Harrisburg, PA to Florence, SC train with Amtrak

Sun, Dec 21
+ Add return
Amtrak
Regionale
Deutsche Bahn
iryo
Italo
1,000+ travel companies
Amtrak
Regionale
Deutsche Bahn
iryo
Italo
1,000+ travel companies
QR-Code
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
rate4.9
42K ratings
Google Play
rate4.6
136K reviews

The cheapest and fastest trains from Harrisburg, PA to Florence, SC

Showing times and prices for Dec 22

Cheapest price

$279

Average price

$279

Fastest journey

12 h 52 m

Average duration

13 h 29 m

Trains per day

2

Distance

722 km

Cheap tickets

The best way to find a cheap train ticket from Harrisburg, PA to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Harrisburg, PA to Florence, SC will cost around $279 if you buy it on the day, but the cheapest tickets can be found for only $279.

Fast trains

It's difficult to get from Harrisburg, PA to Florence, SC without transferring at least once.

Amtrak
05:00AM12h52
Harrisburg, PA
05:52PMFlorence, SC
$2791One-way
1 transfer
Amtrak
01:05PM14h05
Harrisburg, PA
03:10AMFlorence, SC
$2791One-way
1 transfer

Live departures

Harrisburg, PA to Florence, SC train times

The table below shows live departures for Harrisburg, PA to Florence, SC trains for tomorrow, Monday, December 22. You can also manually refresh the results below to see updated train journeys.

Last updated at 11:35 PM
ProviderDepartsDurationArrivesTransfers
Tickets
amtrak5:00 AM Harrisburg, PA
12h52
5:52 PM Florence, SC1 transfer
amtrak1:05 PM Harrisburg, PA
14h05
3:10 AM Florence, SC1 transfer

This is the last train of the day.

Find all the dates and times for this journey

Compare prices and tickets Harrisburg, PA to Florence, SC by train

Compare train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Mon
Dec 22
Tue
Dec 23
Wed
Dec 24
Thu
Dec 25
Fri
Dec 26
Sat
Dec 27
Sun
Dec 28

Why should you book Harrisburg to Florence trains with Omio?

Amtrak operates all train services from Harrisburg to Florence. Omio is the only official third party seller for Amtrak tickets.

Why book with Omio vs Amtrak?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.

Why book with Omio over Trainline and Rail Europe?

Multiple modes of transport
  • Official reseller: Amtrak tickets can only be bought on Omio or Amtrak's website as Omio is the only official third party seller for Amtrak tickets. Trainline, RailEurope, and Rail.Ninja do not sell Amtrak tickets as they are not official sellers.

Journey information

Overview: Train from Harrisburg, PA to Florence, SC

USAUSA
USAUSA
Icon of train

Trains from Harrisburg, PA to Florence, SC run on average 2 times per day, taking around 12h 8m. Cheap train tickets for this journey start at $281 (€225) if you book in advance.

The earliest train runs at 05:00, the last at 23:32. The fastest train covers the 448 miles (722 km) distance in 12h 52m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
448 miles (722 km)
Average train duration
12h 8m
Cheapest ticket price
$281 (€225)
Trains per day
2
Fastest train
12h 52m
First train
05:00
Last train
23:32
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Train companies: Amtrak from Harrisburg, PA to Florence, SC trainsAmtrak trains will get you between Harrisburg, PA and Florence, SC from $281 (€225). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

Amtrak

About
Amtrak is the main passenger train operator in the United States, providing medium- and long-distance intercity services across 46 states and three Canadian provinces. Operating over 300 trains daily and serving more than 500 destinations, Amtrak connects cities and regions nationwide through routes such as the high-speed Acela in the Northeast Corridor, the scenic Coast Starlight along the West Coast, and the Empire Builder linking Chicago to the Midwest and the Pacific Northwest. Other notable services include the Northeast Regional, Keystone Service, and the unique Auto Train, which allows passengers to bring their cars onboard. Amtrak offers a variety of classes to suit different budgets and travel needs, including Coach, Business, First Class, and Sleeper Class with options like Roomettes, Bedrooms, and Bedroom Suites for overnight journeys. Ticket types include Saver, Value, Flexible, Business, and Premium. Onboard amenities vary by service but may include comfortable seating, Wi-Fi, power outlets, dining options, and lounge access on select trains. Popular routes include Washington, D.C.–Boston, San Diego–San Luis Obispo, San Jose–Sacramento, and Chicago–Seattle.
Luggage & cancellation policy
Average Duration
12h 52m
Cheapest Price
$280 (€224)
Amtrak frequency
2 a day
Luggage included
2 personal items and 2 carry-on bags included free
Luggage storage
Overhead racks, under seats, and designated luggage areas at end of cars
Cancellation Policy
Cancellation policies depend on ticket type and timing
Refund
Full refund if train is canceled by Amtrak
Amenities on board the train
Wifi
Food sold onboard
Café car with snacks, beverages, and light meals. Long-distance trains have full-service dining cars
Seat reservation
Included in ticket price for Business and First Class. Optional fee for Coach Class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible restrooms, Red Cap assistance service, accessible platforms and stations
Pets
Small pets under 20 pounds allowed for $26 fee. Must be in carrier. Service animals travel free
Quiet zone

