Travel Information
Compare bus and flight for Detroit, MI to Key West, FL
Omio recommends booking the bus as it is the most popular option from Detroit, MI to Key West, FL among Omio's users. If you are prioritising price take the bus with prices starting from $229. For those with little time consider booking a flight which can get you there in 5h 58m. The ticket price range depends on the travel mode: a bus costs an average of $229, and a flight costs an average of $244.
Distance: 1230 miles (1980 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$245 Average price Cheapest | $332 Average price | $301 Average price (fuel + tolls) |
42h 40m Average total duration 42h 10m Onboard + 30m Additional time* | 8h 58m Average total duration Fastest 5h 58m Onboard + 3h 0m Additional time* | 23h 9m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Detroit, MI to Key West, FL:
A bus is $87 (€71) less than a flight for this route with tickets for a flight from Detroit, MI to Key West, FL costing on average $332 (€272).
Other travel options to Key West, FL take longer:
Bus takes on average 42h 10m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Detroit, MI to Key West, FL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:15AM | Arrival Time 07:30PM | Duration 43h15 | Departure days Fri | Cheapest price $271 |
Operator Greyhound | Departure Time 12:30AM | Arrival Time 05:30PM | Duration 41h00 | Departure days Sun | Cheapest price $229 |
Operator Greyhound | Departure Time 01:15AM | Arrival Time 07:30PM | Duration 42h15 | Departure days Sun | Cheapest price $234 |
Operator Greyhound USA | Departure Time 07:15AM | Arrival Time 01:02PM | Duration 53h47 | Departure days Wed, Fri | Cheapest price $407 |
Compare prices and tickets Detroit, MI to Key West, FL by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Detroit, MI to Key West, FL buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Detroit, MI to Key West, FL.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Detroit, MI to Key West, FL.
Journey information
Overview: Bus from Detroit, MI to Key West, FL
Buses from Detroit, MI to Key West, FL run on average 2 times per day, taking around 42h 10m. Cheap bus tickets for this journey start at $229 (€187) if you book in advance.
The earliest bus runs at 00:15, the last at 01:15. The fastest bus covers the 1230 miles (1980 km) distance in 41h 0m.
Distance 1230 miles (1980 km) |
Average bus duration 42h 10m |
Cheapest ticket price $229 (€187) |
Buses per day 2 |
Fastest bus 41h 0m |
First bus 12:15 AM |
Last bus 1:15 AM |
Cheapest Month Feb |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Oct - Dec |
Best time to book 70 days |
Bus providers: Greyhound from Detroit, MI to Key West, FLYou can travel by bus between Detroit, MI to Key West, FL with Greyhound for as low as $229 (€187). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Detroit, MI to Key West, FL
Find answers to the most common questions about traveling from Detroit, MI to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Ernest Hemingway Home and Museum, the former residence of the famous author featuring guided tours and a colony of six-toed cats
- Key West Butterfly and Nature Conservatory, a lush habitat housing hundreds of butterflies and exotic birds
- Fort Zachary Taylor Historic State Park, a Civil War-era fort offering beach access, snorkeling, and picnic areas
- Mallory Square, a waterfront plaza known for its nightly sunset celebrations and street performances
- Key West Lighthouse and Keeper's Quarters Museum, offering panoramic views of the island and insights into maritime history.
- Duval Street, stroll along the vibrant street lined with shops, bars, and restaurants
- Dry Tortugas National Park, visit the remote park known for its historic fort and snorkeling opportunities
- Southernmost Point Buoy, take a photo at the iconic landmark marking the southernmost point in the continental USA
- Key West Ghost and Mysteries Tour, embark on a guided tour exploring the haunted history of the island
- Fury Water Adventures, enjoy a variety of water sports including snorkeling, parasailing, and sunset cruises.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Detroit, MI to Key West, FL
Most Detroit, MI to Key West, FL buses use the Detroit, Greyhound Terminal to Key West, South Roosevelt Boulevard (Key West International Airport) station pair. Use this guide to compare Detroit, MI and Key West, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Most popular bus connections from Detroit, MI
More options for your journey from Detroit, MI to Key West, FL
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