- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
Trains from Harrisburg, PA to Florence, SC run on average 2 times per day, taking around 13h 39m. Cheap train tickets for this journey start at $199 (€167) but you can travel from only $119 (€100) by bus.
The earliest train runs at 05:00, the last at 23:32. The fastest train covers the 448 miles (722 km) distance in 12h 49m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Harrisburg, PA to Florence, SC.
Trains from Harrisburg, PA to Florence, SC with Amtrak. Night trains available on this route with Amtrak. High-speed trains available on this route with Amtrak. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
Pulled pork barbecue is a Pee Dee staple, slow-smoked until tender and served with the region's tangy vinegar-pepper sauce.
Smoked pork ribs are common at local barbecue joints, seasoned simply and cooked low and slow for deep smoke flavor.
Shrimp and grits is a South Carolina classic: local shrimp over creamy grits, often enriched with bacon, gravy, or butter.
Upscale downtown restaurant serving refined Southern dishes, steaks, seafood, and cocktails in a polished space.
Casual local favorite for Carolina barbecue, ribs, and classic Southern sides in a relaxed family setting.
Popular casual spot known for barbecue plates, pulled pork, and generous Southern comfort food portions.
Moderate by U.S. small-city standards. Hotels are usually cheaper than major tourist cities, while dining and car-based transport remain fairly typical for the region.
Tip 15-20% at restaurants. Round up or add 10-15% for taxis if service is good. Small change is fine at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Florence, SC.
Find answers to the most common questions about traveling from Harrisburg, PA to Florence, SC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

Most Harrisburg, PA to Florence, SC trains use the Harrisburg Station to Florence Station station pair. Use this guide to compare Harrisburg, PA and Florence, SC train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Harrisburg Station is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg Station has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: The Millworks, Bricco
Free. ATMs are available in the train station.
Ticket office support is available at Harrisburg Station. Information desks are located in the main hall.
Luggage storage is available at Harrisburg Station. Lost and found is available at the station.
Available at Harrisburg Station: Parking, Taxis, WC.
Available at Harrisburg Station: Bike Parking, Car Rental.
Accessibility facilities are available at Harrisburg Station: Elevators, ramps, restrooms.
Nearby hotels include Hilton Harrisburg, Crowne Plaza Harrisburg-Hershey, Radisson Hotel Harrisburg.
Florence Station has practical services for this route, including Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Information Desk, and Luggage Carts.
Food and drink options are available at Florence Station.
Ticket office support is available at Florence Station. Information desks are located in the main hall.
Luggage storage is available at Florence Station. Lost and found is available at the station.
Available at Florence Station: Parking, Taxis, WC.
Accessibility facilities are available at Florence Station: Elevators, ramps.
Nearby hotels include Aloft Florence, Hyatt Place Florence Downtown, Hotel Florence, Tapestry Collection by Hilton.
Check train stations information for Harrisburg, PA and Florence, SC, including where trains depart and arrive on this route.