FAQs: Trains from Harrisburg, PA to Florence, SC

Find answers to the most common questions about traveling from Harrisburg, PA to Florence, SC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

FAQs
To fully explore Florence, SC, two to three days are recommended. This allows time to visit local attractions such as the Florence County Museum, War Between the States Museum, and enjoy the local dining and shopping experiences.
A day trip from Harrisburg, PA to Florence, SC is not feasible as the journey takes 12h 52m and covers a distance of 448 miles (722 km). Additionally, the frequency is 2 trips per day for trains.
The distance by train from Harrisburg, PA to Florence, SC is 448 miles (722 km).
The first train from Harrisburg, PA to Florence, SC leaves at 5:00 AM.
Train ticket prices from Harrisburg, PA to Florence, SC can vary. The cheapest ticket starts at $281 (€225), while the average price is around $281 (€225).
The train journey from Harrisburg, PA to Florence, SC offers a mix of urban and rural scenery, with views of rolling hills, small towns, and stretches of countryside, though it is not particularly renowned for being scenic.
The last train from Harrisburg, PA to Florence, SC leaves at 11:32 PM.
The cheapest way to get from Harrisburg, PA to Florence, SC is by train, with a cost of around $281 (€225).
There is no direct train service currently available from Harrisburg, PA to Florence, SC.
There is no high speed train available from Harrisburg, PA to Florence, SC.
Yes, you can take the train from Harrisburg, PA to Florence, SC.
The train from Harrisburg, PA to Florence, SC takes 12h 52m and runs 2 per day.
The train station in Harrisburg, PA that goes to Florence, SC is Harrisburg Station, Harrisburg, PA, which connects to Florence Station, Florence, SC.
Unfortunately, there is no night train available from Harrisburg, PA to Florence, SC.

popular train stations

Popular train stations from Harrisburg, PA to Florence, SC

Harrisburg
Florence
The major train station for departures in Harrisburg is Harrisburg Station. Find all the information you need to know about services, amenities and connections at Harrisburg Station for your trip from Harrisburg to Florence.
Harrisburg StationWifiLockersParkingDiningATMTaxisAccessibilityWCHotelLost and Found OfficeTicket OfficeBike ParkingCar RentalInformation DeskLuggage Carts
Amenities at train station
WifiWifi
LockersLockers
ParkingParking
DiningDining
ATMATM
TaxisTaxis
AccessibilityAccessibility
WCWC
HotelHotel
Lost and Found OfficeLost and Found Office
Ticket OfficeTicket Office
Bike ParkingBike Parking
Car RentalCar Rental
Information DeskInformation Desk
Luggage CartsLuggage Carts
information
phone
Phone Number
ticketOfficeHours
Ticket Office Hours
  • 6:00 AM - 10:00 PM Monday - Sunday
ticketOfficeHours
Distance to city center
1 km
platformCount
Number of platforms
5
Wifi
Wifi
  • Free
Parking
Parking
  • Parking available on-site with both short-term and long-term options.
Dining
Dining
  • The Millworks
  • Bricco
Taxis
Taxis
  • Outside the main entrance.
Accessibility
Accessibility
  • Elevators, ramps, restrooms.
WC
WC
  • $0.50
Hotel
Hotel
  • Hilton Harrisburg
  • Crowne Plaza Harrisburg-Hershey
  • Radisson Hotel Harrisburg
Lost and Found Office
Lost and Found Office
  • Located in the main hall
Car Rental
Car Rental
  • Enterprise
  • Hertz
Information Desk
Information Desk
  • Located in the main hall
Luggage Carts
Luggage Carts
  • Free
Station Plan
  • Hall 1: main entrance, ticket office, and waiting area
  • Hall 2: platforms for Amtrak and regional trains
  • Hall 3: bus connections and car rental services
Public transit options for Harrisburg Station
  • Bus: CAT (Capital Area Transit) services available
  • Greyhound and other intercity bus services

More options for your journey from Harrisburg, PA to Florence, SC

Here are some other resources that might have the information you need

Most popular trains to and from Florence, SC and Harrisburg, PA

HomeTrainsTrains in USATrain Times to Florence, SCHarrisburg, PA to Florence, SC train

The Omio App Makes Travel Planning Easy

We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.

ios-badge
android-badge
Hand With Phone