Travel Information
Compare train, bus, and flight for Frankfurt am Main to Pisa
Omio recommends booking the flight as it is the most popular option from Frankfurt am Main to Pisa among Omio's users. If you are prioritising price take the bus with prices starting from $65. For those with little time consider booking a flight which can get you there in 2h 20m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.7 - 1.8kg. The ticket price range depends on the travel mode: a bus costs an average of $65, and a flight costs an average of $254.
Distance: 449 miles (723 km)
Compare train with
| Train | Most popular Flight | Bus |
|---|---|---|
$317 Average price | $663 Average price | $105 Average price Cheapest |
18h 23m Average total duration 17h 53m Onboard + 30m Additional time* | 5h 20m Average total duration Fastest 2h 20m Onboard + 3h 0m Additional time* | 16h 46m Average total duration 16h 16m Onboard + 30m Additional time* |
- CO2 emissions | 2.2 - 4.3kg CO2 emissions | 0.7 - 1.8kg CO2 emissions Lowest |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare prices and tickets Frankfurt am Main to Pisa by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Frankfurt am Main to Pisa trains with Omio?
Why book with Omio vs Deutsche Bahn?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Deutsche Bahn with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Frankfurt am Main to Pisa.
Why book with Omio over Trainline or Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Frankfurt am Main to Pisa.
Journey information
Overview: Train from Frankfurt am Main to Pisa
Trains from Frankfurt am Main to Pisa run on average 2 times per day, taking around 17h 53m. Cheap train tickets for this journey start at $268 (€213) but you can travel from only $65 (€52) by bus.
The earliest train runs at 01:06, the last at 23:28. The fastest train covers the 449 miles (723 km) distance in 13h 38m.
Distance 449 miles (723 km) |
Average train duration 17h 53m |
Cheapest ticket price $268 (€213) |
Trains per day 2 |
Fastest train 13h 38m |
First train 01:06 |
Last train 23:28 |
Train companies: Deutsche Bahn from Frankfurt am Main to Pisa trainsDeutsche Bahn trains will get you between Frankfurt am Main and Pisa from $65 (€52). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Deutsche Bahn
A Bordrestaurant (restaurant car) where you can sit and eat.
A Bordbistro (bistro bar) with snacks, hot meals, and drinks to-go.
At-seat service in 1st class: staff will take your order and serve food/drinks directly to your seat.
Regional trains (RE / RB / S-Bahn):
No onboard catering.
You’re welcome to bring your own food and drinks.
Not included by default.
You can add a seat reservation when booking (recommended for busy routes).
Costs around €4.90 per seat (or €5.90 if booked separately later).
First Class:
Yes, always included in the ticket price.
Allowed for free if they can fit in a transport box (max. size: hand luggage).
Must stay in the box for the entire journey.
Large dogs:
Require a separate (paid) ticket — typically half the price of a regular second-class ticket.
Must be leashed and wear a muzzle while on the train.
Cannot sit on seats.
Assistance dogs:
Travel free of charge.
Do not need a muzzle or leash if medically not required.
Allowed to accompany the passenger at all times.
FAQs: Trains from Frankfurt am Main to Pisa
Find answers to the most common questions about traveling from Frankfurt am Main to Pisa by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Pisa, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Frankfurt am Main to Pisa
- Merals Imbiss
- Bootshaus am Eisernen Steg
- Freigut
- Holbein's
- Hotel am Berg
- Leonardo Royal Hotel Frankfurt
- Hotel Ritter
- Lindner Main Plaza
- Immer Satt
- Café Crumble
- Café Albatros
- Cafe Extrablatt
- Frankfurt Marriott Hotel
- Imperial
- Sophien Hotel
- Hotel Isha
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- The car park is open 24/7, accessible via Terminal 1 and Terminal 2 parking areas.
- Restaurant Käfer's
- McDonald's
- Asia Snack Box
- Outside the main entrance.
- Elevators, ramps.
- €1
- Sheraton Frankfurt Airport Hotel
- Hilton Frankfurt Airport
- Hilton Garden Inn Frankfurt Airport
- Cost €6
- Located in the main hall
- Located in the main hall
- Avis
- Europcar
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-4 for long-distance and regional trains
- Hall 2: connection to Terminal 1 of the airport
- Hall 3: connection to Terminal 2 of the airport
- S-Bahn: Lines S8, S9
- Bus: Several lines available
- Long-distance buses: Available at the airport
Most popular train connections from Frankfurt am Main
More options for your journey from Frankfurt am Main to Pisa
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