- Must visit
Ernest Hemingway Home and Museum
The Ernest Hemingway Home and Museum lets visitors tour the writer's residence, gardens, and rooms tied to his Key West years.
Buses from Gainesville, FL to Key West, FL run on average 5 times per day, taking around 14h 15m. Cheap bus tickets for this journey start at CHF 42 if you book in advance.
The earliest bus runs at 10:00, the last at 17:00. The fastest bus covers the 353 miles (569 km) distance in 11h 20m.
Distance 353 miles (569 km) |
Average bus duration 14h 15m |
Cheapest ticket price CHF 42 |
Buses per day 5 |
Fastest bus 11h 20m |
First bus 10:00 AM |
Last bus 5:00 PM |
Cheapest Month Aug |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Gainesville, FL to Key West, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:35AM | Arrival Time 03:30PM | Duration 14h55 | Departure days Sat | Cheapest price CHF 110 |
Operator Greyhound | Departure Time 08:20AM | Arrival Time 09:30AM | Duration 25h10 | Departure days Sat | Cheapest price CHF 110 |
Operator Greyhound | Departure Time 07:00PM | Arrival Time 09:30AM | Duration 14h30 | Departure days Sat | Cheapest price CHF 88 |
Operator Greyhound | Departure Time 11:20PM | Arrival Time 03:30PM | Duration 16h10 | Departure days Sat | Cheapest price CHF 88 |
The table below shows live departures for Gainesville, FL to Key West, FL buses for today, Saturday, November 14. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
· · · | 8:20 AM Gainesville, NW 23rd St (North Walmart Supercenter), FL | 25h10 | 9:30 AM Key West, South Roosevelt Boulevard (Key West International Airport), FL | 3 transfers | |
FlixBus+ · | 7:00 PM Gainesville, Rosa Parks Transfer station | 14h30 | 9:30 AM Key West, South Roosevelt Boulevard (Key West International Airport), FL | 2 transfers | |
FlixBus+ · | 11:20 PM Gainesville, Rosa Parks Transfer station | 16h10 | 3:30 PM Key West, South Roosevelt Boulevard (Key West International Airport), FL | 2 transfers | |
This is the last bus of the day. | |||||
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Discover the best of Key West, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Key West, FL trip today.
The Ernest Hemingway Home and Museum lets visitors tour the writer's residence, gardens, and rooms tied to his Key West years.
The Key West Butterfly and Nature Conservatory features a glass habitat with butterflies, birds, and tropical plants in a calm setting.
The Key West Museum of Art and History at the Custom House presents island history, art, and rotating exhibitions in a grand landmark building.
Duval Street is Key West's main historic thoroughfare, lined with shops, galleries, and lively architecture across the old town.
Mallory Square is a waterfront plaza known for harbor views, public space, and easy access to the historic seaport district.
Fort Zachary Taylor Historic State Park combines a coastal fort, walking paths, shaded grounds, and one of the island's best natural beaches.
Tangy pie made with Key lime juice, sweetened condensed milk, and a graham cracker crust. It is the island's signature dessert and a classic Florida Keys specialty.
Fresh local pink shrimp, usually simply peeled and chilled or lightly cooked. They are prized in the Keys for their sweet flavor and local waters.
Whole snapper, often yellowtail, seasoned and grilled or baked. It reflects Key West's strong fishing culture and the abundance of fresh local catch.
Polished seafood restaurant focused on Florida fish, oysters, and seasonal ingredients in a refined but approachable dining room.
Beloved casual spot for Cuban coffee, breakfast, sandwiches, and Cuban toast. A dependable choice for everyday local flavors.
Historic seafood house known for pink shrimp, conch dishes, and classic Key lime pie in a lively, casual Old Town setting.
Very pricey versus many US beach towns; hotels, seafood, and drinks run high, while transit is limited and parking can add costs.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and small change at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Key West, FL.
Find answers to the most common questions about traveling from Gainesville, FL to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

Most Gainesville, FL to Key West, FL buses use the Gainesville, NW 23rd St (North Walmart Supercenter) to Key West, South Roosevelt Boulevard (Key West International Airport) station pair. Use this guide to compare Gainesville, FL and Key West, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Gainesville, NW 23rd St (North Walmart Supercenter) is 7 km from Gainesville city centre. Public transport options include:
Gainesville, NW 23rd St (North Walmart Supercenter) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Gainesville, NW 23rd St (North Walmart Supercenter). ATMs are available at Gainesville, NW 23rd St (North Walmart Supercenter).
Ticket office support is available at Gainesville, NW 23rd St (North Walmart Supercenter).
Available at Gainesville, NW 23rd St (North Walmart Supercenter): Parking, Taxis, WC.
Accessibility facilities are available at Gainesville, NW 23rd St (North Walmart Supercenter): Bus stop has basic accessibility features.
Gainesville, Rosa Parks Transfer station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi is available at the station. ATMs are available at Gainesville, Rosa Parks Transfer station.
Ticket office support is available at Gainesville, Rosa Parks Transfer station.
Available at Gainesville, Rosa Parks Transfer station: Parking, Taxis, WC.
Accessibility facilities are available at Gainesville, Rosa Parks Transfer station: The station is wheelchair accessible.
Key West, South Roosevelt Boulevard (Key West International Airport) is 2 km from Key West city centre. Public transport options include:
Key West, South Roosevelt Boulevard (Key West International Airport) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Key West, South Roosevelt Boulevard (Key West International Airport). ATMs are available at Key West, South Roosevelt Boulevard (Key West International Airport).
Ticket office support is available at Key West, South Roosevelt Boulevard (Key West International Airport).
Available at Key West, South Roosevelt Boulevard (Key West International Airport): Parking, Taxis, WC.
Accessibility facilities are available at Key West, South Roosevelt Boulevard (Key West International Airport): The station is wheelchair accessible.
Check bus stations information for Gainesville, FL and Key West, FL, including where buses depart and arrive on this route.
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