinks to-go.
At-seat service in 1st class: staff will take your order and serve food/drinks directly to your seat.
Regional trains (RE / RB / S-Bahn):
No onboard catering.
You’re welcome to bring your own food and drinks.
A Bordrestaurant (restaurant car) where you can sit and eat.
A Bordbistro (bistro bar) with snacks, hot meals, and drinks to-go.
At-seat service in 1st class: staff will take your order and serve food/drinks directly to your seat.
Regional trains (RE / RB / S-Bahn):
No onboard catering.
You’re welcome to bring your own food and drinks.
Seat reservation
Second Class:
Not included by default.
You can add a seat reservation when booking (recommended for busy routes).
Costs around €4.90 per seat (or €5.90 if booked separately later).
First Class:
Yes, always included in the ticket price.
Not included by default.
You can add a seat reservation when booking (recommended for busy routes).
Costs around €4.90 per seat (or €5.90 if booked separately later).
First Class:
Yes, always included in the ticket price.
Toilets
USB plugs
Accessibility
DB trains are equipped with facilities for passengers with reduced mobility, including wheelchair spaces, accessible restrooms, and assistance services.
Pets
Small pets (e.g. cats, small dogs, etc.):
Allowed for free if they can fit in a transport box (max. size: hand luggage).
Must stay in the box for the entire journey.
Large dogs:
Require a separate (paid) ticket — typically half the price of a regular second-class ticket.
Must be leashed and wear a muzzle while on the train.
Cannot sit on seats.
Assistance dogs:
Travel free of charge.
Do not need a muzzle or leash if medically not required.
Allowed to accompany the passenger at all times.
Allowed for free if they can fit in a transport box (max. size: hand luggage).
Must stay in the box for the entire journey.
Large dogs:
Require a separate (paid) ticket — typically half the price of a regular second-class ticket.
Must be leashed and wear a muzzle while on the train.
Cannot sit on seats.
Assistance dogs:
Travel free of charge.
Do not need a muzzle or leash if medically not required.
Allowed to accompany the passenger at all times.
Quiet zone
Regionale
About
Regionale is the regional train service of national carrier Trenitalia connecting all of Italy. It is the most convinient way to travel to both big cities and the smallest villages all over the Italian country. The regional trains have different names depending on the region they serve, such as Treno Regionale Veloce (TRV) and Treno Regionale Lento (TRL). Treno Rock and Treno pop are the two new trains part of Trenitalia regionale fleet. Trenitalia Regionale offers a variety of ticket types, including single tickets (economy and standard), return tickets, and season tickets. Onboard facilities include free Wi-Fi, air conditioning, and power sockets. The most popular routes for Regionale are between Rome and Milan, Naples and Florence, and Turin and Venice.
Luggage & cancellation policy
Average Duration
11h 0m
Cheapest Price
$287 (€229)
Regionale frequency
2 a day
Luggage included
Free hand luggage allowance included in ticket price
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Bar service available on some trains with snacks and beverages
Seat reservation
Seat reservation included in ticket price for most services
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle
Quiet zone
FAQs: Trains from Pisa to Frankfurt am Main
Find answers to the most common questions about traveling from Pisa to Frankfurt am Main by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Frankfurt am Main, this guide helps you travel smarter and with confidence.
Train ticket prices from Pisa to Frankfurt am Main can vary. The cheapest ticket starts at $287 (€229), while the average price is around $309 (€247).
The train from Pisa to Frankfurt am Main runs once a day and takes approximately 11h 0m.
The first train from Pisa to Frankfurt am Main leaves at 1:42 AM.
The distance by train from Pisa to Frankfurt am Main is 449 miles (723 km).
The last train from Pisa to Frankfurt am Main leaves at 11:28 PM.
There is no high speed train available from Pisa to Frankfurt am Main.
There is no direct train service currently available from Pisa to Frankfurt am Main.
Unfortunately, there is no night train available from Pisa to Frankfurt am Main.
The cheapest way to get from Pisa to Frankfurt am Main is by bus, with a cost of around $70 (€56).
The train journey from Pisa to Frankfurt am Main offers scenic views, including picturesque Tuscan landscapes, rolling hills in northern Italy, and parts of the Rhine Valley in Germany, known for its charming vineyards and castles.
A day trip from Pisa to Frankfurt am Main is not feasible since the journey takes 11h 0m and there is only 1 train per day covering a distance of 449 miles (723 km).
In Frankfurt am Main, visitors can enjoy panoramic views from the Main Tower and explore the vibrant Kleinmarkthalle for a variety of foods. The Senckenberg Natural History Museum offers fascinating dinosaur fossils, while a walk along the River Main provides scenic vistas. Shop at the lively Zeil or visit the Römer, a historic city hall. Art enthusiasts can explore the Städel Museum, while nature lovers will appreciate the Palmengarten. Delve into literary history at the Goethe House and admire the Gothic architecture of Frankfurt Cathedral.
Typically, spending 2 to 3 days in Frankfurt am Main is sufficient to explore its main attractions, such as the Römer, Städel Museum, and Palmengarten, while also enjoying the city's vibrant dining and shopping scenes.
Yes, you can take the train from Pisa to Frankfurt am Main.
Since both Pisa and Frankfurt am Main are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
Popular day trips by train from Frankfurt am Main include Heidelberg, Mannheim, Karlsruhe, Baden-Baden, Würzburg.
We recommend using the flight as it is the most popular way to get from Pisa to Frankfurt am Main among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
Germany uses the euro (€) as its currency. Travelers generally find it convenient to use cards, especially contactless payments, in cities and larger establishments. However, cash is still widely accepted and sometimes preferred in smaller shops, markets, and rural areas. Carrying some cash is recommended for flexibility.
In Frankfurt am Main, travelers should be cautious of pickpocketing, especially in crowded areas like train stations, public transport, and popular tourist spots. Common scams include distraction techniques where one person diverts attention while another steals belongings. It's also important to be wary of unofficial taxi drivers overcharging and to use licensed services. Staying alert in nightlife districts and avoiding poorly lit areas at night can help ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular train stations
Popular train stations from Pisa to Frankfurt am Main
Pisa
Frankfurt am Main
Frankfurt (Main) Süd
Amenities at train station
WifiLockersShoppingParkingDiningATMTaxisAccessibilityWCHotelLoungeLost and Found OfficeTicket OfficeBike ParkingBike RentalCar RentalInformation Deskinformation
Distance to city center
1 kmDining
- Merals Imbiss
- Bootshaus am Eisernen Steg
- Freigut
- Holbein's
Hotel
- Hotel am Berg
- Leonardo Royal Hotel Frankfurt
- Hotel Ritter
- Lindner Main Plaza
Frankfurt (Main) West
Amenities at train station
WifiLockersShoppingParkingDiningATMTaxisAccessibilityWCHotelLoungeLost and Found OfficeTicket OfficeBike ParkingBike RentalCar RentalInformation Deskinformation
Distance to city center
3 kmDining
- Immer Satt
- Café Crumble
- Café Albatros
- Cafe Extrablatt
Hotel
- Frankfurt Marriott Hotel
- Imperial
- Sophien Hotel
- Hotel Isha
Most popular train connections from Pisa
More options for your journey from Pisa to Frankfurt am Main
Here are some other resources that might have the information you need
Most popular trains to and from Frankfurt am Main and Pisa
Most popular train connections to Frankfurt am Main
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