Travel Information
Compare train, bus, and flight for Frankfurt am Main to Pisa
Omio recommends booking the bus as it is the most popular option from Frankfurt am Main to Pisa among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $127 For those with little time, consider booking a flight, which has an average total journey time of 4h 50m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.7 - 1.8kg. Average ticket prices depend on the travel mode: a bus costs an average of $127, while a flight costs an average of $552.
Distance: 449 miles (723 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$127 Average price Cheapest | $552 Average price | $280 Average price (fuel + tolls) |
17h 31m Average total duration 17h 1m Onboard + 30m Additional time* | 4h 50m Average total duration Fastest 2h 50m Onboard + 2h 0m Additional time* | 10h 28m Average total duration (door-to-door) |
0.7 - 1.8kg CO2 emissions Lowest | 2.2 - 4.3kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Frankfurt am Main to Pisa
Compare the available ways to get from Frankfurt am Main to Pisa, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Frankfurt am Main to Pisa:
A bus is $426 less than a flight for this route with tickets for a flight from Frankfurt am Main to Pisa costing on average $552.
Other travel options to Pisa take longer:
Bus takes on average 17h 31m.
Tickets start at around $127 compared to roughly $280 in fuel and tolls — a saving of about $154. The journey takes 17h 1m versus 10h 28m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Frankfurt am Main to Pisa
How to get from Frankfurt am Main to Pisa by train, bus or flight.
Our recommendation
The best way to travel from Frankfurt am Main to Pisa is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus10:30 PM 19h35 Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) 6:05 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) $90 1 One-way 1 transfer
Cheapest
FlixBus · FlixBus10:30 PM 19h35 Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) 6:05 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) $90 1 One-way 1 transfer
Fastest
KL1822+
KL26576:35 PM 14h40 Frankfurt am Main Airport 9:15 AM Pisa International Airport $1,142 1 One-way 1 transfer
Other options
FlixBus · FlixBus · FlixBus1:05 AM 19h40 Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) 8:45 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) $90 1 One-way 2 transfers
FlixBus · FlixBus · FlixBus11:05 PM 22h30 Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) 9:35 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) $92 1 One-way 2 transfers
FlixBus · FlixBus · FlixBus10:45 PM 22h50 Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) 9:35 PM Pisa, Via delle Fiamme Gialle (Park Pietrasantina) $94 1 One-way 2 transfers
KL1818+
KL265711:45 AM 21h30 Frankfurt am Main Airport 9:15 AM Pisa International Airport $500 1 One-way 1 transfer
KL1816+
KL265710:15 AM 23h00 Frankfurt am Main Airport 9:15 AM Pisa International Airport $500 1 One-way 1 transfer
KL1814+
KL26576:50 AM 26h25 Frankfurt am Main Airport 9:15 AM Pisa International Airport $500 1 One-way 1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
More than 1,000 travel companies trust us to sell their tickets all in one place.
FAQs: Travel from Frankfurt am Main to Pisa
Travel to Pisa easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Frankfurt am Main to Pisa.

This is compared to other travel options from Frankfurt am Main to Pisa:
A bus is $426 less than a flight for this route with tickets for a flight from Frankfurt am Main to Pisa costing on average $552.
Other travel options to Pisa take longer:
Bus takes on average 17h 31m.
- Around 9 flights per day.
- Around 9 buses per day.
However, we recommend checking specific travel dates for your route between Frankfurt am Main and Pisa as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Pisa International Airport.
- Trains mostly depart from Frankfurt Airport long-distance station and arrive in Pisa Centrale.
- Buses mostly depart from Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) and arrive in Pisa, Via delle Fiamme Gialle (Park Pietrasantina).
- Travel with Transavia France, Air Dolomiti, British Airways to go to Pisa by flight.
- Travel with FlixBus to go to Pisa by bus.
- 3 direct flights per day with Air Dolomiti.
Travelling from Frankfurt am Main to Pisa: related information
Here are some other resources that might have the information you need
