Compare prices and tickets Gainesville, FL to Key West, FL by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Gainesville, FL to Key West, FL buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Gainesville, FL to Key West, FL
Buses from Gainesville, FL to Key West, FL run on average 5 times per day, taking around 25h 30m. Cheap bus tickets for this journey start at $100 (€81) if you book in advance.
The earliest bus runs at 13:00, the last at 13:00. The fastest bus covers the 353 miles (569 km) distance in 25h 30m.
Distance 353 miles (569 km) |
Average bus duration 25h 30m |
Cheapest ticket price $100 (€81) |
Buses per day 5 |
Fastest bus 25h 30m |
First bus 13:00 |
Last bus 13:00 |
Bus providers: FlixBus from Gainesville, FL to Key West, FLYou can travel by bus between Gainesville, FL to Key West, FL with FlixBus for as low as $100 (€81). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Gainesville, FL to Key West, FL
Find answers to the most common questions about traveling from Gainesville, FL to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Ernest Hemingway Home and Museum, the former residence of the famous author featuring guided tours and a colony of six-toed cats
- Key West Butterfly and Nature Conservatory, a lush habitat housing hundreds of butterflies and exotic birds
- Fort Zachary Taylor Historic State Park, a Civil War-era fort offering beach access, snorkeling, and picnic areas
- Mallory Square, a waterfront plaza known for its nightly sunset celebrations and street performances
- Key West Lighthouse and Keeper's Quarters Museum, offering panoramic views of the island and insights into maritime history.
- Duval Street, stroll along the vibrant street lined with shops, bars, and restaurants
- Dry Tortugas National Park, visit the remote park known for its historic fort and snorkeling opportunities
- Southernmost Point Buoy, take a photo at the iconic landmark marking the southernmost point in the continental USA
- Key West Ghost and Mysteries Tour, embark on a guided tour exploring the haunted history of the island
- Fury Water Adventures, enjoy a variety of water sports including snorkeling, parasailing, and sunset cruises.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Gainesville, FL to Key West, FL
Most popular bus connections from Gainesville, FL
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