- Recommended
Museo delle Sinopie
Pisa's main museum displays sculptures, paintings, manuscripts, and treasures from the cathedral complex and the city.
Omio recommends booking the bus as it is the most popular option from Frankfurt am Main to Pisa among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €118 For those with little time, consider booking a flight, which has an average total journey time of 4h 51m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.7 - 1.8kg. Average ticket prices depend on the travel mode: a bus costs an average of €118, while a flight costs an average of €460.
Distance: 449 miles (723 km)
| Train | Most popular Bus | Flight | Driving |
|---|---|---|---|
€118 Average price Cheapest | €460 Average price | €235 Average price (fuel + tolls) | |
17h 31m Average total duration 17h 1m Onboard + 30m Additional time* | 4h 51m Average total duration Fastest 2h 51m Onboard + 2h 0m Additional time* | 10h 28m Average total duration (door-to-door) | |
- CO2 emissions | 0.7 - 1.8kg CO2 emissions Lowest | 2.2 - 4.3kg CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Frankfurt am Main to Pisa:
A bus is €342 less than a flight for this route with tickets for a flight from Frankfurt am Main to Pisa costing on average €460.
Other travel options to Pisa take longer:
Bus takes on average 17h 1m.
The table below shows live departures for Frankfurt am Main to Pisa trains for today, Friday, August 28. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 10:20 PM Frankfurt am Main | 19h40 | 6:00 PM Pisa | 3 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a train from Frankfurt am Main to Pisa and enjoy the approximately 449 miles (723 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest train runs at 01:05, the last at 23:28.
Distance 449 miles (723 km) |
First train 1:05 AM |
Last train 11:28 PM |
High Season Oct - Dec |
Low Season Jan - Mar |
Discover the best of Pisa — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Pisa trip today.
Pisa's main museum displays sculptures, paintings, manuscripts, and treasures from the cathedral complex and the city.
Museum of preparatory sinopias from Camposanto frescoes, offering rare insight into medieval artistic techniques and restoration.
Museum in Palazzo Lanfranchi with 19th- and 20th-century art, including works by Tuscan artists and temporary exhibitions.
Pisa's UNESCO square gathers the Leaning Tower, cathedral, baptistery, and cemetery in one extraordinary monumental ensemble.
Historic square framed by noble buildings and the Scuola Normale, central to Pisa's medieval civic and political life.
Lively riverside promenade ideal for walking, with historic palaces, bridges, and classic views of the Arno through the city center.
Cecina is a thin wood-fired chickpea flour pancake, crisp outside and soft inside. It is a classic street food across Pisa and coastal Tuscany.
Pappa al pomodoro is a thick bread and tomato soup with garlic, basil, and olive oil. It is a beloved Tuscan peasant dish often found in Pisa.
Ribollita is a hearty Tuscan soup of bread, beans, and vegetables, traditionally reheated the next day. It reflects the frugal home cooking of the area.
Well-known traditional trattoria serving classic Tuscan plates and local specialties in a warm, rustic atmosphere.
Casual, established spot famous for cecina and pizza in a lively local setting. Ideal for trying one of Pisa’s signature foods.
Historic Pisan restaurant known for refined Tuscan seafood and meat dishes in an elegant, traditional setting near the center.
Moderate for Italy. Budget eats and local transit are reasonable, but hotels near the Leaning Tower and peak-season dining cost more than in smaller Tuscan towns.
Service is often included or minimal. Round up or leave €1-2 at cafes, 5-10% for great restaurant service, and round up taxi fares.
Find answers to the most common questions about traveling from Frankfurt am Main to Pisa by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Pisa, this guide helps you travel smarter and with confidence.

Most Frankfurt am Main to Pisa trains use the Frankfurt (Main) Süd to station pair. Use this guide to compare Frankfurt am Main and Pisa train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Frankfurt (Main) Süd is 1 km from Frankfurt am Main city centre. Public transport options include:
Frankfurt (Main) Süd has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: Merals Imbiss, Bootshaus am Eisernen Steg, Freigut, Holbein's
Wi-Fi is available at Frankfurt (Main) Süd. ATMs are available at Frankfurt (Main) Süd.
Ticket office support is available at Frankfurt (Main) Süd. Information desks are available at Frankfurt (Main) Süd.
Luggage storage is available at Frankfurt (Main) Süd. Lost and found is available at the station.
Available at Frankfurt (Main) Süd: Parking, Taxis, WC.
Available at Frankfurt (Main) Süd: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Frankfurt (Main) Süd.
Nearby hotels include Hotel am Berg, Leonardo Royal Hotel Frankfurt, Hotel Ritter, Lindner Main Plaza.
Frankfurt (Main) West is 3 km from Frankfurt am Main city centre. Public transport options include:
Frankfurt (Main) West has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: Immer Satt, Café Crumble, Café Albatros, Cafe Extrablatt
Wi-Fi is available at Frankfurt (Main) West. ATMs are available at Frankfurt (Main) West.
Ticket office support is available at Frankfurt (Main) West. Information desks are available at Frankfurt (Main) West.
Luggage storage is available at Frankfurt (Main) West. Lost and found is available at the station.
Available at Frankfurt (Main) West: Parking, Taxis, WC.
Available at Frankfurt (Main) West: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Frankfurt (Main) West.
Nearby hotels include Frankfurt Marriott Hotel, Imperial, Sophien Hotel, Hotel Isha.
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