Travel Information
Compare train and bus for Harrisburg, PA to Florence, SC
Omio recommends booking the train as it is the most popular option from Harrisburg, PA to Florence, SC among Omio's users. If you are prioritising price take the train with prices starting from $194. For those with little time consider booking a train which can get you there in 12h 8m. The ticket price range depends on the travel mode: a train costs an average of $194, and a bus costs an average of $183.
Distance: 448 miles (722 km)
Compare train with
Most popular Train | Bus |
|---|---|
$223 Average price Cheapest | $232 Average price |
12h 38m Average total duration Fastest 12h 8m Onboard + 30m Additional time* | 24h 23m Average total duration 23h 53m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Compare prices and tickets Harrisburg, PA to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Mar 28
Mar 29
Journey information
Overview: Train from Harrisburg, PA to Florence, SC
Trains from Harrisburg, PA to Florence, SC run on average 2 times per day, taking around 12h 8m. Cheap train tickets for this journey start at $194 (€157) but you can travel from only $183 (€148) by bus.
The earliest train runs at 05:00, the last at 23:32. The fastest train covers the 448 miles (722 km) distance in 12h 52m.
Distance 448 miles (722 km) |
Average train duration 12h 8m |
Cheapest ticket price $194 (€157) |
Trains per day 2 |
Fastest train 12h 52m |
First train 05:00 |
Last train 23:32 |
Cheapest month Dec |
Cheapest day Thu |
High season Jan - Mar |
Low season Jan - Mar |
Train companies: Amtrak from Harrisburg, PA to Florence, SC trainsAmtrak trains will get you between Harrisburg, PA and Florence, SC from $183 (€148). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Harrisburg, PA to Florence, SC
Find answers to the most common questions about traveling from Harrisburg, PA to Florence, SC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Harrisburg, PA to Florence, SC
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- Parking available on-site with both short-term and long-term options.
- The Millworks
- Bricco
- Outside the main entrance.
- Elevators, ramps, restrooms.
- $0.50
- Hilton Harrisburg
- Crowne Plaza Harrisburg-Hershey
- Radisson Hotel Harrisburg
- Located in the main hall
- Enterprise
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, ticket office, and waiting area
- Hall 2: platforms for Amtrak and regional trains
- Hall 3: bus connections and car rental services
- Bus: CAT (Capital Area Transit) services available
- Greyhound and other intercity bus services
- 6:00 AM - 11:00 PM Monday - Sunday
- Parking is available at the station.
- Outside the main entrance.
- Elevators, ramps.
- Aloft Florence
- Hyatt Place Florence Downtown
- Hotel Florence, Tapestry Collection by Hilton
- Located in the main hall
- Located in the main hall
- Free
- The station has an enclosed waiting area.
- Bus: Greyhound services available nearby
Most popular train connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to Florence, SC
Here are some other resources that might have the information you need
