The cheapest and fastest trains from Chicago, IL to Florence, SC
Cheapest price
$350
Average price
$350
Fastest journey
1 d 8 h 30 m
Average duration
1 d 8 h 30 m
Trains per day
1
Distance
1095 km
The best way to find a cheap train ticket from Chicago, IL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Florence, SC will cost around $350 if you buy it on the day, but the cheapest tickets can be found for only $350.
It's difficult to get from Chicago, IL to Florence, SC without transferring at least once.


Travel Information
Compare train and bus for Chicago, IL to Florence, SC
Omio recommends booking the bus as it is the most popular option from Chicago, IL to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from €115. For those with little time consider booking a bus which can get you there in 23h 34m. The ticket price range depends on the travel mode: a bus costs an average of €115, and a train costs an average of €231.
Distance: 680 miles (1095 km)
Compare train with
| Train | Most popular Bus |
|---|---|
€264 Average price | €127 Average price Cheapest |
25h 41m Average total duration 25h 11m Onboard + 30m Additional time* | 24h 4m Average total duration Fastest 23h 34m Onboard + 30m Additional time* |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Live departures
Chicago, IL to Florence, SC train times
The table below shows live departures for Chicago, IL to Florence, SC trains for today, Sunday, December 21. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:40 PM Chicago, IL | 32h30 | 3:10 AM Florence, SC | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Chicago, IL to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 22
Dec 23
Dec 24
Dec 25
Dec 26
Dec 27
Dec 28
Why should you book Chicago to Florence trains with Omio?
Amtrak operates all train services from Chicago to Florence. Omio is the only official third party seller for Amtrak tickets.
Why book with Omio vs Amtrak?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Amtrak with all available travel options, which are train and bus to ensure you get the best deal for traveling from Chicago to Florence.
Why book with Omio over Trainline and Rail Europe?
- Official reseller: Amtrak tickets can only be bought on Omio or Amtrak's website as Omio is the only official third party seller for Amtrak tickets. Trainline, RailEurope, and Rail.Ninja do not sell Amtrak tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Chicago to Florence.
Journey information
Overview: Train from Chicago, IL to Florence, SC
Trains from Chicago, IL to Florence, SC run on average 2 times per day, taking around 25h 11m. Cheap train tickets for this journey start at $288 (€231) but you can travel from only $143 (€115) by bus.
The earliest train runs at 17:55, the last at 23:32. The fastest train covers the 680 miles (1095 km) distance in 31h 30m.
Distance 680 miles (1095 km) |
Average train duration 25h 11m |
Cheapest ticket price $288 (€231) |
Trains per day 2 |
Fastest train 31h 30m |
First train 17:55 |
Last train 23:32 |
Train companies: Amtrak from Chicago, IL to Florence, SC trainsAmtrak trains will get you between Chicago, IL and Florence, SC from $143 (€115). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Chicago, IL to Florence, SC
Find answers to the most common questions about traveling from Chicago, IL to Florence, SC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Chicago, IL to Florence, SC
- 5:00 AM - 12:00 AM Monday - Sunday
- Free
- The car park is open 7 days a week from 5:00 a.m. to 12:00 a.m. Departures can be made outside of opening hours. Access via Canal Street.
- The Chicago Firehouse Restaurant
- Lou Mitchell's
- Outside the main entrance.
- Elevators, ramps, restrooms.
- $1
- The Kimpton Gray Hotel
- JW Marriott Chicago
- W Chicago - City Center
- Located in the main hall
- Located in the main hall
- Avis
- Budget
- Enterprise
- Located in the main hall
- Free
- Hall 1: main entrance, Amtrak services
- Hall 2: Metra services
- Hall 3: food court and retail shops
- Bus: Several lines available
- CTA: Blue Line, Pink Line
- 6:00 AM - 11:00 PM Monday - Sunday
- Parking is available at the station.
- Outside the main entrance.
- Elevators, ramps.
- Aloft Florence
- Hyatt Place Florence Downtown
- Hotel Florence, Tapestry Collection by Hilton
- Located in the main hall
- Located in the main hall
- Free
- The station has an enclosed waiting area.
- Bus: Greyhound services available nearby
Most popular train connections from Chicago, IL
More options for your journey from Chicago, IL to Florence, SC
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