Travel Information
Compare bus and flight for Orlando, FL to Key West, FL
Omio recommends booking the bus as it is the most popular option from Orlando, FL to Key West, FL among Omio's users. If you are prioritising price take the bus with prices starting from €39. For those with little time consider booking a flight which can get you there in 1h 55m. The ticket price range depends on the travel mode: a bus costs an average of €39, and a flight costs an average of €34.
Distance: 276 miles (445 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
€52 Average price Cheapest | €122 Average price |
9h 48m Average total duration 9h 18m Onboard + 30m Additional time* | 4h 55m Average total duration Fastest 1h 55m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Compare prices and tickets Orlando, FL to Key West, FL by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Orlando, FL to Key West, FL
Buses from Orlando, FL to Key West, FL run on average 5 times per day, taking around 9h 18m. Cheap bus tickets for this journey start at $49 (€39) but you can travel from only $43 (€34) by flight.
The earliest bus runs at 00:45, the last at 22:35. The fastest bus covers the 276 miles (445 km) distance in 9h 25m.
Distance 276 miles (445 km) |
Average bus duration 9h 18m |
Cheapest ticket price $49 (€39) |
Buses per day 5 |
Fastest bus 9h 25m |
First bus 00:45 |
Last bus 22:35 |
Bus providers: FlixBus, Greyhound from Orlando, FL to Key West, FLYou can travel by bus between Orlando, FL to Key West, FL with FlixBus, Greyhound for as low as $43 (€34). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Orlando, FL to Key West, FL
Find answers to the most common questions about traveling from Orlando, FL to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Ernest Hemingway Home and Museum, the former residence of the famous author featuring guided tours and a colony of six-toed cats
- Key West Butterfly and Nature Conservatory, a lush habitat housing hundreds of butterflies and exotic birds
- Fort Zachary Taylor Historic State Park, a Civil War-era fort offering beach access, snorkeling, and picnic areas
- Mallory Square, a waterfront plaza known for its nightly sunset celebrations and street performances
- Key West Lighthouse and Keeper's Quarters Museum, offering panoramic views of the island and insights into maritime history.
- Duval Street, stroll along the vibrant street lined with shops, bars, and restaurants
- Dry Tortugas National Park, visit the remote park known for its historic fort and snorkeling opportunities
- Southernmost Point Buoy, take a photo at the iconic landmark marking the southernmost point in the continental USA
- Key West Ghost and Mysteries Tour, embark on a guided tour exploring the haunted history of the island
- Fury Water Adventures, enjoy a variety of water sports including snorkeling, parasailing, and sunset cruises.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Orlando, FL to Key West, FL, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- Additional luggage can be purchased for a fee.
- Greyhound
- $15 per additional bag.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
popular bus stations
Popular bus stations from Orlando, FL to Key West, FL
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