The cheapest and fastest buses from Detroit, MI to Key West, FL
Cheapest price
$642
Average price
$642
Fastest journey
2 d 5 h
Average duration
2 d 5 h
Buses per day
1
Distance
1980 km
The best way to find a cheap bus ticket from Detroit, MI to Key West, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Detroit, MI to Key West, FL will cost around $642 if you buy it on the day, but the cheapest tickets can be found for only $642.
It's difficult to get from Detroit, MI to Key West, FL without transferring at least 2 times.


Live departures
Detroit, MI to Key West, FL bus times
The table below shows live departures for Detroit, MI to Key West, FL buses for tomorrow, Sunday, December 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:40 AM Detroit, MI | 53h00 | 11:40 AM Key West, FL | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Detroit, MI to Key West, FL by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Detroit, MI to Key West, FL
Buses from Detroit, MI to Key West, FL run on average 2 times per day, taking around 53h 0m. Cheap bus tickets for this journey start at $650 (€521) if you book in advance.
The earliest bus runs at 06:40, the last at 06:40. The fastest bus covers the 1230 miles (1980 km) distance in 53h 0m.
Distance 1230 miles (1980 km) |
Average bus duration 53h 0m |
Cheapest ticket price $650 (€521) |
Buses per day 2 |
Fastest bus 53h 0m |
First bus 06:40 |
Last bus 06:40 |
Bus providers: Greyhound from Detroit, MI to Key West, FLYou can travel by bus between Detroit, MI to Key West, FL with Greyhound for as low as $650 (€521). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Detroit, MI to Key West, FL
Find answers to the most common questions about traveling from Detroit, MI to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Ernest Hemingway Home and Museum, the former residence of the famous author featuring guided tours and a colony of six-toed cats
- Key West Butterfly and Nature Conservatory, a lush habitat housing hundreds of butterflies and exotic birds
- Fort Zachary Taylor Historic State Park, a Civil War-era fort offering beach access, snorkeling, and picnic areas
- Mallory Square, a waterfront plaza known for its nightly sunset celebrations and street performances
- Key West Lighthouse and Keeper's Quarters Museum, offering panoramic views of the island and insights into maritime history.
- Duval Street, stroll along the vibrant street lined with shops, bars, and restaurants
- Dry Tortugas National Park, visit the remote park known for its historic fort and snorkeling opportunities
- Southernmost Point Buoy, take a photo at the iconic landmark marking the southernmost point in the continental USA
- Key West Ghost and Mysteries Tour, embark on a guided tour exploring the haunted history of the island
- Fury Water Adventures, enjoy a variety of water sports including snorkeling, parasailing, and sunset cruises.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Detroit, MI to Key West, FL, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Detroit, MI to Key West, FL
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