- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
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Travel Information
Compare bus for Harrisburg, PA to Florence, SC
Omio recommends booking the bus as it is the most popular option from Harrisburg, PA to Florence, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $185 For those with little time, consider booking a bus, which has an average total journey time of 12h 3m. Average ticket prices depend on the travel mode: a bus costs an average of $185, while a bus costs an average of $185.
Distance: 448 miles (722 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
$185 Average price Cheapest | $105 Average price (fuel + tolls) |
12h 3m Average total duration Fastest 11h 33m Onboard + 30m Additional time* | 8h 13m Average total duration (door-to-door) |
 Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
The cheapest way to travel from Harrisburg, PA to Florence, SC is a bus with an average price of $185 (€151).
This is compared to other travel options from Harrisburg, PA to Florence, SC:
A bus is $190 (€156) less than a train for this route with tickets for a train from Harrisburg, PA to Florence, SC costing on average $375 (€307).
The fastest way to travel from Harrisburg, PA to Florence, SC is by bus with an average journey time of 11h 33m.
Other travel options to Florence, SC take longer:
Train takes on average 13h 52m.
Yes, you can take a bus between Harrisburg, PA and Florence, SC.
We recommend using the train as it is the most popular way to get from Harrisburg, PA to Florence, SC among Omio's users.
Take the train. It's the cheaper option, and the extra time on board is usually more relaxing than driving it.
Tickets start at around $375 (€307) compared to roughly $105 (€86) in fuel and tolls — a saving of about $-270.71 (€-221.53). The journey takes 13h 52m versus 8h 13m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Compare prices and tickets Harrisburg, PA to Florence, SC by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Train from Harrisburg, PA to Florence, SC
USAUSA
Trains from Harrisburg, PA to Florence, SC run on average 2 times per day, taking around 13h 52m. Cheap train tickets for this journey start at $356 (€291) but you can travel from only $122 (€99) by bus.
The earliest train runs at 05:00, the last at 23:32. The fastest train covers the 448 miles (722 km) distance in 12h 49m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $122 (€99)
Distance 448 miles (722 km) |
Average train duration 13h 52m |
Cheapest ticket price $356 (€291) |
Trains per day 2 |
Fastest train 12h 49m |
First train 5:00 AM |
Last train 11:32 PM |
Cheapest Month Mar |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $122 (€99)
Train companies: Amtrak from Harrisburg, PA to Florence, SC trainsAmtrak trains will get you between Harrisburg, PA and Florence, SC from $122 (€99). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
About
Amtrak is the main passenger train operator in the United States, providing medium- and long-distance intercity services across 46 states and three Canadian provinces. Operating over 300 trains daily and serving more than 500 destinations, Amtrak connects cities and regions nationwide through routes such as the high-speed Acela in the Northeast Corridor, the scenic Coast Starlight along the West Coast, and the Empire Builder linking Chicago to the Midwest and the Pacific Northwest. Other notable services include the Northeast Regional, Keystone Service, and the unique Auto Train, which allows passengers to bring their cars onboard. Amtrak offers a variety of classes to suit different budgets and travel needs, including Coach, Business, First Class, and Sleeper Class with options like Roomettes, Bedrooms, and Bedroom Suites for overnight journeys. Ticket types include Saver, Value, Flexible, Business, and Premium. Onboard amenities vary by service but may include comfortable seating, Wi-Fi, power outlets, dining options, and lounge access on select trains. Popular routes include Washington, D.C.–Boston, San Diego–San Luis Obispo, San Jose–Sacramento, and Chicago–Seattle.
Luggage & cancellation policy
Average Amtrak Duration
12h 49m
Cheapest Amtrak Price
$356 (€291)
Amtrak frequency
2 a day
Luggage included
2 personal items and 2 carry-on bags included free
Luggage storage
Overhead racks, under seats, and designated luggage areas at end of cars
Cancellation Policy
Cancellation policies depend on ticket type and timing
Refund
Full refund if train is canceled by Amtrak
Amenities on board the train
Wifi
Food sold onboard
Café car with snacks, beverages, and light meals. Long-distance trains have full-service dining cars
Seat reservation
Included in ticket price for Business and First Class. Optional fee for Coach Class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible restrooms, Red Cap assistance service, accessible platforms and stations
Pets
Small pets under 20 pounds allowed for $26 fee. Must be in carrier. Service animals travel free
Quiet zone
Complete guide to Florence, SC
Things to do in Florence, SC
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
- Must visit
Galleria dell'Accademia
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
- Recommended
Museo dell'Opera del Duomo
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
- Must visit
Piazza della Signoria
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
- Must visit
Piazzale Michelangelo
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
- Recommended
Boboli Gardens
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
FAQs: Trains from Harrisburg, PA to Florence, SC
Find answers to the most common questions about traveling from Harrisburg, PA to Florence, SC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
Train ticket prices from Harrisburg, PA to Florence, SC can vary. The cheapest ticket starts at $356 (€291), while the average price is around $375 (€307).
