- Must visit
Ernest Hemingway Home and Museum
The Ernest Hemingway Home and Museum lets visitors tour the writer's residence, gardens, and rooms tied to his Key West years.
The best way to find a cheap bus ticket from Tampa, FL to Key West, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Tampa, FL to Key West, FL will cost around €139 if you buy it on the day, but the cheapest tickets can be found for only €135.
It's difficult to get from Tampa, FL to Key West, FL without transferring at least once.
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Buses from Tampa, FL to Key West, FL run on average 4 times per day, taking around 11h 44m. Cheap bus tickets for this journey start at €37 if you book in advance.
The earliest bus runs at 10:00, the last at 22:35. The fastest bus covers the 237 miles (383 km) distance in 11h 0m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Tampa, FL to Key West, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 04:00PM | Arrival Time 09:30AM | Duration 17h30 | Departure days Mon, Tue, Wed, Thu, Fri | Cheapest price €49 |
Operator Greyhound | Departure Time 04:35PM | Arrival Time 09:30AM | Duration 16h55 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price €49 |
Operator Greyhound | Departure Time 08:15PM | Arrival Time 09:30AM | Duration 13h15 | Departure days Sun | Cheapest price €140 |
Operator FlixBus | Departure Time 10:25PM | Arrival Time 12:30PM | Duration 14h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price €55 |
Operator Greyhound | Departure Time 10:25PM | Arrival Time 03:30PM | Duration 17h05 | Departure days Wed | Cheapest price €51 |
Operator FlixBus | Departure Time 10:35PM | Arrival Time 12:30PM | Duration 13h55 | Departure days Everyday | Cheapest price €51 |
The table below shows live departures for Tampa, FL to Key West, FL buses for today, Saturday, October 31. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus+![]() | 10:25 PM Tampa, USF Holly Drive (Central Plant), FL | 15h05 | 12:30 PM Key West, South Roosevelt Boulevard (Key West International Airport), FL | 2 transfers | |
FlixBus+![]() | 10:35 PM Tampa, Marion Transit Center | 14h55 | 12:30 PM Key West, South Roosevelt Boulevard (Key West International Airport), FL | 1 transfer | |
| Sunday, November 1 | |||||
FlixBus+ · | 4:35 PM Tampa, USF Holly Drive (Central Plant), FL | 16h55 | 9:30 AM Key West, South Roosevelt Boulevard (Key West International Airport), FL | 2 transfers | |
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Find all the dates and times for this journey
Buses from Tampa, FL to Key West, FL with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Key West, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Key West, FL trip today.
The Ernest Hemingway Home and Museum lets visitors tour the writer's residence, gardens, and rooms tied to his Key West years.
The Key West Butterfly and Nature Conservatory features a glass habitat with butterflies, birds, and tropical plants in a calm setting.
The Key West Museum of Art and History at the Custom House presents island history, art, and rotating exhibitions in a grand landmark building.
Duval Street is Key West's main historic thoroughfare, lined with shops, galleries, and lively architecture across the old town.
Mallory Square is a waterfront plaza known for harbor views, public space, and easy access to the historic seaport district.
Fort Zachary Taylor Historic State Park combines a coastal fort, walking paths, shaded grounds, and one of the island's best natural beaches.
Tangy pie made with Key lime juice, sweetened condensed milk, and a graham cracker crust. It is the island's signature dessert and a classic Florida Keys specialty.
Fresh local pink shrimp, usually simply peeled and chilled or lightly cooked. They are prized in the Keys for their sweet flavor and local waters.
Whole snapper, often yellowtail, seasoned and grilled or baked. It reflects Key West's strong fishing culture and the abundance of fresh local catch.
Polished seafood restaurant focused on Florida fish, oysters, and seasonal ingredients in a refined but approachable dining room.
Beloved casual spot for Cuban coffee, breakfast, sandwiches, and Cuban toast. A dependable choice for everyday local flavors.
Historic seafood house known for pink shrimp, conch dishes, and classic Key lime pie in a lively, casual Old Town setting.
Very pricey versus many US beach towns; hotels, seafood, and drinks run high, while transit is limited and parking can add costs.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and small change at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Key West, FL.
Find answers to the most common questions about traveling from Tampa, FL to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

Most Tampa, FL to Key West, FL buses use the Tampa, Marion Transit Center to Key West, South Roosevelt Boulevard (Key West International Airport) station pair. Use this guide to compare Tampa, FL and Key West, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Tampa, Marion Transit Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, Marion Transit Center. ATMs are available at Tampa, Marion Transit Center.
Ticket office support is available at Tampa, Marion Transit Center.
Available at Tampa, Marion Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at Tampa, Marion Transit Center: Wheelchair accessible with ramps.
Tampa, USF Holly Drive (Central Plant) is 13 km from Tampa city centre. Public transport options include:
Tampa, USF Holly Drive (Central Plant) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, USF Holly Drive (Central Plant). ATMs are available at Tampa, USF Holly Drive (Central Plant).
Ticket office support is available at Tampa, USF Holly Drive (Central Plant).
Available at Tampa, USF Holly Drive (Central Plant): Parking, Taxis, WC.
Accessibility facilities are available at Tampa, USF Holly Drive (Central Plant): Wheelchair accessible facilities.
Key West, South Roosevelt Boulevard (Key West International Airport) is 2 km from Key West city centre. Public transport options include:
Key West, South Roosevelt Boulevard (Key West International Airport) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Key West, South Roosevelt Boulevard (Key West International Airport). ATMs are available at Key West, South Roosevelt Boulevard (Key West International Airport).
Ticket office support is available at Key West, South Roosevelt Boulevard (Key West International Airport).
Available at Key West, South Roosevelt Boulevard (Key West International Airport): Parking, Taxis, WC.
Accessibility facilities are available at Key West, South Roosevelt Boulevard (Key West International Airport): The station is wheelchair accessible.
Check bus stations information for Tampa, FL and Key West, FL, including where buses depart and arrive on this route.