The cheapest and fastest trains from Harrisburg, PA to Florence, SC
Cheapest price
$266
Average price
$266
Fastest journey
12 h 52 m
Average duration
12 h 52 m
Trains per day
1
Distance
722 km
The best way to find a cheap train ticket from Harrisburg, PA to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Florence, SC will cost around $266 if you buy it on the day, but the cheapest tickets can be found for only $266.
Of the 1 trains that leave Harrisburg, PA for Florence, SC on Thu, May 07, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, May 07 the direct trains cover the 722 km distance in an average of 12 h 52 m but if you time it right, some trains will get you there in just 12 h 52 m .
On Thu, May 07 the slowest trains will take 12 h 52 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
10:00 AM12h52Harrisburg, PA10:52 PMFlorence, SC$2661One-way0 transfers
10:00 AM12h52Harrisburg, PA10:52 PMFlorence, SC$2661One-way0 transfers
Travel Information
Compare bus and train for Harrisburg, PA to Florence, SC
Omio recommends booking the train as it is the most popular option from Harrisburg, PA to Florence, SC among Omio's users. If you are prioritising price take the train with prices starting from $198. For those with little time consider booking a train which can get you there in 12h 8m. The ticket price range depends on the travel mode: a train costs an average of $198, and a bus costs an average of $186.
Distance: 448 miles (722 km)
Compare train with
Most popular Train | Bus |
|---|---|
$227 Average price Cheapest | $236 Average price |
12h 38m Average total duration Fastest 12h 8m Onboard + 30m Additional time* | 24h 23m Average total duration 23h 53m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Harrisburg, PA to Florence, SC train times
The table below shows live departures for Harrisburg, PA to Florence, SC trains for tomorrow, Thursday, May 7. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 10:00 AM Harrisburg, PA | 12h52 | 10:52 PM Florence, SC | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Harrisburg, PA to Florence, SC by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 07
May 08
May 09
May 10
May 11
May 12
May 13
Journey information
Overview: Train from Harrisburg, PA to Florence, SC
Trains from Harrisburg, PA to Florence, SC run on average 2 times per day, taking around 12h 8m. Cheap train tickets for this journey start at $198 (€157) but you can travel from only $186 (€148) by bus.
The earliest train runs at 05:00, the last at 23:32. The fastest train covers the 448 miles (722 km) distance in 12h 52m.
Distance 448 miles (722 km) |
Average train duration 12h 8m |
Cheapest ticket price $198 (€157) |
Trains per day 2 |
Fastest train 12h 52m |
First train 5:00 AM |
Last train 11:32 PM |
Cheapest Month Dec |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Oct - Dec |
Train companies: Amtrak from Harrisburg, PA to Florence, SC trainsAmtrak trains will get you between Harrisburg, PA and Florence, SC from $186 (€148). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Harrisburg, PA to Florence, SC
Find answers to the most common questions about traveling from Harrisburg, PA to Florence, SC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Harrisburg, PA to Florence, SC
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- Parking available on-site with both short-term and long-term options.
- The Millworks
- Bricco
- Outside the main entrance.
- Elevators, ramps, restrooms.
- $0.50
- Hilton Harrisburg
- Crowne Plaza Harrisburg-Hershey
- Radisson Hotel Harrisburg
- Located in the main hall
- Enterprise
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, ticket office, and waiting area
- Hall 2: platforms for Amtrak and regional trains
- Hall 3: bus connections and car rental services
- Bus: CAT (Capital Area Transit) services available
- Greyhound and other intercity bus services
- 6:00 AM - 11:00 PM Monday - Sunday
- Parking is available at the station.
- Outside the main entrance.
- Elevators, ramps.
- Aloft Florence
- Hyatt Place Florence Downtown
- Hotel Florence, Tapestry Collection by Hilton
- Located in the main hall
- Located in the main hall
- Free
- The station has an enclosed waiting area.
- Bus: Greyhound services available nearby
Most popular train connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to Florence, SC
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