The train from Harrisburg, PA to Florence, SC takes 12h 49m and runs 2 per day.
The distance by train from Harrisburg, PA to Florence, SC is 448 miles (722 km).
The first train from Harrisburg, PA to Florence, SC leaves at 5:00 AM.
The last train from Harrisburg, PA to Florence, SC leaves at 11:32 PM.
There is no high speed train available from Harrisburg, PA to Florence, SC.
There is no direct train service currently available from Harrisburg, PA to Florence, SC.
Unfortunately, there is no night train available from Harrisburg, PA to Florence, SC.
The train station in Harrisburg, PA that goes to Florence, SC is Harrisburg Station, Harrisburg, PA, which connects to Florence Station, Florence, SC.
The cheapest way to get from Harrisburg, PA to Florence, SC is by bus, with a cost of around $122 (€99).
The train journey from Harrisburg, PA to Florence, SC offers a mix of urban and rural scenery, with views of rolling hills, small towns, and stretches of countryside, though it is not particularly renowned for being scenic.
A day trip from Harrisburg, PA to Florence, SC is not feasible as the journey takes 12h 49m and covers a distance of 448 miles (722 km). Additionally, the frequency is 2 trips per day for trains.
To fully explore Florence, SC, two to three days are recommended. This allows time to visit local attractions such as the Florence County Museum, War Between the States Museum, and enjoy the local dining and shopping experiences.
Yes, you can take the train from Harrisburg, PA to Florence, SC.
Since neither Harrisburg, PA nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
Popular day trips by train from Florence, SC include Charleston, SC, Kingstree, SC.
We recommend using the train as it is the most popular way to get from Harrisburg, PA to Florence, SC among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular train stations
Popular train stations from Harrisburg, PA to Florence, SC
Most Harrisburg, PA to Florence, SC trains use the Harrisburg Station to Florence Station station pair. Use this guide to compare Harrisburg, PA and Florence, SC train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Departure train stations in Harrisburg
Arrival train stations in Florence
Which Harrisburg, PA station do trains to Florence, SC leave from?
Trains from Harrisburg, PA to Florence, SC leave from Harrisburg Station. The station is 0 miles (1 km) from Harrisburg, PA city centre at 4th and Chestnut Streets, Harrisburg, PA 17101, USA.
Harrisburg Station4th and Chestnut Streets, Harrisburg, PA 17101, USA+1 800-872-7245
City-centre transport
Getting to Harrisburg Station from Harrisburg city centre
Harrisburg Station is 1 km from Harrisburg city centre. Public transport options include:
Bus2, 7, 81X, A, B, C, D, M, E, 322 · 6m · $2 · every ~6 min
2, M, 7, D, A, B, 81X, C, 322, E · 7m · $2 · every ~6 min
Hbg Com Kng B · 15m · $2
Harrisburg Station train station facilities and services
Harrisburg Station has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food and drink
Food options include: The Millworks, Bricco
Wi-Fi and ATMs
Free. ATMs are available in the train station.
Tickets and information
Ticket office support is available at Harrisburg Station. Information desks are located in the main hall.
Luggage and lost property
Luggage storage is available at Harrisburg Station. Lost and found is available at the station.
Parking, taxis and toilets
Available at Harrisburg Station: Parking, Taxis, WC.
Bike and car services
Available at Harrisburg Station: Bike Parking, Car Rental.
Accessibility
Accessibility facilities are available at Harrisburg Station: Elevators, ramps, restrooms.
Shops, hotels and contact
Nearby hotels include Hilton Harrisburg, Crowne Plaza Harrisburg-Hershey, Radisson Hotel Harrisburg.
Which Florence, SC station do trains from Harrisburg, PA arrive at?
Trains from Harrisburg, PA to Florence, SC arrive at Florence Station. Florence Station is 0 miles (1 km) from Florence, SC city centre.
Florence Station805 East Day Street, Florence, SC 29506, USA+1 800-872-7245
City-centre transport
Getting to Florence Station from Florence city centre
BusGreyhound services available nearby
Florence Station train station facilities and services
Florence Station has practical services for this route, including Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Information Desk, and Luggage Carts.
Food and drink
Food and drink options are available at Florence Station.
Tickets and information
Ticket office support is available at Florence Station. Information desks are located in the main hall.
Luggage and lost property
Luggage storage is available at Florence Station. Lost and found is available at the station.
Parking, taxis and toilets
Available at Florence Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence Station: Elevators, ramps.
Shops, hotels and contact
Nearby hotels include Aloft Florence, Hyatt Place Florence Downtown, Hotel Florence, Tapestry Collection by Hilton.
Most popular train connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to Florence, SC
Here are some other resources that might have the information you need
Most popular trains to and from Florence, SC and Harrisburg, PA
Most popular train connections to Florence, SC
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